何宏軒

何宏軒，男，漢族，1968年出生，河南內鄉人，博士，研究員，博士生導師；中國科學院動物研究所動物疫病研究組組長。

基本介紹

• 中文名：何宏軒
• 民族：漢族
• 出生地：河南內鄉
• 出生日期：1968年
• 職業：教師
• 性別：男

個人履歷

1993年7月畢業於河南職業技術師範學院，獲學士學位，1998年6月畢業於解放軍農牧大學，獲碩士學位，2002年6月畢業於解放軍軍需大學，獲博士學位，2003年在清華大學生物科學與技術系作博士後研究，2004年在美國康乃爾大學作博士後研究。曾經獲得河南省優秀中青年骨幹教師，河南省教育系統學術技術帶頭人，河南省傑出青年等榮譽。曾在河南科技學院工作，自1996年起先後擔任教研室主任、系副主任、系主任、副院長等職務。1999年7月任講師，2002年6月任副教授，2005年8月任教授。2004年被河北師範大學和河南農業大學聘為碩士生導師，2006年被中國科學院動物研究所聘為博士生導師。

所獲榮譽

曾主持或參加國家重點基礎研究發展計畫（973計畫）、國家高技術研究發展計畫（863）、國家自然科學基金、中國博士後基金以及河南省傑出青年基金等20餘項。獲得省部級科研獎7項。在《DNA and Cell Biology》、《Journal of Nanoscience and Nanotechnology》、《生物化學和生物物理進展》等國內外期刊發表學術論文120餘篇。編寫著作9部。

研究領域

·病原分子生態學在了解主要疾病疫源地生態和主要宿主遷徙動態、生境利用及其與家畜和人類活動關係的基礎上，開展病原的檢測和溯源研究，探討病原在野生宿主和自然環境中的分布，評估病原對野生動物、家畜以及人類的威脅，建立疾病發生和擴散模型，提出相應的疾病爆發預測指標，為國家主要疫病的防控和生物安全預警提供科學依據。·病原多樣性以及病原與宿主的協同進化關係從人獸共患病病原體和宿主的關係入手，根據生物信息學原理和協同進化理論，運用病原學和分子生物學方法，調查野生動物病原多樣性，探討病原的宿主適應性以及與宿主的協同進化關係，進一步尋找病原的科學分類方法，為該病的致病機理和免疫逃避機制的研究提供新的依據。·微量元素影響病毒感染的分子機制建立並利用微量元素動物模型，揭示微量元素對病毒毒力變異的作用機制，結合我國主要野生動物源人獸共患病毒病和微量元素地理分布關係的調查分析，闡明宿主棲息地點與疾病爆發的內在關係。

社會任職

國家林業局中國科學院野生動物疫病研究中心常務副主任

國家林業局野生動物疫病預警與防控專家組成員

亞太野生動物疫病合作網路中方負責人

國際野生動物疫病協會理事

亞洲生物技術協會聯合會委員

國際動物學會會員

《中國媒介生物學及控制雜誌》編委

《Integrative Zoology（整合動物學）》編委

《Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases》特約審稿人

《American Journal of Tropical Medicine & Hygiene》特約審稿人

《Journal of Helminthology》特約審稿人

《PloS one》特約審稿人

科研項目

國家科技支撐計畫課題，項目名稱：人獸共患病感染動物模型技術研究及我國特有野生動物實驗動物化，課題名稱：重要人獸共患病野生動物野生和室內種群實驗室感染模型的建立及差異性研究

