韓之明，女，博士，副研究員，畢業於北京師範大學。
基本介紹
- 中文名：韓之明
- 國籍：中國
- 畢業院校：北京師範大學
- 主要成就：發表學術論文53篇，其中SCI文章總計43篇
- 性別：女
- 學位：博士
- 職稱：副研究員
個人信息,簡歷,代表論著,
個人信息
姓 名:韓之明
學 科:生理學
簡歷
韓之明，女，博士，副研究員。
1996年畢業於北京師範大學生物學專業，獲理學學士學位。1996至1997年在中國科學院動物研究所生殖生物學國家重點實驗室受精生物學研究組工作，從事受精機理的研究。1997至2002年為北京師範大學生命科學學院碩博連讀研究生，主要在中國科學院動物研究所從事動物克隆的研究，參與了中國科學院知識創新和科技部攀登項目“異種克隆大熊貓研究”，國家自然科學基金“體細胞克隆牛研究”，“973”課題“異種克隆中線粒體命運研究”以及“治療性克隆靈長類動物模型的建立”等課題的研究工作。2002年7月於北京師範大學獲理學博士學位。2002年12月赴美國坦普爾大學醫學院費爾斯腫瘤與分子生物學研究所從事博士後研究工作，研究方向為動物克隆及胚胎髮育機理，參與了“小鼠克隆的表觀遺傳學研究”，“克隆胚胎的核重編程研究” 及“著床前胚胎的卵裂球胞質碎片化研究”等多項美國國立衛生研究院課題的研究工作。2007年12月任中國科學院動物研究所副研究員，主要從事哺乳動物受精、克隆和早期胚胎髮育的研究。現承擔國家自然科學基金面上項目、國家高技術研究發展計畫（863項目）課題以及中國科學院動物研究所青年科技創新人才資助項目。已在 Biology of Reproduction, Molecular Reproduction and Development, Developmental Biology, Genetics, Trends in Biotechnology, Molecular Biology of the Cell等學術期刊上發表學術論文53篇，其中SCI文章總計43篇，已被引用200餘次。
代表論著
Han Z, Liang CG, Cheng Y, Duan X, Zhong Z, Potireddy S, Moncada C, Merali S, Latham KE. 2010. Oocyte Spindle Proteomics Analysis Leading to Rescue of Chromosome Congression Defects in Cloned Embryos. J Proteome Res
Han Z, Cheng Y, Liang CG, Latham KE. 2010. Nuclear transfer in mouse oocytes and embryos. Methods Enzymol
Han Z, Mtango NR, Zhong Z, Vassena R, Latham KE. 2010. Early transcription from the maternal genome controlling blastomere integrity in mouse two-cell-stage embryos. Am J Physiol Cell Physiol.
Han Z, Mtango NR, Patel BG, Sapienza C, Latham KE. 2008. Hybrid Vigor and Transgenerational Epigenetic Effects on Early Mouse Embryo Phenotype. Biology of Reproduction.
Han Z, Vassena R, Chi MM, Potireddy S, Sutovsky M, Moley KH, Sutovsky P, Latham KE. 2008. Role of glucose in cloned mouse embryo development. Am J Physiol Endocrinol Metab.
Liang CG, Han Z, Cheng Y, Zhong Z, Latham KE. 2009. Effects of ooplasm transfer on paternal genome function in mice. Hum Reprod.
Wang J, Zhang M, Zhang Y, Kou Z, Han Z, Chen DY, Sun QY, Gao S. 2009. The Histone Demethylase JMJD2C Is Stage-Specifically Expressed in Preimplantation Mouse Embryos and Is Required for Embryonic Development. Biol Reprod.
Shi LH, Ai JS, Ouyang YC, Huang JC, Lei ZL, Wang Q, Yin S, Han ZM, Sun QY, Chen DY. 2008. Trichostatin A and nuclear reprogramming of cloned rabbit embryos. Journal of animal science
Shi LH, Miao YL, Ouyang YC, Huang JC, Lei ZL, Yang JW, Han ZM, Song XF, Sun QY, Chen DY. 2008. Trichostatin A (TSA) improves the development of rabbit-rabbit intraspecies cloned embryos, but not rabbit-human interspecies cloned embryos. Developmental Dynamics.
Han Z, Vandevoort CA, Latham KE. 2007. Therapeutic cloning: status and prospects. Current opinion in molecular therapeutics.
Vassena R, Han Z, Gao S, Latham KE. 2007. Deficiency in recapitulation of stage-specific embryonic gene transcription in two-cell stage cloned mouse embryos. Molecular Reproduction and Development.
