劉朗夏

劉朗夏

劉朗夏，在廣州暨南大學獲得生物學學士學位，在法國巴黎第六和巴黎第七大學相繼取得生物化學學士學位，細胞與分子生物學碩士學位和分子微生物學博士學位(1998年）。1999年至2001年在法國國家健康與醫學研究院進行博士後研究。2001年至2007年間在巴黎血管與血液研究所及法國國家健康與醫學研究院擔任研究員。從2008年7月起被暨南大學聘為教授，博導，為廣東省高校“千百十”人才工程省級培養對象。

基本介紹

  • 中文名：劉朗夏
  • 國籍：中國
  • 職業：教師
  • 畢業院校：狄德羅大學
  • 學位/學歷：博士
  • 專業方向：癌症發病分子機理等
人物經歷,學習經歷,工作經歷,研究方向,主要論文,

人物經歷

學習經歷

學士: 1988,暨南大學
學士: 1992,巴黎第七大學(狄德羅大學)，法國
碩士: 1994,巴黎第六大學(皮埃爾和瑪麗居里大學)，法國
博士: 1998,巴黎第七大學(狄德羅大學)，法國
　　

工作經歷

1999-2001：博士後研究員，法國國立健康與醫學研究院342研究單位
2001-2004：研究員，法國巴黎血管與血液研究所
2004-2007：研究員，法國國立健康與醫學研究院(Cochin研究所)傳染病部
2008至今，教授， 博導，暨南大學生命科學技術學院

