基本介紹
人物經歷,研究方向,主要成就,代表性論文,研究課題,獲獎記錄,
人物經歷
2005.09-2009.06 西南交通大學，生物工程學士
2009.09-2012.06 上海海洋大學，水產學碩士
2012.09-2016.06 華東師範大學，動物學博士
2015.09-2016.09 Washington University in St. Louis, School of Medicine，聯合培養博士
2016.06-2020.04 Washington University in St. Louis, School of Medicine，博士後
2020.04-今 安徽醫科大學生命科學學院，教授
研究方向
過氧化物酶體及相關基因
主要成就
代表性論文
1. He, A., Dean, J.M., and Lodhi, I.J. (2021). Peroxisomes as Cellular Adaptors to Metabolic and Environmental Stress. Trends Cell Biol., https://doi.org/10.1016/j.tcb.2021.02.005.
2. He, A., Dean, J.M., Lu, D., Chen, Y., and Lodhi, I.J. (2020). Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation. Autophagy 16, 1727-1728.
3. He, A., Chen, X., Tan, M., Chen, Y., Lu, D., Zhang, X., Dean, J.M., Razani, B., and Lodhi, I.J. (2020). Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation. Mol Cell 79, 30-42.e34.
4. Dean, J.M., He, A., Tan, M., Wang, J., Lu, D., Razani, B., and Lodhi, I.J.* (2020). MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARγ-Dependent Gene Expression. Cell Rep., 33, 108228.
5. Park, H., He, A., Tan, M., Johnson, J.M., Dean, J.M., Pietka, T.A., Chen, Y., Zhang, X., Hsu, F.-F., Razani, B., and Lodhi I.J.* (2019). Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission. J. Clin. Invest., 129, 694-711.
6. Ning, L., He, A., Li, J., Lu, D., Jiao, J., Li, L., Li, D., Zhang, M., Chen, L., and Du, Z*. (2016). Mechanisms and metabolic regulation of PPARα activation in Nile tilapia (Oreochromis niloticus). Biochim Biophys Acta Mol Cell Biol Lipids. 1861, 1036-1048.
7. He, A., Ning, L., Chen, L., Chen, Y., Xing, Q., Li, J., Qiao, F., Li, D., Zhang, M., and Du, Z. (2015). Systemic adaptation of lipid metabolism in response to low‐and high‐fat diet in Nile tilapia (Oreochromis niloticus). Physiol Rep. 3, e12485.
8. He, A., Liu, C., Chen, L., Ning, L., Qin, J., Li, J., Zhang, M., and Du, Z. (2015). Molecular characterization, transcriptional activity and nutritional regulation of peroxisome proliferator activated receptor gamma in Nile tilapia (Oreochromis niloticus). Gen. Comp. Endocrinol., 223, 139-147.
9. He, A., Liu, C., Chen, L., Ning, L., Zhang, M., Li, E., and Du, Z. (2014). Identification, characterization and nutritional regulation of two isoforms of acyl-coenzyme A oxidase 1 gene in Nile tilapia (Oreochromis niloticus). Gene 545, 30-35.
10. He, A., Luo, Y., Yang, H., Liu, L., Li, S., and Wang, C. (2011). Complete mitochondrial DNA sequences of the Nile tilapia (Oreochromis niloticus) and Blue tilapia (Oreochromis aureus): genome characterization and phylogeny applications. Mol. Biol. Rep., 38, 2015-2021.
註：#共同第一作者；*通信作者。
研究課題
1. 安徽醫科大學引進人才科研啟動項目，0801028201，2020/04-2025/04，主持。
2. 生命科學學院科研水平提升計畫，0801028101，2021/01-2022/12，主持。
3. 國家自然科學基金委員會，面上項目，31472290，線粒體和過氧化物酶體在魚類脂肪酸β-氧化中的協作機制研究，2015-01-01 至 2018-12-31，結題，參與。
4. 國家自然科學基金面上項目，31272676，羅非魚對 n-6 系多不飽和脂肪酸的細胞代謝機制研究，課題的重要執行者。
5. R01, DK118333, Metabolic Link between Peroxisome and Mitochondria in the Regulation of Thermogenesis. 課題的主要完成者。
6. R01, DK115867, Regulation of Adipose Tissue Remodeling and Energy Homeostasis. 課題的重要參與者。
獲獎記錄
1. 碩士畢業論文被評為 “校優秀畢業論文” 。
2. 論文《尼羅羅非魚應對低脂和高脂飼料的脂類代謝系統適應策略》獲得2015-2016年度上海市水產學會優秀論文一等獎。
