基本介紹
- 中文名:全大萍
- 畢業院校:武漢理工大學
- 學位/學歷:博士
- 專業方向:複合材料
- 任職院校:中山大學
人物經歷,教育經歷,工作經歷,講授課程,科研方向,學術成果,科研項目,論著一覽,相關成果,
人物經歷
教育經歷
· 1983.07 復旦大學化學系高分子專業,理學學士學位。
· 1998.12 武漢理工大學複合材料專業,工學博士學位。
工作經歷
· 1983.09-1993.10 助教,講師,武漢理工大學
· 1998.11-2000.10 博士後,講師,中山大學化學與化學工程學院
· 2001.11-2009.12 副教授,中山大學化學與化學工程學院
· 2010.01-至今 教授,中山大學化學與化學工程學院
講授課程
本科生:《高分子物理實驗》、《高分子化學實驗》
研究生:《生物醫用高分子》
科研方向
主要從事的學科領域為生物醫用高分子材料與組織工程。
研究興趣包括可吸收功能聚酯的設計與合成、神經組織工程(中樞神經、外周神經)、眼科中基因/藥物的納/微米傳輸。
產業化方向包括:高強度可吸收骨折內固定器件(骨螺釘、克氏針、骨板等)、可吸收高分子植入器械(膜、片、夾等)以及各類二類醫療器械。
在研項目包括:NSFC-廣東聯合基金重點項目、國家自然科學面上基金、廣東省科技計畫重點科技專項等。
學術成果
科研項目
主要學術成績
多年從事可吸收聚乳酸類材料的合成、加工與套用。在神經組織工程研究中,課題組設計構建出具有納米纖維結構的多通道神經導管,並實現了生長因子的溫和固定與零級釋放,這種模仿了天然神經基質結構的神經導管其功能在外周和脊髓損傷修復中得到很好的驗證。課題組在可吸收聚乳酸類材料的結構與性能方面有很好的積累,研發的高強度可吸收內固定器械已經產業化。
論著一覽
2013年
1. Shuo Tang, Jixiang Zhu, Yangbin Xu, Andy Peng Xiang, Mei Hua Jiang,Daping Quan*, “The effects of gradients of nerve growth factor immobilized PCLA scaffolds on neurite outgrowth in vitro and peripheral nerve regeneration in rats”,Biomaterials. 2013, 34: 7086-7096(2012 IF=7.604)
2. Chen-guang Zeng, Yi Xiong, Gaoyi Xie, Peng Dong,Daping Quan*. “Fabrication and evaluation of PLLA multi-channel conduits with nano-fibrous microstructure for the differentiation of NSCs in vitro”,Tissue Engineering Part A. doi:10.1089/ten.TEA.2013.0277. (2012 IF=4.065)
3. Na Qiang, Weihong Yang, Longfei Li, Peng Dong, Jiangxiang Zhu, Tao Wang, Chenguang Zeng,Daping Quan*, “Synthesis of pendent carboxyl-containing poly(ε-caprolactone-co-β-malic acid)-block-poly(l-lactide) copolymers for fabrication of nano-fibrous scaffolds”,Polymer, 2012, 53: 4993-5001(2012 IF=3.379)
4. Zhao Liu, Qiang Zhou, Jixiang Zhu, Jianhui Xiao, Pengxia Wan, Chenjing Zhou, Zheqian Huang, Na Qiang, Wei Zhang, Zheng Wu,Daping Quan**, Zhichong Wang,* “Using genipin-crosslinked acellular porcine corneal stroma for cosmetic corneal lens implants”,Biomaterials, 2012, 33: 7336-7346(2012 IF=7.604)
5. Jixiang Zhu, Yi Xiong, Chenguang Zeng, Na Qiang,Daping Quan*and Jun Wan* “Elastic chitosan conduits with multiple channels and well defined microstructure”.International Journal of Biological Macromolecules. 2012, 51:105-112(2012 IF=2.596)
6. Yan Mingfa, Wang Tao, Qiang Na, Huang Yongkai,Quan Daping*, “Controllable Ring-opening Polymerization of Trimethylene Carbonate Catalyzed by Aliphatic Tertiary Amines in the Presence of Benzyl Alcohol or F127”.Polymer International. 2012, 61: 1525-1531(2012 IF= 2.125)
