馮紅，男，四川大學博士，四川大學生命科學學院教授。
基本介紹
- 中文名：馮紅
- 國籍：中國
- 畢業院校：四川大學
- 學位/學歷：博士
- 職稱：教授
人物經歷,研究方向,教學工作,主要貢獻,科研項目,發明專利,發表論文,
人物經歷
四川農業大學，學士（1985.07）；四川農業大學，碩士(1988.07)；四川大學，博士(2000.07)。
1988.07-1997.09— 四川農業大學，副教授(1996)。
2000.07-2001.12— 成都百奧生物信息科技有限公司，研究發展部經理。
2001.12-2004.08 —美國Clemson University遺傳與生物化學系博士後。
2004.12-至今—四川大學生命科學學院任教，教授(2007)。
研究方向
分子微生物學和生物技術相關領域，主要研究方向包括原核功能基因及其轉錄調控機理，工業酶的生物化學與酶工程以及套用。具體包括:
短小芽孢桿菌（Bacillus pumilus）鹼性蛋白酶基因轉錄調控機理的研究，涉及相關轉錄因子（hpr,degU/S,SinR等）的克隆、表達、與啟動子DNA的互作、基因敲除以及在鹼性蛋白酶基因表達等方面的生物學功能。
工業酶（鹼性蛋白酶、環氧化物水解酶、角蛋白酶等）的催化特性和分子改造，主要採用3D 結構模型的預測與設計，利用定點突變和分子進化策略改造分析這些工業用酶的催化特性，以期獲得更加符合工業套用工藝和技術的突變體酶，同時分析研究結構與功能關係。
在生物技術領域，研究開發農業廢棄蛋白質等生物資源的生物轉化和利用。
教學工作
· 本科生教學：《基因工程》、《生物化工》
· 研究生教學：《基因工程原理》、《基因表達調控》。
主要貢獻
科研項目
· 科技部“863”專題項目《製革用鹼性蛋白酶基因的分子進化研究》
· 科技部支撐計畫項目《西南甘薯為原料的燃料乙醇關鍵技術的產業化與示範》子課題
· 自然科學基金《短小芽胞桿菌鹼性蛋白酶基因的轉錄調控》
· 四川省教育廳創新團隊《農業廢棄資源的生物轉化與利用》
· 橫向項目《雲南野生稻抗病基因資源的挖掘與利用》
發明專利
尹海濱，馮紅，楊冬，黃迎春 (2002) 用於轉基因植物的監測基因晶片. 專利號: ZL 01 2 14517.3
尹海濱，馮紅，楊冬，黃迎春. (2002) 用於動植物及其產品檢疫的基因檢測晶片,專利號: ZL 01 2 06357.6
尹海濱，馮紅，楊冬，黃迎春 (2001) 用於疾病診斷的檢測型基因晶片. 專利號: ZL 00 2 44776.2
發表論文
(*通訊作者)
1. Dong G, M-X He, Feng H* (2016) Functional characterization of CRISPR-Cas system in the ethanologenic bacterium Zymomonas mobilis ZM4. Adv. Microbiol. 6: 178-189.
2. Wan M-Y, Dong G, Yang B-Q, Feng H* (2016) Identification and characterization of a novel antioxidant peptide from feather keratin hydrolysate. Biotech. Lett. 38(4): 643-649.
3. Huang R, Yang Q, Feng H*. (2015) Single amino acid mutation alters thermostability of the alkaline protease from Bacillus pumilus: thermodynamics and temperature dependence. Acta Biochim. Biophys. Sin. 47(2): 98-105.
4. Shao H, Cao Q, Zhao, H, Tan X, Feng H* (2015) Construction of novel shuttle expression vectors for gene expression in Bacillus subtilis and Bacillus pumilus. J. Gen. Appl. Microbiol. 61(2): 124-131.
5. Jing Z, Feng H*(2015) Studies on the molecular docking and amino acid residues involving in recognition of substrate in proline iminopeptidase by site-directed mutagenesis. Protein J. 34(3):173-180.
