陳瑱賢

陳瑱賢，男，漢族，長安大學工程機械學院高級工程師，碩士生導師。主要從事醫療器械的數位化設計與製造方面的研究工作，包括結構最佳化和智慧型設計方法、生物力學與摩擦學功能評價、定製化設計與3D列印製造等方面。

基本介紹

• 中文名：陳瑱賢
• 國籍：中國
• 民族：漢
• 畢業院校：西安交通大學
• 職業：教師
• 學位/學歷：博士
• 專業方向：康復器械/植入物數位化設計與製造、生物力學、生物摩擦學

個人經歷

2010/09-2016/06，西安交通大學，機械工程專業，碩博連讀；

2006/09-2010/06，成都理工大學，機械工程及其自動化專業，本科；

2016.08-至今，長安大學。

研究領域

研究方向

康復器械/植入物數位化設計、定製化康復器械/植入物的3D列印製造、康復器械/植入物生物力學/生物摩擦學功能評估。

方向特點

以機械工程學科為主體，醫工結合、學科交叉、技術前沿。

涉及內容

人工關節、填充塊、固定板等醫療器械產品的結構設計；有限元分析、骨骼肌肉動力學分析；3D列印製造；功能和性能實驗測試。

結構圖

學術成果

科研項目

主持國家自然科學青年基金1項，陝西省青年基金、面上基金各1項，中央高校基礎研究基金2項，醫院合作課題1項，參與國家自然科學基金、陝西省自然科學基金多項，中央高校創新團隊項目1項。

1.國家自然科學基金青年項目,11902048,UKA手術校準對膝關節宏微運動生物力學的影響規律及假體鬆動和軟骨退化風險防控機理研究,2020/1-2022/12。

2.陝西省自然科學基金面上項目,2023-JC-YB-402,脛骨高位截骨的固定-填充系統植入物的個體化定製設計研究,2023/1-2024/12。

3.陝西省自然科學基金青年項目,2019JQ-243,人工膝關節精準置換的個體化定位截骨器械的快速數位化設計,2019/1-2020/12。

4.中央高校基礎研究培育項目,300102252106,OWHTO固定系統定製化設計研究，2022/1-2023/12。

5.中央高校基礎研究培育項目,300102258104,基於3D列印的人工膝關節個體化手術校準器械的設計方法研究,2018/1-2019/12。

6.唐都醫院橫向課題,220125200322,人體下肢骨骼肌肉動力學仿真研究,2020/7-2020/12。

7.中央高校創新團隊支持項目,310825173702,基於先進制造技術的仿生設計研究,2017/1-2018/12。

學術論文

在國內外學術期刊上發表論文50餘篇，其中SCI論文37篇，以第一作者和通訊作者發表論文26篇，被同行引用500餘次（Web of Science），H-index 14；參編英文專著2部，參編國家醫藥行業標準1項，授權國家專利4項，博士畢業論文曾獲西安交通大學優秀博士論文。

• Journal articles (*corresponding author)

[54] Qida Zhang, Zhenxian Chen, Yinghu Peng, Zhongmin Jin, Ling Qin. The novel magnesium–titanium hybrid cannulated screws for the treatment of vertical femoral neck fractures: Biomechanical evaluation[J]. Journal of Orthopaedic Translation. 2023, 42:127–136. (SCI)

[53] 張嘉寧，袁霄，張靜，高永昌，張志峰，陳瑱賢*.開放式脛骨高位截骨術的解剖型固定板的生物力學研究[J]. 醫用生物力學, 2023.

[52] 任佳軒，陳瑱賢*，張靜，高永昌，喬鋒，靳忠民.單髁膝關節置換術股骨部件不同內外側安裝位置的骨肌多體動力學研究[J].生物醫學工程學雜誌, 2023, 40(3): 508-514.

