《integrin αvβ3 陽性腫瘤的分子顯像與放射靶向治療》是王凡為項目負責人，北京大學為依託單位的重點項目。
基本介紹
- 中文名：integrin αvβ3 陽性腫瘤的分子顯像與放射靶向治療
- 項目類別 ：重點項目
- 項目負責人：王凡
- 依託單位 ：北京大學
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | Noninvasive detection of human induced pluripotent stem cell (hiPSC)-derived teratoma with an integrin targeting agent 99mTc-3PRGD2 | 期刊論文 | Zhu, Zhaohui|Jia, Bing|Li, Fang|Wang, Fan| |
2 | Radioimmunotherapy of Human Colon Cancer Xenografts with I-131-Labeled Anti-CEA Monoclonal Antibody | 期刊論文 | Liu, Zhaofei|Jin, Cunjing|Yu, Zilin|Zhang, Jing|Liu, Yan|Zhao, Huiyun|Jia, Bing|Wang, Fan| |
3 | 99mTc-labeled VQ peptide: a new imaging agent for the early detection of tumors or premalignancies | 期刊論文 | Xiaona Jin|Huiyun Zhao|Fang Li|Fan Wang| |
4 | 99mTc-3PRGD2 for integrin receptor imaging of lung cancer: a multi-center study | 期刊論文 | Liu Z|Zhao Z|Wang F|Li F| |
5 | Evaluation of 188Re-MAG(2)-RGD-bombesin for potential prostate cancer therapy | 期刊論文 | Liyang Cui|Zhaofei Liu|Xiaona Jin|Bing Jia|Fang Li|Fan Wang| |
6 | Peptide-based radiopharmaceuticals for targeted tumor therapy | 期刊論文 | Chengyan Dong|Zhaofei Liu|Fan Wang| |
7 | Tc-99m-Labeled RGD-BBN Peptide for Small-Animal SPECT/CT of Lung Carcinoma | 期刊論文 | Jia, Bing|Zhu, Zhaohui|Li, Fang|Wang, Fan| |
8 | Tumor Uptake of the RGD Dimeric Probe Tc-99m-G(3)-2P(4)-RGD2 is Correlated with Integrin alpha(v)beta(3) Expressed on both Tumor Cells and Neovasculature | 期刊論文 | Liu, Zhaofei|Jia, Bing|Shi, Jiyun|Jin, Xiaona|Zhao, Huiyun|Li, Fang|Liu, Shuang|Wang, Fan| |
9 | Blood Clearance Kinetics, Biodistribution, and Radiation Dosimetry of a Kit-Formulated Integrin alpha(v)beta(3)-Selective Radiotracer (99m)Tc-3PRGD(2) in Non-Human Primates | 期刊論文 | Jia, Bing|Liu, Zhaofei|Zhu, Zhaohui|Shi, Jiyun|Jin, Xiaona|Zhao, Huiyun|Li, Fang|Liu, Shuang|Wang, Fan| |
10 | 99mTc-labeled dimeric octreotide peptide: a radiotracer with high tumor uptake for SPECT imaging of SSTR2-positive tumors | 期刊論文 | Fan Wang|Huiyun Zhao|Sujuan Yang|Jiyun Shi|Jinming Huang|Liyang Cui|Lijun Zhong|Xiaona Jin|Fang Li| |
11 | Specific Targeting of Human Integrin alpha(v)beta(3) with (111)In-Labeled Abegrin (TM) in Nude Mouse Models | 期刊論文 | Liu, Zhaofei|Jia, Bing|Zhao, Huiyun|Chen, Xiaoyuan|Wang, Fan| |
12 | An I-125-labeled octavalent peptide fluorescent nanoprobe for tumor-homing imaging in vivo | 期刊論文 | Fan, Di|Lu, Lisen|Wang, Fan|Zhang, Zhihong| |
13 | Epidermal Growth Factor Receptor-Targeted Radioimmunotherapy of Human Head and Neck Cancer Xenografts Using Y-90-Labeled Fully Human Antibody Panitumumab | 期刊論文 | Liu, Zhaofei|Liu, Yan|Jia, Bing|Zhao, Huiyun|Jin, Xiaona|Li, Fang|Chen, Xiaoyuan|Wang, Fan| |
14 | Potential Therapeutic Radiotracers: Preparation, Biodistribution and Metabolic Characteristics of Lu-177-labeled Cyclic RGDfK Dimer | 期刊論文 | Shi, Jiyun|Liu, Zhaofei|Jia, Bing|Yu, Zilin|Zhao, Huiyun|Wang, Fan| |
15 | Dual-Targeted Molecular Probes for Cancer Imaging | 期刊論文 | Liu, Zhaofei|Wang, Fan| |
16 | Bio-behavior in normal and tumor-bearing mice of tobacco mosaic virus | 期刊論文 | Quan Zhou|Fan Wang|Zhongwei Niu|Yong Huang| |
17 | Two (90)Y-Labeled Multimeric RGD Peptides RGD4 and 3PRGD2 for Integrin Targeted Radionuclide Therapy | 期刊論文 | Wang, Fan|Shi, Jiyun|Jia, Bing|Yu, Zilin|Liu, Yan|Zhao, Huiyun|Li, Fang|Tian, Jie|Chen, Xiaoyuan| |
18 | Development of RGD-based radiotracers for tumor imaging and therapy: translating from bench to bedside | 期刊論文 | Zhaofei Liu|Fan Wang| |
項目摘要
腫瘤分子顯像和分子靶向治療是診治腫瘤的重要研究內容，顯像的目的是為了更好地治療。最新研究表明，腫瘤的發生伴隨著多個基因位點突變，靶向下游的某單一靶點的治療效果很可能是有限的。在腫瘤分子靶向治療面臨巨大挑戰的時候，腫瘤放射靶向治療更突顯其優勢。為了使放射性核素標記的多肽分子探針具有更加有效的放射治療效果，目前多採取多肽分子多聚化的辦法提高腫瘤對放射性分子探針的攝取並延長其在腫瘤的滯留時間。但是單純多聚化其負面效應也是非常嚴重的，正常組織特別是腎臟對放射性分子探針的攝取明顯提高。因此單純的多聚化是不切實際的，必須對多肽分子進行結構改造。本課題針對腫瘤表達的integrin αvβ3設計以RGD多肽為靶向分子的放射性分子探針，通過多肽分子結構改造最佳化出具有優良體內外性質的111In標記的顯像探針，並在此基礎上用90Y和177Lu標記性質優良的靶向分子，進行腫瘤放射靶向治療的相關研究。