國家高技術研究發展計畫：重大動物疫病快速檢測試劑的研發

國家重點基礎研究發展計畫（973計畫）：農業鼠害暴發成災規律、預測及可持續控制的基礎研究

科技部十二五支撐, 野生動物跨境傳播重要疫病監測與防控技術研究（“十二五”國家科技支撐計畫

國家自然科學基金，TRX-2抗氧化系統在缺硒狀態宿主中抗微小隱孢子蟲感染的作用機制研究

國家自然科學基金，MicroRNA參與調控微小隱孢子蟲感染缺硒宿主的分子機制研究

國家林業局野生動物疫源疫病監測項目，候鳥禽霍亂疫源地追溯及其預警體系的建立

現代農業產業技術體系北京市家禽創新團隊，疫病控制崗位專家

代表論著

Shelan Liu, Chengliang Chai, Chengmin Wang, Said Amer,Huakun Lv, Hongxuan He, Jimin Sun and Junfen Lin. Systematic review of severe fever with thrombocytopenia syndrome:virology, epidemiology, and clinical characteristics

Guo Yunhai, Hongxuan He. Identification and characterization of a goose-type lysozyme from sewage snail Physa acuta

Liu Huimin, YanJing, WangYutian, YanQi, ZhaoLinping, YanRuoqian, Hongxuan He. Isolation of Moraxella bovoculi from racehorses with keratoconjunctivitis

Liu Huimin, YanJing, Luo Jing, Yan Ruoqian, ChenHao , ChengHai, LiuDawei, Hongxuan He.Mycobacteriosis Associated with Mycobacterium peregrinum Infection in Red-Crowned Cranes (Grus japonensis) in China

GaoShanshan, ZhangMin, AmerSaid, LuoJing, WangChengmin, WuShaoqiang, ZhaoBaohua, Hongxuan He.Development of an immunomagnetic bead separation-coupled quantitative PCR method for rapid and sensitive detection of Cryptosporidium parvum oocysts in calf feces

Liu Huimin, WangYutian, YanJing, WangChengmin, Hongxuan He.Appearance of Multidrug-Resistant Virulent Rhodococcus equi Clinical Isolates Obtained in China

Tao Zhang and Hongxuan He. Test of immunocompetence handicap hypothesis in mice (Mus musculus) infected with Trichinella spiralis

Joy Scaria , Jenn-Wei Chen, Nicodemus Useh, Hongxuan He , Sean P. McDonough , Chunhong Mao , Bruno Sobral , Yung-Fu Chang.Comparative nutritional and chemical phenome of Clostridium difficile isolates determined using phenotype microarrays

Guoying Dong,Jing Luo, Kai Zhou ,Bin Wu,Chao Peng,Guangju Ji,Hongxuan He. Characterization of the amantadine-resistant H5N1 highly pathogenic avian influenza variants isolated from quails in Southern China

Chengmin Wang, Jing Luo,Jing Wang,Wen Su, Shanshan Gao, Min Zhang, Li Xie,Hua Ding, Shelan Liu,Xiaodong Liu,Yu Chen,Yaxiong Jia,Hongxuan He. Novel human H7N9 Influenza Virus in China

Chengmin Wang, Jing Wang, Wen Su, Shanshan Gao, Jing Luo, Min Zhang, Li Xie, Shelan Liu,Xiaodong Liu,Yu Chen,Yaxiong Jia,Hong Zhang, Hua Ding, Hongxuan He. Relationship between domestic and wild birds in live poultry market and a novel human H7N9 virus in China

Yingchun Du, Jing Luo, Chengmin Wang, Qingna Wen, Mingxing Duan, Hong Zhang, and Hongxuan He.Detection of Drug-Resistant Klebsiella pneumoniae in Chinese hares (Lepus sinensis)

Jing Luo, Guoying Dong, Kai Li, Zongji Lv, Xiaowei Huo, and Hongxuan He. Exposure to swine H1 and H3 and avian H5 and H9 influenza A viruses among feral swine in southern China

Jun-Song Wu, Na Zhao, Hao Pan, Cheng-Min Wang, Bin Wu, Hong-Mei Zhang,Hongxuan He, Dan Liu, Said Amer, She-Lan Liu.Patterns of polymorphism and divergence in the VP1 gene of enterovirus 71 circulating in the Asia-Pacific region between 1994 and 2013