[51] Zhang Qida, Peng Yinghu, Chen zhenxian, et al., Conformity design can change the effect of tibial component malrotation on knee biomechanics after total knee arthroplasty[J]. Clinical Biomechanics, 2023. 105: 105985. (SCI)

[50] 張烜, 封碩, 陳瑱賢, 張靜, 靳忠民. 一種液體彈簧式自身力源膝關節助力矯形器的設計思路與生物力學分析[J]. 生物醫學工程學雜誌. 39(6): 1199-1208.

[49] 屈亞飛, 張靜, 陳瑱賢*, 高永昌, 張烜, 靳忠民. 活動式與固定式UKA襯墊的接觸力學和磨損對比研究[J]. 醫用生物力學, 2023.

[48] 任佳軒, 陳瑱賢*, 張靜, 張烜, 馬張穩, 靳忠民. UKA假體關節線安裝誤差的骨肌多體動力學研究[J].醫用生物力學, 2023, 38(2): 290-296.

[47] 張志偉, 陳瑱賢, 張志峰, 王彩梅, 靳忠民. 基於統計形狀模型的股骨快速建模方法[J].生物醫學工程學雜誌, 2022, 39(4): 651-659.

[46] Yanwei Zhang, Zhenxian Chen*, Hongmou Zhao, et al. Comparison of joint load, motions and contact stress and bone-implant interface micromotion of three implant designs for total ankle arthroplasty[J]. Computer Methods and Programs in Biomedicine, 2022, 223:106976.(SCI: 3A0XU)

[45] 陳瑱賢, 張志峰，高永昌，張靜，郭磊，靳忠民. 後穩定型全膝關節假體的骨肌多體動力學研究[J]. 生物醫學工程學雜誌, 2022, 39(5): 1-8.

[44] 張志偉, 張志峰, 陳瑱賢, 王彩梅, 靳忠民. 股骨柄髓外設計對髖關節接觸力影響的骨肌多體動力學研究[J].醫用生物力學, 2023, 38(1): 90-96.

[43] Zhang, Y., Chen Zhenxian*, et al., Articular geometry can affect joint kinematics, contact mechanics, and implant-bone micromotion in total ankle arthroplasty. J Orthop Res, 2022;1-11. doi:10.1002/jor.25381 (SCI: 7W0JG)

[42] Zhang, Y., Chen Zhenxian*, et al., Anatomic ankle implant can provide better tibiotalar joint kinematics and loading. Medical Engineering & Physics, 2022. 103: 103789. (SCI: 0W2OU)

[41] Wu X, Zhang Z, Ma D, et al. Influence of Al2O3 platelets addition on ceramic slurry and local flow induced platelets alignment in ceramic mask stereolithography process [J]. Ceram Int, 2022. (SCI: 0O1SJ)

[40] Zhang Q, Zhang Z, Chen Z, et al. Morphologic differences in the bone cuts of the knee between Han Chinese and Mongolian Chinese and their correlation with current knee prostheses [J]. Singapore medical journal, 2021. (SCI)

[39] Hu Jiayu, Xiong Ran, Chen Xiaofei, Chen Zhenxian, Jin Zhongmin, Effect of components mal-alignment on biomechanics in fixed unicompartmental knee arthroplasty using multi-body dynamics model during a walking cycle. Medical Engineering & Physics, 2022. 100: p. 103747.(SCI: 6F0ND)

[38] Li Pengyu, Tang Hao, Liu Xiaoyu, Chen Zhenxian, Zhang Xiaogang, Zhou Yixin, Jin Zhongmin.Reconstruction of Severe Acetabular Bone Defects with Porous Metal Augment in Total Hip Arthroplasty: A Finite Element Analysis Study [J]. Proceedings of the Institution of Mechanical Engineers Part H, Journal of engineering in medicine, 2021. (SCI: PIHMEQ)

[37] 林偉健, 李俊言, 陳瑱賢*, 靳忠民. 正常和早期膝骨關節炎的軟骨生物力學研究[J]. 力學學報, 2021, 53(11): 1-10.