7. Lihong Duana, Xiaoning Li, Liangqi Ouyang,Daping Quan*, Qiongjuan Zheng, Jian Ma, Qianying Gao, Jian Ge*. “Synthesis of a novel CS-g-MMCs conjugate and the inhabitation on the proliferation of Tenon’s capsule fibroblasts in vitro”,European Journal of Pharmaceutical Sciences. 2012, 46: 357-366(2012 IF=2.987)
8. Yi Xiong, Ji-Xiang Zhu, Zheng-Yu Fang, Cheng-Guang Zeng, Chao Zhang, Guo-Long Qi, Man-Hui Li, Wei Zhang,Da-Ping Quan*, Jun Wan*. “Coseeded Schwann cells myelinate neuritis from differentiated neural stem cells in neurotrophin-3-loaded PLGA carriers”.International Journal of Nanomedicine. 2012:7 1977–1989(2012 IF=3.463)
9. Yan-qing Zhang, Liu-min He, Bin Xing, Xiang Zeng, Chen-guang Zeng, Wei Zhang,Da-ping Quan, Yuan-shan Zeng. “Neurotrophin-3 Gene-Modified Schwann Cells Promote TrkC Gene-Modified Mesenchymal Stem Cells to Differentiate into Neuron-Like Cells in Poly(Lactic-Acid-Co-Glycolic Acid) Multiple-Channel Conduit”.Cells Tissues Organs. 2012, 195, 313-322(2012 IF=1.961)
10. Shuo Tang, Jingjing Zhao, Shuyun Xu, Jingfeng Li, Yu Teng,Daping Quanand Xiaodong Guo. “Bone induction through controlled release of novel BMP-2-related peptide from PTMC11-F127-PTMC11 hydrogels”.Biomed. Mater. 2012, 7, 1-9(2012 IF=2.174)
11. 劉池拽,呂偉明,殷恆諱,曾晨光,全大萍,王文見. 組織工程帶瓣靜脈支架的製備[J].中華醫學雜誌,2012, 15, 92
12. 朱繼翔,全大萍. PCL-b-PLLA嵌段共聚物納米纖維結構支架的製備及體外降解[J].中國科技論文,2012, 6, 447-453,2011
13. Jian-Wei Rao, Liang-Qi Ouyang, Xian-lei Jia,Da-Ping Quan*and Yang-Bin Xu. “The Fabrication and Characterization of 3D Porous Sericin/Fibroin Blended Scaffolds”.Biomedical Engineering: Applications, Basis and Communications, 2011, 23, 1-12(2012 IF=0.233)
14. Jianwei Rao,Daping Quan*, Linmei Peng, Gaoyi Xie and Yangbin Xu. “The Fabrication and Characterization of Linearly Oriented Lamellar-like Multiple-Channel Silk Fibroin Nerve Conduits”.Biomedical Engineering: Applications, Basis and Communications, 2011, 23, 403-417(2012 IF=0.233)
15. Bao-Ling Du, Yi Xiong, Chen-Guang Zeng, Liu-Min He, Wei Zhang,Da-Ping Quan, Jin-Lang Wu, Yan Li, Yuan-Shan Zeng. “Transplantation of artificial neural construct partly improved spinal tissue repair and functional recovery in rats with spinal cord transection”,Brain Research, 2011, 1400, 87- 98(2012 IF=2.879)
16. Chenguang Zeng, Puyi Sheng, Gaoyi Xie, Jixiang Zhu, Peng Dong,Daping Quan*. “Fabrication of PLLA nanofibrous multi-channel conduits for neural tissue engineering”,Journal of Controlled Release, 2011, 152, 234-236(2012 IF=7.633)
17. Lihong Duan, Qiongjuan Zheng, Xiaoning Li,Daping Quan, Jian Ge. “Synthesis and controlled release of mitomycin C from a chitosan-based polymeric prodrug”,Journal of Controlled Release, 2011, 152, 18-20(2012 IF=7.633)
