侯 勇,男,博士,西南大學教授,博士生導師。2007年畢業於西南大學蠶學與系統生物學研究所,獲理學博士學位。成功利用蛋白質組學等手段對家蠶發育時期血液等進行分析,並對變態發育時期關鍵蛋白質進行研究;2010年10月至2011年11月赴新加坡國立大學結構生物學實驗室從事結構生物學研究,解析家蠶arylphorin 型貯藏蛋白、BmNPV P33、BmNPV ORF75、Sumo12等蛋白結構,回國以後從事病毒蛋白結構解析及病毒與宿主的互作研究,建立桿狀病毒與宿主互作研究小組,包括博士研究生1人,碩士研究生6人。主持國家自然科學基金面上項目、國家自然科學基金青年項目重慶市自然科學基金、教育部中央高校重點項目、菸草重大專項(子課題)等項目10餘項,先後在Proteomics、Protein Science、Journal of General Virology、Insect Biochemistry and Molecular Biology、International Journal of Molecular Sciences、Biochemical and Biophysical Research Communications、Bioscience Biotechnology and Biochemistry、Insect Science、 Proteome Science、DNA Sequence、中國農業科學、生物工程學報、蠶業科學等雜誌發表論文30餘篇。
基本介紹
- 中文名:侯勇
- 國籍:中國
- 職業:教師
- 職稱:教授
- 學位:博士
- 性別:男
人物經歷,研究方向,主要貢獻,
人物經歷
1998-2002, 河北農業大學本科生;
2007-2016,西南詢拜多大學副教授;
2007-2016,西南大學教授,博士生導師
研究方向
主要科研領域與方向:
1. 利求兆院煮用蛋白拘墓達質組等技術方法,尋晚駝找家蠶絲合成、變態發育等重要蛋白質。
2. 利用結構生物學的定斷希研究方法,研究家蠶NPV與家蠶互做機制狼端兆背。
主要貢獻
代表性論文:
Yang H, Li J, Liu Q, Zhang Z, Gong J, Hou Y*. Purification and characterization of two cysteine proteinase inhibitors from silkworm, Bombyx mori. Biochem Biophys Res Commun. 2018. pii: S0006-291X(18)31784-4. doi:
Tian S, Zhang Z, Zhang R, Liu Q, Xu S, Gong J, Hou Y*. Analysis of cysteine protease inhibitor gene (BmCPI) promoter activity in silkworms using bac-to-bac baculovirus systems. Biosci Biotechnol Biochem. 2018, 82(9):1488-1496. doi:doi: 10.1080/09168451.
Li ZL, Tian S, Yang H, Zhou X, Xu SP, Zhang ZY, Gong J,Hou Y*, Xia QY. Genome-wide identification of chitin-binding proteins and characterization of BmCBP1 in the silkworm, Bombyx mori. Insect Sci. 2017 . doi: 10.1111/1744-7917.
Hou Y, Zhang Y, Gong J, Tian S, Li J, Dong Z, Guo C, Peng L, Zhao P, Xia Q. Comparative proteomics analysis of silkworm hemolymph during the stages of metamorphosis via liquid chromatography and mass spectrometry. Proteomics. 2016, 16(9):1421-31.
Gong J, Tian S, Zhou X, Yang H, Zhu Y*, Hou Y*. Transcriptional Response of Silkworm (Bombyx mori) Eggs to O2祝試滲 or HCl Treatment. Int J Mol Sci. 2016, 17(12), pii: E1838.
Hou Y,Li J, Li Y, Dong Z, Xia Q, Yuan YA. Crystal structure of Bombyx mori arylphorins reveals a 3:3 heterohexamer with multiple papain cleavage sites. Protein Sci. 2014, 23(6):735-46.
Hou Y, Xia Q, Yuan YA. Crystal structure of Bombyx mori nucleopolyhedrovirus ORF75 reveals a pseudo-dimer of thiol oxidase domains with a putative substrate-binding pocket. J Gen Virol. 2012,93:2142-51
Yong Hou, Yong Zou, Fei Wang, Jing Gong, Xiaowu Zhong, Qingyou Xia, Ping Zhao .Comparative analysis of proteome maps of silkworm hemolymph during different developmental stages.Proteome Science, 2010, 8:45
Hou Y, Xia Q , Zhao P, Zou Y, Liu H, Guan J, Gong J, Xiang Z. Studies on middle silk gland and posteriorsilk gland of silkworm (Bombyx mori) using two-dimensional electrophoresis and mass spectrometry. Insect Biochemistry and Molecular Biology 2007,37:486-496
Li Y, Wang X,Hou Y,Zhou X, Chen Q, Guo C, Xia Q, Zhang Y, Zhao P. Integrative Proteomics and Metabolomics Analysis of Insect Larva Brain: Novel Insights into the Molecular Mechanism of Insect Wandering Behavior. J Proteome Res. 2016, 4, 15(1):193-204.
Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha X, Cheng T, Chai C, Pan G, Xu J, Liu C, Lin Y, Qian J,Hou Y, et al. A draft sequence for the genome of the domesticated silkworm(Bombyx mori). 2004, Science 306:1937-1940
Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha X, Cheng T, Chai C, Pan G, Xu J, Liu C, Lin Y, Qian J,Hou Y, Wu Z, Li G, Pan M, Li C, Shen Y, Lan X, Yuan L, Li T, Xu H, Yang G, Wan Y, Zhu Y, Yu M, Shen W, Wu D, Xiang Z, Yu J, Wang J, Li R, Shi J, Li H, Li G, Su J, Wang X, Li G, Zhang Z, Wu Q, Li J, Zhang Q, Wei N, Xu J, Sun H, Dong L, Liu D, Zhao S, Zhao X, Meng Q, Lan F, Huang X, Li Y, Fang L, Li C, Li D, Sun Y, Zhang Z, Yang Z, Huang Y, Xi Y, Qi Q, He D, Huang H, Zhang X, Wang Z, Li W, Cao Y, Yu Y, Yu H, Li J, Ye J, Chen H, Zhou Y, Liu B, Wang J, Ye J, Ji H, Li S, Ni P, Zhang J, Zhang Y, Zheng H, Mao B, Wang W, Ye C, Li S, Wang J, Wong GK, Yang H; Biology Analysis Group. A draft sequence for the genome of the domesticated silkworm(Bombyx mori).2004, Science 306:1937-1940.
李懿,周小英,黎治浪,李建偉,陳世達,郭超,侯勇*,趙萍.家蠶組織蛋白酶基因家族的鑑定及表達特徵分析, 生物工程學報,2016, 32(1), 1-13.
李建偉,李懿,周小英,黎治浪,陳世達,田莎,侯勇*,夏慶友。家蠶半胱氨酸蛋白酶抑制劑BmCPI40鑑定及時空表達特徵,中國農業科學,2015,48(13):2645-2655
李建偉,王阿蓉,李懿,黎治浪,龔競,侯勇*,夏慶友。家蠶芳基貯藏蛋白新成員BmSP3的基因克隆與表達分析,蠶業科學,2014,40(4),613-619。
侯勇,楊歡,李建偉,龔競,周霞,田莎,郭超,夏慶友。家蠶半胱氨酸蛋白酶抑制劑基因 (bcpi) 的克隆與表達分析,2016, 4(12),1915-1924。
侯勇,楊歡,周霞,陳世達,楊歡,趙萍,夏慶友。家蠶蛻皮液蛋白質雙向電泳及質譜分析,生物工程學報 2017, 33 (1) :99-110
侯勇,官建,趙萍,劉鴻麗,鄒勇,夏慶友。家蠶中腸蛋白質組學研究.蠶業科學2007,33(2):216-222
侯勇,趙萍,劉鴻麗,鄒勇,官建,夏慶友。家蠶脂肪體蛋白質組學研究。生物工程學報,2007,23(5):867-872.
侯勇,趙萍,鄒勇,鐘曉武,夏慶友。家蠶5齡第3天血液蛋白雙向電泳及質譜分析。蠶業科學,2008,34(4),670-675.
劉鴻麗,夏慶友,侯勇,趙萍,鄒勇,官建。家蠶絲腺蛋白質組學研究方法的建立.生物工程學報,2007,23,112~116.
林英,趙萍,侯勇,李娟,龔達平,孫全,夏慶友,向仲懷.家蠶卵黃原蛋白及其受體基因。動物學報2005, 51(1):117-125.
官建,趙萍,侯勇,劉鴻麗,鄒勇,夏慶友.家蠶體液低分子蛋白Apolipophorin Ⅲ 的質譜鑑定及表達分析,動物學報. 2008, 54(1): 122-127
Li ZL, Tian S, Yang H, Zhou X, Xu SP, Zhang ZY, Gong J,Hou Y*, Xia QY. Genome-wide identification of chitin-binding proteins and characterization of BmCBP1 in the silkworm, Bombyx mori. Insect Sci. 2017 . doi: 10.1111/1744-7917.
Hou Y, Zhang Y, Gong J, Tian S, Li J, Dong Z, Guo C, Peng L, Zhao P, Xia Q. Comparative proteomics analysis of silkworm hemolymph during the stages of metamorphosis via liquid chromatography and mass spectrometry. Proteomics. 2016, 16(9):1421-31.
Gong J, Tian S, Zhou X, Yang H, Zhu Y*, Hou Y*. Transcriptional Response of Silkworm (Bombyx mori) Eggs to O2 or HCl Treatment. Int J Mol Sci. 2016, 17(12), pii: E1838.
Hou Y,Li J, Li Y, Dong Z, Xia Q, Yuan YA. Crystal structure of Bombyx mori arylphorins reveals a 3:3 heterohexamer with multiple papain cleavage sites. Protein Sci. 2014, 23(6):735-46.