She-Lan Liu, Jing Wang, Xu-Hui Yang, Jin Chen, Ren-Jie Huang,Bing Ruan, Hongxuan He, Chengmin Wang, Hong-Mei Zhang,Zhou Sun, Li Xie and Hui Zhuang. Pandemic influenza A(H1N1) 2009 virus in pregnancy

Chengmin Wang，Hongxuan He. Leptospira spp. in Commensal Rodents, Beijing, China

Chengmin Wang, Yanyu Zhang, Bin Wu, Shelan Liu, Ping Xu, Yanmin Lu, Jing Luo, Dale Louis Nolte, Thomas Jude Deliberto, Mingxing Duan, Hong Zhang, Hongxuan He. Evolutionary characterization of the pandemic H1N1/2009 Influenza Virus in humans based on non-structural genes

Shanshan Gao,Na Zhaoa, Said Amer, Mingming Qian, Mengxi Lv, Yuliang Zhao, Xin Su, Jieying Cao, Hongxuan He, Baohua Zhao.Protective efficacy of PLGA microspheres loaded with divalent DNA vaccine encoding the ompA gene of Aeromonas veronii and the hly gene of Aeromonas hydrophila in mice

Liu H, Yan Q, Zhao B, Luo J, Wang C, Du Y, Yan J, Hongxuan He. Isolation, molecular characterization, and phylogenetic analysis of encephalomyocarditis virus from South China tigers in China

Liu H, Yan Q, Hongxuan He. Complete Nucleotide Sequence of Encephalomyocarditis Virus Isolated from South China Tigers in China

Zhang Min and Hongxuan He. Parasite-mediated selection of major histocompatibility complex variability in wild brandt’s voles (Lasiopodomys brandtii) from Inner Mongolia, China

Hu Yi , LIU Peng-Peng, ZHANG Zhi-Ming, LU He-Zhen, LUO Jing, WANG Cheng-Min,LIU Jun-Xu, ZHAO Bao-Hua, Hongxuan He.Inhibition of Highly Pathogenic Avian Influenza A Virus H5N1 Growth and Induction of Inflammatory Mediators by Geldanamycin Progress in Biochemistry and Biophysics

Chengmin Wang,Jing Wang,Jing Luo,Li Xie,Hua Ding,Shelan Liu,Xiaodong Liu,Yu Chen,Yaxiong Jia,Hongxuan He. Relationship between H7subtype avian influenza virus and poultry and human

Wenjie Dong, Jing Luo, Hongxuan He, Long Jiang. A reinforced composite structure composed of polydiacetylene assemblies deposited on polystyrene microspheres and its application to H5N1 virus detection

Shelan Liu, Chengliang Chai, Chengmin Wang, Said Amer,Huakun Lv, Hongxuan He, Jimin Sun and Junfen Lin.Systematic review of severe fever with thrombocytopenia syndrome:virology, epidemiology, and clinical characteristics

Shelan Liu, Jing Wang, Xului Yang, Jin Chen, Renjie Huang, Bing Ruan, Hongxuan He, Chengmin Wang, Hongmei Zhang, Zhou Sun, Li Xie, Hui Zhuang. Pandemic influenza A(H1N1) 2009 virus in pregnancy

Jing Luo, Zhigao Zeng, Yanling Song, Hongxuan He. Brucellosis in Takins, China

Sarah N. Bevins, John A. Baroch, Dale L. Nolte, Min Zhang, Hongxuan He. Yersinia pestis: examining wildlife plague surveillance in China and the USA

Didi Chen, Pei Guo, Sha Chen, Yu Cao, Wanzhen Ji, Xia Lei, Lina Liu, Peiguang zhao, Ruihong Wang, Chao qi, Yanli Liu, Hongxuan He. Properties of xyloglucan hydrogel as the biomedical sustained-release carriers. Journal of Materials Science: Materials in Medicine

Qiumei Shi, Yanying Zhang, Qiuyue Wang, Guisheng Gao, Hai Fang, Fuchun Miao, Zengqiang Yuan and Hongxuan He. Phylogenetic analysis of virulence factor gene of Salmonella isolated from clinically symptomatic Chickens

