劉曉東(西湖大學生命科學學院教師)

劉曉東(西湖大學生命科學學院教師)

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劉曉東，2011年畢業於澳大利亞莫納什大學，2019年獲得澳大利亞莫納什大學博士學位，師從Jose Polo教授。現就職於西湖大學生命科學學院。

基本介紹

人物經歷,研究方向,獲獎記錄,代表論文,

人物經歷

2011年獲得澳大利亞莫納什大學理學榮譽學士學位；
2019年獲得澳大利亞莫納什大學博士學位；
2019-2021年在莫納什大學和澳洲再生醫學研究所從事表觀遺傳學和重編程相關博士後研究
2021年開始在英國弗朗西斯·克里克研究所及劍橋大學Kathy Niakan實驗室進行基因編輯與人類胚胎髮育等方向博士後研究。

研究方向

劉曉東實驗室的研究主要以套用單細胞測序和表觀遺傳組學測序等技術揭示了人源體細胞到誘導幹細胞(iPSC)重編程過程中的動態細胞命運調控, 利用誘導重編程捕捉了原始多能幹細胞，滋養層幹細胞等細胞狀態 （Nature Methods, 2017; Nature, 2020），並發現了重編程過程中細胞命運的調控機制和首次構建了人源三維類囊胚結構(Nature 2021)。實驗室將利用前沿交叉學科技術，如單細胞多組學，時空組學，生物信息學分析和算法開發，幹細胞培養和誘導重編程，小鼠，大動物及人胚胎操作，幹細胞和胚胎基因編輯，譜系追蹤，實時成像/雷射片層掃描顯微鏡, 人工智慧，類器官和生物材料工程等進一步了解胚胎和器官發育，誘導重編程，幹細胞命運調控和終端功能細胞分化過程中的細胞命運的調控機制，並將研究成果轉化到在通用型幹細胞療法，器官培養和移植等再生醫學領域的套用。

獲獎記錄

曾獲得Carmela and Carmelo Ridolfo Prize in Stem Cell Research，發現生物醫學研究所優秀博士生畢業論文獎，國際幹細胞大會科學優秀獎，國家優秀自費留學生獎學金等獎項，併入選英國1851研究獎學金展覽皇家委員會和歐洲分子生物學組織 (EMBO) postdoc fellowship。
2023年12月，入選2023達摩院青橙獎名單。

