趙元慧，83年獲東北師大學士學位，86年獲南京大學碩士學位，畢業後在東北師大環境科學系工作4年，任職為講師。
基本介紹
- 中文名：趙元慧
- 國籍：中國
- 出生日期：1961年生
- 職業：講師
- 畢業院校：南京大學
- 主要成就：有機污染物定量結構與活性相關
- 性別：男
人物經歷,主講課程,研究方向,主要貢獻,科研項目,科研成果,獲獎記錄,
人物經歷
90年去南京大學攻讀博士學位，93年獲博士學位後，在南京大學環境科學系工作1年，並提升為副教授，擔任系副主任。94年回東北師大環境科學系工作，並於96年獲英國皇家獎學金，在英國利物浦John Moores大學作高級訪問學者一年，99年在東北師大破格提升為教授，2000年被評為博士生導師。從1999年到2007，在英國倫敦大學，大學學院化學系做博士後、研究員，目前在城環院工作，從事有機物定量結構與活性相關，有機污染物在環境中的遷移轉化歸趨的研究。
2007-至今：教授，博士生導師，東北師範大學城市與環境科學學院。
1999-2007 ：研究員，英國倫敦大學大學學院化學系。
1998-1999：教授，系主任，博士生導師，東北師範大學環境科學系。
1997-1998 ：訪問學者，獲國家教委出國留學基金資助，英國倫敦大學大學學院。
1996-1997 ：高級訪問學者, 獲英國皇家協會獎學金，英國利物浦John Moores大學。
1994-1996 ：副教授，東北師範大學環境科學系。
1993-1994 ：講師、副教授、副系主任，南京大學環境科學系。
1990-1993 ：博士研究生，南京大學環境科學系，專業環境化學，導師王連生。
1986-1990 ：助教、講師,東北師範大學環境科學系。
1983-1986 ：碩士生，東北師範大學環境科學系，導師郎佩珍，專業環境化學。
1979-1983 ：本科生，東北師範大學化學系。
主講課程
本科生：
環境儀器分析、環境科學進展 。
碩士研究生：
高等環境化學、環境統計 。
博士研究生：
學科理論與方法專題研討, 有機污染物化學。
環境儀器分析、環境科學進展 。
碩士研究生：
高等環境化學、環境統計 。
博士研究生：
學科理論與方法專題研討, 有機污染物化學。
研究方向
1.有機污染物化學：有機污染物生物富集、生物降解、土壤吸附、水解、光解、揮發。
2.環境毒理化學：有機污染物對水生生物的毒性（魚、大型蚤、綠藻等）、機理及風險性評價。
3.有機污染物定量結構與活性相關：有機污染物對水生生物毒性與結構相關性；有機污染物在環境中遷移轉化與結構相關性。
主要貢獻
從1986年工作以來，主持3項國家自然科學基金，1項霍英東教育基金，並申請到1項英國皇家協會科研獎學金，主要參與1項國家重大自然科學基金和多項國家自然科學基金項目的研究。
自從90年以來，先後發表論文100餘篇（第一作者40餘篇），合寫論著2部，其中被SCI收錄論文36篇。論文總共被引用次數330餘次以上，其中單篇最高引用次數達120餘次。
科研項目
2010.1-2012.12：基於Abraham線性溶劑化方程研究可離子化有機污染對水生生物的毒性(20977015)，國家自然科學基金，主持。
2008.1-2010.12：典型有機污染物在環境中遷移轉化及構效關係，東北師大，主持。
1998.1-2001.12：有機物在水和沉積物中的生物降解性及定量結構與活性相關(29877004），國家自然科學基金，主持。
1996.6-1997.5：有機污染物生態毒理效應及構效關係，英國皇家協會，主持。
1996.1-1998.12：取代芳烴化合物定量結構與活性相關研究，霍英東教育基金，主持。
1995,1-1997,12：一種定量結構與活性相關方程的深化研究(29407052)，國家自然科學基金.青年，主持。
科研成果
代表性論文(*通訊作者）：
1. Zhao Y.H.,* Zhang X.J., Wen Y., Sun F.T., Guo Z., Qin W.C., Qin H.W., Xu J.L., Sheng L.X., Abraham M.H. Toxicity of organic chemicals to Tetrahymena pyriformis: Effect of polarity and ionization on toxicity. Chemosphere 2010, 79, 72–77 。
2. Zhang X.J., Qin H.W., Su L.M., Qin W.C., Zou M.Y., Sheng L.X., Zhao Y.H.,* Abraham M.H. Interspecies correlations of toxicity to eight aquatic organisms: Theoretical considerations. Sci. Total Environ. 2010, 408, 4549–4555 。
3. Qin W.C., Su L.M., Zhang X.J., Qin H.W., Wen Y., Guo Z., Sun F.T., Sheng L.X., Zhao Y.H.,* Abraham M.H. Toxicity of organic pollutants to seven aquatic organisms: effect of polarity and ionization. SAR QSAR Environ. Sci. 2010, 21, 389–401 。
4. Su L.M., Zhao Y.H., Yuan X., Mu C.F., Wang N. Yan J.C. Evaluation of Combined Toxicity of Phenols and Lead to Photobacterium phosphoreum and quantitative structure–activity relationships. Bull. Environ. Contam. Toxicol. 2010, 84, 311–314 。