Hua Fu, Liguo Liu, Xiaobing Zhang, Yafang Zhu, Lina Zhao, Junping Peng, Hongxuan He, Qi Jin.Common Changes in Global Gene Expression Induced by RNA Polymerase Inhibitors in shigella flexneri

Qiumei Shi, Guisheng Gao,Yanying Zhang, Hua xiang, Zengqiang Yuan, Hongxuan He. Cloning of structural protein VP1 gene of foot and mouth Disease virus and its expression in Escherichia coli

Hanwei Jiao,Li Du,Yongchang Hao,Ying Cheng ,Jing Luo,wenhua Kuang,Donglin Zhang, Ming Lei ,Xiaoxiao Jia, Xiaoru Zhang , Chao Qi, Hongxuan He,Fengyang Wang. Effective inhibition of mRNA accumulation and protein expression of H5N1 avian influenza virus NS1 gene in vitro by small interfering RNAs

Wang BaoLin, Liu Bo, Chen Ling, Zhang JianYong, Hongxuan He,Zhang Hong. Qualitative and quantitative analyses of influenza virus receptors in trachea and lung tissues of humans, mice, chickens and ducks

Wei Lei,Qinglong Liang,Luo Jing,Chengmin Wang, Xiaobing Wu,Hongxuan He. BoLA-DRB3 gene polymorphism and FMD resistance or susceptibility in Wanbei cattle

Chengmin Wang, Jing Luo, Said Amer, Yunhai Guo, Yi Hu, Yanmin Lu, Haijing Wang, Mingxing Duan, Hongxuan He. Multivalent DNA vaccine induces protective immune responses and enhanced resistance against Cryptosporidium parvum infection

Kai Li, Jing Luo, Chengmin Wang, Hongxuan He. a-Galactosylceramide potently augments M2e-induced protective immunity against highly pathogenic H5N1 avian influenza virus infection in mice

Qing-long Liang, Jing Luo, Kai Zhou, Jian-xin Dong, Hongxuan He. Immune-related gene expression in response to H5N1 avian influenza virus infection in chicken and duck embryonic fibroblasts

Guoying Dong, Jing Luo, Hong Zhang, Chengmin Wang, Mingxing Duan, Thomas Jude Deliberto,Dale Louis Nolte, Guangju Ji, Hongxuan He.Phylogenetic Diversity and Genotypical Complexity of H9N2 Influenza A Viruses Revealed by Genomic Sequence Analysis

Guoying Dong, Cong Xu, Chengmin Wang, Bin Wu, Jing Luo, Hong Zhang, Dale Louis Nolte, Thomas Jude Deliberto, Mingxing Duan, Guangju Ji, Hongxuan He.Reassortant H9N2 Influenza Viruses Containing H5N1-Like PB1 Genes Isolated from Black-Billed Magpies in Southern China

Liu SL, Zhang Z, Wang C, Dong Y, Pan H, Sun Z, Yang XH, Wang J, Ruan B, Xie L, Deng J, Hongxuan He. Evolutionary Characterization of Human H1N1 Influenza Virus Hemagglutinin Genes Isolated from 1947 to 2009 in China

Yuelan Zhao, Chengmin Wang, Yanmin Lu, Said Amer, Ping Xu,Jianyong Wang, Junxia Lu, Yongzhan Bao, Bolin Deng, Hongxuan He,Jianhua Qin. Prokaryotic Expression and Identification of 3-1E Gene of merozoite surface antigen of Eimeria acervulina

Qiumei Shi, Guisheng Gao, Yanying Zhang,Hua Xiang,Zengqiang Yuan, Hongxuan He. Cloning of structural protein VP1 gene of foot and mouth virus and its expression in Escherichia coli

Yu cao, didi chen, peiguang zhao, lina liu, xueying huang, chao qi, yanli liu,Hongxuan He, qian wang, yang liu, and sha chen. Intracellular Delivery of Mitomycin C with Targeted Polysaccharide Conjugates Against Multidrug Resistance

