陳乃宏

陳乃宏，教授，博士，博士生導師，湖南中醫藥大學藥學院院長，中國醫學科學院藥物研究研究員，神經科學中心副主任。

基本介紹

• 中文名：陳乃宏
• 畢業院校：日本國立琦玉大學
• 職務：湖南中醫藥大學藥學院院長

人物經歷

1993年 考取國費獎學金 赴日攻讀博士

1997年3月 於日本 國立 琦玉大學 獲博士學位(Ph. D)

1997.04― 日本 三菱公司 生命科學研究所 博士後 / 外國人研究員

2000.07― 日本 理化研究所 前沿研究部門 研究員

2002.09― 日本 北里大學 醫學院 客座教授（Visiting Professor）

2001.09― 中國醫學科學院 藥物研究所 研究員

2013.05― 中國醫學科學院神經科學中心 副主任

2014.10― 湖南中醫藥大學藥學院院長

陳乃宏任湖南中醫藥大學藥學院院長

社會兼職

中國藥理學會 副秘書長

中國藥理學會 神經精神藥理專業委員會 副主任委員

中國藥理學會 補益藥藥理專業委員會 主任委員

北京市藥理學會 神經精神藥理專業委員會 副主任委員

《神經藥理學報》 副主編

研究方向

本課題組主要從事神經藥理學、神經分子生物學、中藥藥理學、神經系統疾患及炎症相關疾患的創新藥物開發及機理研究。主要研究內容包括：1、抗神經退行性疾病（PD/AD）創新藥物研發及機制分析; 2、螢光可視化技術在神經精神系統藥物研究中的套用; 3、抗抑鬱症創新藥物研發及機制分析；4、抗腦缺血創新藥物研發及機制研究; 5、基於CKLF1為靶點的創新藥物研發及機制分析; 6、天然產物及中藥創新藥物的發現及作用機制研究。

獲獎與著作

近年來主持和參與國內外科研項目二十餘項。主編和參與學術專著10餘部，申請專利6項，參與完成的項目曾獲得中華醫學科技獎二等獎（2010年和2012年各一項），及北京市科學技術獎二等獎（2011年）、三等獎（2012年）各一項。

發表論文

2014年通訊作者發表SCI論文

1. Zuo W, Chen J, Zhang S, Tang J, Liu H, Zhang D, Chen NH*. IMM-H004 prevents toxicity induced by delayed treatment of tPA in a rat model of focal cerebral ischemia involving PKA-and PI3K-dependent Akt activation. Eur J Neurosci 2014; 39:2107-2118.

2. Zuo W, Zhang S, Xia CY, Guo XF, He WB, Chen NH*. Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: The role of inhibition of Drp1 in ischemic brain damage. Neuropharmacology 2014; 86C:103-115.

3. Ma KL, Song LK, Yuan YH, Zhang Y, Han N, Gao K, Chen NH*. The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle.Neuropharmacology 2014; 82:132-142.

4. Ma KL, Song LK, Yuan YH, Zhang Y, Yang JL, Zhu P, Chen NH*. alpha-Synuclein is prone to interaction with the GC-box-like sequence in vitro. Cell Mol Neurobiol 2014; 34:603-609.

5. Zhang S, Zuo W, Guo XF, He WB, Chen NH*. Cerebral glucose transporter: the possible therapeutic target for ischemic stroke. Neurochem Int 2014; 70:22-29.

6. Zhang S, He WB, Chen NH*. Causes of death among persons who survive an acute ischemic stroke. Curr Neurol Neurosci Rep 2014; 14:467.

7. Kong LL, Wang ZY, Han N, Zhuang XM, Wang ZZ, Li H*, Chen NH*. Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats. J Neuroinflammation 2014; 11:112.

8. Kong LL, Wang ZY, Hu JF, Yuan YH, Han N, Li H*, Chen NH*. Inhibition of chemokine-like factor 1 protects against focal cerebral ischemia through the promotion of energy metabolism and anti-apoptotic effect. Neurochem Int 2014; 76C:91-98.

9. Zhang Z, Zhang Y, Mou Z, Chu SF, Chen XY, He WB, Guo XF, Yuan YH, Takahashi M, Chen NH*. Tyrosine 402 phosphorylation of pyk2 is involved in ionomycin-induced neurotransmitter release. PLoS One 2014; 9:e94574.