Kuzmin A, Han Z, Golding MC, Mann MR, Latham KE, Varmuza S. 2008. The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues. Gene Express Patterns.
Hao L, Vassena R, Wu G, Han Z, Cheng Y, Latham KE, Sapienza C. 2009. The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome. Biol Reprod.
Cheng Y, Wang K, Kellam LD, Lee YS, Liang CG, Han Z, Mtango NR, Latham KE. 2009. Effects of Ooplasm Manipulation on DNA Methylation and Growth of Progeny in mice. Biology of Reproduction.
Vassena R, Han Z, Gao S, Baldwin DA, Schultz RM, Latham KE. 2007. Tough beginnings: alterations in the transcriptome of cloned embryos during the first two cell cycles. Developmental Biology.
Latham KE, Gao S, Han Z. 2007. Somatic cell nuclei in cloning: strangers traveling in a foreign land. Advances in experimental medicine and biology.
Miyara F, Han Z, Gao S, Vassena R, Latham KE. 2006. Non-equivalence of embryonic and somatic cell nuclei affecting spindle composition in clones. Developmental Biology.
Han Z, Chung YG, Gao S, Latham KE. 2005. Maternal factor controlling blastomere fragmentation in early mouse embryos. Biology of Reproduction.
Gao S, Wu G, Han Z, de la Casa E, Sapienza C, Latham KE. 2005. Recapitulation of the Ovum mutant (Om) phenotype and loss of Om locus polarity in cloned mouse embryos. Biology of Reproduction.
Nolan L, Gao S, Han Z, Chung YG, Bartolomei M, Latham KE. 2005. Aberrant X chromosome regulation in cloned mice. Developmental Biology.
Wu G, Hao L, Han Z, Gao S, Latham KE, Pardo-Manuel de Villena F, Sapienza C. 2005. Maternal transmission ratio distortion at the mouse Om locus results from meiotic drive at the second meiotic division. Genetics.
Becker M, Becker A, Miyara F, Han Z, Kihara M, Brown DT, Hager GL, Latham K, Adashi EY, Misteli T. 2005. Differential in vivo binding dynamics of somatic and oocyte-specific linker histones in oocytes and during ES cell nuclear transfer. Molecular Biology of the Cell.
Gao S, Han Z, Kihara M, Adashi E, Latham KE. 2005. Effects of protease inhibitor MG132 on nuclear reprogramming in cloned mouse embryos. Trends in Biotechnology.
Gao S, Czirr E, Chung YG, Han Z, Latham KE. 2004. Genetic variation in oocyte phenotype revealed through parthenogenesis and cloning: correlation with differences in pronuclear epigenetic modification. Biology of Reproduction.
Han ZM, Chen DY, Li JS, Sun QY, Wan QH, Kou ZH, Rao G, Lei L, Liu ZH, Fang SG. 2004. Mitochondrial DNA heteroplasmy in calves cloned by using adult somatic cell. Molecular Reproduction and Development.
Han ZM, Chen DY, Li JS, Sun QY, Wang PY, Du J, Zhang HM. 2003. Flow cytometric cell-cycle analysis of cultured fibroblasts from the giant panda, Ailuropoda melanoleuca L. Cell Biology International.
Yang CX, Han ZM, Wen DC, Sun QY, Zhang KY, Zhang LS, Wu YQ, Kou ZH, Chen DY. 2003. In vitro development and mitochondrial fate of macaca-rabbit cloned embryos. Molecular Reproduction and Development.
Zhu ZY, Chen DY, Li JS, Lian L, Lei L, Han ZM, Sun QY. 2003. Rotation of meiotic spindle is controlled by microfilaments in mouse oocytes. Biology of Reproduction.
Zhu ZY, Wen DC, Han ZM, Lei L, Liu ZH, Kou ZH, Xu Y, Wang MK, Chen DY. 2003. The dynamics and functions of cytoskeleton during meiotic resumption induced by parthenogenetic activation in mouse oocytes. Progress in Biochemistry andBiophysics.
Chen DY, Li JS, Han ZM, Lei L, Liu ZH, Kou ZH, Ma SY, Du QK, Sun QY. 2003. Somatic cell bovine cloning: Effect of donor cell and recipients. Chinese Science Bulletin.
. 陳大元，李勁松，韓之明，雷蕾，劉忠華，寇朝輝，馬世援，杜啟科，孫青原. 2003. 體細胞克隆牛：供體細胞和受體的影響. 科學通報.
