劉嘉，男，華中科技大學免疫學博士，德國杜伊斯堡-埃森大學博士後、助理教授。現為華中科技大學同濟醫學院附屬協和醫院感染科副研究員。
基本介紹
- 中文名：劉嘉
- 國籍：中國
- 民族：漢
- 出生地：湖北省宜昌市
研究方向,主要成就,社會任職,
研究方向
肝臟免疫及抗病毒宙趨項漏免疫應答，特別是對肝炎病毒感染過程中T細胞功能的調抹剃巴控櫻府雄機制進行了深入研究。
主要成就
發表學術論文60餘篇，其中以第一作者和通訊作者身份發刪戰想表在Journal of Hepatology、PLoS Pathogens、Journal of Immunology等國際知名期刊上發表高水平論文20餘篇。主持國家自然科學基金重大研究計畫、國際(地區)合作與交流項目、國家傳染病重大專項子課題及省乘夜射、校、院各級科研項目多項，經費300餘萬元嚷拘背兆。習提近年來參加本領域國際學術會議做口頭報告10餘次。
代表性論著
1. Huang H, Rückborn M, Le-Trilling VTK, ZhuD, Yang S, Zhou W, Yang X, Feng X, Lu Y, Lu M, Dittmer U, Yang D, Trilling M, Liu J. Prophylactic andTherapeutic HBV Vaccination by an HBs-expressing Cytomegalovirus Vector Lackingan Interferon Antagonist in Mice. Eur J Immunol. 2021 Feb;51(2):393-407.
2. YangS, Wang L, Pan W, Bayer W, Thoens C, Heim K, Dittmer U, Timm J, Wang Q, Yu Q,Luo J, Liu Y, Hofmann M, Thimme R, Zhang X, Chen H, Wang H, Feng X, Yang X, LuY, Lu M, Yang D, Liu J. MMP2/MMP9-mediated CD100 shedding iscrucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBVclearance. J Hepatol. 2019 Oct;71(4):685-698.
3. Liu J, Yu Q, Wu W, Huang X, Broering R, Werner M, Roggendorf M, YangD, Lu M. TLR2 Stimulation Strengthens Intrahepatic Myeloid-DerivedCell-Mediated T Cell Tolerance through Inducing Kupffer Cell Expansion andIL-10 Production. Journal of Immunology. 2018 Apr 1;200(7):2341-2351.
4. Wang Q, Pan W, Liu Y,Luo J, Zhu D, Lu Y, Feng X, Yang X, Dittmer U, Lu M, Yang D, Liu J. Hepatitis BVirus-Specific CD8+ T Cells Maintain Functional Exhaustion after AntigenReexposure in an Acute Activation Immune Environment. Front Immunol. 2018 Feb12;9:219.
5. Xu C, Lu Y, Zheng X,Feng X, Yang X, Timm J, Wu J, Wang B, Lu M, Yang D, Liu J. TLR2 Expression in Peripheral CD4+ T Cells PromotesTh17 Response and Is Associated with Disease Aggravation of Hepatitis BVirus-Related Acute-On-Chronic Liver Failure. Front Immunol. 2017 Nov23;8:1609.
6. Wu W, Dietze KK, Gibbert K, Lang KS, Trilling M,Yan H, Wu J, Yang D, Lu M, Roggendorf M, Dittmer U, Liu J. TLR ligand induced IL-6counter-regulates the anti-viral CD8(+) T cell response during an acuteretrovirus infection. Sci Rep. 2015 May 21;5:10501.
7. Liu J, Zhang E, Ma Z, Kosinska A, ZhangX, Möller I, Seiz P, Glebe D, Wang B, Yang D, Lu M, Roggendorf M. EnhancingVirus-Specific Immunity In Vivo by Combining Therapeutic Vaccination and PD-L1Blockade in Chronic Hepadnaviral Infection.PLoS Pathogens. 2014 Jan;10(1):e1003856.
8. Liu J, Jiang M,Ma Z, Zelinskyy G, Dietze K, Dittmer U, Schlaak J, Roggendorf M, Lu M. TLR1/2Ligand–Stimulated Mouse Liver Endothelial Cells Secrete IL-12 and Trigger CD8+T Cell Immunity In Vitro. Journal of Immunology. 2013 Dec15;191(12):6178-90.
9. Liu J,Zheng X, Tong Q, Li W, Wang B, Sutter K, Trilling M, Lu M, Dittmer U, Yang D.Overlapping and discrete aspects of the pathology and pathogenesis of theemerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV. JMed Virol. 2020 May;92(5):491-494.