[36] Chen Zhenxian, Fan Xunjian, Gao Yongchang, et al. Effect of Rotator Cuff Deficiencies on Muscle Forces and Glenohumeral Contact Force after Anatomic Total Shoulder Arthroplasty Using Musculoskeletal Multibody Dynamics Simulation[J].Frontiers in Bioengineering and Biotechnology Biomechanics, 2021:9. (SCI: TK7PE)

[35] Zhang Qida, Chen Zhenxian, Jin Zhongmin, Muratoglu Orhun, Varadarajan Karti.Patient-specific musculoskeletal models as a framework for comparing ACL function in unicompartmental vs. bicruciate retaining arthroplasty. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine.2021: 235(8):861-872. (SCI: TJ3YV)

[34] 楊抒, 崔文,張小剛, 張亞麗,任旭輝, 陳瑱賢, 靳忠民. 國內全髖關節置換磨損測試及數值模擬研究進展[J]. 摩擦學學報, 2021.

[33] 崔文, 楊抒, 張小剛, 張亞麗, 張靜, 張驍, 陳瑱賢, 靳忠民. 國內全膝關節置換磨損測試及數值模擬研究進展[J]. 中華骨科雜誌, 2021: 41(7):459-470.

[32] Weijian Lin, Qingen Meng , Junyan Li , Zhenxian Chen* and Zhongmin Jin. The effect of highly inhomogeneous poroelastic properties on mechanical behaviour of articular cartilage. Computer Methods and Programs in Biomedicine. 2021. (SCI: SU8XR)

[31] Zhang Yanwei, Chen Zhenxian, Peng Yinghu, et al. Predicting ground reaction and tibiotalar contact forces after total ankle arthroplasty during walking. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 2020.234(12):1432-1444. (SCI:OT0QZ)

[30] Zhang Qida, Chen Zhenxian, Zhang Zhifeng, et al. Leveraging subject-specific musculoskeletal modeling to assess effect of anterior cruciate ligament retaining total knee arthroplasty during walking gait. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 2020: 234(12):1445-1456. (SCI:OT0QZ)

[29] Gao YongChang, Zhao Xuan, Chen ShiBin, Zhang Jing, Chen Zhenxian, Jin Zhongmin. Effects of Daily Activities and Position on Kinematics and Contact Mechanics of Dual Mobility Hip Implant. Journal of healthcare engineering. 2020; 2020: 12.(SCI:KY1QY)

[28] Yinghu Peng, Duo Wai-Chi Wong, Yan Wang, Tony Lin-Wei Chen, Qitao Tan, Zhenxian Chen, Zhongmin Jin, Ming Zhang. Immediate Effects of Medially Posted Insoles on Lower Limb Joint Contact Forces in Adult Acquired Flatfoot: A Pilot Study. Int J Environ Res Public Health. 2020; 17. (SCI: LK3LI)

[27] 張靜，陳瑱賢，高永昌，張烜，靳忠民. 膝關節二次運動學研究進展[J]. 中華骨科雜誌, 2019, 39(18): 1157-1164.

[26] Zhang Yanwei, Chen Zhenxian*, Zhao Hongmou, Liang Xiaojun, Sun Cheng, Jin Zhongmin. Musculoskeletal modeling of total ankle arthroplasty using force-dependent kinematics for predicting in vivo joint mechanics [J]. Proceedings of the Institution of Mechanical Engineers Part H, Journal of engineering in medicine. 2019. (SCI: KE3QQ).

[25] 彭迎虎,陳瑱賢,胡家渝,張志峰,靳忠民,尉萍萍.人體足地接觸模型的步速適用性[J].醫用生物力學,2019,34(5):514-521

[24] Zhang Jing, Chen Zhenxian, Gao Yongchang, Zhang Xuan ,Guo Lei ,Jin Zhongmin .Computational wear prediction for impact of kinematics boundary conditions on wear of total knee replacement using two cross-shear models[J]. Journal of Tribology.2019.(SCI:KC0SN).

