鐘芳銳

鐘芳銳，男，華中科技大學化學與化工學院教授。湖北省第七批百人計畫入選者。研究方向為有機合成方法，不對稱催化。

基本介紹

• 中文名：鐘芳銳
• 出生日期：1986年4月
• 畢業院校：慕尼黑工業大學，新加坡國立大學，浙江大學
• 學位/學歷：博士
• 專業方向：有機合成
• 職稱：教授

工作經歷

2015.12年起華中科技大學化學與化工學院（教授，博士生導師）

2013-2015德國慕尼黑工業大學，洪堡學者、博士後研究員(導師：Thorsten Bach教授)

2008-2012新加坡國立大學，有機化學博士(導師：Yixin LU教授)

2004-2008浙江大學化學系，理學學士

研究方向

研究領域為有機合成方法學，主要研究方向為不對稱催化合成，包括新型手性催化劑、手性官能化配體的設計，複雜結構生物活性分子的快速構建，重點探索基於仿生理念，次級鍵誘導的有機小分子和過渡金屬催化中的立體化學選擇性。

已在國際學術期刊上發表論文29 篇，分別發表在J. Am. Chem. Soc.、Angew.Chem.Int.Ed.、Chem. Sci.、Org. Lett.等一流期刊上，其中影響因子＞5的論文20篇，多篇被SYNFACTS等作亮點評論。論文被引用1300餘次，單篇最高引用＞200, H-因子18.

發表論文

1. Tianli Wang, Xiaoyu Han,Fangrui Zhong, WeijunYao, Yixin Lu. "Amino acid-derived Bifunctional Phosphines for Enantioselective Transformations"Acc. Chem. Res.,2016, 49, 1369.

2.Fangrui Zhong, Alexander Pöthig, Thorsten Bach. “Synergistic Stereocontrol in the Enantioselective Ruthenium-catalyzedSulfoxidation of Spirodithiolane-Indolones”Chem. Eur. J.2015,21, 10310.

3. Tianli Wang, Weijun Yao,Fangrui Zhong, Guohao Pang, Yixin Lu. “Phosphine-Catalyzed Enantioselective g-Addition of 3-Substituted Oxindoles to 2,3-Butadienoates and 2-Butynoates: Use of Prochiral Nucleophiles”,Angew. Chem. Int. Ed.2014, 53, 2964.

4.Fangrui Zhong, Thorsten Bach. “Enantioselective Construction of 2,3-Dihydrofuro[2,3-b]quinolines through Supramolecular Hydrogen Bonding Interactions”Chem. Eur. J.2014,20, 13522.

5.Fangrui Zhong,Xiaowei Dou, Weijun Yao, Qiang Zhu, Yixin Lu.“Chiral Phosphine-Catalyzed Asymmetric Michael Addition of Oxindoles”Angew. Chem. Int.Ed.2013,52, 943.(highlighted inSYNFACTS2013, 216, times cited ＞45)

6. Jie Luo, Haifei Wang,Fangrui Zhong, Jacek, Kwiatkowski, Li-Wen Xu, Yixin Lu. “Highly diastereoselective and enantioselective direct Michael addition of phthalide derivatives to nitroolefins”Chem. Commun.2013,49, 5775.

7. Xiaowei Dou, Bo Zhou, Weijun Yao,Fangrui Zhong, Chunhui Jiang, Yixin Lu. “A Facile and Versatile Approach for the Asymmetric Synthesis of Oxindoles with a 3-Sulfenyl -substituted Quaternary Stereocenter”.Org. Lett.2013, 15, 4920.

8.Fangrui Zhong,Jie Luo, Guo-Ying Chen, Xiaowei Dou, Yixin Lu. “Highly Enantioselective Regiodivergent Allylic Alkylations of MBH Adducts with Phthalides”J. Am. Chem. Soc.2012,134, 10222.(highlighted inSYNFACTS2012, 906, times cited＞55)

9.Fangrui Zhong, Xiaoyu Han, Youqing Wang, Yixin Lu. “Highly Enantioselective [4 + 2] Annulations Catalyzed by Amino Acid-Based Phosphines: Synthesis of Functionalized Cyclohexenes and 3-Spirocyclohexene-2-oxindoles”,Chem. Sci.2012,3, 1231.(times cited ＞65)

10. Xiaoyu Han,Fangrui Zhong,Youqing Wang, Yixin Lu. “Versatile Enantioselective [3 + 2] Cyclization between Imines and Allenoates Catalyzed by Dipeptide-Based Phosphines”,Angew. Chem. Int. Ed.2012, 51,767. (times cited＞65)

11. Jie Luo, Haifei Wang,Fangrui Zhong, Jacek Kwiatkowski, Li-Wen Xu, Yixin Lu. “Direct Asymmetric Mannich Reaction of Phthalides: Facile Access to Chiral Substituted Isoquinolines and Isoquinolinones”,Chem. Commun.2012,48, 4707.

