何華偉

何華偉：博士，西南大學生物技術學院教授，入選重慶市第三批“百名海外高層次人才集聚計畫”。

簡歷：
2011.5- 西南大學生物技術學院，家蠶基因組生物學國家重點實驗室 重慶，中國
教授，入選重慶市第三批“百名海外高層次人才集聚計畫”
2008.1-2011.4 德克薩斯州州立大學西南醫學中心（達拉斯）藥理系和生物化學系，美國
博士後，研究方向：信號傳導，生物物理學，生物化學與分子生物學
2002.9-2008.7 清華大學生物科學與技術系，北京，中國
博士，專業：生物化學與分子生物學
1998.9-2002.7 北京林業大學生命科學學院，北京，中國
學士，專業：生物學

　　主要科研領域與方向:

研究方向：家蠶發育生物學，家蠶發育過程中的信號傳導及調控
代表性論文：
  1. Yuxiao Wang*, Huawei He*, Nishi Srivastava, Sheikh Vikarunnessa, Yong-bin Chen, Jing Jiang, Christopher W. Cowan & Xuewu Zhang. Plexins are GTPase Activating Proteins for Rap and are Activated by Induced Dimerization. Science Signaling. 2011 5(207): ra6 (Available online on 17 January 2012) (*, co-first author).
  2. Yejing Wang, Huawei He, Sen Li. Effect of Ficoll 70 on Thermal Stability and Structure of Creatine Kinase. Biochemistry (Moscow). 2010 75(5):648-54.
  3. Huawei He, Taehong Yang, Jonathan R. Terman & Xuewu Zhang. Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration. Proc. Natl. Acad. Sci. U.S.A. 2009 106(37):15610-5.
  4. Zhu Jiang, He Hua-Wei, Li Sen. Macromolecular crowding enhances thermal stability of rabbit muscle creatine kinase. Tsinghua Science and Technology. 2008 13(4):454-9.
  5. He Hua-Wei*, Feng Shan*, Pang Min, Zhou Hai-Meng, Yan Yong-Bin. Role of the linker between the N- and C-terminal domains in the stability and folding of rabbit muscle creatine kinase. Int. J. Biochem. Cell Biol. 2007 39(10):1816-27 (*, co-first author).
  6. He Hua-Wei*, Li Jie*, Zhao Tong-Jin, Ma Yong, Shi Feng, Zhou Hai-Meng. Exploration of the polar microenvironment around the reactive cysteine in rabbit muscle creatine kinase. Int. J. Biol. Macromol. 2007 41(4):361-8 (*, co-first author).
  7. Shi Feng*, Zhao Tong-Jin*, He Hua-Wei, Li Jie, Zeng Xian-Gang, Zhou Hai-Meng, Wu Ping. Sodium barbital is a slow reversible inactivator of rabbit-muscle creatine kinase. Biochem. Cell Biol. 2006 84(2):142-7 (*, co-first author).
  8. Zhang Jun, He Hua-Wei, Wang Qi, Yan Yong-Bin. Sequential events in ribonuclease A thermal unfolding characterized by two-dimensional infrared correlation spectroscopy. Protein Pept. Lett. 2006 13(1):33-40.
  9. Yan Yong-Bin, Zhang Jun, He Hua-Wei, Zhou Hai-Meng. Oligomerization and aggregation of bovine pancreatic ribonuclease A: characteristic events observed by FTIR spectroscopy. Biophys. J. 2006 90(7):2525-33.
  10. He Hua-Wei, Zhang Jun, Zhou Hai-Meng, Yan Yong-Bin. Conformational change in the C-terminal domain is responsible for the initiation of creatine kinase thermal aggregation. Biophys. J. 2005 89(4):2650-8.
  11. Meng Fan-Guo*, Hong Yuan-Kai*, He Hua-Wei, Lyubarev A. E., Kurganov B. I., Yan Yong-Bin, Zhou Hai-Meng. Osmophobic effect of glycerol on irreversible thermal denaturation of rabbit creatine kinase. Biophys. J. 2004 87(4):2247-54 (*, co-first author).
  12. Yan Yong-Bin, Wang Qi, He Hua-Wei, Zhou Hai-Meng. Protein thermal aggregation involves distinct regions: sequential events in the heat-induced unfolding and aggregation of hemoglobin. Biophys. J. 2004 86(3):1682-90.
  13. Yan Yong-Bin*, Wang Qi*, He Hua-Wei, Hu Xin-Yao, Zhang Ri-Qing, Zhou Hai-Meng. Two-dimensional infrared correlation spectroscopy study of sequential events in the heat-induced unfolding and aggregation process of myoglobin. Biophys. J. 2003 85(3):1959-67 (*, co-first author).

　　

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