《Mg-Ca-Sr合金的腐蝕降解及其降解產物的生物學效應》是鄭玉峰為項目負責人，北京大學為依託單位的青年科學基金項目。
基本介紹
- 中文名：Mg-Ca-Sr合金的腐蝕降解及其降解產物的生物學效應
- 項目類別 ：面上項目
- 依託單位 ：北京大學
- 項目負責人：鄭玉峰
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | Effect of sterilization process on surface characteristics and biocompatibility of pure Mg and MgCa alloys | 期刊論文 | W.R. Zhou|Y.H. Wu|Y. Cheng|Y.F. Zheng| |
2 | Novel Magnesium Alloys Developed for Biomedical Application: A Review | 期刊論文 | Nan Li|Yufeng Zheng| |
3 | Surface chemistry of bulk nanocrystalline pure iron and electrochemistry study in gas-flow physiological saline | 期刊論文 | Nie, F. L.|Zheng, Y. F.| |
4 | Surface Characterization and Cell Response of Binary Ti-Ag Alloys with CP Ti as Material Control | 期刊論文 | Qiu, K. J.|Wang, B. L.|Li, L.|Zheng, Y. F.| |
5 | In vitro and in vivo studies on Ti-based bulk metallic glass as potential dental implant material | 期刊論文 | H.F. Li|Y. Cheng|Y.F. Zheng|L.Q. Ruan| |
6 | In vitro study on newly designed biodegradable Fe-X composites (X = W, CNT) prepared by spark plasma sintering | 期刊論文 | Cheng, J.|Zheng, Y. F.| |
7 | Screening on binary Zr–1X (X = Ti, Nb, Mo, Cu, Au, Pd, Ag, Ru, Hf and Bi) alloys with good in vitro cytocompatibility and magnetic resonance imaging compatibility | 期刊論文 | T. Huang|B.L. Wang|L. Li|Y.F. Zheng| |
8 | Design and characterizations of novel biodegradable ternary Zn-based alloys with IIA nutrient alloying elements Mg, Ca and Sr | 期刊論文 | Yufeng Zheng|Feiyu Zhou|Kejin Qiu|Xiang Wang| |
9 | In vitro degradation and biocompatibility of Fe-Pd and Fe-Pt composites fabricated by spark plasma sintering | 期刊論文 | Huang, T.|Cheng, J.|Zheng, Y. F.| |
10 | Effect of surface mechanical attrition treatment on biodegradable Mg-1Ca alloy | 期刊論文 | Y.X. Li|Y.H. Wu|Y.F. Zheng|Y. Han| |
11 | 可降解鎂合金醫療器械的研發現狀 | 期刊論文 | 周維瑞|鄭玉峰| |
12 | Corrosion resistance and cytotoxicity of a MgF2 coating on biomedical Mg-1Ca alloy via vacuum evaporation deposition method | 期刊論文 | Li, M.|Cheng, Y.|Wu, Y. H.|Zheng, Y. F.| |
13 | Microstructures, mechanical behavior, cellular response, and hemocompatibility of bulk ultrafine-grained pure tantalum | 期刊論文 | Nie, F. L.|Zheng, Y. F.|Wang, Y.|Wang, J. T.| |
14 | Microstructure, corrosion behavior and cytotoxicity of Zr-Nb alloys for biomedical application | 期刊論文 | Li, L.|Wang, Y. B.|Nie, F. L.|Zheng, Y. F.| |
15 | Unique antitumor property of the Mg-Ca-Sr alloys with addition of Zn | 期刊論文 | Li Kang|Zheng Guan|Zheng Yufeng|Yin Qingshui| |
16 | In vitro and in vivo studies on biodegradable CaMgZnSrYb high-entropy bulk metallic glass | 期刊論文 | Y.B. Wang|Y.F. Zheng|W.H. Wang|L. Qin| |