代表論文

1. Xiaodong Liu*, Jia Ping Tan*, Jan Schröder, Asma Aberkane, John F. Ouyang, Monika Mohenska, Sue Mei Lim, Yu B.Y. Sun, Joseph Chen, Guizhi Sun, Yichen Zhou, Daniel Poppe, Ryan Lister, Amander T. Clark, Owen J. L. Rackham, Jennifer Zenker and Jose M. Polo. Modelling human blastocysts by reprogramming fibroblasts into iBlastoids. Nature 591, 627-632 (2021).
-Selected as Cover article
-Featured or highlighted in Nature, Science, The Guardian UK, NBC in US, New Scientist, Washington Post, Financial Times (UK), San Francisco Chronicle, France 24, NPR, El Pais (Spain), Cosmos Magazine, The Telegraph UK, The Spinoff NZ, ABC News in US, WebMD (US), The Scientist (US), Daily Herald (Chicago), NBC South Carolina affiliate, Daily Mail UK, The Independent UK…etc.
2. Xiaodong Liu*, John F. Ouyang*, Fernando J. Rossello*, Jia Ping Tan, Kathryn C. Davidson, Daniela S. Valdes, Jan Schröder, Yu B.Y. Sun, Joseph Chen, Anja S. Knaupp, Guizhi Sun, Hun S. Chy, Ziyi Huang, Jahnvi Pflueger, Jaber Firas, Vincent Tano, Sam Buckberry, Jacob M. Paynter, Michael R. Larcombe, Daniel Poppe, Xin Yi Choo, Carmel M. O’Brien, William A. Pastor, Di Chen, Anna L. Leichter, Haroon Naeem, Pratibha Tripathi, Partha P. Das, Alexandra Grubman, David R. Powell, Andrew L. Laslett, Laurent David, Susan K. Nilsson, Amander T. Clark, Ryan Lister, Christian M. Nefzger, Luciano G. Martelotto, Owen J. L. Rackham and Jose M. Polo. Reprogramming roadmap reveals route to human induced trophoblast stem cells. Nature 586, 101–107 (2020).
-Featured or highlighted in Science, Science Daily, Phys, EurekAlert, Scimex, ANI News, Yahoo, Big News Network, Technology Networks.
3. Xiaodong Liu*, Christian M Nefzger*, Fernando J Rossello, Joseph Chen, Anja S Knaupp, Jaber Firas, Ethan Ford, Jahnvi Pflueger, Jacob M Paynter, Hun S Chy, Carmel M O'Brien, Cheng Huang, Ketan Mishra, Margeaux Hodgson-Garms, Natasha Jansz, Sarah M Williams, Marnie E Blewitt, Susan K Nilsson, Ralf B Schittenhelm, Andrew L Laslett, Ryan Lister and Jose M Polo. Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming. Nature Methods 2017; 14:1055-1062.
4. Jaber Firas*, Xiaodong Liu*, Sue Mei Lim, Jose M. Polo. Transcription factor-mediated reprogramming: epigenetics and therapeutic potential. Immunology & Cell Biology 2015 Mar;93(3):284-9.
5. Jaber Firas*, Xiaodong Liu*, Jose M. Polo.  Epigenetic memory in somatic cell nuclear transfer and induced pluripotency: Evidence and implications. Differentiation 2014 Jul;88(1):29-32.
6. Jaber Firas*, Xiaodong Liu*, Christian M. Nefzger, Jose M. Polo. GM-CSF and MEF-conditioned media support feeder-free reprogramming of mouse granulocytes to iPS cells. Differentiation 2014 Jun;87(5):193-9.
7. Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F. Ouyang, Guizhi Sun, Nathan P. Croft, Fernando J. Rossello, Rebecca Simmons, Sam Buckberry, Dulce Vargas Landin, Jahnvi Pflueger, Teresa H. Vandekolk, Zehra Abay, Yichen Zhou, Xiaodong Liu, Joseph Chen, Michael Larcombe, John M. Haynes, Catriona McLean, Sarah Williams, Siew Yeen Chai, Trevor Wilson, Ryan Lister, Colin W. Pouton, Anthony W. Purcell, Owen J. L. Rackham, Enrico Petretto & Jose M. Polo. Transcriptional signature in microglia associated with Aβ plaque phagocytosis. Nature Communications 12, Article number: 3015 (2021).
8. Anja S Knaupp, Monika Mohenska, Michael R Larcombe, Ethan Ford, Sue Mei Lim, Kayla Wong, Joseph Chen, Jaber Firas, Cheng Huang, Xiaodong Liu, Trung Nguyen, Yu B Y Sun, Melissa L Holmes, Pratibha Tripathi, Jahnvi Pflueger, Fernando J Rossello, Jan Schröder, Kathryn C Davidson, Christian M Nefzger, Partha P Das, Jody J Haigh, Ryan Lister, Ralf B Schittenhelm, Jose M Polo. TINC- A Method to Dissect Regulatory Complexes at Single-Locus Resolution- Reveals an Extensive Protein Complex at the Nanog Promoter. Stem Cell Reports 2020 Dec 8;15(6):1246-1259.
9. Uma S Kamaraj, Joseph Chen, Khairunnisa Katwadi, John F Ouyang, Yu Bo Yang Sun, Yu Ming Lim, Xiaodong Liu, Lusy Handoko, Jose M Polo, Enrico Petretto and Owen J L Rackham. EpiMogrify Models H3K4me3 Data to Identify Signaling Molecules that Improve Cell Fate Control and Maintenance. Cell Systems 2020 Oct 6;S2405-4712(20)30334-3.
10. Janette Tong, Kyung Min Lee, Xiaodong Liu, Christian M Nefzger, Prasidhee Vijayakumar, Ziarih Hawi, Ken C Pang, Clare L Parish, Jose M Polo, Mark A Bellgrove. Generation of four iPSC lines from peripheral blood mononuclear cells (PBMCs) of an Attention Deficit Hyperactivity Disorder (ADHD) individual and a healthy sibling in an Australia-Caucasian family. Stem Cell Research 34, 101353.
11. William A. Pastor, Wanlu Liu, Di Chen, Jamie Ho, Rachel Kim, Timothy Hunt, Anastasia Lukianchikov, Xiaodong Liu, Jose M. Polo, Steven E. Jacobsen and Amander T. Clark.  TFAP2C regulates transcription in human naive pluripotency by opening enhancers. Nature Cell Biology 20, 553–564 (2018).
12. Joseph Chen, Christian M. Nefzger, Fernando J. Rossello, Yu B.Y. Sun, Sue Mei Lim, Xiaodong Liu, Suzan de Boer Anja S. Knaupp, Jinhua Li, Kathryn C. Davidson, Jose M. Polo, Tiziano Barberi. Fine Tuning of Canonical Wnt Stimulation Enhances Differentiation of Pluripotent Stem Cells Independent of β-Catenin-Mediated T-Cell Factor Signaling. Stem Cells 36, 822–833.
13. Christian M. Nefzger, Fernando J. Rossello, Joseph Chen, Xiaodong Liu, Anja S. Knaupp, Jaber Firas, Jacob M. Paynter, Jahnvi Pflueger, Sam Buckberry, Sue Mei Lim, Brenda Williams, Sara Alaei, Keshav Faye-Chauhan, Enrico Petreto, Susan K. Nilsson, Ryan Lister, Mirana Ramialison, David R. Powel, Owen J.L. Rackham and Jose M. Polo. Cell type of origin dictates the route to pluripotency. Cell Reports 2017 Dec 5; 21(10): 2649-2660.
14. Carmel M. O'Brien, Hun S. Chy, Qi Zhou, Shiri Blumenfeld, Jack W. Lambshead, Xiaodong Liu, Joshua Kie, Bianca D. Capaldo, Tung-Liang Chung, Timothy E. Adams, Tram Phan, John D. Bentley, William J. McKinstry, Karen Oliva, Paul J. McMurrick, Yu-Chieh Wang, Fernando J. Rossello, Geoffrey J. Lindeman, Di Chen, Thierry Jarde, Amander T. Clark, Helen E. Abud, Jane E. Visvader, Christian M. Nefzger, Jose M. Polo, Jeanne F. Loring, and Andrew L. Laslett. New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells. Stem Cells. 2017 Mar; 35(3): 626–640.

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