10. Yan JQ, Yuan YH, Gao YN, Huang JY, Ma KL, Gao Y, Zhang WQ, Guo XF, Chen NH*. Overexpression of Human E46K Mutant alpha-Synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway. Mol Neurobiol 2014; 50:685-703.

11. Li JP, Gao Y, Chu SF, Zhang Z, Xia CY, Mou Z, Song XY, He WB, Guo XF, Chen NH*. Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl-induced hepatic fibrosis. Acta Pharmacol Sin 2014; 35:1031-1044.

12. Gao Y, Chu SF, Li JP, Zuo W, Wen ZL, He WB, Yan JQ, Chen NH*. Do glial cells play an anti-oxidative role in Huntington's disease? Free Radic Res 2014; 48:1135-1144.

13. Song XY, Hu JF, Sun MN, Li ZP, Zhu ZX, Song LK, Yuan YH, Liu G, Chen NH*. IMM-H004, a novel coumarin derivative compound, attenuates the production of inflammatory mediatory mediators in lipopolysaccharide-activated BV2 microglia. Brain Res Bull 2014; 106:30-38.

14. Li G*, Li GY, Wang ZZ, Ji HJ, Wang DM, Hu JF, Yuan YH, Liu G, Chen NH*. The chemokine-like factor 1 induces asthmatic pathological change by activating nuclear factor-kappaB signaling pathway. Int Immunopharmacol 2014; 20:81-88.

15. Li ZP, Ji HJ, Song XY, Hu JF, Han N, Chen NH*. Osthole attenuates the development of carrageenan-induced lung inflammation in rats. Int Immunopharmacol 2014; 20:33-36.

16. Wu MM, Yuan YH, Chen J, Li CJ, Zhang DM, Chen NH*. Polygalasaponin F against rotenone-induced apoptosis in PC12 cells via mitochondria protection pathway. J Asian Nat Prod Res 2014; 16:59-69.

17. Ji HJ, Wang DM, Hu JF, Sun MN, Li G, Li ZP, Wu DH, Liu G, Chen NH*. IMM-H004, a novel courmarin derivative, protects against oxygen-and glucose-deprivation/restoration-induced apoptosis in PC12 cells. Eur J Pharmacol 2014; 723:259-266.

18. Wei W, Yuan YH, Gao YN, Yan WF, Li CJ, Zhang DM, Chen NH*. Polygalasaponin F inhibits secretion of inflammatory cytokines via NF-kappaB pathway regulation. J Asian Nat Prod Res 2014; 16:865-875.

19. Wang ZZ, Yuan YH, Zhang Y, Wang XF, Chu SF, Han N, Chen NH*. Chemokine-like factor 1 promotes the migration of rat primary cortical neurons by the induction of actin polymerization. Neuroreport 2014; 25: 1221-1226.

20. Li BY, Yuan YH, Zhang WQ, He WB, Hu JF, Chen NH*. Flavin-containing monooxygenase, a new clue of pathological proteins in the rotenone model of parkinsonism. Neurosci Lett 2014; 566:11-16.

2013年通訊作者發表SCI論文

1. Yu-he Yuan , Jian-dong Sun, Miao-miao Wu, Jin-feng Hu , Shan-ying Peng, Nai-Hong Chen*. Neurochem Res, 2013, 38:1553–1560.

2. Ma KL, Song LK, Yuan YH, Zhang Y, Song XY, Niu F, Han N, Chen NH*. Brain Res Bull. 2013,90:127-31.

3. Kai-Li Ma, Lian-Kun Song, Yu-He Yuan, Ying Zhang, Ning Han, Kai Gao, Nai-Hong Chen*. Neuropharmacology. 2013,1-11.

4. X.Y.SONG, J.F.HU, M.N.SUN, Z.P.LI, D.H.WU, H.J.JI, Y.H.YUAN, Z.X.ZHU, N.HAN, N.H.CHEN*. Neuroscience.2013,242:28–38.

5. Xiu-Yun Song, Jin-Feng Hu, Shi-Feng Chu, Zhao Zhang, Yu-He Yuan, Ning Han, Yan Liu, Nai-Hong Chen*.European Journal of Pharmacology. 2013,710(1-3):29-38.

