何創龍，博士。東華大學生物工程系，教授，博士生導師。重慶大學生物醫學工程專業博士學位，同濟大學和密西根大學（公派）博士後。近年來主持科技部、國家自然科學基金委、教育部、上海市科委和上海市教委等資助的科研項目20餘項；發表期刊論文150多篇；發表國際會議論文摘要70多篇；出版譯著一本；申請中國發明專利61項，獲授權26項；系中國機械工程學會高級會員、美國化學會、中國化學會、中國生物材料學會、中國生物醫學工程學會會員；擔任110多個國際期刊的審稿人。
基本介紹
- 中文名：何創龍
- 國籍：中國
- 民族：漢族
- 出生地：江西九江
- 出生日期：1971年
- 職業：教授，博士生導師
- 畢業院校：重慶大學
研究方向,獲獎情況,主要學術兼職,主持的主要科研項目,代表性學術論文,
研究方向
1.生物材料與組織工程；
2.生物墨水與生物製造；
3.用於癌症診斷與治療的生物納米技術。
獲獎情況
1.香港桑麻基金會桑麻獎教金（2018年）
2.第三屆全國大學生生命科學創新創業大賽指導教師一等獎（2018年）
3.上海市科學技術獎自然科學三等獎（2015年）
主要學術兼職
1.上海市生物醫學工程學會生物材料專業委員會，副主任委員；
2.中國醫藥教育協會醫用生物材料與技術專業委員會，副主任委員；
3.中國骨質疏鬆防治聯盟，創始理事；
4.中國機械工程學會生物製造工程分會，常務委員；
5.中國解剖學會血管分會，常務委員；
6.廣東省醫學生物力學重點實驗室學術委員會，委員；
7.中國醫藥生物技術協會3D列印技術分會，委員；
8.上海市松江區分子影像專委會，委員。
主持的主要科研項目
1.國家重點研發計畫課題(2018YFB1105602)，細胞與基質材料一體化的組織適配性“生物墨水”及列印技術研發，2018.5-2021.4；
2.國家自然科學基金面上項目(31771048)，“診療一體化”骨支架的仿生構建與骨再生的動態監測，2018.1-2021.12；
3.國家自然科學基金面上項目(31570984)，促血管祖細胞募集的小口徑血管支架構建與原位再生研究，2016.1-2019.12；
4.國家自然科學基金面上項目(31271028)，雙因子程式釋放的骨支架構建及促血管化和成骨活性研究，2013.1-2016.12；
5.教育部中央高校基本科研業務費學科交叉重點計畫項目(2232018A3-07)，基於多模態影像技術的可視化組織工程研究，2018.1-2020.12；
6.上海市科委國際科技合作項目(15540723400)，石墨烯基納米骨支架的構建及其在骨缺損治療中的套用，2015.10-2018.9；
7.上海市教委科研創新重點項目(13ZZ051)，外場作用下的電化學協同沉積與仿生骨支架研究，2013.1-2015.12；
8.上海市自然科學基金(11ZR1400100)，納米纖維的電化學協同自組裝修飾及具有血管化潛能的骨支架研究，2011.4.1-2014.3.31；
9.上海市自然科學基金(07ZR14001)，纖維蛋白納米纖維組織工程血管的基礎研究，2007.12-2009.11；
10.上海市科委納米科技項目(11nm0505500)，具有誘導血管生成和成骨活性的納米纖維骨修復材料研究，2011.11-2014.9；
11.教育部留學回國人員科研啟動基金，具有促血管化潛能的複合納米纖維骨支架的研究，2012.1-2014.12；
12.教育部博士點基金(200802551014)，納米纖維的電化學仿生礦化及用於骨支架材料的研究，2009.1-2011.12；
13.上海市白玉蘭科技人才基金(2010B001)，有機/無機複合骨組織工程支架的研究，2010.6-2011.5。
代表性學術論文
1. Wang WZ, Nie W, Zhou XJ, Feng W, Chen L, Zhang QQ, You ZW, Shi QS*, Peng C*,He CL*. Fabrication of heterogeneous porous bilayered nanofibrous vascular grafts by two-step phase separation technique.Acta Biomater. 2018; 79: 168-181.
2. Zhang QQ, Qin M, Zhou XJ, Nie W, Wang WZ, Li L*,He CL*. Porous nanofibrous scaffold incorporated with S1P loaded mesoporous silica nanoparticles and BMP-2 encapsulated PLGA microspheres for enhancing angiogenesis and osteogenesis.J. Mater. Chem. B. 2018; 6(42): 6731-6743.(Inside front cover)
3. Nie W, Dai XY, Li DJ, Gillispie GJ, Zhang YZ, Yu BQ*,He CL*. One-pot synthesis of silver nanoparticle incorporated mesoporous silica granules for hemorrhage control and antibacterial treatment.ACS Biomater. Sci. Eng. 2018; 4: 3588-3599.
