劉文靜，女，博士，雲南大學醫學院副研究員。
基本介紹
- 中文名：劉文靜
- 國籍：中國
- 畢業院校：香港中文大學
- 學位/學歷：博士
- 專業方向：腎臟疾病病理機制
人物經歷,學術成果,代表論文,
人物經歷
2014年畢業於香港中文大學並獲得博士學位。博士期間主要從事腎臟損傷修復機制研究。畢業後繼續在夏銀教授實驗室從事博士後研究。2015年完成博士後課題後應聘至雲南大學醫學院工作。
學術成果
現主要從事腎臟疾病病理機制的研究，主持國家自然科學基金、省基金項目3項，參加國家基金、省級項目3項。
代表論文
(1) Liu WJ, Chen BB, et al. RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism. Proc Natl Acad Sci U S A, 2018, 115: 1475-1484.
(2) Chen F, Hu Q, ......, Liu WJ*. Follistatin-like protein 1 increases transepithelial resistance in kidney epithelial cells through Akt signaling. Mol Med Rep, 2017, 16(4): 4341-4347.
(3) Chen XJ, Liu WJ, et al. Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats., Sci Rep., 2017, 7:41144. doi: 10.1038/srep41144.
(4)Liu WJ，et al. Dragon (repulsive guidance molecule RGMb) inhibits E-cadherin expression and induces apoptosis in renal tubular epithelial cells., J Biol Chem, 2013, 288(44): 31528-31539.
(5) Liu WJ，Ma LQ, et al. Inhibition of hepatic glycogen synthesis by hyperhomocysteinemia mediated by TRB3.，Am J Pathol, 2011, 178(4):1489-1499.
(6) Zou T，Liu WJ，et al. TRB3 mediates homocysteine-induced inhibition of endothelial cell proliferation.，J Cell Physiol，2011，226(11): 2782-2789.
(7) Huang HH ……, Liu WJ, et al. Lethal (3) malignant brain tumor like 2 (L3MBTL2) protein protects against kidney injury by inhibiting the DNA damage-p53-apoptosis pathway in renal tubular cells. Kidney Int, 2017.
(8) Meng CL，Liu WJ，et al. Repulsive Guidance Molecule b (RGMb) Is Dispensable for Normal Gonadal Function in Mice.，Biol Reprod，2016，94（4）: 78.
(9) Zhao YS，……，Liu WJ，et al. IL-1beta inhibits beta-Klotho expression and FGF19 signaling in hepatocytes.，Am J Physiol Endocrinol Metab，2016，310（4）：E289-E300.
(10) Wu XG，……，Liu WJ，et al. HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression.，Blood，2014，124（8）：1335-1343 co-first author, * corresponding author.
