劉相國，1979年10月21日，男，回族，巢湖學院數學系，助教
基本介紹
- 中文名：劉相國
- 民族：回族
- 出生日期：1979年10月21日
- 性別：男
教育背景,主講課程,科研項目,發表論文,教學效果,論文,
教育背景
2001.09～2003.07北方民族大學專業：信息與計算科學學習
2003.09～2005.07西安交通大學（保送）專業：信息與計算科學學習
2005.09～2008.04西安理工大學：碩士專業：偏微分方程反問題學習
2008年7月-至今巢湖學院數學系工作
主講課程
高等數學線性代數運籌學基礎常微分方程
科研項目
院級自然科學研究項目­——關於水環境反問題的一些研究（主持）
院級教學研究項目——基於現代信息技術的數學建模在《高等數學》教學上的套用研究（參與）
發表論文
1.劉相國，一類二維變係數橢圓方程數值求解.巢湖學院學報.2008，10(6):19-23.
2. 劉相國, 一類二維穩態對流-擴散方程的有限差分法,《巢湖學院學報》,2009年第6期;
3. 劉相國, “二維泊松方程的交替方向疊代法”,《大理學院學報》，2010年第10期
教學效果
參與我校全國大學生數學建模競賽培訓和指導工作。指導的參賽隊獲安徽賽區三等獎一項。
論文
1. Xu L, Su L, Liu X(通訊作者). PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4- ATF3/CHOP axis in Human Lung Cancer Cells. Mol Cancer Ther. 2012 Jul 30.
2. Jia G, Su L, Singhal S, Liu X(通訊作者).Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging. Mol Cell Biochem. （Review article）
3. Liu G, Su L, Hao X, Zhong N, ZHong D, Singhal S, Liu X(通訊作者). Salermide Upregulates Death Receptor 5 Expression through the ATF4-ATF3-CHOP Axis and Leads to Apoptosis in Human Cancer Cells. J. Cell. Mol. Med. 2012;
4. Su L, Liu G, Hao X, Zhong N, ZHong D, Liu X (通訊作者), Singhal S. Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells. Eur. J. Cancer.
5. Oh YT, Liu X( co-first author), Yue P, Kang S, Chen J, Taunton J, Khuri FR, Sun SY.ERK/RSK signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1. J Biol Chem. 2010
6. Zhong D, Xiong L, Liu T, Liu X, Liu X, Chen J, Sun SY, Khuri FR, Zong Y, Zhou Q, Zhou W. The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R. J Biol Chem. 2009 Aug 28;
7. Liu X, Sun SY. FLICE Inhibitory protein. In: Encyclopedia of Cancer (Second Edition). Springer Berlin Heidelberg. ISBN：978-3-540- 36847-2 (Print) 978-3-540-47648-1 (Online). (Review essay)
8. Lin YD*，Liu X*（co-first author）, Yue P, Khuri FR, Sun SY. Involvement of c-FLIP and survivin downregulation in Flex-Het-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells. Molecular Cancer Ther. 2008.
9. Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, Sun SY. The Proteasome Inhibitor PS-341 (Bortezomib) Up-Regulates DR5 Expression Leading to Induction of Apoptosis and Enhancement of TRAIL-Induced Apoptosis Despite Up-Regulation of c-FLIP and Survivin Expression in Human NSCLC Cells. Cancer Res. 2007
10. Sun SY, Liu X, Zou W, Yue P, Marcus AI, Khuri FR. The farnesyltransferase inhibitor Lonafarnib induce CHOP-dependent expression of death receptor 5 leading to induction of apoptosis in human cancer cells. J Biol Chem.
11. Qiu Y, Liu X, Zou W, Yue P, Lonial S, Khuri FR, Sun SY. The Farnesyl- transferase Inhibitor R115777 Up-regulates the Expression of Death Receptor 5 and Enhances TRAIL-Induced Apoptosis in Human Lung Cancer Cells. Cancer Res. 2007;
12. Chen S, Liu X, Yue P, Schonthal AH, Khuri FR, Sun SY. CHOP-dependent DR5 induction and ubiquitin/proteasome-mediated c-FLIP downregulation contribute to enhancement of TRAIL-induced apoptosis by dimethyl- celecoxib in human non-small cell lung cancer cells. Mol Pharmacol. 2007
13. Zou W, Liu X, Yue P, Khuri FR, Sun SY. PPARgamma Ligands Enhance TRAIL-induced Apoptosis through DR5 Upregulation and c-FLIP Downregulation in Human Lung Cancer Cells. Cancer Biol Ther. 2007;
14. Zou W, Chen S, Liu X, Yue P, Sporn MB., Khuri FR. and Sun SY. c-FLIP Downregulation Contributes to Apoptosis Induction by the Novel Synthetic Triterpenoid Methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO- Me) in Human Lung Cancer Cells. Cancer Biol Ther. 2007;
15. Liu X, Yue P, Schonthal AH, Khuri FR, Sun SY. Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. Cancer Res. 2006;
16. Liu X, Yue P, Khuri FR, Sun SY. Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity. Cancer Res. 2005
17. Jin F*, Liu X*（co-first author）, Zhou Z, Yue P, Lotan R, Khuri FR, Chung LW, Sun SY. Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res. 2005;