5. Zhao Y.H.,* Yuan X., Su L.M., Qin W.C., Abraham M.H. Classification of toxicity of phenols to Tetrahymena pyriformis and subsequent derivation of QSARs from hydrophobic, ionization and electronic parameters. Chemosphere 2009, 75, 866–871 。
6. Zhao Y.H.,* Qin W.C., Su L.M., Yuan X., Lu G.H., Abraham M.H. Toxicity of substituted benzenes and algae (Scenedesmus obliquus) with solvation equation. Chinese Sci. Bull. 2009, 54, 1690-1696
7. Yu R., Yuan X., Zhao Y.H*., Hu G., Tu X. Heavy metal pollution in intertidal sediments from Quanzhou Bay, China. J. Environ. Sci. 2008, 20, 1–6 。
8. Zhao Y.H., Abraham M.H., Ibrahim A. Fish P.V., Cole S., Lewis M.L., de Groot M.J., Reynolds D.P. Predicting Penetration Across the Blood-Brain Barrier from Simple Descriptors and Fragmentation Schemes. J. Chem. Inf. Model. 2007, 47, 170–175 。
9. Abraham M.H., Ibrahim A. Zhao Y.H., Acree Jr W. A data base for partition of volatile organic compounds and drugs from blood/plasma/serum to brain, and an LFER analysis of the data. J. Pharm. Sci. 2006, 95,2091–2100 。
10. Zhao Y.H., Abraham M.H. Octanol/water partition of ionic species, including 544 ions. J. Org. Chem., 2005, 70, 2633–2640 。
11. Abraham M.H., Zhao Y.H. Characterisation of the water/o-nitrophenol octyl ether system in terms of the partition of nonelectrolytes and of ions. Phys. Chem. Chem. Phys. 2005, 7, 2418–2422 。
12. Abraham M.H., Zhao Y.H. Determination of solvation descriptors for ionic species, hydrogen bond acidity and basicity. J. Org. Chem. 2004, 69, 4677–4685 。
13. Abraham M.H., Zhao Y.H. Le, J., Hersey A., Luscombe C.N., Sherborne B. Quantitative relationship between rat intestinal absorption and Abraham descriptors. Eur. J. Med. Chem. 2003, 38, 939–947 。
14. Zhao Y. H., Abraham M.H., Zissimos A.M. Fast Calculation of van der Waals Volume as a Sum of Atomic and Bond Contributions and its Application to Drug Compounds. J. Org. Chem. 2003, 63, 7368–7373 。
15. Zhao Y.H., Abraham M.H. Zissimos A.M. Determination of McGowan volumes for ions and correlation with van der Waals volumes. J. Chem Inf. Comput. Sci. 2003, 43, 1848–1854 。
16. Zhao Y.H., Abraham M.H., Le, J., Hersey A. Evaluation of rat intestinal Absorption data and correlation with human intestinal absorption. Eur. J. Med. Chem. 2003, 38,233–243.
17. GraBmann S., Apelt J., Sippl W., Zhao Y.H., Ganellin C.R. Imidazole Derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities. Bioorg. Med. Chem. 2003, 11, 2163–2174 。
18. Zhao, Y.H., Abraham M.H., Le J., Hersey A., Luscombe C.N., Beck G., Sherborne B., Cooper I. Rate-limited steps of human oral absorption, QSAR Studies. Pharm. Res., 2002, 19, 1446–1457.