[23] 范勛健, 陳瑱賢, 曹卓, 夏志輝, 陳軍, 靳忠民. 個體化骨肌多體動力學和有限元聯合建模的肩胛骨鎖定板生物力學評估方法 [J]. 西安交通大學學報. 2019. 53(07): p. 168-176.

[22] Chen Zhenxian, Zhang jing, et al. Effects of interference assembly of a tibial 1nsert on the tibiofemoral contact mechanics in total knee replacement. Proc Inst Mech Eng H, 2019. 233(9): 948-953. (SCI:IM0DE)

[21] Zhang, Z.F., Zhang, Q. D., Zhao, G. H., Huang, J., Chen, Zhenxian.et al., Morphological Measurements of the Normal Distal Femur and Proximal Tibia between Han Chinese and Mongolian Chinese in a Healthy Chinese Population. International Journal of Morphology, 2019. 37(2): p. 664-670. (SCI: HW9BA)

[20]Liu Xiaoyu, Chen Zhenxian*,Gao Yongchang, et al. High Tibial Osteotomy: Review of techniques and biomechanics.Journal of Healthcare Engineering. 2019. (SCI:IF9MX)

[19]. Zhang Qida, Chen Zhenxian*,Zhang Jing, et al. 1nsert conformity variation affects kinematics and wear performance of total knee replacements.Clinical Biomechanics.2019;65:19-25.(SCI:IB3UF)

[18].Hu Jiayu, Xin Hua, Chen Zhenxian et al. The role of menisci in knee contact mechanics and secondary kinematics during human walking[J]. Clinical biomechanics (Bristol, Avon), 2018, 61: 58-63. (SCI:HO1ZY)

[17].Chen Zhenxian, Gao Yongchang, et al. Biomechanics and wear comparison between mechanical and kinematic alignments in total knee arthroplasty[J]. Proc Inst Mech Eng H, 2018: 232(12): 1209–1218 (SCI: HE7HN)

[16].Hu Jiayu; Chen Zhenxian*; Xin Hua; Zhang Qida; Jin Zhongmin. Musculoskeletal multibody dynamics simulation of the contact mechanics and kinematics of a natural knee joint during a walking cycle[J]. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine.2018. 232(5):508~519 (SCI:GH0LK)

[15].Gao Yongchang, Chen Zhenxian, et al. Effect of inclination and anteversion angles on kinematics and contact mechanics of dual mobility hip implants[J]. Clin Biomech (Bristol, Avon), 2018, 57: 48-55. (SCI:GP3TG)

[14].Peng Yinghu, Zhang Zhifeng, Gao Yongchang, Chen Zhenxian*, et al. Concurrent prediction of ground reaction forces and moments and tibiofemoral contact forces during walking using musculoskeletal modelling[J].Medical Engineering and Physics, 2018. 52: 31~40. (SCI:GC1BB)

[13].Chen Shibin, Ma Jingcun, Yao Yunshi, Gao Yongchang, Chen Zhenxian, Ping Lin. Investigation of combining dipole antennas with three dimensional photonic crystals[J]. Journal of Physics: Conference Series, 2018, 1053: 012082. (SCI)

[12].Zhang Jing, Chen Zhenxian*, Wang Ling, Li Dichen, Jin Zhongmin. A patient-specific wear prediction framework for an artificial knee joint with coupled musculoskeletal multibody-dynamics and finite element analysis[J]. Tribology International, 2017, 109: 382-389. (SCI: EM9DM)

[11].Zhang Jing, Chen Zhenxian*, Wang Ling, et al. Load application for the contact mechanics analysis and wear prediction of total knee replacement[J]. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 2017, 231:444-454. (SCI:ET3RX)

[10].Fan Xunjian, Chen Zhenxian*, Jin Zhongmin, et al. Parametric study of patient-specific femoral locking plates based on a combined musculoskeletal multibody dynamics and finite element modeling[J]. Proceedings of the Institution of Mechanical Engineers Part H, Journal of engineering in medicine, 2017. 232(2):114~126. (SCI:FV2KB)