4. Wang WZ, Nie W, Liu DH, Du HB, Zhou XJ, Chen L, Whang HS, Mo XM, Li L*,He CL*. Macroporous nanofibrous vascular scaffold with improved biodegradability and smooth muscle cells infiltration prepared by dual phase separation technique.Int. J. Nanomed. 2018; 13: 7003-7018.
5. Li DJ, Nie W, Chen L, McCoul D, Liu DH, Zhang X, Ji Y, Yu BQ*,He CL*. Self-assembled hydroxyapatite-graphene scaffold for photothermal cancer therapy and bone regeneration.J. Biomed. Nanotechnol. 2018; 14: 2003-2017.
6. Zhou XJ, Wang WZ, Chen B, Feng W, Weng WZ, Zhang QQ, Nie W, Chen L, Mo XM, Su JC*,He CL*. Mesoporous silica nanoparticles/gelatin porous composite scaffolds with localized and sustained release of vancomycin for treatment of infected bone defects.J. Mater. Chem. B. 2018; 6: 740-752.
7. Wang WZ, Miao YK, Zhou XJ, Nie W, Chen L, Liu DH, Du HB,He CL*. Local delivery of BMP-2 from PLGA microspheres incorporated into porous nanofibrous scaffold for bone tissue regeneration.J. Biomed. Nanotechnol. 2017; 13(11): 1446-1456.
8. Chen L, Zhou XJ, Nie W, Feng W, Zhang QQ, Wang WZ, Zhang YZ, Chen ZG, Huang P*,He CL*. Marriage of albumin-gadolinium complexes and MoS2 nanoflakes as cancer theranostics for dual-modality magnetic resonance/photoacoustic imaging and photothermal therapy.ACS Appl. Mater. Interfaces. 2017; 9 (21):17786-17798.
9. Chen L, Feng YH, Zhou XJ, Zhang QQ, Nie W, Wang WZ, Zhang YZ,He CL*. One-pot synthesis of MoS2nanoflakes with desirable degradability for photothermal cancer therapy.ACS Appl. Mater. Interfaces. 2017; 9 (20): 17347-17358.
10. Nie W, Peng C, Zhou XJ, Chen L, Wang WZ, Zhang YZ, Ma PX*,He CL*. Three-dimensional porous scaffold by self-assembly of reduced graphene oxide and nano-hydroxyapatite composites for bone tissue engineering.Carbon. 2017; 126: 325-337.
11. Wang WZ, Miao YK, Zhou XJ, Nie W, Chen L, Liu DH, Du HB,He CL*. Local delivery of BMP-2 from PLGA microspheres incorporated into porous nanofibrous scaffold for bone tissue regeneration.J. Biomed. Nanotechnol. 2017; 13: 1-11.
12.Chen L, Zhou XJ, Nie W, Zhang QQ, Wang WZ, Zhang YZ,He CL*. Multifunctional redox-responsive mesoporous silica nanoparticles for efficient targeting drug delivery and magnetic resonance imaging.ACS Appl. Mater. Interfaces. 2016, 8 (49): 33829-33841.
13. Zhou XJ, Chen L, Nie W, Wang WZ, Qin M, Mo XM, Wang HS,He CL*. Dual-responsive mesoporous silica nanoparticles mediated co-delivery of doxorubicin and Bcl-2 siRNA for targeted treatment of breast cancer.J. Phys. Chem. C.2016; 120(39): 22375-22387.
14. Jia YT, Wang WZ, Zhou XJ, Nie W, Chen L,He CL*. Synthesis and characterization of poly(glycerol sebacate)-based elastomeric copolyesters for tissue engineering applications.Polym. Chem. 2016; 7: 2553-2564.
15. Qiu KX, Chen B, Nie W, Zhou XJ, Feng W, Wang WZ, Chen L, Mo XM, Wei YZ,He CL*. Electrophoretic deposition of dexamethasone-loaded mesoporous silica nanoparticles onto poly(L-lactic acid)/poly(ε–caprolactone) composite scaffold for bone tissue engineering.ACS Appl. Mater. Interfaces. 2016; 8 (6): 4137-4148.
