何歡(南昌大學藥學院專任教師、副教授)

何歡，女，回族，江西南昌人，南昌大學藥學院專任教師、副教授，碩士生導師，南昌大學“215工程”贛江青年學者。

基本介紹

• 中文名：何歡
• 國籍：中國
• 民族：回族
• 出生地：江西南昌

人物經歷

2005.9~2008.7： 南昌大學，臨床醫學專業，專科學歷

2008.9~2010.7： 贛南醫學院，臨床醫學專業，醫學學士

2010.9~2016.7：南昌大學，內科學，臨床醫學博士（碩博連續）

2012.11~2015.5： 美國波士頓大學，交流訪問

2023.9~2023.12： 英國倫敦瑪麗女王大學，交流訪問

2016．9~ 南昌大學藥學院藥理教研室教師

研究方向

心血管藥理、心肌損傷保護、線粒體功能障礙；

主要成就

主持並完成國家自然科學基金青年基金項目，主持在研國家自然科學基金地區基金項目1項；作為主要人員參加國家自然科學基金項目多項；主持完成江西省青年科學基金項目、江西省科技廳套用研究培育計畫各一項。在國內外著名學術期刊發表論文36 篇（其中SCI 收錄雜誌31篇；通訊作者16 篇，第一作者15 篇），獲中國專利一項。

獲獎記錄

2018年南昌大學“215工程”贛江青年學者

2019年南昌大學第六屆教師授課競賽一等獎

2023年贛鄱俊才支持計畫-青年人才

社會任職

中國藥理學會心血管藥理專業委員會青年委員

中國藥理學會化療專業委員會青年委員

中國藥理學會教學與科普專業委員會青年委員

《中國臨床藥理學與治療學》青年編委

國家自然科學基金通訊評審專家

科研課題

[1] 何歡，國家自然科學青年基金項目， HSF5/HSPB7 和14-3-3η互動作用與心肌損傷保護，№: 81803534，21.5萬元，2019.1~2021.12

[2] 何歡，國家自然科學地區基金項目， ADMA/DDAHⅡ/eNOS/NO 介導的阿黴素內皮毒性與鐵死亡及葛根素干預機制， №:82160685，34萬元，2022.1~2025.12

[3] 何歡，贛鄱俊才支持計畫-主要學科學術和技術帶頭人培養項目--青年人才， AMPKα1線粒體定位對順鉑腎毒性損傷影響及其EGCG干預， 20232BCJ23041，30萬元，2024.1~2026.12

[4] 何歡，江西省省級科技計畫——“套用研究培育計畫”,葛根素保護線粒體功能對抗鐵過載誘發血管內皮細胞損傷， №：20181BBG78059，6萬元，2018.1~2020.12

[5] 何歡，江西省自然科學基金青年項目，14-3-3η/HSF5/HSPS信號通路在心肌細胞急性缺氧/復氧損傷及其保護中的作用，№：20171BAB215077，6萬元，2017.7~2020.6

代表論文

[1] He H#, Wang L, Qiao Y, Yang B, Yin D, He M. Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy. Redox Biol. 2021 Nov 11;48:102185.

[2] Qiao Y, Wang L, Hu T, Yin D, He H*, He M. Capsaicin protects cardiomyocytes against lipopolysaccharide-induced damage via 14-3-3γ-mediated autophagy augmentation. Front Pharmacol. 2021 Apr 27;12:659015.

[3] He H#, Wang L, Qiao Y, Zhou Q, Yang B, Yin L, Yin D, He M. Vinegar/Tetramethylpyrazine Induces Nutritional Preconditioning Protecting the Myocardium Mediated by VDAC1. Oxid Med Cell Longev. 2021 Apr 20;2021:6670088.

[4] 4.Peng Y, Wang L, Zhang Z, He X, Fan Q, Cheng X, Qiao Y, Huang H, Lai S, Wan Q, He M, He H*. Puerarin activates adaptive autophagy and protects the myocardium against doxorubicin-induced cardiotoxicity via the 14-3-3γ/PKCε pathway. Biomed Pharmacother. 2022 Sep;153:113403.

[5] Peng Y, Wang L, Zhao X, Lai S, He X, Fan Q, He H*, He M. Puerarin attenuates lipopolysaccharide-induced myocardial injury via the 14-3-3γ/PKCε pathway activating adaptive autophagy. Int Immunopharmacol. 2022 Jul;108:108905.