19. Abraham M. H., Zhao Y. H., Le J., Hersey A., Luscombe C. N., Reynolds D. P., Beck G., Sherborne B., Cooper I. On the mechanism of human intestinal absorption. Eur J. Med Chem. 2002,37, 595–605 。
20. Abraham M.H., Ibrahim A., Zissimos A.M., Zhao Y.H., Comer J., Reynolds D. Application of hydrogen bonding calculations in property based drug design. Drug Discov. Today, 2002, 7, 1056–1060 。
21. Zhao Y.H., Le J., Abraham M.H., Hersey A., Beck G., Sherborne B., Cooper I., Platts J.A. Evaluation of human oral absorption data for use in QSAR studies and a quattitative relationship obtained with the Abraham descriptors. J. Pharm. Sci. 2001, 90, 749–784 。
22. Platts J.A., Abraham M.H., Zhao Y.H., Hersey A., Ijaz L., Butina D. Correlation and prediction of a large blood-brain distribution data set – an LFER study. Eur J. Med Chem. 2001, 36, 719–730 。
23. Lu G.H., Yuan X., Zhao Y.H. QSAR study on the toxicity of substituted benzenes to the algae (Scenedesmus obliquus), Chemosphere 2001, 44 (3), 437–440 。
24. Cronin M.T.D., Zhao Y.H., Yu R.L. pH-dependence and QSAR analysis of the toxicity of phenols and anilines to Daphnia magna. Quant. Struct.-Act. Relat. 2000, 15 (2), 140–148 。
25. Dearden J.C., Cronin M.T.D., Zhao Y.H. QSAR studies of compounds acting by polar and non-polar narcosis: An examination of the role of polarisability and hydrogen bonding. Quant. Struct.-Act. Relat. 2000, 19 (1), 3–9 。
26. Zhao Y.H., Cronin M.T.D., Dearden J.C. Quantitative structure-activity relationship of chemicals acting by non-polar narcosis------ theoretical considerations. Quant. Struct.-Act. Relat. 1998,17(2),131–138 。
27. Zhao Y.H., Ji G. D., Cronin M.T.D., Dearden J.C. QSAR study of the toxicity of benzoic acids to Vibrio fischeri, Daphnia magna and carp. The Sci. of Total Environ., 1998,216,205–215 。
28. Zhao Y.H. Quantitative structure-activity relationships of nitroaromatic compounds to four aquatic organisms. Chemosphere 1997, 34(8),1837–1844 。
29. Zhao Y.H. Quantitative structure-activity relationships of organic acids, bases. Bull. of Environ. Contamin. Toxicol. 1996, 57(2),242–249 。
30. Zhao Y.H., Wang L.S. Evaluation of the partitioning of hydrophobic pollutants between aquatic and solid phases in natural systems. Sci. of the Total Environ. 1996, 177,1–7 。
31. Chen J.W., Liao Y.Y., Zhao Y.H., Wang L.S. Quantitative structure-activity relationships and mixture toxicity studies of heterocyclic nitrogen-compounds. Bull. Environ. Contamin. Toxicol. 1996,57(1),77–83 。
32. Feng L., Wang L.S., Zhao Y.H., Shong B. Effect of substituted anilines and phenols on root elongation of cabbage seed. Chemosphere 1996,32(8),1575–1583 。
33. Zhao Y.H., Wang L. S. Quantitative structure-activity relationships of hydrophobic organic chemicals. Toxicol. Environ. Sci. 1995, 50,167 。
34. Zhao Y.H., Wang L. S. Predicting toxicities of substituted aromatic hydrocarbons to fish by toxicities to Daphnia magna or Photobacterium phosphoreum. Toxicol. Environ. Sci. 1995, 51,191 。
35. Zhao Y.H. Wang L. S. Relationship between molecular connectivity index and physio-chemical parameters of nitrated aromatic hydrocarbons. Adv. in Natural Sci. 1995, 5,496 。
36. Zhao Y.H. Lang P.Z., Wang L.S. A rapid determination method of adsorption-desorption kinetics constants of aromatic hydrocarbons on natural sediment. Environ. Chem. 1994, 13, 222 。
37. Zhao Y.H. Lang P.Z., Wang L.S. A rapid determination method of bioconcentration factors of aromatic hydrocarbons. Environ. Chem. 1994, 13,203 。
38. Zhao Y.H., Wang L. S. QSAR--Relationship between toxicity of organic chemicals to fish and to Photobacterium phosphoreum. Chemosphere 1993,26(11),1971 。
39. Zhao Y.H., Wang L. S. Quantitative structure-activity relationships of organic pollutants. Chinese Sci. Bull. 1993, 38(6),516 。
40. Zhao Y.H. Lang P.Z., Wang L.S. Calculation and determination of sorption-desorption kinetics constants of organic compounds on sediments. Environ. Chem. 1993, 12(2),154 。
