《Innate Immunity and Inflammation》是2014年 Cold Spring Harbor Laboratory Press出版的圖書，作者是Ruslan Medzhitov 。
基本介紹
- 中文名：Innate Immunity and Inflammation
- 作者：Ruslan Medzhitov
- 出版社： Cold Spring Harbor Laboratory Press
- 出版時間：2014年10月31日
- ISBN：9781621820291
內容簡介,作者簡介,
內容簡介
The innate immune system is rapidly activated in response to infection and injury. It is a generic rather than pathogen-specific response that recruits immune cells, promotes inflammation, and mobilizes the adaptive immune system. Excessive or chronic inflammation may cause tissue damage, so a careful balance is required to restore homeostasis.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the cellular and molecular mechanisms involved in innate immunity and all types of inflammation. The contributors examine the cell types that make up the innate immune system, their use of pattern recognition receptors (e.g., Toll-like receptors) to identify pathogens and damaged tissues, and how they trigger signaling pathways that culminate in inflammation, pathogen destruction, and tissue repair. The numerous chemical signals and factors involved in innate immunity and inflammation are described, as are those that keep inflammation in check.
The authors also discuss the diseases that can result when these processes go awry, such as rheumatoid arthritis and cancer. This volume is therefore a valuable reference for all immunologists, cell biologists, and medical scientists wishing to understand these protective processes and their implications for human health and disease.
作者簡介
Ruslan Medzhitov was born in Tashkent, Uzbekistan, and earned a B.S. at Tashkent State University before going on to pursue a Ph.D. in biochemistry at Moscow University in 1990. He performed his postdoctoral studies with the late Charles A. Janeway Jr. at Yale University Medical School.