16. Feng W, Chen L, Qin Ming, Zhou XJ, Zhang QQ, Miao YK, Qiu KX, Zhang YZ,He CL*. Flower-like PEGylated MoS2nanoflakes for near-infrared photothermal cancer therapy.Sci. Rep.-UK. 2015;5:17422.
17. Zhou XJ, Feng W, Qiu KX, Chen L, Wang WZ, Nie W, Mo XM,He CL*. BMP-2 derived peptide and dexamethasone incorporated mesoporous silica nanoparticles for enhanced osteogenic differentiation of bone mesenchymal stem cells.ACS Appl. Mater. Interfaces. 2015; 7 (29): 15777-15789.
18. Feng W, Zhou XJ, Nie W, Chen L, Qiu KX, Zhang YZ,He CL*. Au/polypyrrole@Fe3O4nanocomposites for MR/CT dual-modal imaging guided- photothermal therapy: an in vitro study.ACS Appl. Mater. Interfaces. 2015; 7(7): 4354-4367.
19. Feng W, Nie W, Cheng YH, Zhou XJ, Chen L, Qiu KX, Chen ZG*, Zhu MF,He CL*. In vitro and in vivo toxicity studies of copper sulfide nanoplates for potential photothermal applications.Nanomedicine: NBM. 2015; 11(4): 901-912.
20.He CL*, Nie W, Feng W. Engineering of biomimetic nanofibrous matrices for drug delivery and tissue engineering.J. Mater. Chem. B. 2014; 2(45): 7828-7848.(Front cover)
21. Zhou XJ, Cheng X, Feng W, Qiu KX, Chen L, Nie W, Yin ZQ, Mo XM, Wang HS,He CL*. Synthesis of hollow mesoporous silica nanoparticles with tunable shell thickness and pore size by using amphiphilic block copolymers as core templates.Dalton Trans. 2014; 43: 11834-11842.
22. Feng W, Nie W,He CL*, Zhou XJ, Chen L, Qiu KX, Wang WZ, Yin ZQ. Effect of pH-responsive alginate/chitosan multilayers coating on delivery efficiency, cellular uptake and biodistribution of mesoporous silica nanoparticles based nanocarriers.ACS Appl. Mater. Interfaces. 2014; 6 (11): 8447-8460.
23.He CL, Jin XB, Ma PX. Calcium phosphate deposition rate, structure and osteoconductivity on electrospun poly(l-lactic acid) matrix using electrodeposition or simulated body fluid incubation.Acta Biomater. 2014; 10(1): 419-427.
24. Feng W, Zhou XJ,He CL*, Qiu KX, Nie W, Chen L, Wang HS, Mo XM, Zhang YZ. Polyelectrolyte multilayer functionalized mesoporous silica nanoparticles for pH-responsive drug delivery: layer thickness-dependent release profiles and biocompatibility.J. Mater. Chem. B. 2013; 1(43): 5886-5898.(Front cover)
25. Qiu KX,He CL*, Feng W, Wang WZ, Zhou XJ, Yin ZQ, Chen L, Wang HS, Mo XM. Doxorubicin-loaded electrospun poly(L-lactic acid)/mesoporous silica nanoparticles composite nanofibers for potential postsurgical cancer treatment.J. Mater. Chem. B. 2013; 1(36): 4601-4611.
26.He CL*, Zhang F, Cao LJ, Feng W, Zhang YZ, Wang HS, Mo XM, Wang JW. Rapid mineralization of porous gelatin scaffolds by electrodeposition for bone tissue engineering.J. Mater. Chem. 2012; 22(5): 2111-2119.
27. Zhang F,He CL*, Cao LJ, Feng W, Wang HS, Mo XM, Wang JW. Fabrication of gelatin-hyaluronic acid hybrid scaffolds with tunable porous structures for soft tissue engineering.Int. J. Biol. Macromol. 2011; 48(3): 474-481.
28.He CL*, Feng W, Cao LJ, Fan LP. Crosslinking of poly(L-lactide) nanofibers with triallyl isocyanutrate by gamma-irradiation for tissue engineering application.J. Biomed. Mater. Res., Part A. 2011; 99A (4): 655-665.
29.He CL*, Xu XH, Zhang F, Wang HS, Mo XM. Fabrication of fibrinogen/ P(LLA-CL) hybrid nanofibrous scaffold for potential soft tissue engineering applications.J. Biomed. Mater. Res., Part A. 2011; 97A (3): 339-347.
30.He CL, Xiao GY, Jin XB, Sun CH, Ma PX. Electrodeposition on nanofibrous polymer scaffolds: rapid mineralization, tunable calcium phosphate composition and topography.Adv. Funct. Mater. 2010; 20(20):3568-3576.
