幹細胞因子(SCF),也稱為KIT配體或鋼因子[1],是一種結合CD117(c-KIT)的細胞因子。SCF也被稱為“鋼鐵因子”或“c-kit配體”。SCF以兩種形式存在,細胞表面結合的SCF和可溶性(或游離)的SCF。可溶性SCF是由金屬蛋白酶分解表面結合的SCF產生的。
Stem cell factor (SCF), otherwise known as KIT ligand or Steel factor[1],is a cytokine which binds CD117 (c-Kit). SCF is also known as "steel factor" or "c-kit ligand". SCF exists in two forms, cell surface bound SCF and soluble (or free) SCF. Soluble SCF is produced by the cleavage of surface bound SCF by metalloproteases.
SCF is a growth factor important for the survival, proliferation, and differentiation of hematopoietic stem cells and other hematopoietic progenitor cells. One of its roles is to change the BFU-E(burst-forming unit-erythroid) cells, which are the earliest erythrocyte precursors in the erythrocytic series, into the CFU-E (colony-forming unit-erythroid) . SCF, along with bFGF (basic fibroblast growth factor) and LIF (lymphocyte inhibitory factor), prevents spontaneous differentiation of primitive embryonic stem cell in cell culture[1].
Ancestim is a recombinant form of SCF.
安塞司亭(ancestim)是SCF的重組形式。
References(摘自)
^ a b Freshney, Ian R. Culture of Animal Cells: A manual of basic technique. John Wiley & Sons, Inc., Hoboken, New Jersey. ISBN 13 978-0-471-45329-1
^ da Silva MG, Pimentel P, Carvalhais A, et al (2004). "Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or growth factor-induced peripheral blood progenitor cell (PBPC) mobilization in patients with a prior insufficient PBPC collection". Bone Marrow Transplant. 34 (8): 683–91. doi:10.1038/sj.bmt.1704602. PMID 15322567