Lei Wei, Xinwei Wang, Chengmin Wang and Hongxuan He. A survey of ectoparasites from wild rodents and Anourosorex squamipes in Sichuan Province, Southwest China

Said Amer, Chengmin Wang and Hongxuan He. First Detection of Cryptosporidium baileyi in Ruddy Shelduck (Tadorna ferruginea) in China. J. Vet

Chengmin Wang, Bin Wu, Said Amer, Jing Luo, Hongmei Zhang, Yunhai Guo, Guoying Dong, Baohua Zhao,Hongxuan He. Phylogenetic analysis and molecular characteristics of seven variant Chinese field isolates of PRRSV

Bin Wu, Chengmin Wang, Guoying Dong, Yunhai Guo, Dale Louis Nolte, Thomas Jude Deliberto, Jianguo Xu,Mingxing Duan, Hongxuan He.New Evidences Reveal Southern China Is a common Source of Multiple H5N1 Clusters

Qinglong Liang, Lei Wei, Xinwei Wang, Hongxuan He.MHC Class I Loci from the Bar-Headed Goose (Anser indicus)

Yuelan Zhao, Said Amer, Jianyong Wang, Chengmin Wang,Ying Gao, Guiying Kang, Yongzhan Bao, Hongxuan He,Jianhua Qin. Construction, screening and identification of a phage display antibody library against the Eimeria acervulina merozoite

Yu Cao, Ying Gu, Hong Ma, Jing Bai, Lina Liu, Peiguang Zhao, Hongxuan He.Self-assembled nanoparticle drug delivery systems from galactosylated polysaccharide–doxorubicin conjugate loaded doxorubicin

Qinglong Liang, Kai Zhou, Hongxuan He. Retrocyclin 2: a new therapy against H5N1 virus in vivo and vitro

Tang Yi, CHU Guang-yue, Hongxuan He, YU Cui-ping, AN Jian-xiong, GUO Xiang-yang. Screening of differentially expressed genes in the hypothalamus of a rat neuropathic pain model following sciatic nerve injury

SheLan Liu, Zhi-Ruo Zhang, Chengmin Wang, Ying Dong, Lun-Biao Cui, Xu-Hui Yang, Zhou Sun, Jing Wang, Jin Chen, Ren-Jie Huang, Fan Miao, Bing Ruan, Li Xie, Hongxuan He, Jing Dengpandemic characteristics and controlling experiences of influenza H1N1 virus 1 year after the inception in Hangzhou, China

Wu B, Wang C M, Dong G Y, Hongxuan He. Molecular characterization of H1N1 influenza A viruses from human cases in North America

Chengmin WANG, Hongxuan HE, Ming LI, Fumin LEI, J. Jeffrey Root, Yanyun WU, Jianhua QIN. Parasite species associated with wild plateau pika (Ochotona curzoniae) in south-eastern Qinghai Province, China

Chengmin Wang, Yanyun Wu, Jianhua Qin, Haoxue Sun, and Hongxuan He. Induced susceptibility of host is associated with an impaired antioxidant system following infection with Cryptosporidium parvum in Se-deficient mice

Chengmin Wang, Hongxuan He, Mingxing Duan Development and evaluation of a recombinant CP23 antigen-based ELISA for serodiagnosis of Cryptosporidium parvum

Zhou Kai, Hongxuan He. Avian Influenza and Swine Influenza:New Understanding of Crossing Species Barrier

Wang xinwei, Hongxuan He, Zelin Wang, Yanyun Wu, Chengmin Wang. Detection on antigen of infectious bronchitis virus in chicken by silver-enhanced colloidal gold assay

Liqiang Feng,Feng Li,Xuehua Zheng,Weiqi Pan,Kai Zhou,Yichu Liu,Hongxuan He,Ling Chen. The mouse Pol I terminator is more efficient than the hepatitis delta virus ribozyme in generating influenza virus-like RNAs with precise 3' ends in a plasmid-only-based virus rescue system