41. Zhao Y.H., Wang L.S. Predicting aqueous solubility and octanol/water partition coefficients of organic chemicals from molar volume. Environ. Chem. 1992,11(1),55 。
42. Zhao Y.H., Lang P.Z. Adsorption behaviour of organic pollutants on natural sediments: effect of solid concentration on adsorption partition coefficients. Environ. Sci. 1991,12(5)23 。
43. Zhao Y.H., Lang P.Z. Studies on adsorption model of organic compounds to natural sediments with Langmuir. Environ. Chem. 1990,9(1),12 。
44. Zhao Y.H., Lang P.Z. Adsorption theory of organic compounds on sediments. Progress in Environ. Sci. 1990,11(2),41 。
45. Zhao Y.H., Lang P.Z. and Ding Y.Z. Simulation experiments to determine the volatilization rate of organic compounds in river. Environ. Sci. 1990,11(3),53 。
1. Zhao Y.H.,* Zhang X.J., Wen Y., Sun F.T., Guo Z., Qin W.C., Qin H.W., Xu J.L., Sheng L.X., Abraham M.H. Toxicity of organic chemicals to Tetrahymena pyriformis: Effect of polarity and ionization on toxicity. Chemosphere 2010, 79, 72–77 。
2. Zhang X.J., Qin H.W., Su L.M., Qin W.C., Zou M.Y., Sheng L.X., Zhao Y.H.,* Abraham M.H. Interspecies correlations of toxicity to eight aquatic organisms: Theoretical considerations. Sci. Total Environ. 2010, 408, 4549–4555 。
3. Qin W.C., Su L.M., Zhang X.J., Qin H.W., Wen Y., Guo Z., Sun F.T., Sheng L.X., Zhao Y.H.,* Abraham M.H. Toxicity of organic pollutants to seven aquatic organisms: effect of polarity and ionization. SAR QSAR Environ. Sci. 2010, 21, 389–401 。
4. Su L.M., Zhao Y.H., Yuan X., Mu C.F., Wang N. Yan J.C. Evaluation of Combined Toxicity of Phenols and Lead to Photobacterium phosphoreum and quantitative structure–activity relationships. Bull. Environ. Contam. Toxicol. 2010, 84, 311–314 。
5. Zhao Y.H.,* Yuan X., Su L.M., Qin W.C., Abraham M.H. Classification of toxicity of phenols to Tetrahymena pyriformis and subsequent derivation of QSARs from hydrophobic, ionization and electronic parameters. Chemosphere 2009, 75, 866–871 。
6. Zhao Y.H.,* Qin W.C., Su L.M., Yuan X., Lu G.H., Abraham M.H. Toxicity of substituted benzenes and algae (Scenedesmus obliquus) with solvation equation. Chinese Sci. Bull. 2009, 54, 1690-1696
7. Yu R., Yuan X., Zhao Y.H*., Hu G., Tu X. Heavy metal pollution in intertidal sediments from Quanzhou Bay, China. J. Environ. Sci. 2008, 20, 1–6 。
8. Zhao Y.H., Abraham M.H., Ibrahim A. Fish P.V., Cole S., Lewis M.L., de Groot M.J., Reynolds D.P. Predicting Penetration Across the Blood-Brain Barrier from Simple Descriptors and Fragmentation Schemes. J. Chem. Inf. Model. 2007, 47, 170–175 。
9. Abraham M.H., Ibrahim A. Zhao Y.H., Acree Jr W. A data base for partition of volatile organic compounds and drugs from blood/plasma/serum to brain, and an LFER analysis of the data. J. Pharm. Sci. 2006, 95,2091–2100 。
10. Zhao Y.H., Abraham M.H. Octanol/water partition of ionic species, including 544 ions. J. Org. Chem., 2005, 70, 2633–2640 。
11. Abraham M.H., Zhao Y.H. Characterisation of the water/o-nitrophenol octyl ether system in terms of the partition of nonelectrolytes and of ions. Phys. Chem. Chem. Phys. 2005, 7, 2418–2422 。
12. Abraham M.H., Zhao Y.H. Determination of solvation descriptors for ionic species, hydrogen bond acidity and basicity. J. Org. Chem. 2004, 69, 4677–4685 。
13. Abraham M.H., Zhao Y.H. Le, J., Hersey A., Luscombe C.N., Sherborne B. Quantitative relationship between rat intestinal absorption and Abraham descriptors. Eur. J. Med. Chem. 2003, 38, 939–947 。
14. Zhao Y. H., Abraham M.H., Zissimos A.M. Fast Calculation of van der Waals Volume as a Sum of Atomic and Bond Contributions and its Application to Drug Compounds. J. Org. Chem. 2003, 63, 7368–7373 。
15. Zhao Y.H., Abraham M.H. Zissimos A.M. Determination of McGowan volumes for ions and correlation with van der Waals volumes. J. Chem Inf. Comput. Sci. 2003, 43, 1848–1854 。
16. Zhao Y.H., Abraham M.H., Le, J., Hersey A. Evaluation of rat intestinal Absorption data and correlation with human intestinal absorption. Eur. J. Med. Chem. 2003, 38,233–243.