10. Liu J*, Li S*, LiuJ*, Liang B, Wang X, Wang H, Li W, Tong Q, Yi J, Zhao L, XiongL, Guo C, Tian J, Luo J, Yao J, Pang R, Shen H, Peng C, Liu T, Zhang Q, Wu J,Xu L, Lu S, Wang B, Weng Z, Han C, Zhu H, Zhou R, Zhou H, Chen X, Ye P, Zhu B,Wang L, Zhou W, He S, He Y, Jie S, Wei P, Zhang J, Lu Y, Wang W, Zhang L, Li L,Zhou F, Wang J, Dittmer U, Lu M, Hu Y, Yang D, Zheng X. Longitudinalcharacteristics of lymphocyte responses and cytokine profiles in the peripheralblood of SARS-CoV-2 infected patients. EBioMedicine. 2020 May;55:102763.
11. Xu L*, Liu J*,Lu M, Yang D, Zheng X. Liver injury during highly pathogenic human coronavirusinfections. Liver Int. 2020 Mar;40(5):998-1004.
12. Wang S, Trilling M, Sutter K, Dittmer U, Lu M, Zheng X, Yang D, Liu J. A Crowned Killer'sRésumé: Genome, Structure, Receptors, and Origin of SARS-CoV-2. Virol Sin. 2020Dec;35(6):673-684.
社會任職
現任中華醫學會肝病學分會青年委員；亞太醫學生物免疫學會理事、委員；中國實驗動物學會免疫與細胞治療專業委員會委員；中國研究型醫院病毒腫瘤專業委員會；湖北省醫學會感染病學分會委員；湖北省肝膽疾病學會委員；湖北省免疫學會委員；武漢免疫學會常委、副秘書長；中德病毒感染與免疫研究網（SGVIVI）科研秘書。
5. Xu C, Lu Y, Zheng X,Feng X, Yang X, Timm J, Wu J, Wang B, Lu M, Yang D, Liu J. TLR2 Expression in Peripheral CD4+ T Cells PromotesTh17 Response and Is Associated with Disease Aggravation of Hepatitis BVirus-Related Acute-On-Chronic Liver Failure. Front Immunol. 2017 Nov23;8:1609.
6. Wu W, Dietze KK, Gibbert K, Lang KS, Trilling M,Yan H, Wu J, Yang D, Lu M, Roggendorf M, Dittmer U, Liu J. TLR ligand induced IL-6counter-regulates the anti-viral CD8(+) T cell response during an acuteretrovirus infection. Sci Rep. 2015 May 21;5:10501.
7. Liu J, Zhang E, Ma Z, Kosinska A, ZhangX, Möller I, Seiz P, Glebe D, Wang B, Yang D, Lu M, Roggendorf M. EnhancingVirus-Specific Immunity In Vivo by Combining Therapeutic Vaccination and PD-L1Blockade in Chronic Hepadnaviral Infection.PLoS Pathogens. 2014 Jan;10(1):e1003856.
8. Liu J, Jiang M,Ma Z, Zelinskyy G, Dietze K, Dittmer U, Schlaak J, Roggendorf M, Lu M. TLR1/2Ligand–Stimulated Mouse Liver Endothelial Cells Secrete IL-12 and Trigger CD8+T Cell Immunity In Vitro. Journal of Immunology. 2013 Dec15;191(12):6178-90.
9. Liu J,Zheng X, Tong Q, Li W, Wang B, Sutter K, Trilling M, Lu M, Dittmer U, Yang D.Overlapping and discrete aspects of the pathology and pathogenesis of theemerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV. JMed Virol. 2020 May;92(5):491-494.
10. Liu J*, Li S*, LiuJ*, Liang B, Wang X, Wang H, Li W, Tong Q, Yi J, Zhao L, XiongL, Guo C, Tian J, Luo J, Yao J, Pang R, Shen H, Peng C, Liu T, Zhang Q, Wu J,Xu L, Lu S, Wang B, Weng Z, Han C, Zhu H, Zhou R, Zhou H, Chen X, Ye P, Zhu B,Wang L, Zhou W, He S, He Y, Jie S, Wei P, Zhang J, Lu Y, Wang W, Zhang L, Li L,Zhou F, Wang J, Dittmer U, Lu M, Hu Y, Yang D, Zheng X. Longitudinalcharacteristics of lymphocyte responses and cytokine profiles in the peripheralblood of SARS-CoV-2 infected patients. EBioMedicine. 2020 May;55:102763.
11. Xu L*, Liu J*,Lu M, Yang D, Zheng X. Liver injury during highly pathogenic human coronavirusinfections. Liver Int. 2020 Mar;40(5):998-1004.
12. Wang S, Trilling M, Sutter K, Dittmer U, Lu M, Zheng X, Yang D, Liu J. A Crowned Killer'sRésumé: Genome, Structure, Receptors, and Origin of SARS-CoV-2. Virol Sin. 2020Dec;35(6):673-684.
社會任職
現任中華醫學會肝病學分會青年委員；亞太醫學生物免疫學會理事、委員；中國實驗動物學會免疫與細胞治療專業委員會委員；中國研究型醫院病毒腫瘤專業委員會；湖北省醫學會感染病學分會委員；湖北省肝膽疾病學會委員；湖北省免疫學會委員；武漢免疫學會常委、副秘書長；中德病毒感染與免疫研究網（SGVIVI）科研秘書。
