金洪傳，男，漢族，1974年7月出生於浙江東陽，教授，博導。1999年畢業於浙江大學醫學院後留校在醫學院附屬邵逸夫醫院腫瘤內科工作。2001年12月-2004年12月赴德國Karlsruhe大學攻讀博士學位；後分別在德國Jena生物技術研究所和香港中文大學威爾斯親王醫院包玉剛癌症中心接受博士後訓練，2007年10月晉升香港中文大學醫學院研究助理教授，2009年2月獲聘浙江大學求是特聘教授後回國。
現任民革中央委員，浙江大學委員會副主委，浙江省生物治療重點實驗室主任，邵逸夫醫院醫學研究中心副主任；省政協委員，省科協委員。
基本介紹
- 中文名：金洪傳
- 出生日期：1974年7月
- 畢業院校：浙江醫科大學
- 教學職稱：教授
- 執業地點： 浙江大學醫學院附屬邵逸夫醫院
- 性別：男
人物經歷,研究方向,著作譯作,學術任職,
人物經歷
1991年7月畢業於浙江醫科大學臨床醫學（五年制）系後，留校攻讀腫瘤學碩士（1996-1999）。1999年7月始在浙江大學醫學院附屬邵逸夫醫院腫瘤內科從事臨床工作，2001年晉升主治醫師。2001年12月-2004年11月在德國karlsruhe大學攻讀分子腫瘤學博士。2004年12月-2007年10月先後在德國Jena分子生物技術研究所和中國香港中文大學腫瘤學系從事博士後工作。2007年11月-2009年10月在香港中文大學消化病研究所任研究助理教授，研究小組組長（PI）。2009年11月始獲聘浙江大學求是特聘教授並全職回國工作。
中國國民黨革命委員會第十四屆中央委員會委員
研究方向
惡性腫瘤的發病機制和臨床防治策略。
著作譯作
如在《中國腫瘤》上發布的《川楝素對乳腺癌細胞的生長抑制作用》。
在國際著名刊物如Nature, PNAS, Gastroenterology、Hepatology、Gut、Oncogene 等雜誌上發表研究論四十多篇。
代表性論文
第一和通訊作者論文
Pre-2009
1. Jin H., Sperka T., Herrlich P. and Morrison H. Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase. Nature 2006;442(7102):576-9 (IF：36.1)
2. Jin H.*, Wang X.*, Ying J., Wong AH, Li H, Lee KY, Chan AT, Yeo W, Ma BB, Lung ML, Shen ZY, Xu LY, Langford C and Tao Q. Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in multiple carcinomas. Oncogene. 2007;26(53):7490-7498 (IF：7.2)
3. Jin H., Wang X, Ying J, Wong AH, Cui Y, Shen ZY, Li EM, Zhang Q, Jin J, Kupzig S, Chan AT, Cullen PJ and Tao Q. Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in cancers. Proceedings of the National Academy of Sciences 2007;104(30):12353-8 (IF：9.8)
4. Cheng YY*, Jin H*, Liu X, Siu JM, Wong YP, Ng EK, Yu J, Leung WK, Sung JJ and Chan FK. Fibulin 1 (FBLN1) is downregulated through promoter hypermethylation in gastric cancer. British J. of Cancer. 2008;99(12):2083-2087*: 共同第一作者 (IF：4.9)
2009
5. Liu X, Lam EK, Wang X, Zhang JB, Cheng YY, Lam YW, Ng EKO, Yu J, Chan FKL, Jin HC* and Sung JJY. Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer. Tumor Biology 2009;242-248 *:通訊作者 (IF：2.0)
6. Wang X, Lam EK, Zhang JB, Jin HC*, Sung JJ. MicroRNA-122a functions as a novel tumor suppressor downstream of adenomatous polyposis coli in gastrointestinal cancers Biochem Bioph Res Com 2009; 387(2):376-380 *:通訊作者 (IF：2.6)
7. Wang LJ, Jin HC*, Wang X, Lam EK, Zhang JB, Liu X, Chan FK, Si JM, Sung JJ*. ZIC1 is downregulated through promoter hypermethylation in gastric cancer. Biochem Bioph Res Com 2009;379(4):959-63 *:通訊作者 (IF：2.6)
2010
8. Wang X and Jin H*. The epigenetic basis of Warburg effect Epigenetics 2010;5(7):566-568 *:通訊作者 (IF：4.7)
9. Liu X, Wang X, Zhang JB, Lam EK, Shin VY, Cheng YY, Cheng AS, Yu J, Chan FK, Sung JJ and Jin HC*. Warburg effect revisited: an epigenetic link between aerobic glycolysis and gastric carcinogenesis Oncogene 2010;29:442-450 *:通訊作者 (IF：7.2)
2011
