龍少軍，男，博士，中國農業大學動物醫學院預防獸醫學系教授、博士生導師。
基本介紹
- 中文名：龍少軍
- 出生日期：1978年9月
- 畢業院校：捷克國家科學院寄生蟲學研究所
- 學位/學歷：博士
- 專業方向：細胞與分子寄生蟲學
- 任職院校：中國農業大學
人物經歷,研究方向,發表論文,
人物經歷
2018年校引進“傑出人才”。2009年12月在捷克國家科學院寄生蟲學研究所獲得細胞與分子寄生蟲學方向的博士學位，隨後在英國紐卡斯爾大學以瑪麗居里學者(Marie Curie Intra-European Fellow)繼續從事寄生蟲學研究，於2013年6月在美國聖路易斯華盛頓大學從事重要人獸共患寄生原蟲-弓形蟲的細胞與分子生物學研究。龍博士從2005年至2017年底一直在具有重要國際影響的寄生蟲學科研團隊學習和工作，受到了嚴格的訓練，以第一作者在Nature Communications、PLoS Pathogens、PNAS、Infection and Immunity、Molecular Microbiology等學術期刊發表多篇研究論文，並參與多項基礎理論和藥物開發相關的課題研究。
研究方向
近3年來，龍博士在弓形蟲入侵宿主的細胞與分子機制、和弓形蟲分子遺傳研究技術方面取得了系列的重要進展，對解析弓形蟲的生物學和致病機制具有直接的推動作用。龍博士的研究方向將包括以下幾個方面：以重要人獸共患寄生原蟲-弓形蟲為研究模型，深入探討重要原蟲的入侵/逸出機制、原蟲與宿主的互作、原蟲生活周期中蟲體的發育與分化、以及重要原蟲的防控措施等。
發表論文
1.Long S, Anthony B, Drewry L, Sibley LD. 2017. A Conserved ankyrin repeat containing protein CPH1 regulates conoid stability, motility and cell invasion in Toxoplasma. Nature Communications. 2017.12.21,8(1). 影響因子=12.124
2.Long S; Brown KM; Drewry LL; Anthony B; Phan IQ; Sibley LD. 2017. Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii. PLoS Pathogens. 2017.5.5, 13(5):e1006379. F1000 recommendations - Microbiology. 影響因子=6.608
3.Long S, Wang Qiuling, Sibley David. 2016. Analysis of noncanonical calcium-dependent protein kinases in Toxoplasma gondii by targeted gene deletion using CRISPRCas9. Infection and Immunity. 2016.4.22. 84(5):1262-73. 5年影響因子=3.593
Commentary: Bzik DJ. 2016. Serial Dissection of Parasite Gene Families. Infect Immun. 84(5):1252-4. Doi:10.1128IAI.00175-16.
4.Long S, Brown KM, Sibley LD. 2018. Protein interactomes defined by BirA labeling in Toxoplasma gondii. Bio-Protocol. 8(6). pii: e2768.
5.Brown KM, Long S, Sibley LD. 2018. Conditional Knockdown of Proteins Using Auxin-inducible Degron (AID) Fusions in Toxoplasma gondii. Bio-Protocol. 2018.2.20, 8(4).
6.Long S, Jirků M, Ayala FJ, Lukeš J. 2008. Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei. Proc. Natl. Acad. Sci. USA. 2008.9.9, 105: 13468-13473. 影響因子=9.661
7.Long S, Jirků M, Mach J, Ginger ML, Sutak R, Des Richardson R, Tachezy J, Lukeš J. 2008. Ancestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes. Mol. Microbiol. 2008.7, 69: 94-109. 影響因子=3.898
8.Long S, Piya C, Tsaousis DA, Skalicky T, Verner Z, Wen YZ, Roger AJ, Lukeš J. 2011. Stage-specific essentiality of Isa1 and Isa2, mitochondrial Fecluster assembly proteins in the excavate protist Trypanosoma brucei. Mol. Microbiol. 2011.9, 81: 1403-1418. 影響因子=3.898
9.Long S, Vavrova Z, Lukeš J. 2008. The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei. Mol. Biochem. Parasitol. 2008.11, 162: 100-104. 影響因子=2.536
合作作者論文：
10.Molik S, Goldberg AV, Hacker C, Freibert SA, Dean P, Williams TA, Nakjang S, Long S, Sendra K, Heinz E, Hirt RP, Lucocq JM, Embley TM, Lill R. 2017. Evolutionary conservation and in vitro reconstitution of microsporidian iron-sulfur cluster biosynthesis. Nature Communications. 2017.1.4, 8:13932. 影響因子=12.124
11.Rutaganira F, Barks J, Dhason M, Wang Q, Lopez M, Long S, Radke J, Jones N, Maddirala A, Janetka J, El Bakkouri M, Hui R, Shokat K, Sibley LD. 2017. Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii. J Med Chem. 2017.12.28. 60(24):9976-9989. 影響因子=6.259
12.Brown K, Long S, Sibley LD. 2017. Plasma membrane-association by N-acylation governs PKG function in Toxoplasma gondii. mBio. 2017.5.2, 8(3):e00375-17. 影響因子=6.956
13.Kuhlenschmidt TB, Rutaganira FU, Long S, Tang K, Shokat KM, Kuhlenschmidt MS, Sibley LD. 2015. Inhibition of calcium-dependent protein kinase 1 (CDPK1) in vitro pyrazolopyrimidine derivatives does not correlate with sensitivity of Cryptosporidium parvum growth in cell culture. Antimicrob Agents Chemother. 2015.11.9. 60(1):570-9. 影響因子=4.302
14.Piya C, Horáková E, Long S, Černotíková-Stříbrná E, Lindsay M. Esteban JM. Bontempi, Lukeš J. 2013. Both human ferredoxins equally efficiently rescue ferredoxin deficiency in trypanosomes. Mol. Microbiol. 2013.7, 89: 135-51. 影響因子=3.898
15.Tsaousis AD., Ollagnier-de Choudens S, Gentekaki E, Long S, Gaston D, Stechmann A, Vinella D, Py B, Fontecave M, Barras F, Lukeš J and Roger AJ. 2012. The evolution of Fe-S cluster biogenesis in the anaerobic parasite Blastocystis. Proc. Natl. Acad. Sci. USA. 2012.6.26,109: 10426-10431. 影響因子=9.661
16.Bang S, Brown L, Long S, Sibley LD. 2017. Development of CRISPRCas9 for efficient genome editing in Toxoplasma gondii. Methods in Molecular and Cellular Biology. 1498:79-103.
17.Týč J, Long S, Jirků M, Lukeš J. 2010. YCF45 protein, usually associated with plastids, is targeted into the mitochondrion of Trypanosoma brucei. Mol. Biochem. Parasitol. 173: 43-47. 影響因子=2.157
18.Wohlgamuth-Benedum JM, Rubio MT, Paris Z, Long S, Poliak P, Lukeš J, Alfonzo JD. 2009. Thiolation controls cytoplasmic tRNA stability and acts as a negative determinant for tRNA editing in mitochondria. J. Biol. Chem. 284: 23947-23953. 影響因子=4.32
