基本介紹
- 中文名：何昕
- 學位/學歷：博士研究生
人物經歷,教學簡介,科研簡介,
人物經歷
工作經歷：
2017-06至今，湖南農業大學，農學院，2011南方糧油作物協同創新中心“油菜分子生物學創新團隊”引進人才，講師。主要開展早熟油菜逆境分子生物學研究。
學習經歷：
2008-09至2016-12，華中農業大學，植物科學技術學院/作物遺傳改良國家重點實驗室，作物遺傳育種，碩-博士，導師：張獻龍教授。
教學簡介
講授《育種學總論》、《現代農業概論》、《現代農業生物技術》等課程。
科研簡介
湖南農業大學碩導，2011南方糧油作物協同創新中心“油菜分子生物學創新團隊”骨幹，湖南農業大學油菜團隊骨幹。
主要開展早熟油菜逆境分子生物學研究：蒐集自然群體，創建突變體，篩選鑑定優良早熟抗逆甘藍型油菜種質，利用全基因組關聯分析、圖位克隆、反向遺傳等技術手段挖掘和克隆參與調控甘藍型油菜早熟抗逆（特別是抗寒抗凍）的基因，揭示其作用分子機理；同時結合基因編輯等生物技術手段，創造出滿足“南方稻田作物多熟制”生產重大需求的早熟抗寒且農藝性狀優良的油菜種質，為油菜基因組設計育種提供理論基礎和基因資源。
先後主持、參與國家自然科學基金、國家重大專項、湖南省教育廳科學研究優秀青年基金等科研項目10餘項；在Plant Journal，Plant physiology，Plant Biotechnology Journal，Communications Biology等雜誌上發表SCI論文26篇，其中第一作者發表SCI論文9篇。
科研項目
基於CRISPR/Cas9技術靶向突變BnFLCs編碼區及其啟動子順式元件E-box創造早熟抗寒甘藍型油菜的探索研究，主持，31801398，國家自然科學基金青年項目；2019.01.01-2021.12.31。
- 甘藍型油菜CaM/CML家族基因鑑定和BnaCML24/38/49功能研究；19B264，湖南省教育廳科學研究優秀青年基金項目，主持，2020.01.01-2021.12.31。
- BnaCML24和BnaCML49在甘藍型油菜抗凍性中的功能研究；湖南農業大學作物學科優秀人才基金項目，主持，2019.01.01-2020.12.31。
- 南方三熟制早熟油菜品種花期耐寒性及其生理生化特性研究；17QN24，湖南農業大學科學基金項目，主持，2017.01.01-2019.12.31。
- 轉基因油菜新品種培育及產業化研究子課題：長江中游轉基因油菜新品種培育；SQ2018ZD080068，國家科技重大專項項目，參與，2018.01.01-2020.12.31。
- 解析油菜滯綠基因BnNYE1啟動子光回響順式元件的變異及其對葉綠素含量和含油量的影響；31801399，國家自然科學基金青年項目，參與，2019.01.01-2021.12.31。
- 棉花GhCIPK6 的克隆及其調控棉花抗旱的分子機理研究；31371675，國家自然科學基金面上項目，參與，2014.01.01-2017. 12.31。
- SSN基因家族調控棉花抗黃萎病反應的功能解析；31271772，國家自然科學基金面上項目，參與，2013.01.01-2016. 12.31。
- 油菜產業技術體系（種質創新崗位）；湖南省現代農業產業技術體系崗位專家，參與，2019.01.01-2020.12.31。
- 甘藍型油菜Bn.C3VIN3基因的功能驗證分析；17QN23，湖南農業大學科學基金項目，參與，2017.01.01-2019.12.31。
代表性著作和論文
- Xin He, Xiangyin Luo, Tianyi Wang, Shiming Liu, Xianlong Zhang, Longfu Zhu, GhHB12 negatively regulates abiotic stress tolerance in Arabidopsis and cotton, Environmental and Experimental Botany, 2020, 176, 104087, https://doi.org/10.1016/j.envexpbot.2020.104087.
- He Xin, Liao Li, Xie Sai, Yao Min, Xie Pan, Liu Wei, Kang Yu, Huang Luyao, Wang Mei, Qian Lunwen, Liu Zhongsong, Guan Chunyun, Guan Mei*, Hua Wei*. Comprehensive analyses of the annexin (ANN) gene family in Brassica rapa, Brassica oleracea and Brassica napus reveals their roles in stress response. Scientific Reports, 2020, 10(1): 4295.