10. Han W, Sun J, Feng L, Wang K, Li D, Pan Q, Chen Y, Jin W, Wang X, Pan H* and Jin H*. Autophagy Inhibition Enhances Daunorubicin-induced Apoptosis in K562 cells PLoS One 2011;e028491 *: 通訊作者 (IF：4.8)
11. Feng LF, Wang X* and Jin HC*. Rabbit monoclonal antibody: potential application in cancer therapy American Journal of Translational Research 2011;3(3):269-274 *: 通訊作者
12. Han W, Pan H*, Chen Y, Sun J, Wang Y, Li J, Ge W, Feng L, Lin X, Wang XJ, Wang X, Jin H*. EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells PLoS One 2011;6(6):e18691 *:通訊作者 (IF：4.8)
13. Lam EK, Wang X*, Shin V, Zhang S, Morrison H, Sun J, Ng EK, Yu J and Jin H*. A microRNA contribution to aberrant Ras activation in gastric cancer. American Journal of Translational Research 2011;3(2):209-218 *:通訊作者
14. Wang L, Wang X*, Wang XJ, Pan J, Lu HQ, Zhang SJ, Lin XY, Lam EK, Cui Y, Yu J and Jin HC*. Klotho is silenced through promoter hypermethylation in gastric cancer American Journal of Cancer Research 2011;1(1):111-119 *:通訊作者
2012
15. Zhang S, Jiang T, Feng L, Sun J, Lu H, Wang Q, Pan M, Huang D, Wang X, Wang L* and Jin H*. Yin Yang-1 suppresses differentiation of hepatocellular carcinoma cells through the downregulation of CCAAT/enhancer-binding protein alpha Journal of Molecular Medicine 2012 Sep;90(9):1069-77 *: 通訊作者 (IF：5.2)
16. Wang L, Chen S, Xue M, Zhong J, Wang X, Gan L, Lam E, Liu X, Zhang J, Zhou T, Yu J, Jin H* and Si J*. Homeobox D10 gene, a candidate tumor suppressor, is downregulated through promoter hypermethylation and associated with gastric carcinogenesis Molecular Medicine 2012 May 9;18(1):389-400 *: 通訊作者 (IF：5.9)
17. Feng L, Pan M, Sun J, Lu H, Shen Q, Zhang S, Jiang T, Liu L, Jin W, Chen Y, Wang X*, Jin H*. Downregulation of p53 Up-regulated Modulator of Apoptosis by histone deacetylase 3 in gastric cancer Journal of Molecular Medicine 2012 Accepted *: 通訊作者 (IF: 5.2)
其他論文
Pre-2009
18. Ma W, Yu H, Wang Q, Bao J, Yan J, Jin H. In vitro biological activities of transmembrane superantigen staphylococcal enterotoxin A fusion protein. Cancer Immunol Immunother. 2004;53(2):118-24 (IF：4.3)
19. Ma W., Yu H., Wang Q., Jin H., and Labhasetwar V. A Novel approach for Cancer Immunotherapy: Tumor Cells Anchored with SEA Generate Effective Antitumor Immunity. Journal of Clinical Immunology 2004;24(2):294-301 (IF：3.3)
20. Chan L., Cui Y., Hasselt A., Li, HY, Srivastava G., Jin H., Ng M, Wang Y, Lee KY, Tsao GS, Zhong S, Chan AT and Tao Q. The tumor suppressor Wnt inhibitory factor 1 (WIF1) is frequently methylated in nasopharyngeal and esophageal carcinomasLaboratory Investigation 2007; 87(7):644-50 (IF：4.4)
21. Shin VY, Jin HC, Ng EK, Yu J, Leung WK, Cho CH and Sung JJ. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways. Toxicol Appl Pharmacol. 2008; 233(2):254-261 (IF：3.9)