6. Wei Zuo, WeiZhang, Ni-Hong Chen*. European Journal of Pharmacology. 2013,711:73–79.

7. J. W. Li, N. Ning, Y. Z. Ma, R. Zhang, F. Tan, N. H. Chen*. Free Radical Research. 2013, 47(6-7):488-97.

8. Zhipeng Li, Jinfeng Hu, Mingna Sun, Xiuyun Song, Gang Li, Yan Liu, Guangyan Li, Haijie Ji, Gang Liu, Naihong Chen*. International Immunopharmacology. 2013,17: 400–403.

9. Rui Zhang, Ming Zhao, Hai-jie Ji, Yu-he Yuan, Nai-hong Chen*. Neuroinflammation Model. ISRN Neurol. 2013: 496079.

10. Yin-zhong MA, Na NING, Wen-bin HE, Jing-wei LI, Jin-feng HU1, Shi-feng CHU, Nai-hong CHEN*. Acta Pharmacologica Sinica. 2013: 1-9.

2012年通訊作者發表SCI論文

1. Sun JD, Liu Y, Yuan YH, Li J Naihong Chen*, Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats. Neuropsychopharmacology. 2012;37(5): 1305-1320 . (IF=7.996)

2. Ning N, Hu JF, Sun JD, Han N, Zhang JT*, Naihong Chen*, (-)Clausenamide facilitates synaptic transmission at hippocampal Schaffer collateral-CA1 synapses. European Journal of Pharmacology. 2012;682(1-3):50-55.

3. Ling-Lei Kong, Jin-Feng Hu, Wei Zhang, Yu-He Yuan, Ning Han Naihong Chen*, . C19, a C-terminal peptide of chemokine-like factor 1, protects the brain against focal brain ischemia in rats. . Neuroscience Letters . 2012;(508):13–16.

4. Sun F, Sun JD, Han N, Li CJ, Yuan YH, Zhang DM Naihong Chen*, . Polygalasaponin F induces long-term potentiation in adult rat hippocampus via NMDA receptor activation. Acta.Phama.Sin. 2012;33(4):431-437.

5. Hu JF, Niu F, Ning N, Duan WZ, Chu SF, Xue W, Yuan YH, Naihong Chen*, Zhang JT*. Activation of ERK1/2-CREB pathway during potentiating synaptic transmission of clausenamide in rat dentate gyrus. .Journal of asian natural products research. 2012;14(3):256-262.

6. Lin Yang, Lirui Qiao ,Dan Xie,Yuhe Yuan, Naihong Chen, Jungui Dai*,Shunxing Guo. 2-(2-Phenylethyl)chromones from Chinese eaglewood. Phytochemistry. 2012;76C: 92–97.

7. Na NING, Jin-feng HU, Yu-he YUAN, Xin-yuan ZHANG, Jun-gui DAI, Naihong Chen*, . Huperzine A derivative M3 protects PC12 cells against sodium nitroprusside-induced apoptosis.Acta.Phama.Sin. 2012;33(1):34-40.

8. Na Ning, Jiandong Sun, Guohua Du, Ning Han, Juntian Zhang, *, Naihong Chen*, . (+)-epi-Clausenamide, but not (−)-epi-clausenamide, showed more potential than (−)-clausenamide on facilitating synaptic transmission in CA1 region of hippocampal synapses Neuroscience Letters 523 (2012) 99–103

9. Zhi peng Li, Jinfeng Hu, Mingna Sun, Haijie Ji, Shifeng Chu, Gang Liu, *, Naihong Chen*, . Anti-inflammatory effect of IMMLG5521, a coumarin derivative, on Sephadex-induced lung inflammation in rats. International Immunopharmacology. 2012（14）145–149

10. Zhen-Zhen Wang, Yi Zhang, Yu-He Yuan, Naihong Chen*, .Developmental expression of chemokine-like factor 1, a novel member of chemokines family, in postnatal rat cerebral cortex. Neuroscience Letters 2012 (519) 51– 55.

2011年通訊作者發表SCI論文

1. Bo-Yu Li, Yun Zhang, Yu-he Yuan, Naihong Chen*. A new perspective in Parkinson’s Disease, chaperone-mediated autophagy, Pharkinsonism and Relat D, 2011；17: 231-235.

2. Zhi-Peng Li, Jin-Feng Hu, Ming-Na Sun, Hai-Jie Ji, Ming Zhao, Dong-Hui Wu, Guang-Yan Li,Gang Liu, Naihong Chen*, . Effect of compound IMMLG5521, a novel coumarin derivative, on carrageenan -induced pleurisy in rats European Journal of Pharmacology 2011；661: 118-123.

