陳曉，山東大學“傑出中青年學者”教授，聚焦真核生物內穩態的表觀遺傳調控研究。
基本介紹
工作經歷,教育經歷,研究方向,主持項目,所獲榮譽,教學貢獻,學會成員,研究成果,
工作經歷
2024/01 至今 教授，傑出中青年學者·山東大學·海洋學院
2022/01 - 2023/12 研究員，齊魯青年學者·山東大學·海洋學院
2021/04 - 2021/09副研究科學家（Associate Research Scientist）·美國哥倫比亞大學·遺傳發育系
2018/04 - 2021/04 博士後研究員·美國哥倫比亞大學醫學中心·遺傳發育系
教育經歷
2016/10 - 2017/09 國家公派聯合培養博士·美國密西根大學·醫學院
2012/09 - 2018/01 水生生物學博士·中國海洋大學·海洋生物多樣性與進化研究所
2008/09 - 2012/07 理學學士·中國海洋大學·生命科學系
研究方向
真核生物內穩態的表觀遺傳調控
主持項目
2023/01- 2026/12國家自然科學基金面上項目
2022/07- 2025/06江蘇省自然科學基金青年科學基金項目
2022/01 - 2027/01 山東大學“齊魯青年學者”人才項目
所獲榮譽
2022年 青島市科學技術獎自然科學獎一等獎
2021年 山東大學“齊魯青年學者”稱號
2019年 山東省優秀博士畢業論文
2017年 國際原生動物學會 “Holz-Conner” 獎
教學貢獻
2022/09 至今 講授研究生課程《專業外語》
學會成員
2017/07 至今 國際原生動物學會（International Society of Protistologists）成員
2019/05 - 2021/09 紐約科學院（NewYork Academy of Sciences）成員
研究成果
發表 SCI 文章 40 余篇，累計影響因子 600 余點，累計引用 1500 余次。核心成果發表在 Nature Communications、PNAS、Molecular Cell、Nucleic Acids Research、Protein & Cell 等國際知名期刊上。
代表性工作
1. Xiao Chen, Yinglu Li, Fang Zhu, Xinjing Xu, Brian Estrella, Manuel A. Pazos II, John T. McGuire, Dimitris Karagiannis, Varun Sahu, Mustafo Mustafokulov, Claudio Scuoppo, Francisco J. Sánchez-Rivera, Yadira M.Soto-Feliciano, Laura Pasqualucci, Alberto Ciccia, Jennifer E. Amengual & ChaoLu (2023). Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma. Nature Communications. 14(1),4259. DOI: 10.1038/s41467-023-39990-5.
2. Yimeng Fang, Vaibhav S. Mangipudy, Chao Lu, Songtao Jia & Xiao Chen (corresponding author) (2023). Recognition of Histone Methylation and DNA by PWWP Domain: Mechanism and Function. In Chromatin Readers in Health and Disease.Trygve O Tollefsbol, Olivier Binda (eds). Academic Press, New York. ISBN:9780128233764. (Book chapter)
3. Wen Song, Huixin Jiao, Juan Yang, Danxu Tang,Tingting Ye, Lu Li, Lei Yang, Lifang Li, Weibo Song, Saleh A. Al-Farraj, HunterN. Hines, Weiwei Liu & Xiao Chen (corresponding author) (2023). New evidence of consistency between phylogeny and morphology for two taxa in ciliated protists, the subclasses Oligotrichia and Choreotrichia (Protista, Ciliophora). Molecular Phylogenetics and Evolution. In press. DOI: 10.1016/j.ympev.2023.107911.
4. Yinglu Li, Elizabeth M.Goldberg, Xiao Chen (co-first author), Xinjing Xu, John T. McGuire, Giuseppe Leuzzi, Dimitris Karagiannis, Tiffany Tate, Nargess Farhangdoost, Cynthia Horth, EstherDai, Zhiming Li, Zhiguo Zhang, Benjamin Izar, Jianwen Que, Alberto Ciccia, Jacek Majewski, Angela J. Yoon, Laurie Ailles, Cathy Lee Mendelsohn & ChaoLu (2022). Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas. Molecular Cell, 82(20), 3901-3918. DOI: 10.1016/j.molcel.2022.09.007.
5. Kartik N. Rajagopalan, Xiao Chen (co-first author), Daniel N. Weinberg, HaifenChen, Jacek Majewski, C. David Allis & Chao Lu (2021). Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation. PNAS, 118(9), e2021795118. DOI: 10.1073/pnas.2021795118.
6. Xiao Chen, Yaohan Jiang, Feng Gao, Weibo Zheng, Timothy J. Krock, Naomi A. Stover, ChaoLu, Laura A. Katz & Weibo Song (2019). Genome analyses of the new model protist Euplotes vannus focusing on genome rearrangement and resistance to environmental stressors. Molecular Ecology Resources, 19(5), 1292-1308. DOI: 10.1111/1755-0998.13023.
7. Xiao Chen, Yurui Wang, Yalan Sheng, Alan Warren & Shan Gao (2018). GPSit: an automated method for evolutionary analysis of nonculturable ciliated microeukaryotes. Molecular Ecology Resources, 18(3),700-713. DOI: 10.1111/1755-0998.12750.
8. Yuanyuan Wang, Xiao Chen (co-first author), Yalan Sheng, Yifan Liu & Shan Gao(2017). N-adenine DNA methylation is associated with H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena. Nucleic Acids Research, 45(20), 11594-11606. DOI:10.1093/nar/gkx883.
9. Xiao Chen, Shan Gao, Yifan Liu, Yuanyuan Wang, Yurui Wang & Weibo Song (2016). Enzymatic and chemical mapping of nucleosome distribution in purified micro- and macronuclei of the ciliated model organism, Tetrahymena thermophila. Science China Life Sciences, 59(9), 909-919. DOI: 10.1007/s11427-016-5102-x.
10. Xiao Chen, Xiaolu Zhao, Xiaohui Liu, Alan Warren, Fangqing Zhao & Miao Miao (2015). Phylogenomics of non-model ciliates based on transcriptomic analyses. Protein & Cell, 6(5), 373-385. DOI: 10.1007/s13238-015-0147-3.