Hou Y, Xia Q, Yuan YA. Crystal structure of Bombyx mori nucleopolyhedrovirus ORF75 reveals a pseudo-dimer of thiol oxidase domains with a putative substrate-binding pocket. J Gen Virol. 2012,93:2142-51
Yong Hou, Yong Zou, Fei Wang, Jing Gong, Xiaowu Zhong, Qingyou Xia, Ping Zhao .Comparative analysis of proteome maps of silkworm hemolymph during different developmental stages.Proteome Science, 2010, 8:45
Hou Y, Xia Q , Zhao P, Zou Y, Liu H, Guan J, Gong J, Xiang Z. Studies on middle silk gland and posteriorsilk gland of silkworm (Bombyx mori) using two-dimensional electrophoresis and mass spectrometry. Insect Biochemistry and Molecular Biology 2007,37:486-496
Li Y, Wang X,Hou Y,Zhou X, Chen Q, Guo C, Xia Q, Zhang Y, Zhao P. Integrative Proteomics and Metabolomics Analysis of Insect Larva Brain: Novel Insights into the Molecular Mechanism of Insect Wandering Behavior. J Proteome Res. 2016, 4, 15(1):193-204.
Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha X, Cheng T, Chai C, Pan G, Xu J, Liu C, Lin Y, Qian J,Hou Y, et al. A draft sequence for the genome of the domesticated silkworm(Bombyx mori). 2004, Science 306:1937-1940
Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha X, Cheng T, Chai C, Pan G, Xu J, Liu C, Lin Y, Qian J,Hou Y, Wu Z, Li G, Pan M, Li C, Shen Y, Lan X, Yuan L, Li T, Xu H, Yang G, Wan Y, Zhu Y, Yu M, Shen W, Wu D, Xiang Z, Yu J, Wang J, Li R, Shi J, Li H, Li G, Su J, Wang X, Li G, Zhang Z, Wu Q, Li J, Zhang Q, Wei N, Xu J, Sun H, Dong L, Liu D, Zhao S, Zhao X, Meng Q, Lan F, Huang X, Li Y, Fang L, Li C, Li D, Sun Y, Zhang Z, Yang Z, Huang Y, Xi Y, Qi Q, He D, Huang H, Zhang X, Wang Z, Li W, Cao Y, Yu Y, Yu H, Li J, Ye J, Chen H, Zhou Y, Liu B, Wang J, Ye J, Ji H, Li S, Ni P, Zhang J, Zhang Y, Zheng H, Mao B, Wang W, Ye C, Li S, Wang J, Wong GK, Yang H; Biology Analysis Group. A draft sequence for the genome of the domesticated silkworm(Bombyx mori).2004, Science 306:1937-1940.
李懿,周小英,黎治浪,李建偉,陳世達,郭超,侯勇*,趙萍.家蠶組織蛋白酶基因家族的鑑定及表達特徵分析, 生物工程學報,2016, 32(1), 1-13.
李建偉,李懿,周小英,黎治浪,陳世達,田莎,侯勇*,夏慶友。家蠶半胱氨酸蛋白酶抑制劑BmCPI40鑑定及時空表達特徵,中國農業科學,2015,48(13):2645-2655
李建偉,王阿蓉,李懿,黎治浪,龔競,侯勇*,夏慶友。家蠶芳基貯藏蛋白新成員BmSP3的基因克隆與表達分析,蠶業科學,2014,40(4),613-619。
侯勇,楊歡,李建偉,龔競,周霞,田莎,郭超,夏慶友。家蠶半胱氨酸蛋白酶抑制劑基因 (bcpi) 的克隆與表達分析,2016, 4(12),1915-1924。
侯勇,楊歡,周霞,陳世達,楊歡,趙萍,夏慶友。家蠶蛻皮液蛋白質雙向電泳及質譜分析,生物工程學報 2017, 33 (1) :99-110
侯勇,官建,趙萍,劉鴻麗,鄒勇,夏慶友。家蠶中腸蛋白質組學研究.蠶業科學2007,33(2):216-222
侯勇,趙萍,劉鴻麗,鄒勇,官建,夏慶友。家蠶脂肪體蛋白質組學研究。生物工程學報,2007,23(5):867-872.
侯勇,趙萍,鄒勇,鐘曉武,夏慶友。家蠶5齡第3天血液蛋白雙向電泳及質譜分析。蠶業科學,2008,34(4),670-675.
劉鴻麗,夏慶友,侯勇,趙萍,鄒勇,官建。家蠶絲腺蛋白質組學研究方法的建立.生物工程學報,2007,23,112~116.
林英,趙萍,侯勇,李娟,龔達平,孫全,夏慶友,向仲懷.家蠶卵黃原蛋白及其受體基因。動物學報2005, 51(1):117-125.
官建,趙萍,侯勇,劉鴻麗,鄒勇,夏慶友.家蠶體液低分子蛋白Apolipophorin Ⅲ 的質譜鑑定及表達分析,動物學報. 2008, 54(1): 122-127