[6] Chen T, Niu L, Wang L, Zhou Q, Zhao X, Lai S, He X, He H*, He M. Ferulic acid protects renal tubular epithelial cells against anoxia/reoxygenation injury mediated by AMPKα1. Free Radic Res. 2022 Feb;56(2):173-184.

[7] Wang Z, Yang B, Chen X, Zhou Q, Li H, Chen S, Yin D, He H*, He M. Nobiletin Regulates ROS/ADMA/DDAHII/eNOS/NO Pathway and Alleviates Vascular Endothelium Injury by Iron Overload. Biol Trace Elem Res. 2020 Nov;198(1):87-97.

[8] Chen X, Li H, Wang Z, Zhou Q, Chen S, Yang B, Yin D, He H*, He M. Quercetin protects the vascular endothelium against iron overload damages via ROS/ADMA/DDAHⅡ/eNOS/NO pathway. Eur J Pharmacol. 2020 Feb 5;868:172885.

[9] Wu W, Yang B, Qiao Y, Zhou Q, He H*, He M. Kaempferol protects mitochondria and alleviates damages against endotheliotoxicity induced by doxorubicin. Biomed Pharmacother. 2020 Jun;126:110040.

[10] He H#, Wang L, Qiao Y, Zhou Q, Li H, Chen S, Yin D, Huang Q, He M. Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway. Front Pharmacol. 2020 Jan 10;10:1531.

[11] Yang B, Li H, Qiao Y, Zhou Q, Chen S, Yin D, He H*, He M. Tetramethylpyrazine attenuates the endotheliotoxicity and the mitochondrial dysfunction by doxorubicin via 14-3-3γ/Bcl-2. Oxid Med Cell Longev. 2019; 2019: 5820415.

[12] Luo Y, Wan Q, Xu M, Zhou Q, Chen X, Yin D, He H*, He M. Nutritional preconditioning induced by astragaloside Ⅳ on isolated hearts and cardiomyocytes against myocardial ischemia injury via improving Bcl-2- mediated mitochondrial function. Chem Biol Interact. 2019; 309:108723.

[13] Chen X, Peng X, Luo Y, You J, Yin D, Xu Q, He H*, He M. Quercetin protects cardiomyocytes against doxorubicin-induced toxicity by suppressing oxidative stress and improving mitochondrial function via 14-3-3γ. Toxicol Mech Methods. 2019; 29(5): 344-54.

[14] He H#, Qiao Y, Zhang Z, Wu Z, Liu D, Liao Z, Yin D, He M*. Dual action of vitamin C in iron supplement therapeutics for iron deficiency anemia: prevention of liver damage induced by iron overload. Food Funct, 2018, 9, 5390-401.

[15] He H#, Luo Y, Qiao Y, Zhang Z, Yin D, Yao J, You J, He M*. Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14-3-3γ. Food Funct. 2018; 9, 4404-18.

[16] Zhang ZY#, He H#, Qiao Y, Huang JY, Wu ZL, Xu P, Yin D, He M*. TanshinoneⅡA pretreatment protects H9c2 cells against anoxia/reoxygenation injury: involvement of the translocation of Bcl-2 to mitochondria mediated by 14-3-3η. Oxid Med Cell Longev. 2018; 2018: 3583921.

[17] Huang B, You J, Qiao Y, Wu Z, Liu D, Yin D, He H*, He M. Tetramethylpyrazine attenuates lipopolysaccharide-induced cardiomyocyte injury via improving mitochondrial function mediated by 14-3-3γ. Eur J Pharmacol. 2018; 832: 67-74.

[18] Liu Z, Yang L, Huang J, Xu P, Zhang Z, Yin D, Liu J, He H*, He M. Luteoloside attenuates anoxia/reoxygenation-induced cardiomyocytes injury via mitochondrial pathway mediated by 14-3-3η protein. Phytother Res. 2018; 32: 1126-34.

[19] Huang J, Liu Z, Xu P, Zhang Z, Yin D, Liu J, He H*, He M. Capsaicin prevents mitochondrial damage, protects cardiomyocytes subjected to anoxia/ reoxygenation injury mediated by 14-3-3η/Bcl-2. Eur J Pharmacol. 2018; 819: 43-50.