研究方向

癌症發病分子機理
細胞信號通路
破骨細胞分化機制
病原微生物致病機理
蛋白質相互作用及功能

主要論文

  1. Liu Xiaohui, Ma Jie, Feng Junxia, Zhang Yunfang*,Liu Langxia*. Regulation and related mechanism of GSN mRNA level by hnRNPK in lung adenocarcinoma cells.Biol. Chem.2018. doi:10.1515/hsz-2018-0417.
  2. Li Zhipeng, Liu Xiaohui*, Ma Jie, Zhang Tingting, Gao Xuejuan,Liu Langxia*. hnRNPK modulates selective quality-control autophagy by downregulating the expression of HDAC6 in 293 cells.Int. J. Oncol.2018, 53:2200-12.
  3. Wang Cuihua, Chen Kezhi, Liao Shengyou, Gu Wei, Lian Xinlei, Zhang Jing, Gao Xuejuan, Liu Xiaohui, Wang Tong, He Qingyu,Zhang Gong,Liu Langxia*. The flightless I protein interacts with RNA-binding proteins and is involved in the genome-wide mRNA post-transcriptional regulation in lung carcinoma cells.Int. J. Oncol.2017, 51:347-61.
  4. Lu Wen-hui, Shi Yu-xun, Ma Zheng-lai, Wang Guang,Liu Langxia, Chuai Manli, Song Xiaoyu, Münsterberg Andrea, Cao Liu, Yang Xuesong. Proper autophagy is indispensable for angiogenesis during chick embryo development.Cell Cycle2016, 15:1742-54.
  5. Gao Xuejuan, Xu Fengmei, Zhang Huan-Tian, Chen Miaojuan, Huang Wensi, Zhang Qihao, Zeng Qingzhong,Liu Langxia*. PKCα–GSK3β–NF-κB signaling pathway and the possible involvement of TRIM21 in TRAIL-induced apoptosis.Biochem. Cell Biol.2016, 94:256-64.
  6. Gao Xuejuan, Feng Junxia, He Yujiao, Xu Fengmei, Fan Xiaoqin, Huang Wensi, Xiong Haiting, Liu Qiuyu, Liu Wanting, Liu Xiaohui,Sun Xuesong, He Qing-Yu, Zhang Qihao*,Liu Langxia*. hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells.Sci. Rep.2016, 6:22999-99.
  7. Fan Xiaoqin, Xiong Haiting, Wei Jinmei, Gao Xuejuan, Feng Yuan, Liu Xiaohui, Zhang Gong, He Qingyu*, Xu Jiake*,Liu Langxia*. Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation.Sci. Rep.2016, 5:17732-32.
  8. Wang Cuihua, Gao Xuejuan, Liao Shengyou, Feng Junxia, Luo Bin,Liu Langxia*. Transcriptome analysis of human breast cancer cell lines MCF-7 and MDA-MB- 435 by RNA-seq.Mol. Biol.2015, 49:244-52.
  9. Gao Xuejuan, Dan Songsong, Xie Yingying, Qin Huanhuan, Tang Donge, Liu Xiaohui, He Qingyu,Liu Langxia*. 14‐3‐3ζReduces DNA Damage by Interacting With and Stabilizing Proliferating Cell Nuclear Antigen.J. Cell. Biochem.2015, 116:158-69.
  10. Fan Xiaoqin, Wei Jinmei, Xiong Haiting, Liu Xiaohui, Benichou Serge, Gao Xuejuan*,Liu Langxia*. A homogeneous time-resolved fluorescence-based high-throughput screening for discovery of inhibitors of Nef-sdAb19 interaction.Int. J. Oncol.2015, 47:1485-93.
  11. Li Nan, Yang Xiao-Yan, Guo Zhong, Zhang Jing, Cao Kun, Han Junlong, Zhang Gong,Liu Langxia, Sun Xuesong, He Qing-Yu. Varied metal-binding properties of lipoprotein PsaA in Streptococcus pneumoniae.JBIC.2014, 19:829-38.
  12. Gao Xue Juan, Feng Jun Xia, Zhu Sen, Liu Xiao Hui, Tardieux Isabelle,Liu Langxia*. Protein Phosphatase 2C of Toxoplasma Gondii Interacts with Human SSRP1 and Negatively Regulates Cell Apoptosis.Biomed. Environ. Sci.2014, 27:883-93.
  13. Gao Xuejuan, He Yujiao, Gao Lingmei, Feng Junxia, Xie Yingying, Liu Xiaohui,Liu Langxia*. Ser9-phosphorylated GSK3β induced by 14-3-3ζ actively antagonizes cell apoptosis in a NF-κB dependent manner.Biochem. Cell Biol.2014, 92:349-56.
  14. Chen Miaojuan, Liu Tengfei, Xu Lina, Gao Xuejuan, Liu Xiaohui, Wang Cuihua, He Qingyu, Zhang Gong,Liu Langxia*. Direct Interaction of 14-3-3ζ with Ezrin Promotes Cell Migration by Regulating the Formation of Membrane Ruffle.J. Mol. Biol.2014, 426:3118-33.
  15. Chen Miaojuan, Gao Xuejuan, Xu Lina, Liu Tengfei, Liu Xiaohui,Liu Langxia*. Ezrin is required for epithelial-mesenchymal transition induced by TGF-β1 in A549 cells.Int. J. Oncol.2014, 45:1515-22.
  16. Gao Xuejuan, Wang Jianying, Gao Lingmei, Yin Xingfeng,Liu Langxia*. Identification and analysis of glycogen synthase kinase 3 beta1 interactome.Cell Biol. Int.2013, 37:768-79.
  17. Yan Guangrong, Xu Songhui, Tan Zilu,Liu Langxia, He Qingyu. Global identification of miR‐373‐regulated genes in breast cancer by quantitative proteomics.Proteomics2011, 11:912-20.
  18. Li Liping, Lu Chunhua, Chen Zhipeng, Ge Feng, Wang Tong, Wang Wei, Xiao ChuanlLe, Yin Xinfeng,Liu Langxia, He Jianxing. Subcellular proteomics revealed the epithelial–mesenchymal transition phenotype in lung cancer.Proteomics2011, 11:429-39.
  19. Lemay Julie, Maidoupeindara Priscilla, Cancio Reynel, Ennifar Eric, Coadou Gael, Maga Giovanni, Rain Jeanchristophe, Benarous Richard,Liu Langxia*. AKAP149 Binds to HIV-1 Reverse Transcriptase and Is Involved in the Reverse Transcription.J. Mol. Biol.2008, 383:783-96.
  20. Lemay Julie, Maidoupeindara Priscilla, Bader Thomas, Ennifar Eric, Rain Jeanchristophe, Benarous Richard,Liu Langxia*. HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells.Retrovirology2008, 5:47-47.
  21. Hainaud Patricia, Contreres Jeanolivier, Villemain Aude,Liu Langxia, Plouet Jean, Tobelem Gerard, Dupuy Evelyne. The Role of the Vascular Endothelial Growth Factor–Delta-like 4 Ligand/Notch4-Ephrin B2 Cascade in Tumor Vessel Remodeling and Endothelial Cell Functions.Cancer Res.2006, 66:8501-10.
  22. Liu Lang Xia, Heveker Nikolaus, Fackler Oliver T, Arold Stefan, Le Gall Sylvie, Janvier Katy, Peterlin B Matija, Dumas Christian, Schwartz Olivier, Benichou Serge. Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions.J. Virol.2000, 74:5310-19.
  23. Selig L, Pages J-C, Tanchou V, Preveral S, Berlioz-Torrent C,Liu Lang Xia, Erdtmann L, Darlix J-L, Benarous R, Benichou S. Interaction with the p6 domain of the gag precursor mediates incorporation into virions of Vpr and Vpx proteins from primate lentiviruses.J. Virol.1999, 73:592-600.
  24. Liu Lang Xia, Janvier Katy, Berteaux-Lecellier Véronique, Cartier Nathalie, Benarous Richard, Aubourg Patrick. Homo-and heterodimerization of peroxisomal ATP-binding cassette half-transporters.J. Biol. Chem.1999, 274:32738-43.
  25. Le Gall Sylvie, Erdtmann Lars, Benichou Serge, Berlioz-Torrent Clarisse,Liu Langxia, Benarous Richard, Heard Jean-Michel, Schwartz Olivier. Nef interacts with the μ subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules.Immunity1998, 8:483-95.
  26. Liu Lang Xia, Margottin Florence, Le Gall Sylvie, Schwartz Olivier, Selig Luc, Benarous Richard, Benichou Serge. Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation.J. Biol. Chem.1997, 272:13779-85.
  27. Benichou S,Liu LangXia, Erdtmann L, Selig L, Benarous R. Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein.Res. Virol.1997, 148:71-73.
  28. Margottin Florence, Benichou Serge, Durand Hervé, Richard Virginie,Liu Lang Xia, Gomas Emmanuel, Benarous Richard. Interaction between the Cytoplasmic Domains of HIV-1 Vpu and CD4: Role of Vpu Residues Involved in CD4 Interaction andin VitroCD4 Degradation.Virology1996, 223:381-86.

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