趙金存(國家傑出青年科學基金獲得者、廣州醫科大學呼吸疾病國家重點實驗室主任)

趙金存、博士、教授，博士生導師、呼吸疾病國家重點實驗室主任、國家傑出青年科學基金獲得者、長江學者獎勵計畫抗疫特崗，享受政府特殊津貼人選、中組部青年人才計畫學者、廣東特支計畫科技創新領軍人才、廣東省醫學領軍人才、廣州市傑出專家、廣州市醫學重點人才等。

基本介紹

• 中文名：趙金存
• 畢業院校：北京大學
• 主要成就：2020年12月被授予“廣州市抗擊新冠肺炎疫情先進個人”稱號
• 職務：呼吸疾病國家重點實驗室主任

人物經歷

2002年本科畢業於北京大學基礎醫學系；2007年獲北京大學免疫學博士學位；之後前往美國愛荷華大學微生物與免疫學系深造；2015年入選中組部青年人才項目，並全職加入廣州醫科大學附屬第一醫院/廣州呼吸健康研究院/呼吸疾病國家重點實驗室工作。

政協第十三屆廣東省委員會委員、常務委員

主要成就

長期從事人類新發突發呼吸系統傳染病致病機制及相關預防、治療方法研究。迄今在Cell、Lancet Infect Dis、Immunity、Sci Immunol、J Clin Invest、J Exp Med、Euro Res J、Signal Transduct Target Ther、ASC Nano、Genome Med、PNAS、Plos Pathog、J Virol等雜誌共發表SCI論文近100篇。作為牽頭人先後主持國家重點研發計畫、國家自然科學基金重大研究計畫、國際(地區)合作與交流項目等。

研究工作

1、首次闡明MERS病毒感染人體後誘導特異性T細胞免疫應答特徵

2、中國首例中東呼吸綜合徵冠狀病毒ChinaGD01毒株成功分離

3、MERS、SARS和甲型流感致病及肺損傷機制研究

4、MERS小鼠動套寒物模型構建和應急救治抗體研發

科研項目

1、國家自然科學基金組織器官區域免疫特性與疾病重大研究計畫（9184210009），肺泡槳陵晚戶駐留流感病毒特異性CD4 T細胞來源、穩態維持和保護作用機制研究，趙金存；

2、國家自然科學基金國際(地區)合作與交流項目（8181101118），探索不同人冠狀病毒之間的交叉免疫保護作用，趙金存；

3、國家自然科學基金面上項目（81772191），中東呼吸捉擔協綜合徵新型人源應急救治單克隆抗體保護作用機制研究，趙金存；

4、國家自然科學基金面上項目（81771694），病毒特異性Treg分泌的炎性因子調控自身細胞功能和穩定性的機制研究，肇靜嫻；

5、國家重章付拜點研發計畫項目“生物安全關鍵技術研發”重點專項，突發急性和烈性傳染病臨床救治關鍵技術研究（2018YFC1200100），趙金存；

6、愛滋病和病毒性肝炎等重大傳染病防治科技重大專項（SQ2018ZX100101），“一帶一路” 重要傳染病流行規律和預警應對技術研究，肇靜嫻；

7、愛滋病和病毒性肝炎等重大傳染病防治科技重大專項（2018ZX10301403），防治重大呼吸道病毒感染疾病的原創生物技術產品研發及戰略儲備，趙探仔店金存；

8、廣州市健康醫療協同創新重大專項三期（201604020011），新發突發烈性傳染病防控及治犁棄滲局療新技術研究，趙金存；肯鍵府

9、廣州醫科大學高水平大學建設創新團隊：呼吸道病毒臨床診療與轉化研究，趙金存、肇靜嫻；

10、廣州市健康醫療協同創新重大專項（201704020226），寨卡病毒病診、治新策略及適宜防控新技術的套用與臨床轉化研究，肇靜嫻；

人物榮譽

1、2016年，獲中華醫學會高影響力呼吸學術論文獎；

2、共青團廣州市委員會《廣州市青年工匠獎》；

3、《廣州市高層次衛生人才》醫學重點人才；

4、2020年12月，被授予“廣州市抗擊新冠肺炎疫情先進個人”稱號。

代表性學術論文

1、Zhao J#, Alshukairi AN#, *, Baharoon SA, Ahmed WA, Bokhari AA, Nehdi AM, Layqah LA, Alghamdi MG, Al Gethamy MM, Dada AM, Khalid I, Boujelal M, Al Johani SM, Vogel L, Subbarao K, Mangalam A, Wu C, Ten Eyck P, Perlman S*, Zhao J*. Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses. Sci Immunol. 2017 Aug 4;2(14). pii: eaan5393. (Cover of the issue)

2、Zhao J#, *, Zhao J#, Mangalam AK, Channappanavar R, Fett C, Meyerholz DK, Agnihothram S, Baric RS, David CS, Perlman S*. Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses. Immunity. 2016 Jun 21;44(6):1379-91.