22. Yu J, Tao Q, Cheung K, Jin H, Poon FF, Wang X, Li H, Cheng YY, Roechen C, Ebert MP, Chan AT and Sung JJ. Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors Hepatology 2008;48(2):508-518 (IF：10.9)
2009
23. Ng KO, Chong W, Jin H, Lam EK, Shin V, Yu J, Poon T, Ng S, Sung JJ. Differential expression of microRNAs in plasma of colorectal cancer patients: A potential marker for colorectal cancer screening Gut 2009;58(10):1375-81 (IF：10.6)
24. Li J, Ng EKO, Ng YP, Wong CYP, Yu J, Jin H, Cheng VYY, Go MYY, Cheung PKF, Ebert MPA, Tong J, To KF, Chan FKL, Sung JJY, Ip NY and Leung WK. Identification of retinoic acid-regulated nuclear matrix-associated protein as a novel regulator of gastric cancer British J. of Cancer 2009;101(4):691-698 (IF：4.8)
25. Ng EK, Tsang WP, Ng SS, Jin H, Yu J, Li JJ, Rocken C, Ebert M, Kwok TT and Sung JJ. MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer. British J. of Cancer 2009; 101(4):699-706 (IF：4.8)
26. Yu J, Cheng YY, Tao Q, Cheung K, Lam C, Geng H, Tian L, Wong Y, Tong J, Ying J, Jin H, To K, Chan K, Sung J. Methylation of protocadherin 10, a novel tumor-suppressor, is associated with poor prognosis in patients with gastric cancer. Gastroenterology 2009;136(2):640-651 (IF：12.0)
2010
27. Huang C, Zhao J, Li Z, Li D, Xia D, Wang Q and Jin H. Multi-chaperone-peptide-rich mixture from colo-carcinoma cells elicits potent anticancer immunity Cancer Epidemiology 2010;34(4):494-500 (IF：1.2)
28. Li LL, Tao Q, Jin H, Hasselt A, Poon FF, Wang X, Zeng MS, Jia WH, Zeng YX, Chan AT and Cao Y. The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling, and is frequently silenced in nasopharyngeal carcinoma. Clinical Cancer Research 2010;16(1):2949-58 (IF：7.3)
29. Shin VY, Jin HC, Ng EK, Sung JJ, Chu KM and Cho CH. Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth Cancer letters 2010; 292(2):237-45 (IF：4.9)
30. Tsang WP, Ng EKO, Ng SSM, Jin H, Yu J, Sung JJ, Kwok TT. Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer Carcinogenesis 2010;31(3):350-8 (IF：5.4)
2011
31. Ng EKO, Leung C, Su S, Chan A, Wong CL, Ma ES, Jin HC and Kwong A. Quantitative analysis and diagnostic significance of methylated SLC19A3 DNA in the plasma of breast and gastric cancer patients PLoS One 2011;6(7):e22233 (IF：4.8)
32. Feng LF, Wang JT, Jin H, Qian K and Geng JG. SHKBP1 prevents EGFR degradation by the interruption of c-Cbl-CIN85 complex Cell Biochem and Function 2011;29(7):589-96 (IF：1.7)
33. Pan J, Zhong J, Gan LH, Chen SJ, Jin HC, Wang X, Wang LJ. Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer Tumor Biology 2011;32(4):729-735 (IF：2.0)
34. Cheng AS, Lau SS, Chen Y, Kondo Y, Li M, Feng H, Ching A, Cheung P, Wong H, Tong J, Jin H, Choy K, Yu J, To, K, Wong N, Huang T, Sung J. EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis Cancer Research 2011; June 1;71(11):4028-4039 (IF：8.2)