- He Xin, Sai Xie, Pan Xie, Min Yao, Wei Liu, Lunwen Qin, Zhongsong Liu, Ming Zheng, Hongfang Liu, Mei Guan, Wei Hua. Genome-wide identification of stress-associated proteins (SAP) with A20/AN1 zinc finger domains associated with abiotic stresses responses in Brassica napus. Environmental and Experimental Botany, 2019, 165:108-119.
- He Xin, Ni Xianchao, Xie Pan, Liu Wei, Yao Min, Kang Yu, Qin Lunwen and Hua Wei. Comparative Transcriptome Analyses Revealed Conserved and Novel Responses to Cold and Freezing Stress in Brassica napus L. G3: Genes, Genomes, Genetics, 2019, 9(8): 2723-2737.
- He, X., Wang, T., Xu, Z., Liu, N., Wang, L., Hu, Q., Luo, X., Zhang, X., and Zhu, L. The cotton HD-Zip transcription factor GhHB12 regulates flowering time and plant architecture via the GhmiR157-GhSPL pathway. Communications Biology, 2018, 1: 229.
- He, X., Wang, T., Zhu, W., Wang, Y., and Zhu, L. GhHB12, a HD-ZIP I Transcription Factor, Negatively Regulates the Cotton Resistance to Verticillium dahliae. International Journal of Molecular Sciences, 2018, 19:3997.
- He, X., Zhu, L., Wassan, G. M., Wang, Y., Miao, Y., Shaban, M., Hu, H., Sun, H., Zhang, X.*, GhJAZ2 attenuates cotton resistance to biotic stresses via the inhibition of the transcriptional activity of GhbHLH171. Molecular Plant Pathology, 2018, 19(4), 896-908.
- Hu, H.#, He, X.#, Tu, L., Zhu, L., Zhu, S., Ge, Z., Zhang, X.*, GhJAZ2 negatively regulates cotton fiber initiation by interacting with the R2R3-MYB transcription factor GhMYB25-like. The Plant Journal, 2016, 88(6): 921-935
- He, X., Zhu, L.*, Xu, L., Guo, W., Zhang, X., GhATAF1, a NAC transcription factor, confers abiotic and biotic stress responses by regulating phytohormonal signaling networks. Plant Cell Reports, 2016, 35(10): 2167-2179.
參與作者論文：
- M. Yao, M. Guan, Z. Zhang, Q. Zhang, Y. Cui, H. Chen, W. Liu, H.U. Jan, K.P. Voss-Fels, C.R. Werner, X. He, Z. Liu, C. Guan, R.J. Snowdon, W. Hua, L. Qian, GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content accumulation in Brassica napus, BMC genomics, 2020, 21:320
- X. Luo, C. Li, X. He, X. Zhang, L. Zhu, ABA signaling is negatively regulated by GbWRKY1 through JAZ1 and ABI1 to affect salt and drought tolerance, Plant Cell Reports, 2020, 39:181-194
- Y. Zhou, L. Sun, G.M. Wassan, X. He, M. Shaban, L. Zhang, L. Zhu, X. Zhang, GbSOBIR1 confers Verticillium wilt resistance by phosphorylating the transcriptional factor GbbHLH171 in Gossypium barbadense, Plant biotechnology journal, 2019, 17:152-163.
- Y. Miao, L. Xu, X. He, L. Zhang, M. Shaban, X. Zhang, L. Zhu, Suppression of tryptophan synthase activates cotton immunity by triggering cell death via promoting SA synthesis, The Plant journal, 2019, 98:329-345.
- Y. Miao, L. Xu, X. He, L. Zhang, M. Shaban, X. Zhang, L. Zhu, Suppression of tryptophan synthase activates cotton immunity by triggering cell death via promoting SA synthesis, The Plant journal, 2019, 98:329-345.
- T. Qin, S. Liu, Z. Zhang, L. Sun, X. He, K. Lindsey, L. Zhu, X. Zhang, GhCyP3 improves the resistance of cotton to Verticillium dahliae by inhibiting the E3 ubiquitin ligase activity of GhPUB17, Plant molecular biology, 2019, 99:379-393.
