陳笑艷， 女 1994 年畢業於瀋陽藥科大學， 1999 年獲得瀋陽藥科大學藥物分析學博士學位。現任中國科學院上海藥物研究所教授、博士研究生導師、藥物代謝研究中心課題組長。
基本介紹
- 中文名：陳笑艷
- 國籍：中國
- 畢業院校：瀋陽藥科大學
- 職稱：中國科學院上海藥物研究所教授
人物簡介,研究方向,專家類別,職務,承擔科研項目情況,獲獎及榮譽,代表論著,
人物簡介
長期從事藥物代謝與藥物動力學領域的研究。 在藥物動力學研究新方法開發方面做出卓越的貢獻，建立了200多種藥物及代謝產物的生物樣品分析方法，其中有70餘種新分析方法發表在國內外學術期刊。 在反應性代謝產物與藥物毒性關係的研究中，發現了異喹啉類生物鹼由CYP450酶催化的反應性代謝中間體與其肝、肺毒性有關；證明了魚腥草素分子結構中的酮醛基可快速與血清白蛋白等發生共價結合，這一共價結合過程可能導致了藥物的過敏反應。 在手性藥物立體選藥動學研究方面，證明了多沙唑嗪、普羅帕酮和亞葉酸等藥物在人體內的立體選擇性藥動學，主要與對映體代謝途徑和代謝速率差異直接相關；昂當司瓊立體選擇性藥動學主要與對映體血漿蛋白結合差異有關。
研究方向
藥物代謝活化過程與藥物不良反應機理研究
手性藥物立體選擇性藥動學和代謝機理研究
藥動學生物樣品分析技術研究
創新藥物開發過程的藥物代謝和動力學研究
專家類別
職務
中科院上海藥物所研究員、博士生導師、研究組長
承擔科研項目情況
主持和參加國家自然科學基金項目
國家“863”臨床前藥物代謝動力學關鍵技術及平台研究項目
獲獎及榮譽
“108 種製劑的藥物動力學和生物等效性研究”獲瀋陽市科技進步一等獎和遼寧省科技進步二等獎
代表論著
Jin H, Li L, Zhong DF, Liu J, Chen XY*, Jiang Zheng*. Pulmonary toxicity and metabolic activation of tetrandrine in CD-1 Mice. Chem Res Toxicol
Chen MX, Liu K, Zhong DF, Chen XY*. Trimethylsilyldiazomethane derivatization coupled with solid-phase extraction for the determination of alendronate in human plasma by LC-MS/MS. Anal Bioanal Chem
Xie C, Yu K, Zhong DF, Yuan T, Ye F, Jarrell J, Millar A, Chen XY*. Investigation of isomeric transformations of chlorogenic acid in buffers and biological matrices by ultraperformance liquid chromatography coupled with hybrid quadrupole/ion mobility/orthogonal acceleration time-of-flight mass spectrometry. J Agric Food Chem
Xie C, Yang SL, Zhong DF, Dai XJ, Chen XY*. Simultaneous determination of dronedarone and its active metabolite debutyldronedarone in human plasma by liquid chromatography–tandem mass spectrometry: Application to a pharmacokinetic study. J Chromatogr B
Deng P, Zhong DF, Nan FJ, Liu S, Li D, Yuan T, Chen XY*, Zheng J*. Evidence for the bioactivation of 4-nonyphenol to quinine methide and ortho-benzoquinone metabolites in human liver microsomes. Chem Res Toxicol,
Liu K, Zhong DF, Chen XY*. Enantioselective determination of doxazosin in human plasma by liquid chromatography-tandem mass spectrometry using ovomucoid chiral stationary phase. J Chromatogr B
Liu K, Zhong DF, Zou HY, Chen XY*. Determination of tegafur, 5-fluorouracil, gimeracil and oxonic acid in human plasma using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal
Liu K, Zhong DF, Chen XY*. Enantioselective quantification of chiral drugs in human plasma with LC–MS/MS. Bioanalysi
Wang YY, Zhong DF, Chen XY*, Zheng J*. Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile. Chem Res Toxicol
Liu K, Dai XJ, Deng P, Ma JF, Zhong DF, Chen XY*. Simultaneous determination of 6R-leucovorin, 6S-leucovorin and 5-methyltetrahydrofolate in human plasma using chiral liquid chromatography-tandem mass spectrometry. J Chromatogr B
Zhang HC, Zhong DF, Zhang ZZ, Dai XJ, Chen XY*. Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study. J Chromatogr
Deng P, Zhong DF, Chen XY*. Determination of tropisetron in human plasma by liquid chromatography–tandem mass spectrometry. J Pharm Biomed Anal
Liu K, Dai XJ, Zhong DF, Chen XY*. Quantitative determination of ondansetron in human plasma by enantioselective liquid chromatography-tandem mass spectrometry. J Chromatogr
Duan XT, Zhong DF, Chen XY*. Derivatization of beta-dicarbonyl compound with 2,4-dinitrophenylhydrazine to enhance mass spectrometric detection: Application in quantitative analysis of houttuynin in human plasma. J Mass Spectrom
Zhong S, Zhong DF, Chen XY*. Improved and simplified liquid chromatography/electrospray ionization mass spectrometry method for the analysis of underivatized glucosamine in human plasma. J Chromatogr B
Gao J, Zhong DF, Duan XT, Chen XY*. Liquid chromatography/negative ion electrospray tandem mass spectrometry method for the quantification of rosuvastatin in human plasma: Application to a pharmacokinetic study. J Chromatogr B
Chen XY, Deng P, Dai XJ, Zhong DF. Simultaneous determination of amodiaquine and its active metabolite in human blood by ion-pair liquid chromatography-tandem mass spectrometry. J Chromatogr
Chen XY, Duan XT, Dai XJ, Zhong DF Development and validation of a liquid chromatographic/ tandem mass spectrometric method for the determination of sertraline in human plasma. Rapid Communications in mass spectrometry
Chen XY, Liu D, Luan Y, Zhong DF. Determination of zolmitriptan in human plasma by liquid chromatography-tandem mass spectrometry method: Application to a pharmacokinetic study. J Chromatogr B
Chen XY, Cui L, Duan XT, Zhong DF. Pharmacokinetics and metabolism of the flavonoid scutellarin in humans after a single oral administration. Drug Metab Dispos