6. Liu RF, Huang CL, Feng H* (2015) Salt stress represses production of extracellular proteases in Bacillus pumilus. Genet. Mol. Res. 14(2): 4339-4948
7. Zhang K, Shao H, Cao Q, He M-X, Wu B, Feng H* (2015) Transcriptional analysis of adaptation to high glucose concentrations in Zymomonas mobilis. Appl. Microbiol. Biotechnol. 99(4), 2009-2022
8. Wu B, He M-X, Feng H, Shui Z-X, Tang X-Y, Hu Q-C, Zhang Y-Z (2014) Construction of a novel secretion expression system guided by native signal peptide of PhoD in Zymomonas mobilis. Biosci. Biotechnol Biochem. 78(4):708-713
9. 馮紅*,董閣,雍彬,李維 (2014) 原核CRISPR-Cas系統的結構及套用. 四川師範大學學報(自然版). 37(2):268-281
10. Yong B, Yang B-Q, Zhao C-W, Feng H* (2013) Draft genome sequence of Bacillus subtilis strain S1-4, which degrades feathers efficiently. Genome Announcements. 1(5):e00766-13. doi:10.1128/genomeA.00766-13.
11. Yong B, Yang B-Q, Feng H* (2013) Efficient degradation of raw chicken feather into soluble peptides and free amino acids by a newly isolated Bacillus subtilis S1-4. Res. J. BioTechnol. 8(9):48-55.
12. Xing K-K, Feng H* (2013) Role of amino acid residues involved in the active cavity of proline iminopeptidase in catalytic activity. Adv. Biol. Chem. 3(3):288-294.
13. Wu B, He M-X, Feng H, Zhang Y, Hu Q-C, Zhang Y-Z (2013) Construction and characterization of restriction-modification deficient mutants in Zymomonas mobilis ZM4. Chin J Appl Environ Biol. 19(2):189-197
14. Wang Z, Wang H-Y, Feng H* (2013) A simple and reproducible method for directed evolution: Combination of random mutation with dITP and DNA fragmentation with endonuclease V. Mol. Biotechnol. 53(1):49-54.
15. Zhao C-W, Wang H-Y, Zhang Y-Z, Feng H* (2012) Draft genome sequence of Bacillus pumilus BA06, a producer of alkaline serine protease with leather-dehairing function. J. Bacterial. 194(23):6668-6669.
16. Shao H-H, Cao Q-H, Tao X, Gu T-H, Chang M-J, Huang C-L, Zhang Y-Z, Feng H* (2011) Cloning and characterization of ATP synthase CF1 α gene from sweet potato. Afr. J. Biotechnol. 10(82), 19035-19042.
17. Zhang, Lin-Fen; Wu, Jin-Ming; Feng, Hong* (2011) Homology modeling and site-directed mutagenesis studies of the epoxide hydrolase from Phanerochaete chrysosporium. J. Biochem. 149(6):673-684.
18. Liang Y-J, Zhang X-Y, Luo W-J, Zhong Z-T, Lv M, Feng H, Zhao Y, Huang Q. (2011) Different multiwalled carbon nanotubes--Enzyme system and enzymatic activity. Prep. Biochem. Biotech. 2011, 41(3):243-251.
19. Li N, Wu J-M, Zhang Y-Z, Feng H* (2010) Characterization of a unique proline iminopeptidase from white-rot basidiomycetes Phanerochaete chrysosporium. Biochim. 92(7):779-788.
20. Zhang K, Feng H* (2010) Fermentation potentials of Zymomonas mobilis and its application in ethanol production from low-cost raw sweet potato. Afr. J. Biotech. 9(37):6122-6128.
21. 張昆,邵歡歡,馮紅* (2010) 運動發酵單胞菌利用澱粉基質生產乙醇研究進展 （閻文昭 主編）四川省科技出版社
22. 楊慶軍,張小煒,張義正,馮紅* (2010）脫毛鹼性蛋白酶定點突變的初步分析, 四川大學學報(自然版), 47(4)：936-940.
23. 楊錦,馮紅,萬民遠，焦惠科，張曉露 張義正 (2010) 短小芽孢桿菌鹼性蛋白酶基因的隨機突變，套用環境生物學報, 16(1):96-99.
24. He M-X, Li Y, Bai F, Liu X, Feng H, Zhang Y-Z. (2009) Ethanol production from raw sweet potato starch by mixed-culture of Paenibacillus sp. and Zymomonas mobilis. Ann. Microbiol. 59(4):749-754.