18. Chang LJ, Liu X, He J. Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1.Gene Ther.
19. Liu X, Yue P, Zhou Z, Khuri FR, Sun SY. Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004;
20. Liu X, Yue P, Khuri FR, Sun SY. p53 upregulates death receptor 4 expression through an intronic p53 binding site. Cancer Res. 2004
21. Zou W, Liu X, Yue P, Zhou Z, Sporn MB, Lotan R, Khuri FR, Sun SY. c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl- 2-cyano– 3 ,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells. Cancer Res.
2. Jia G, Su L, Singhal S, Liu X(通訊作者).Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging. Mol Cell Biochem. （Review article）
3. Liu G, Su L, Hao X, Zhong N, ZHong D, Singhal S, Liu X(通訊作者). Salermide Upregulates Death Receptor 5 Expression through the ATF4-ATF3-CHOP Axis and Leads to Apoptosis in Human Cancer Cells. J. Cell. Mol. Med. 2012;
4. Su L, Liu G, Hao X, Zhong N, ZHong D, Liu X (通訊作者), Singhal S. Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells. Eur. J. Cancer.
5. Oh YT, Liu X( co-first author), Yue P, Kang S, Chen J, Taunton J, Khuri FR, Sun SY.ERK/RSK signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1. J Biol Chem. 2010
6. Zhong D, Xiong L, Liu T, Liu X, Liu X, Chen J, Sun SY, Khuri FR, Zong Y, Zhou Q, Zhou W. The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R. J Biol Chem. 2009 Aug 28;
7. Liu X, Sun SY. FLICE Inhibitory protein. In: Encyclopedia of Cancer (Second Edition). Springer Berlin Heidelberg. ISBN：978-3-540- 36847-2 (Print) 978-3-540-47648-1 (Online). (Review essay)
8. Lin YD*，Liu X*（co-first author）, Yue P, Khuri FR, Sun SY. Involvement of c-FLIP and survivin downregulation in Flex-Het-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells. Molecular Cancer Ther. 2008.
9. Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, Sun SY. The Proteasome Inhibitor PS-341 (Bortezomib) Up-Regulates DR5 Expression Leading to Induction of Apoptosis and Enhancement of TRAIL-Induced Apoptosis Despite Up-Regulation of c-FLIP and Survivin Expression in Human NSCLC Cells. Cancer Res. 2007
10. Sun SY, Liu X, Zou W, Yue P, Marcus AI, Khuri FR. The farnesyltransferase inhibitor Lonafarnib induce CHOP-dependent expression of death receptor 5 leading to induction of apoptosis in human cancer cells. J Biol Chem.
11. Qiu Y, Liu X, Zou W, Yue P, Lonial S, Khuri FR, Sun SY. The Farnesyl- transferase Inhibitor R115777 Up-regulates the Expression of Death Receptor 5 and Enhances TRAIL-Induced Apoptosis in Human Lung Cancer Cells. Cancer Res. 2007;
12. Chen S, Liu X, Yue P, Schonthal AH, Khuri FR, Sun SY. CHOP-dependent DR5 induction and ubiquitin/proteasome-mediated c-FLIP downregulation contribute to enhancement of TRAIL-induced apoptosis by dimethyl- celecoxib in human non-small cell lung cancer cells. Mol Pharmacol. 2007
13. Zou W, Liu X, Yue P, Khuri FR, Sun SY. PPARgamma Ligands Enhance TRAIL-induced Apoptosis through DR5 Upregulation and c-FLIP Downregulation in Human Lung Cancer Cells. Cancer Biol Ther. 2007;
14. Zou W, Chen S, Liu X, Yue P, Sporn MB., Khuri FR. and Sun SY. c-FLIP Downregulation Contributes to Apoptosis Induction by the Novel Synthetic Triterpenoid Methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO- Me) in Human Lung Cancer Cells. Cancer Biol Ther. 2007;
15. Liu X, Yue P, Schonthal AH, Khuri FR, Sun SY. Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. Cancer Res. 2006;
16. Liu X, Yue P, Khuri FR, Sun SY. Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity. Cancer Res. 2005
17. Jin F*, Liu X*（co-first author）, Zhou Z, Yue P, Lotan R, Khuri FR, Chung LW, Sun SY. Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res. 2005;
18. Chang LJ, Liu X, He J. Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1.Gene Ther.
19. Liu X, Yue P, Zhou Z, Khuri FR, Sun SY. Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004;
20. Liu X, Yue P, Khuri FR, Sun SY. p53 upregulates death receptor 4 expression through an intronic p53 binding site. Cancer Res. 2004
21. Zou W, Liu X, Yue P, Zhou Z, Sporn MB, Lotan R, Khuri FR, Sun SY. c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl- 2-cyano– 3 ,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells. Cancer Res.