3、Zhao J#, *, Vijay R, Zhao J, Gale M Jr, Diamond MS, Perlman S*. MAVS expressed by hematopoietic cells is critical for control of West Nile virus infection and pathogenesis. J Virol. 2016 Jul 27;90(16):7098-108.

4、Corti D#, Zhao J#, Pedotti M, Simonelli L, Agnihothram S, Fett C, Fernandez-Rodriguez B, Foglierini M, Agatic G, Vanzetta F, Gopal R, Langrish CJ, Barrett N.A, Sallusto F, Baric RS, Varani L, Zambon M, Perlman S, Lanzavecchia A*. Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. Proc Natl AcadSci U S A. 2015 Aug; 112:10473-8. (Commentary byDennis R. Burtona and Erica Ollmann Saphire)

5、Zhao J#, Perera RA, Kayali G, Meyerholz D, Perlman S*, Peiris M*. Passive immunotherapy with dromedary immune serum in an experimental animal model for MERS coronavirus infection. J Virol. 2015 Jun; 89:6117-20.

6、Zhao J#,Zhao J, Perlman S*. Virus-specific regulatory T cells ameliorate encephalitis by repressing effector T cell functions from priming to effector stages. Plos Pathog. 2014 Aug; 10:e1004279

7、Zhao J#, Li K, Wohlford-Lenane C, Agnihothram SS, Fett C, Zhao J, Gale MJ Jr, Baric RS, Enjuanes L, Gallagher T, McCray PB Jr, Perlman S*. Rapid generation of a mouse model for Middle East Respiratory Syndrome.Proc Natl Acad Sci U S A. 2014 Apr; 111:4970-4975. (Cited by Nature, Science and Faculty 1000).

8、Zhao J#, *, Wohlford-Lenane C, Zhao J, Fleming E, Lane TE, McCray PB Jr, Perlman S*. Intranasal treatment with poly I:C protects aged mice from lethal respiratory viral infections. J Virol. 2012 Nov;86:11416-11424.

9、Zhao J#, Zhao J, Legge K, Perlman S*. Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J Clin Invest. 2011 Dec; 121:4921-4930. (Commentary by T. Kim and T. Braciale, Cited by Nature/SCIBX and Faculty 1000)

10、Zhao J#, Zhao J, Fett C, Trandem K, Fleming E, Perlman S*. IFN-gamma- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis. J Exp Med. 2011 Aug; 208:1571-1577. (Cited by Faculty 1000)

11、Zhao J#, Zhao J, Perlman S*. T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice. J Virol. 2010 Sep;84:9318-9325.

12、Zhao J#, Zhao J, Van Rooijen N, Perlman S*. Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice. PLoS Pathog. 2009 Oct; 5:e1000636. (Cited by Faculty 1000)

13、Zhao J#, Zhao J, Perlman S*. De novo recruitment of antigen-experienced and naive T cells contributes to the long-term maintenance of antiviral T cell populations in the persistently infected central nervous system. J Immunol. 2009 Oct; 183:5163-5170.

14、.Zhao J#, Falcón A#, Zhou H, Netland J, Enjuanes L, Pérez Breña P, Perlman S*. Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication. J Virol. 2009 Mar; 83:2368-2373.

15、Zhao J#, Huang Q#, Wang W, Zhang Y, Lv P, Gao XM*. Identification and characterization of dominant helper T-cell epitopes in the nucleocapsid protein of severe acute respiratory syndrome coronavirus. J Virol.2007, June; 81:6079-6088.