25. He M-X, Feng H, Bai F, Li Y, Liu X, Zhang Y-Z. (2009) Direct production of ethanol from raw sweet potato starch using genetically engineered Zymomonas mobilis. Afr. J. Microbiol. Res. 3(11):721-726.
26. Jiang M-F, Li X, Zhang L, Feng H, Zhang Y-Z. (2009) Gene expression analysis of Phanerochaete chrysosporium during the transition time from primary growth to secondary metabolism. J. Microbiol. 47(3):308-318.
27. Li Nian, Zhang Y-Z, Feng H* (2009) Biochemical characterization and transcriptional analysis of the epoxide hydrolase from white-rot fungus Phanerechaete chrysosporium. Acta Biochim. Biophys. Sin. 41(8):638-647.
28. Wan M-Y, Wang H-Y, Zhang Y-Z, Feng H.* (2009) Substrate specificity and thermostability of the dehairing alkaline protease from Bacillus pumilus. Appl. Biochem. Biotechnol. 159(2):394-403.
29. He M-X, Feng H, Zhang Y-Z. (2008) Construction of a novel cell-surface display system for heterologous gene expression in Escherichia coli by using an outer membrane protein of Zymomonas mobilis as anchor motif. Biotechnol. Lett. 30:2111-2117.
30. Feng H* (2007) Mutational analysis of bacterial NAD-dependent DNA ligase: roles of motif IV in ligation catalysis. Acta Biochim. Biophys. Sin. 39(8):608-616.
31. Wu B, Hu G-K, Feng H, Wu J-M, Zhang Y-Z. (2007) Cloning and expression of an alpha-amylase gene from Phanerochaete chrysosporium. Curr. Microbiol. 55(2):105-113.
32. Feng H, Dong L, Cao W (2006) Catalytic mechanism of endonuclease V: a catalytic and regulatory two-metal model. Biochem. 45(34):10251-9.
33. Hu G-K, Feng H, Zhang T, Yan Y-H, Wu B, Jiang Q, Wu J-M, Zhang Y-Z. (2006) Molecular cloning of cDNAs for 14-3-3 and its protein interactions in a white-rot fungus Phanerochaete chrysosporium. Ann. Microbiol. 56(3):191-166.
34. 胡國庫, 顏永紅, 姜權, 吳波, 馮紅, 張義正 (2006) 黃孢原毛平革菌酵母雙雜交cDNA文庫的構建及套用. 套用與環境生物學報. 12(5):678-682.
35. Feng H, Dong L, Klutz AM, Aghaebrahim N, Cao W. (2005) Defining amino acid residues involved in DNA-protein interactions and revelation of 3'-exonuclease activity in endonuclease V. Biochem. 44(34):11486-95.
36. Feng H, Klutz AM, Cao W. (2005) Active site plasticity of endonuclease V from Salmonella typhimurium. Biochem. 44(2):675-83.
37. 黃迎春, 馮紅, 孫春昀, 陳永兵 (2005) 利用基因晶片檢測性傳播疾病. 四川大學學報(醫學版) 36(4):576-577.
38. Feng, Hong; Parker, Jeremy M.; Lu, Jing; Cao, Weiguo (2004) Effects of deletion and site-directed mutations on ligation steps of NAD+-dependent DNA ligase: a biochemical analysis of BRCA1 C-terminal domain. Biochem. 43(39):12648-59. 被引用次數：19
39. Lu J, Tong J, Feng H, Huang J, Afonso CL, Rock DL, Barany F, Cao W. (2004) Unique ligation properties of eukaryotic NAD+-dependent DNA ligase from Melanoplus sanguinipes entomopoxvirus. Biochim. Biophys. Acta 1701(1-2):37-48.
40. 黃迎春, 孫春昀, 馮紅, 胡曉東, 尹海濱 (2003) 利用基因晶片檢測轉基因作物. 遺傳. 25(3):307-310.
41. 馮紅, 張義正 (2000) 炭疽菌不利用硝酸鹽突變體的篩選及鑑定. 微生物學通報. 27(5):341-345.
42. 馮紅,張義正 (2000) 黃孢原毛平革菌木質素過氧化物酶基因對營養的轉錄應答. 四川大學學報(自然版). 37(Sup):153-160.
43. 馮紅,張義正 (1999) 木質素過氧化物酶基因5′端上游調控序列的分析. 生物化學與生物物理學報. 31(6): 669-674.