3. Jin-Feng Hu, Xiu-Yun Song, Shi-Feng Chu, Ji Chen, Naihong Chen*, Inhibitory effect of ginsenoside Rg1 on lipopolysaccharide-induced microglial activation in mice. Brain Res, 2011; 1374: 8-14.

4. Kai-Li Ma, Yu-He Yuan, Lian-Kun Song, Ning Han, Naihong Chen*, Over-expression of α-synuclein 98 triggers intracellular oxidative stress andenhances susceptibility to rotenone. Neurosci Lett, 2011； 2 :1 48-152.

5..Ling-Lei Kong,Jin-Feng Hu,Wei Zhang,Yu-He Yuan,Kai-Li Ma, Ning Han,Nai-Hong Chen*. Expression of chemokine-like factor 1 after focal cerebral ischemia in the rat.Neuroscience LettersJournal homepage: Neurosci Lett. 2011;505(1):14-18.

6.Jin-Feng Hu, Xiu-Yun Song, Shi-Feng Chu, Chen, Naihong* Inhibitory effect of ginsenoside Rg1 on lipopolysaccharide-induced microglial activation in mice.Brain Res, 2011,1374:8-14.

7. Ling-Lei Kong,Wei ,Yu-He Yuan, Lian-Kun Song, Ning Han, Naihong Chen* Over-expression of α-synuclein 98 triggers intracellular oxidative stress andenhances susceptibility to rotenone. Neurosci Lett, 2011, 491:148-152.

2010年通訊作者發表SCI論文

1. Jin-Feng Hu, Shi-Feng Chu, Na Ning, Yu-He Yuan, Wei Xue, Naihong Chen*, Jun-Tian Zhang*，Protective effect of (−)clausenamide : Neurosci Lett. 483 (2010) 78–82

2. Hai-Jie Ji, Jin-Feng Hu, Yong-Hui Wang, Xiao-Yu Chen, Ran Zhou, Naihong Chen*, nosthole improves chronic cerebral hypoperfusion induced cognitive deficits and neuronal damage in hippocampus, European Journal of Pharmacology, 2010（636）： 96–101

3. Wei Zhang, Hiroshi Kudo, Kengo Kawai, Shiho Fujisaka, Isao Usui, Toshiro Sugiyama, Kazuhiro Tsukada, Naihong Chen*, Terumi Takahara*, Tumor necrosis factor-a accelerates apoptosis of steatotic hepatocytes from3 a murine model of non-alcoholic fatty liver disease. Biochemical and biophysical research communications （BBRC）,2010;391(4):1731-1736.

4. Zhi-Jun Liu, Ming Zhao Yun Zhang, Jian-Fei Xue, Naihong Chen,* Ginsenoside Rg1 Promotes Glutamate Release Via a Calcium/Calmodulin-dependent Protein Kinase Ⅱ-dependent Signaling Pathway，Brain Res. 2010，1333：1 – 8.

5. Gang Li, Dongmei Wang, Mingna Sun, Guangyan Li, Jinfeng Hu, Yun Zhang, Yuhe Yuan, Haijie Ji, Naihong Chen,* Gang Liu*. Discovery and Optimization of Novel 3-Piperazinyl Coumarin Antagonist of Chemokine – like factor 1 with oral Anti-asthma activity in mice. J. Med. Chem. 2010, 53, 1741–1754 .

6. Zhen-Zhen Wang, Gang Li, Xiao-Yu Chen, Ming Zhao, Yu-He Yuan, Xiao-Liang Wang, Naihong Chen*, Chemokine-like factor 1, a novel cytokine, induces nerve cell migration through the non-extracellular Ca2+-dependent tyrosine kinases pathway，Brain Res., 2010, 1308:(13); 24-34,

7. Yuhe Yuan, Jiandong Sun, Ming Zhao, Jinfeng Hu, Xiaoliang Wang, Guohua Du, Naihong Chen*, Overexpression of a-synuclein down-regulates BDNF expression, Cell Mol Neurobio. 2010，30（6）:939–946

8. Y.-Z. Wang, Y.-S. Wang, S.-F. Chu2, Naihong Chen, and J.-T. Zhang*.，Protopanaxatriol metabolites identified byLC-MS/MS after oral administration in mice. International Journal of Clinical Pharmacology and Therapeutics, 2010 48（4）：282-290