12. Xiaowei Dou,Fangrui Zhong,Yixin Lu. “A Highly Enantioslective Synthesis of Functionalized 2,3-Dihydrofurans via a Modified Feist−Bénary Reaction”Chem. Eur. J.2012, 18,13945.

13. Guo-Ying Chen,Fangrui Zhong, Yixin Lu. “Asymmetric Allylic Alkylation of Isatin-derived Morita-Baylis-Hillman Carbonates with Nitroalkanes”,Org. Lett.2012,14, 3955.

14.Fangrui Zhong,Weijun Yao, Xiaowei Dou, Yixin Lu. “Enantioselective Construction of 3-Hydroxy Oxindoles via Decarboxylative Addition of b-Ketoacids to Isatins”Org. Lett.2012,14, 4018.

15.Fangrui Zhong,Guoying Chen, Xiaoyu Han, Weijun Yao, Yixin Lu. “Asymmetric Construction of Functionalized Bicyclic imides via [3+2] Annulation of MBH Carbonates Catalyzed by Dipeptide-based Phosphines”Org. Lett.2012,14, 3764. (times cited＞45)

16.Fangrui Zhong, Xiaoyu Han, Youqing Wang, Yixin Lu. “Highly Enantioselective [3+2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine Derived Bifunctional Phosphines: Creation of 3-Spirocyclopentene-2-oxindoles with Two Consecutive Quaternary Centers”,Angew. Chem. Int. Ed.2011,50, 7837.(highlighted inSYNFACTS2011, 1020, times cited ＞200)

17.Fangrui Zhong, Youqing Wang, Xiaoyu Han, Kuo-Wei Huang, Yixin Lu. “L-Threonine-Derived Bifunctional Phosphine-Sulfonamide Catalyst-Promoted Enantioselective Aza-Morita-Baylis-Hillman Reaction”,Org. Lett.2011,13, 1310. (highlighted inSYNFACTS2011, 551, times cited ＞50)

18.Fangrui Zhong, Guo-Ying Chen, Yixin Lu. “Enantioselective Morita-Baylis-Hillman Reaction of Isatins with Acrylates: Facile Creation of 3-Hydroxy-2-Oxindoles”,Org. Lett.2011,13, 82. (times cited＞80)

19. Xiaoyu Han, Youqing Wang,Fangrui Zhong, Yixin Lu. “Enantioselective [3 + 2] Cycloaddition of Allenes to Acrylates Catalyzed by Dipeptide-derived Novel Phosphines: Facile Creation of Functionalized Cyclopentenes Containing Quaternary Stereogenic Centers”,J. Am. Chem. Soc.2011,133, 1726 (times cited ＞125).

20. Guo-Ying Chen,Fangrui Zhong, Yixin Lu. “Highly Enantioselective and Regiospecific Substitution of Morita-Baylis-Hillman Carbonates with Nitroalkanes”Org. Lett.2011, 13,6070.

21. Xiao Han,Fangrui Zhong, Yixin Lu. “Highly Enantioselective Amination Reactions of Fluorinated Ketoesters Catalyzed by Novel Chiral Guanidines Derived from Cinchona Alkaloids”,Adv. Synth. Catal.2010,352, 2778.

主要榮譽

1.2017 Thieme Chemistry Journal Award

2. 德國洪堡學者

3. 新加坡國立大學 Wang Gungwu Medal & Prize (2012優秀博士論文獎,全校遴選1人)

4. Singapore National Institute of Chemistry Gold Medal (2012優秀博士論文獎,新加坡每年僅1名)

5. 4th HOPE MEETING(新加坡五名代表之一,日本學術振興會JSPS主辦,東京筑波)

6. 2012年Reaxys Phd Prize finalist(全球化學博士生遴選45人)

7. 2011年國家優秀自費留學生獎學金