陳月琴

人物經歷

教育經歷

1984年，西北大學生物系，理學學士；

1987年，北京大學生物系，理學碩士；

1996年，中山大學生科院，理學博士。

工作經歷

2003年至今，聘為中山大學教授；

1999年，被聘為中山大學副教授；

1998-2005年先後在法國國家科研中心（CNRS），哈佛大學，美國陸軍研究所任客座研究員。

1996-1998年，中山大學博士後。

講授課程

《RNA分子生物學》。

所獲榮譽

教育部新世紀優秀人才計畫獲得者，廣東省“千百十工程”省級培養對象，“廣東特支計畫”百千萬工程領軍人才”，國家自然科學二等獎、廣東省自然科學一等獎及“丁穎”科技獎。

學術成就

多年來，一直致力於非編碼RNA在水稻和白血病等民生問題的研究。在這個領域中，解析了一大批與生物能源與生物醫藥息息相關的ncRNA，取得了一系列重大成果，得到國際同行的普遍認可。其中，2013年，在水稻種鑑定的miR-397具有促進水稻產量的研究，得到國際全行業的強烈震撼。目前，陳老師所著成果先後發表在Nature Biotechnology, Genome Biology, Autophagy，PNAS，Science Signaling，Plant Physiology，JBC等國際一流刊物上，總計70餘篇。

承擔課題

先後承擔和主持省部級及國家級重大項目10餘項。

論文專著

近五年發表代表性論文：

Huang W, Wang WT, Fang K, Chen ZH, Sun YM, Han C, Sun LY, Luo XQ, Chen YQ*. MIR-708 promotes phagocytosis to eradicate T-ALL cells by targeting CD47. Mol Cancer. 2018 , 17:12.
Sun LY, Li XJ, Sun YM, Huang W, Fang K, Han C, Chen ZH, Luo XQ, Chen YQ*, Wang WT*. LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1. Mol Cancer. 2018,17:127.
Chen ZH, Wang WT, Huang W, Fang K, Sun YM , Liu SR,Luo XQ, Chen YQ*. The lncRNA HOTAIRM1 regulates the degradation of PML-RARA oncoprotein and myeloid cell differentiation by enhancing the autophagy pathway. Cell Death Differ. 2017,24: 212-24.
Zhang JP, Yu Y, Feng YZ, Zhou YF, Zhang F, Yang YW, Lei MQ, Zhang YC, Chen YQ*. MiR408 Regulates Grain Yield and Photosynthesis via a Phytocyanin Protein. Plant Physiol. 2017 ,175:1175-85.
Lin KY, Ye H, Han BW, Wang WT, Wei PP, He B Li XJ, Chen YQ*. Genome-wide screen identified let-7c/miR-99a/miR-125b regulating tumor progression and stem-like properties in cholangiocarcinoma. Oncogene. 2016,35: 3376-86.
Wang WT, Ye H, Wei PP, Han BW, He B, Chen ZH, Chen YQ*. LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner. J Hematol Oncol. 2016, 9:117.
Zhang YC, Liao JY, Li ZY, Yu Y, Zhang JP, Li QF, Qu LH, Shu WS, Chen YQ*. Genome-wide screening and functional analysis identify a large number of long noncoding RNAs involved in the sexual reproduction of rice. Genome Biology. 2014,15:512.
Zeng CW, Chen ZH, Zhang XJ, Han BW, Lin KY, Li XJ, Wei PP, Zhang H, Li YQ, Chen YQ*. MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy lysosomal pathway in acute promyelocytic leukemia. Autophagy. 2014,10, 1726–37.
Fang K, Han BW, Chen ZH, Lin KY, Zeng CW, Li XJ,Li JH, Luo XQ, Chen YQ*. A distinct set of long non-coding RNAs in childhood MLL-rearranged acute lymphoblastic leukemia: biology and epigenetic target. Hum Mol Genet. 2014, 23: 3278-88.
Wang, CY, Zhang SC, Yu Y, Luo YC, Liu Q Ju CL, Zhang YC, Qu LH, Lucas WJ, Wang XJ, Chen YQ*.MiR397b Regulates Both Lignin Content and Seed number in Arabidopsis via Modulating a Laccase Involved in Lignin Biosynthesis. Plant Biotech J. 2014, 12(8):1132-42.
Wang WT, Zhao YN, Yan JX, Weng MY, Wang Y, Chen YQ*, Hong SJ. Differentially expressed microRNAs in the serum of cervical squamous cell carcinoma patients before and after surgery.J Hematol Oncol. 2014 Jan 10;7:6.
Wang WT, Chen YQ*. Circulating miRNAs in cancer: from detection to therapy. J Hematol Oncol. 2014 ,5;7:86.
Zhang YC, Yu Y, Wang CY, Li ZY, Liu Q, Xu J, Liao JY, Wang XJ, Qu LH, Chen F, Xin P, Yan C, Chu J, Li HQ, Chen YQ*.Overexpression of microRNA OsmiR397 improves rice yield by increasing grain size and promoting panicle branching. Nat Biotechnol. 2013, 31：848-53.
Han BW, Chen YQ*. Potential Pathological and Functional Links Between Long Noncoding RNAs and Hematopoiesis. Sci. Signal. 2013, 6, re5.
Wang WT, Zhao YN, Han BW, Hong SJ, Chen YQ*. Circulating microRNAs identified in a genome-wide serum microRNA expression analysis as noninvasive biomarkers for endometriosis.J Clin Endocrinol Metab. 2013, 98:281-9.
Duan FT, Qian F, Fang K, Lin KY, Wang WT, Chen YQ*. miR-133b, a muscle-specific microRNA, is a novel prognostic marker that participates in the progression of human colorectal cancer via regulation of CXCR4 expression. Mol Cancer. 2013, 13;12:164.

陳月琴

基本介紹