18. 顏明發,王濤,黃永凱,強娜,全大萍**.苄醇存在下脂肪叔胺催化內酯開環聚合[J].高分子學報,2011,11:1231-1236 (2012 IF=0.677)2010
19. Zhen-Yu Lin, Zhi-Xia Duan, Xiao-Dong Guo, Jing-Feng Li, Hong-Wei Lu, Qi-Xin Zheng,Da-Ping Quan, Shu-Hua Yang, “Bone induction by biomimetic PLGA-(PEG-ASP)n copolymer loaded with a novel synthetic BMP-2-related peptide in vitro and in vivo”,Journal of Controlled Release, 2010,144, 190-195(2012 IF=7.633)
20. Liumin He, Susan Liao,Daping Quan, Kun Ma, Casey Chan, S. Ramakrishna, Jiang Lu. “Synergistic effects of electrospun PLLA fiber dimension and pattern on neonatal mouse cerebellum C17.2 stem cells”,Acta Biomaterialia, 2010, 6, 2960-2969(2012 IF=5.093)2009年
21. Liumin He, Bin Liu, Guan Xipeng, Gaoyi Xie, Susan Liao,Daping Quan*, Daozhang Cai, Jiang Lu, S. Ramakrishna. “Microstructure and properties of nano-fibrous PCL-b-PLLA scaffolds for cartilage tissue engineering”,Europe Cells and Materials Journal 2009, 18: 63-74(2012 IF=4.558)
22. Liumin He, Yanqing Zhang, Xiang Zeng,Daping Quan*, Susan Liao, Yuanshan Zeng, Jiang Lu, S. Ramakrishna. “Fabrication and characterization of poly(L-lactic acid) 3D nanofibrous scaffolds with controlled architecture by liquid-liquid phase separation from a ternary polymer-solvent system”,Polymer 2009; 50: 4128-4138(2012 IF=3.379)
23. Liumin He, Susan Liao,Daping Quan*, Michelle Ngiam, Casey Chan, S. Ramakrishna*, Jiang Lu. “The Influence of Laminin-Derived Peptides Conjugated to Lys-Capped PLLA on Neonatal Mouse Cerebellum C17.2 Stem Cells”,Biomaterials 2009; 30(8): 1578-1586(2012 IF=7.604)
24. Xiong Yi, Zeng Yuansan*, Zeng Chenguang, Du Baolin, He Liumin,Quan Dapinget al. “Synaptic transmission of neural stem cells seeded in 3-Dimentional PLGA scaffolds”,Biomaterials2009; 30(22): 3711-3722(2012 IF=7.604)
25. Liumin He, Yanqing Zhang, Chenguang Zeng, MichelleNgiam, Susan Liao3,Daping Quan*, Yuanshan Zeng, Jiang Lu, S. Ramakrishna. “Manufacture of PLGA multiple-channel conduits with precise hierachical pore architectures and in vitro/vivo evaluation for spinal cord injury”,Tissue engineering: part C2009;15(2): 243-255(2012 IF=4.065)2008年
26. Yongheng Duan, Xipeng Guan, Jian Ge*,Daping Quan*, Yehong Zhuo, Hehua Ye, Tingting Shao. “Cationic nano-copolymers mediated IKKβ targeting siRNA inhibit the proliferation of human Tenon’s capsule fibroblasts in vitro”.Molecular Vision, 2008; 14:2616-2628(2012 IF=1.987)
27. Guan Xipeng,Daping Quan*, Liao Kairong et al. “Preparation and Characterization of Cationic Chitosan-modified Poly(D,L-lactide-co-glycolide) Copolymer Nanospheres as DNA Carriers”.Journal of Biomaterials application, 2008, 22(4): 353-372(2012 IF=2.64)2007年