9、廣州醫科大學高水平大學建設創新團隊：呼吸道病毒臨床診療與轉化研究，趙金存、肇靜嫻；

10、廣州市健康醫療協同創新重大專項（201704020226），寨卡病毒病診、治新策略及適宜防控新技術的套用與臨床轉化研究，肇靜嫻；

人物榮譽

1、2016年，獲中華醫學會高影響力呼吸學術論文獎；

2、共青團廣州市委員會《廣州市青年工匠獎》；

3、《廣州市高層次衛生人才》醫學重點人才；

4、2020年12月，被授予“廣州市抗擊新冠肺炎疫情先進個人”稱號。

代表性學術論文

1、Zhao J#, Alshukairi AN#, *, Baharoon SA, Ahmed WA, Bokhari AA, Nehdi AM, Layqah LA, Alghamdi MG, Al Gethamy MM, Dada AM, Khalid I, Boujelal M, Al Johani SM, Vogel L, Subbarao K, Mangalam A, Wu C, Ten Eyck P, Perlman S*, Zhao J*. Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses. Sci Immunol. 2017 Aug 4;2(14). pii: eaan5393. (Cover of the issue)

2、Zhao J#, *, Zhao J#, Mangalam AK, Channappanavar R, Fett C, Meyerholz DK, Agnihothram S, Baric RS, David CS, Perlman S*. Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses. Immunity. 2016 Jun 21;44(6):1379-91.

3、Zhao J#, *, Vijay R, Zhao J, Gale M Jr, Diamond MS, Perlman S*. MAVS expressed by hematopoietic cells is critical for control of West Nile virus infection and pathogenesis. J Virol. 2016 Jul 27;90(16):7098-108.

4、Corti D#, Zhao J#, Pedotti M, Simonelli L, Agnihothram S, Fett C, Fernandez-Rodriguez B, Foglierini M, Agatic G, Vanzetta F, Gopal R, Langrish CJ, Barrett N.A, Sallusto F, Baric RS, Varani L, Zambon M, Perlman S, Lanzavecchia A*. Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. Proc Natl AcadSci U S A. 2015 Aug; 112:10473-8. (Commentary byDennis R. Burtona and Erica Ollmann Saphire)

5、Zhao J#, Perera RA, Kayali G, Meyerholz D, Perlman S*, Peiris M*. Passive immunotherapy with dromedary immune serum in an experimental animal model for MERS coronavirus infection. J Virol. 2015 Jun; 89:6117-20.

6、Zhao J#,Zhao J, Perlman S*. Virus-specific regulatory T cells ameliorate encephalitis by repressing effector T cell functions from priming to effector stages. Plos Pathog. 2014 Aug; 10:e1004279

7、Zhao J#, Li K, Wohlford-Lenane C, Agnihothram SS, Fett C, Zhao J, Gale MJ Jr, Baric RS, Enjuanes L, Gallagher T, McCray PB Jr, Perlman S*. Rapid generation of a mouse model for Middle East Respiratory Syndrome.Proc Natl Acad Sci U S A. 2014 Apr; 111:4970-4975. (Cited by Nature, Science and Faculty 1000).

8、Zhao J#, *, Wohlford-Lenane C, Zhao J, Fleming E, Lane TE, McCray PB Jr, Perlman S*. Intranasal treatment with poly I:C protects aged mice from lethal respiratory viral infections. J Virol. 2012 Nov;86:11416-11424.

9、Zhao J#, Zhao J, Legge K, Perlman S*. Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J Clin Invest. 2011 Dec; 121:4921-4930. (Commentary by T. Kim and T. Braciale, Cited by Nature/SCIBX and Faculty 1000)

10、Zhao J#, Zhao J, Fett C, Trandem K, Fleming E, Perlman S*. IFN-gamma- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis. J Exp Med. 2011 Aug; 208:1571-1577. (Cited by Faculty 1000)

11、Zhao J#, Zhao J, Perlman S*. T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice. J Virol. 2010 Sep;84:9318-9325.

12、Zhao J#, Zhao J, Van Rooijen N, Perlman S*. Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice. PLoS Pathog. 2009 Oct; 5:e1000636. (Cited by Faculty 1000)

13、Zhao J#, Zhao J, Perlman S*. De novo recruitment of antigen-experienced and naive T cells contributes to the long-term maintenance of antiviral T cell populations in the persistently infected central nervous system. J Immunol. 2009 Oct; 183:5163-5170.

14、.Zhao J#, Falcón A#, Zhou H, Netland J, Enjuanes L, Pérez Breña P, Perlman S*. Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication. J Virol. 2009 Mar; 83:2368-2373.

15、Zhao J#, Huang Q#, Wang W, Zhang Y, Lv P, Gao XM*. Identification and characterization of dominant helper T-cell epitopes in the nucleocapsid protein of severe acute respiratory syndrome coronavirus. J Virol.2007, June; 81:6079-6088.