[9].Chen Zhenxian, Zhang Zhifeng, Wang Ling, et al. Evaluation of a Subject-Specific Musculoskeletal Modeling Framework to Predict Load in Total Knee Arthroplasty [J]. Medical Engineering & Physics, 2016. 38(8): 708–716 (SCI:DR7KV )

[8].Chen Zhenxian, Wang Ling, Liu Yaxiong, et al. Effect of Component Mal-rotation on the Knee Loading in Total Knee Arthroplasty using Multi-body Dynamics Modelling Under a Simulated Walking Gait[J]. Journal of Orthopaedic Research, 2015, 33(9): 1287–1296. (SCI:CO60E)

[7].Chen Zhenxian*, Jin Zhongmin. Prediction of In-vivo Kinematics and Contact Track of Total Knee Arthroplasty during Walking[J]. Biosurface and Biotribology, 2016, 2:86-94.

[6].陳瑱賢,王玲,李滌塵,靳忠民. 全膝關節置換的個體化患者右轉步態的骨肌多體動力學仿真[J]. 醫用生物力學, 2015, 30(5).

[5].Zhang Xuan, Chen Zhenxian, Wang L, et al. Prediction of hip joint load and translation using musculoskeletal modelling with force-dependent kinematics and experimental validation[J]. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 2015. 229(7):477-490. (SCI:CL9LI)

[4].Chen Zhenxian, Zhang Xuan, Ardestani MM, et al. Prediction of in vivo joint mechanics of an artificial knee implant using rigid multi-body dynamics with elastic contacts[J]. Proceedings of the Institution of Mechanical Engineers Part H, Journal of engineering in medicine, 2014, 228:564–575. (SCI:AJ9NA)

[3].Ardestani MM, Chen Zhenxian, Wang L, et al. Feed forward artificial neural network to predict contact force at medial knee joint: Application to gait modification[J]. Neurocomputing, 2014, 139: 114-29. (SCI:AJ4QV)

[2].Ardestani MM, Chen Zhenxian, Wang L, et al. A neural network approach for determining gait modifications to reduce the contact force in knee joint implant[J]. Medical Engineering & Physics. 2014, 36: 1253-65. (SCI:AR5ML)

[1].Ardestani MM, Chen Zhenxian, et al. A real-time topography of maximum contact pressure distribution at medial tibiofemoral knee implant during gait: Application to knee rehabilitation[J]. Neurocomputing, 2014, 154:174–188. (SCI:CC1DR)

標準專著

1.國家醫藥行業標準YY/T1426.1-2016/ISO14243-1:2009《中華人民共和國醫藥行業標準—外科植入物全膝關節假體的磨損—第1部分：載荷控制的磨損試驗機的載荷和位移參數及相關的試驗環境條件》[S]。(主要起草人：張述，董雙鵬，李立賓，王玲，陳瑱賢)。

2.Chen zhenxian, zhang jing, Zhang xiao, Jin zhongmin. Chapter 7 Biomechanics and Tribology of Artificial Knee Joint (In book: UHMWPE Biomaterials for Joint Implants)[M]. Springer Science+Business Media Singapore. 2019:191-240.

3.Jin Zhongmin,Li Junyan, Chen Zhenxian. Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System[M]. Elsevier Ltd. 2020.

社會兼職

• Reviewer

1.《Computer Methods and Programs in Biomedicine》

2.《Computers in Biology and Medicine》

3.《Medical Engineering & Physics》

4.《Part H: Journal of Engineering in Medicine》

5.《Applied Bionics and Biomechanics》

6.《Journal of Orthopaedic Surgery and Research》

7.《Journal of Medical Imaging and Health Informatics》

8.《Biosurface and Biotribology》

9.《Frontiers in Bioengineering and Biotechnology》

• Guest Associate Editor

《Frontiers in Bioengineering and Biotechnology》