28. Guan Xipeng,Daping Quan*, Shuai Xintao et al. “Chitosan-graft-poly(ϵ -caprolactone)s: An optimized chemical approach leading to controllable structure and enhanced properties”, Journal of polymer science: Part A.Polymer Chemistry, 2007, 45(12): 2556-2568(2012 IF=3.543)2006年
29. Gangbiao Jiang,Daping Quan*, Kairong Liao et al. "Novel polymer micelles prepared from chitosan grafted hydrophobic palmitoyl groups for drug delivery".Mol. Pharm. 2006; 3(2): 152-160(2012 IF=4.57)
30. Saiyun Hou, H Y Zhang,Daping Quan, Xiaolin Liu, Jiakai Zhu, “Tissue-engineered peripheral nerve grafting by differentiated bone marrow stromal cells”,Neuroscience, 2006, 140 (1): 101-110(2012 IF=3.122)
31. Gangbiao Jiang,Daping Quan*, Kairong Liao et al. “Preparation of Polymeric Micelles Based on Chitosan Bearing a Small Amount of Highly Hydrophobic Groups”Carbohydrate Polymers,2006, 66(4): 514-52(2012 IF=3.479)
32. 官習鵬,全大萍,廖凱榮,麥堪成:殼聚糖修飾PLGA陽離子型納米微球的製備與表征,高等學校化學學報,2006,27(10),1965-1968(2012 IF=0.856)
33. 王曉鶯,廖凱榮,全大萍,伍青:醇鐵化合物引發丙交酯開環聚合的研究,高分子學報,2006(2),229-235(2012 IF=0.677)2005年
34. Jie Zao,Daping Quan*, Kairong Liao, Qing Wu. “PLGA-(L-Asp-alt-diol)x-PLGAs with Different Contents of Pendant Amino Groups : Synthesis and Characterization”.Macromolecule bioscience, 2005, 5, 636-643(2012 IF=3.742)
35. Xiaoying Wang, Kairong Liao,Daping Quan, Qing Wu, “The bulk ring-opening polymerization of lactides initiated by ferric alkoxides”.Macromolecule, 2005, 38, 4611-4617(2012 IF=5.521)
36. 趙潔,全大萍,廖凱榮等:含不同側氨基密度的PLGA-(ASP-Diol)-PLGA共聚物合成與表征,高等學校化學學報,2005(8),1552-1555(2012 IF=0.856)
37. 王曉鶯,廖凱榮,全大萍,伍青:乙醯丙酮鐵催化丙交酯開環聚合的研究,高分子學報,2005(1),113-118(2012 IF=0.677)
38. 羅丙紅,全大萍,廖凱榮等:側鏈含氨基的PLGA-(PEG-ASP)n共聚物的合成與表征,高分子學報,2005(3),327-332(2012 IF=0.677)2003-2004年
39.全大萍,廖凱榮,趙劍豪:物理老化對聚乳酸玻璃化轉變行為的影響,高分子學報,2004(5),726-730(2012 IF=0.677)
40. 羅丙紅,廖凱榮,全大萍:丙交酯-乙交酯共聚中的酯交換及共聚物結構和性質研究,高分子學報,2003(6),803-808(2012 IF=0.677)
41. Kairong Liao,Daping Quan, Zejian Lu,“Effects of physical aging on glass transition behavior of poly (DL-lactide)”.European Polymer Journal. 2002, 38:157-162(2012 IF=2.562)
42. 廖凱榮,全大萍,高建文等:聚(L-丙交酯)/聚(DL-丙交酯)的結晶性能及相容性,高分子學報,2002(4),137-141(2012 IF=0.677)
相關成果
1. 具有多級孔結構的納米纖維管狀支架(專利號:ZL 2010 1 0171672.0)(已授權)
2. 用於製備組織工程管狀支架的專用模具(專利號: CN201020188774.9)(已授權)
3. 製備具有各向異性孔結構的組織工程支架的方法和設備(專利號:ZL 2010 1 0501999.X)(已授權)
4. 具有多級孔結構的組織工程管狀支架的製作方法及模具(專利號:ZL 2010 1 0171659.5)(已授權)
5. 一種在生物醫用材料表面負載活性分子的方法(專利號:201110189686.X)
6. 一種細胞外基質的改性方法(專利號:201110189675.1)
7. 可原位增強溫敏聚合物與可降解的原位增強可注射溫敏水凝膠的合成方法(專利號:201110386870.3)
8. 一種聚(L-乳酸)材料的鍛壓工藝及模具(專利號:ZL 200510121002)(已授權)