35. Shin VY, Jin H, Ng EK, Cho C, Leung WK, Sung JJ and Chu KM. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted gastric cancer growth through E receptors (EP2 and EP4) in vivo and in vitro. Cancer Science 2011;102(5):926-933 (IF：3.8)
36. Gan L, Chen S, Zhong J, Wang X, Lam EK, Liu X, Zhang J, Zhou T, Yu J, Si J, Wang L, Jin H. ZIC1 Is Downregulated through Promoter Hypermethylation, and Functions as a Tumor Suppressor Gene in Colorectal Cancer. PLoS One. 2011 Feb 15;6(2):e16916 (IF：4.8)
37. Shin VY, Jin H, Ng EK, Cheng AS, Chong WW, Wong CY, Leung WK, Sung JJ, Chu KM. NF-{kappa}B targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors. Carcinogenesis. 2011;32(2):240-245 (IF：5.4)
2012
38. Xu L, Li X, Chu E, Zhao J, Go, M, Tao Q, Jin H, Zeng Z, Sung J and Yu J. Epigenetic inactivation of BCL6B, a functional tumor suppressor for gastric cancer, is associated with poor survival of gastric cancer. Gut 2012 Jul;61(7):977-85 (IF：10.6)
39. Zhao JH, Jin HC, Cheung KF, Tong JH, Zhang S, Go MY, Tian L, Kang W, Leung PP, Zeng Z, Li X, To KF, Sung JJ, Yu J. Zinc finger E-box binding factor 1 plays a central role in regulating Epstein-Barr virus latent-lytic switch and acts as a therapeutic target in EBV-associated gastric cancer. Cancer 2012;118(4):924-36 (IF：5.1)
40. Wang Y, Ding L, Wang X, Zhan J, Han W, Feng L, Sun J, Jin H and Wang XJ. Pterostilbene simultaneously induces apoptosis, cell cycle arrest and cyto-protective autophagy in breast cancer cells American Journal of Translational Research 2012;4(1):44-51
41. Wang F, Ma J, Liu J, Jin H and Huang D Synthetic small peptides acting on B7H1 enhance apoptosis in pancreatic cancer cells. Mol Med Report. 2012 Sep;6(3):553-7 (IF：0.418)
42. Zhong J, Chen S, Xue M, Du Q, Cai J, Jin H, Si J, Wang L. ZIC1 modulates cell-cycle distributions and cell migration through regulation of Sonic hedgehog, PI3K and MAPK signaling pathways in gastric cancer. BMC Cancer. 2012 Jul 16;12(1):290 (IF：3.0)
43. Zhang H, Xu F, Xie T, Jin H, Shi L. β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein.Oncol Rep. 2012 Dec;28(6):2083-90
外文論著
Wang X and Jin H. The epigenetic aspect of gastric carcinoma. Gastric Carcinoma 2011 InTech
Jin H. From Inflammation to cancer: molecular basis. From Inflammation to Cancer: Advances in Diagnosis & Therapy for Gastrointestinal & Hepatological Diseases 2012 World Scientific Publishing
Jin H, Shen Q, Ma Y and Wang X. Methylated DNA as biomarkers for cancer detection Methylation In Tech 2013
學術任職
學術兼職
Gerson Lehrman Group Healthcare & Biomedical Council Member、中美腫瘤協會委員、浙江省細胞生物學會醫學細胞生物學專業委員會副主任委員、浙江省抗癌協會腫瘤生物治療專業委員會副主任委員
國際雜誌編委
American Journal of Cancer Biology 資深編委、American Journal of Cancer Research 資深編委、American Journal of Translational Research 編委、World Journal of Medical Genetics 編委、Clinical Reviews and Opinions 編委、World Journal of Medical Genetics 編委
