來濱，神經生物學博士，復旦大學上海醫學院醫學神經生物學國家重點實驗室講師。
基本介紹
- 中文名：來濱
- 職業：教師
- 學位/學歷：博士
- 專業方向：神經生物學
- 就職院校：復旦大學上海醫學院醫學神經生物學國家重點實驗室
個人經歷,研究方向,主講課程,學術成果,
個人經歷
2001-2004：復旦大學醫學神經生物學國家重點實驗室 博士研究生，講師；
2006.2- 2007.5：美國 Buck institute for age research博士後研究。
先後參與國家級課題3項，973項目二項；主持國家自然科學基金青年基金一項，復旦大學青年教師基金一項。
研究方向
1、長期使用阿片類物質對中腦腹側被蓋區-伏隔核多巴胺能神經元電活動和輸入信號的功能重塑作用及分子機制；
2、急、慢性嗎啡處理動物中前額葉皮層-中腦腹側被蓋區等腦區電活動及其功能偶聯，探討這些變化與動物行為學的關係;探討參與調控中腦腹側被蓋區部位多巴胺神經元功能環路重建中有關神經遞質的作用;研究這些神經遞質參與中腦腹側被蓋區多巴胺功能調控中的作用機制。
主講課程
教學上先後承擔主講8年制本科《神經生物學課程》神經元形態和電學特性部分；主講研究生《神經生物學》神經元形態和離子通道部分；主講研究生《神經生物學實驗課程》電生理和雷射掃描共聚焦顯微鏡部分和研究生《生物圖象處理和分析技術課程》雷射共聚焦掃描共聚焦顯微鏡部分。
學術成果
參編書籍1部，發表論文SCI論文9篇。
1.BinLai*, Ping Zheng. The influence of mitochondrial complex inhibition on neuronal ion channel and neurotransmitter release, Acta Physiologica Sinica,64(6), 713–720,2012
2.BinLai,Xiao Ou Mao, Lin Xie, Su-Youne Chang, Zhi-Gang Xiong, Kunlin Jin, David A. Greenberg*. Electrophysiological properties of subventricular zone cells in adult mouse brain, Brain research,1340,96-105,2010
3.BinLai, Li Zhang, Lian-Yan Dong, Yan-Hua Zhu, Feng-Yan Sun, Ping Zheng,* Inhibition of Qi site of mitochondrial complex III with antimycin A decreases persistent and transient sodium currents via reactive oxygen species and protein kinase C in rat hippocampal CA1 cells. Experimental Neurology 194 (2005) 484 – 494
4.BinLai, Xiao Ou Mao, David A. Greenberg and Kunlin Jin.Endothelium-induced Proliferation and Electrophysiological Differentiation of Human Embryonic Stem Cell-derived Neural precursors. Stem cells and development 2008,17:565-572
5.BinLai,Li Zhang , Lian-Yan Dong, Yan-Hua Zhu, Feng-Yan Sun, and PingZheng. Impact of inhibition of Qo site of mitochondrial complex III withmyxothiazol on persistent sodium currents via superoxide and proteinkinase C in rat hippocampal CA1 cells. Neurobiology of Disease 2006 Jan;21(1):206-16.
6.BinLai,LinXie, XiaoOu Mao, Kunlin Jin and David A. Greenberg. Electrophysiological Properties of Cells in the Subventricular Zone and their Links to Morphological Phenotypes in Adult Mouse Brain. Neuroscience letter 442 (2008) 305–308
7. Pei-Ying Wu,Bin Lai, Yi Dong, Ze-Min Wang, Zi-Cheng Li, Ping Zheng*. Different oxidants and PKC isozymes mediate the opposite effect of inhibition of Qi and Qo site of mitochondrial complex III on calcium currents in rat cortical neurons,BBA -MOL CELL RES, 1803,1072–1082,2010
8. Kunlin Jin, XiaoOu Mao, Lin Xie, Veronica Galvan,Bin Lai,Yaoming Wang, Olivia Gorostiza, Xiaomei Wang and David A Greenberg*. Transplantation of human neural precursor cells in Matrigel scaffolding improves outcome from focal cerebral ischemia after delayed postischemic treatment in rats, Journal of Cerebral Blood Flow & Metabolism, 30, 534–544,2010
9. Zicheng Li, Wenjie Luan,Yang Chen,Ming Chen,Yi Dong,Bin Lai, Lan Ma, PingZheng*. Chronic Morphine Treatment Switches the Effect of Dopamine on Excitatory Synaptic Transmission from Inhibition to Excitation in Pyramidal Cells of the Basolateral Amygdala ,The Journal of Neuroscience , 31(48),17527-17536,2011