- W.J. Tang, X. He, L.W. Qian, F. Wang, Z.H. Zhang, C. Sun, L.B. Lin, C.Y. Guan, Comparative Transcriptome Analysis in Oilseed Rape (Brassica napus) Reveals Distinct Gene Expression Details between Nitrate and Ammonium Nutrition, Genes, 2019,10:391.
- LIU Wei, YAO Ming, KANG Yu, WANG Mei, XIE Pan, HE Xin, LIU Zhong-Song, GUAN Chun-Yun, QIAN Wei, HUA Wei, QIAN Lun-Wen, GWAS and Coexpression Network Combination Uncovers Effect Loci in the Accumulation of Glucosinolates Content in Brassica napus, 農業生物技術學報, 2019, 27:1729-1741.
- H. Sun, L. Chen, J. Li, M. Hu, A. Ullah, X. He, X. Yang, X. Zhang, The JASMONATE ZIM-Domain Gene Family Mediates JA Signaling and Stress Response in Cotton, Plant and Cell Physiology, 2017, 58:2139-2154.
- W. Guo, L. Jin, Y. Miao, X. He, Q. Hu, K. Guo, L. Zhu, X. Zhang, An ethylene response-related factor, GbERF1-like, from Gossypium barbadense improves resistance to Verticillium dahliae via activating lignin synthesis, Plant molecular biology, 2016, 91:305-318.
- Y. Wang, S. Jin, L. Min, X. He, Y. Li, Y. Zhu, Y. Nie, X. Zhang, L. Zhu, The Sophora Alopecuroid H+-PPase Gene SaVP1 Confers Multiple Abiotic Stress Tolerance in Arabidopsis, Plant Molecular Biology Reporter, 2015, 33:923-930.
- C. Li, X. He, X. Luo, L. Xu, L. Liu, L. Min, L. Jin, L. Zhu, X. Zhang, Cotton WRKY1 Mediates the Plant Defense-to-Development Transition during Infection of Cotton by Verticillium dahliae by Activating JASMONATE ZIM-DOMAIN1 Expression, Plant Physiology, 2014, 166: 2179-2194.
- L. Xu, W. Zhang, X. He, M. Liu, K. Zhang, M. Shaban, L. Sun, J. Zhu, Y. Luo, D. Yuan, X. Zhang, L. Zhu, Functional characterization of cotton genes responsive to Verticillium dahliae through bioinformatics and reverse genetics strategies, Journal of experimental botany, 2014, 65:6679-6692.
- L. Long, W. Gao, L. Xu, M. Liu, X. Luo, X. He, X. Yang, X. Zhang, L. Zhu, GbMPK3, a mitogen-activated protein kinase from cotton, enhances drought and oxidative stress tolerance in tobacco, Plant Cell, Tissue and Organ Culture (PCTOC), 2014, 116:153-162.
- L. Long, W. Gao, L. Xu, M. Liu, X. Luo, X. He, X. Yang, X. Zhang, L. Zhu, GbMPK3, a mitogen-activated protein kinase from cotton, enhances drought and oxidative stress tolerance in tobacco, Plant Cell, Tissue and Organ Culture (PCTOC), 2014, 116:153-162.
- L. Xu, K.R. Zahid, L. He, W. Zhang, X. He, X. Zhang, X. Yang, L. Zhu, GhCAX3 gene, a novel Ca2+/H+ exchanger from cotton, confers regulation of cold response and ABA induced signal transduction, PloS one, 2013, 8:e66303.
- L. Xu, L. Jin, L. Long, L. Liu, X. He, W. Gao, L. Zhu, X. Zhang, Overexpression of GbWRKY1 positively regulates the Pi starvation response by alteration of auxin sensitivity in Arabidopsis, Plant Cell Reports, 2012, 31:2177-2188.
- L.-f. Zhu, X. He, D.-j. Yuan, L. Xu, L. Xu, L.-l. Tu, G.-x. Shen, H. Zhang, X.-l. Zhang, Genome-Wide Identification of Genes Responsive to ABA and Cold/Salt Stresses in Gossypium hirsutum by Data-Mining and Expression Pattern Analysis, Agricultural Sciences in China, 2011, 10:499-508.
品種授權和專利
- 楊細燕，孫恆，何昕，張獻龍. 超表達GhJAZ1基因增強植物抗低溫脅迫.