17 | Mechanical property, biocorrosion and in vitro biocompatibility evaluations of Mg–Li–(Al)–(RE) alloys for future cardiovascular stent application | 期刊論文 | W.R. Zhou|Y.F. Zheng|M.A. Leeflang|J. Zhou| |
18 | Magnesium alloys as biodegradable biomaterials | 學術專著 | - |
19 | Comparative study on corrosion behaviour of pure Mg and WE43 alloy in static, stirring and flowing Hank's solution | 期刊論文 | Guo, C.|Wu, Y. H.|Zheng, Y. F.|Ruan, L. Q.| |
20 | Influence of biocompatible metal ions (Ag, Fe, Y) on the surface chemistry, corrosion behavior and cytocompatibility of Mg–1Ca alloy treated with MEVVA | 期刊論文 | Nan Li|Kejin Qiu|Yufeng Zheng|Yong Han| |
21 | In vitro and in vivo studies on a Mg-Sr binary alloy system developed as a new kind of biodegradable metal | 期刊論文 | Xie, X. H.|Li, N.|Zheng, Y. F.|Qin, L.| |
22 | Microstructure, mechanical property, biodegradation behavior, and biocompatibility of biodegradable Fe-Fe2O3 composites | 期刊論文 | Cheng, J.|Huang, T.|Zheng, Y. F.| |
23 | Osteoblast response on Ti- and Zr-based bulk metallic glass surfaces after sand blasting modification | 期刊論文 | Li, H. F.|Wang, Y. B.|Zheng, Y. F.|Lin, J. P.| |
24 | Ti-Ge binary alloy system developed as potential dental materials | 期刊論文 | Li, Li|Lin, Jun-Pin|Wang, Yan-Bo|Zheng, Yu-Feng| |
25 | In vitro and in vivo studies on nanocrystalline Ti fabricated by equal channel angular pressing with microcrystalline CP Ti as control | 期刊論文 | Yu, Z. T.|Salimgareeva, G. K.|Polyakov, A. V.|Valiev, R. Z.| |
26 | Development of biodegradable Zn-1X binary alloys with nutrient alloying elements Mg, Ca and Sr | 期刊論文 | S. H. Chen|L. Huang|L. Tian|L. Qin| |
27 | Effect of surface mechanical attrition treatment on biodegradable Mg-1Ca alloy | 期刊論文 | Li, Y. X.|Wu, Y. H.|Zheng, Y. F.|Han, Y.| |
28 | Comparative in？vitro Study on Pure Metals (Fe, Mn, Mg, Zn and W) as？Biodegradable Metals | 期刊論文 | J. Cheng|B. Liu|Y.H. Wu|Y.F. Zheng| |
29 | Biodegradable metals | 期刊論文 | Zheng, Y. F.|Gu, X. N.|Witte, F.| |
30 | In？vitro Study on Biodegradable AZ31 Magnesium Alloy Fibers Reinforced PLGA Composite | 期刊論文 | N. Li|Y. Cheng|Y.F. Zheng|Y. Han| |
項目摘要
Sr是人體的微量元素，可促進骨形成，抑制骨吸收。前人工作發現：口服含Sr的藥物可治療骨質疏鬆，含Sr-HA 骨水泥可促進骨細胞粘附和礦化，有利於骨生長和整合。本課題擬在前期基金項目（30670560）所發展出的Mg-Ca合金（Biomaterials 29 (2008)1329-1344）中添加元素Sr，設計並製備出新型Mg-Ca-Sr 體系可降解金屬材料，考察其冷熱加工性能和力學性能，研究其在體外和體內多種生理環境下的腐蝕降解行為與相關機制，探明其化學成分、加工狀態、腐蝕介質與腐蝕方式之間的關係，揭示Mg、Ca、Sr 離子的溶出規律；通過細胞毒性、細胞粘附、礦化行為研究，探討Mg-Ca-Sr合金降解產物對細胞活性、細胞在其表面粘附能力和礦化能力的影響規律，通過動物體內植入實驗，考察Mg、Ca、Sr 離子共同釋放對於周圍骨組織生長和吸收的影響規律，揭示引發其產生生物學效應的內在機理。
