劉琳，女，1980年生於安徽省合肥市，博士，現為安徽大學生命科學學院教授。
基本介紹
- 中文名：劉琳
- 畢業院校：中國科學技術大學
- 學位/學歷：博士
- 專業方向：生命科學
人物經歷,研究方向,研究項目,研究論文,
人物經歷
2010年入選中國科學院“百人計畫”，2011年獲擇優支持。2017年入選安徽省皖江學者特聘教授。2018年入選教育部2017年度“長江學者獎勵計畫”青年長江學者項目。
2001年和2006年在中國科學技術大學獲得學士和博士學位。2006年至2010年在美國國立衛生研究院（NIH）進行博士後訪問研究。現任中科院植物所研究員，擔任“光合作用的生物化學”研究組組長。
研究方向
（1）光合色素代謝的分子基礎；（2）金屬蛋白的結構與功能；（3）蛋白-核酸的相互作用。
研究項目
（1）面上項目31370759 “植物5-氨基乙醯丙酸合成中GluTR及其調控蛋白的結構基礎”；（2）面上項目31670794 “植物葉黃質合成中細胞色素P450酶的結構與機理研究”。
研究論文
2016
Ying Fang, Shun Zhao, Feilong Zhang, Aiguo Zhao, Wenxia Zhang, Min Zhang, Lin Liu. 2016. The Arabidopsis glutamyl-tRNA reductase (GluTR) forms a ternary complex with FLU and GluTR-binding protein. Scientific Reports, 6:19756.
2015
Juan Feng, Shun Zhao, Xuemin Chen, Wenda Wang, Wei Dong, Jinghua Chen, Jian-Ren Shen, Lin Liu. 2015. Tingyun Kuang. Biochemical and structural study of Arabidopsis hexokinase 1. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 71(2): 367-375.
Chen X, Pu H, Fang Y, Wang X, Zhao S, Lin Y, Zhang M, Dai H, Gong W*, Liu L*. 2015. Crystal structure of the catalytic subunit of magnesium chelatase. Nature Plants, 1:15125.
Chen X, Pu H, Wang X, Long W, Lin R, Liu L*. 2015. Crystal structures of GUN4 in complex with porphyrins. Mol Plant., 8:1125-7. (cover)
Zhang M, Zhang F, Fang Y, Chen X, Chen Y, Zhang W, Dai H, Lin R, Liu L*. 2015. The non-canonical tetratricopeptide-repeat (TPR) domain of Fluorescent (FLU) mediates complex formation with glutamyl-tRNA reductase. J Biol Chem., 290:17559-65.
2014
Chen X, Wang X, Feng J, Chen Y, Fang Y, Zhao S, Zhao A, Zhang M, Liu L*. 2014. Structural insights into the catalytic mechanism of Synechocystis magnesium protoporphyrin IX O-methyltransferase (ChlM). J Biol Chem. 289:25690-8.
Zhao A, Fang Y, Chen X, Zhao S, Dong W, Lin Y, Gong W, Liu L*. 2014. Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein. Proc Natl Acad Sci USA. 111:6630-5.
2013
Sun W, Gao F, Fan H, Shan X, Sun R, Liu L*, Gong W*. 2013. The structures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrA proteases. Acta Crystallogr D Biol Crystallogr. 69: 830-7.
2012
Sun R, Fan H, Gao F, Lin Y, Zhang L, Gong W*, Liu L*. 2012. Crystal structure of Arabidopsis deg2 protein reveals an internal PDZ ligand locking the hexameric resting state. J. Biol. Chem. 287: 37564-37569.
2010年以前
Wang Y, Liu L, Davies DR, Segal DM*. 2010. Dimerization of Toll-like receptor 3 (TLR3) is required for ligand binding. J Biol Chem. 285:36836-41.
Botos I, Liu L, Wang Y, Segal DM, Davies DR*. 2009. The Toll-like receptor 3:dsRNA signaling complex. Biochim Biophys Acta. 1789:667-74.
Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, Davies DR*. 2008. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science. 320: 379-81.
Wang M, Liu L, Wang Y, Wei Z, Zhang P, Li Y, Jiang X, Xu H, Gong W*. 2007. Crystal structure of homoserine O-acetyltransferase from Leptospira interrogans. Biochem Biophys Res Commun. 363: 1050-6.
Zhang C, Liu L, Xu H, Wei Z, Wang Y, Lin Y, Gong W*. 2007. Crystal structures of human IPP isomerase: new insights into the catalytic mechanism. J Mol Biol. 366: 1437-46.
Wang Y, Liu L, Wei Z, Cheng Z, Lin Y and Gong W*. 2006. Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase. J Biol Chem. 281:39642-8.
Wang Y, Wei Z, Liu L, Cheng Z, Lin Y, Ji F, Gong W*. 2005. Crystal structure of human B-type phosphoglycerate mutase bound with citrate. Biochem Biophys Res Commun. 331:1207-15.
Tang L, Huang YB, Liu DQ, Li JL, Mao K, Liu L, Cheng ZJ, Gong WM, Hu J, He JH*. 2005. Effects of the silanized mica surface on protein crystallization. Acta Cryst D Biol Crystallogr. 61:53-9.
Wang Y, Cheng Z, Liu L, Wei Z, Wan M, Gong W*. 2004. Cloning, purification, crystallization and preliminary crystallographic analysis of human phosphoglycerate mutase. Acta Cryst D Biol Crystallogr. 60:1893-4.
Liu L, Wei Z, Wang Y, Wan M, Cheng Z, Gong W*. 2004. Crystal structure of human coactosin-like protein. J Mol Biol. 344: 317-23.
Wang Y, Wei Z, Bian Q, Cheng Z, Wan M, Liu L, Gong W*. 2004. Crystal structure of human bisphosphoglycerate mutase. J Biol Chem. 279:39132-8.
Liu L, Wang Y, Zhang P, Cheng Z, Wan M, Zhou Z, Gong W*. 2004. Expression, purification and preliminary crystallographic studies of human coactosin-like protein. Acta Cryst D Biol Crystallogr. 60:1651-3.