17. GraBmann S., Apelt J., Sippl W., Zhao Y.H., Ganellin C.R. Imidazole Derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities. Bioorg. Med. Chem. 2003, 11, 2163–2174 。
18. Zhao, Y.H., Abraham M.H., Le J., Hersey A., Luscombe C.N., Beck G., Sherborne B., Cooper I. Rate-limited steps of human oral absorption, QSAR Studies. Pharm. Res., 2002, 19, 1446–1457.
19. Abraham M. H., Zhao Y. H., Le J., Hersey A., Luscombe C. N., Reynolds D. P., Beck G., Sherborne B., Cooper I. On the mechanism of human intestinal absorption. Eur J. Med Chem. 2002,37, 595–605 。
20. Abraham M.H., Ibrahim A., Zissimos A.M., Zhao Y.H., Comer J., Reynolds D. Application of hydrogen bonding calculations in property based drug design. Drug Discov. Today, 2002, 7, 1056–1060 。
21. Zhao Y.H., Le J., Abraham M.H., Hersey A., Beck G., Sherborne B., Cooper I., Platts J.A. Evaluation of human oral absorption data for use in QSAR studies and a quattitative relationship obtained with the Abraham descriptors. J. Pharm. Sci. 2001, 90, 749–784 。
22. Platts J.A., Abraham M.H., Zhao Y.H., Hersey A., Ijaz L., Butina D. Correlation and prediction of a large blood-brain distribution data set – an LFER study. Eur J. Med Chem. 2001, 36, 719–730 。
23. Lu G.H., Yuan X., Zhao Y.H. QSAR study on the toxicity of substituted benzenes to the algae (Scenedesmus obliquus), Chemosphere 2001, 44 (3), 437–440 。
24. Cronin M.T.D., Zhao Y.H., Yu R.L. pH-dependence and QSAR analysis of the toxicity of phenols and anilines to Daphnia magna. Quant. Struct.-Act. Relat. 2000, 15 (2), 140–148 。
25. Dearden J.C., Cronin M.T.D., Zhao Y.H. QSAR studies of compounds acting by polar and non-polar narcosis: An examination of the role of polarisability and hydrogen bonding. Quant. Struct.-Act. Relat. 2000, 19 (1), 3–9 。
26. Zhao Y.H., Cronin M.T.D., Dearden J.C. Quantitative structure-activity relationship of chemicals acting by non-polar narcosis------ theoretical considerations. Quant. Struct.-Act. Relat. 1998,17(2),131–138 。
27. Zhao Y.H., Ji G. D., Cronin M.T.D., Dearden J.C. QSAR study of the toxicity of benzoic acids to Vibrio fischeri, Daphnia magna and carp. The Sci. of Total Environ., 1998,216,205–215 。
28. Zhao Y.H. Quantitative structure-activity relationships of nitroaromatic compounds to four aquatic organisms. Chemosphere 1997, 34(8),1837–1844 。
29. Zhao Y.H. Quantitative structure-activity relationships of organic acids, bases. Bull. of Environ. Contamin. Toxicol. 1996, 57(2),242–249 。
30. Zhao Y.H., Wang L.S. Evaluation of the partitioning of hydrophobic pollutants between aquatic and solid phases in natural systems. Sci. of the Total Environ. 1996, 177,1–7 。
31. Chen J.W., Liao Y.Y., Zhao Y.H., Wang L.S. Quantitative structure-activity relationships and mixture toxicity studies of heterocyclic nitrogen-compounds. Bull. Environ. Contamin. Toxicol. 1996,57(1),77–83 。
32. Feng L., Wang L.S., Zhao Y.H., Shong B. Effect of substituted anilines and phenols on root elongation of cabbage seed. Chemosphere 1996,32(8),1575–1583 。
33. Zhao Y.H., Wang L. S. Quantitative structure-activity relationships of hydrophobic organic chemicals. Toxicol. Environ. Sci. 1995, 50,167 。
34. Zhao Y.H., Wang L. S. Predicting toxicities of substituted aromatic hydrocarbons to fish by toxicities to Daphnia magna or Photobacterium phosphoreum. Toxicol. Environ. Sci. 1995, 51,191 。
35. Zhao Y.H. Wang L. S. Relationship between molecular connectivity index and physio-chemical parameters of nitrated aromatic hydrocarbons. Adv. in Natural Sci. 1995, 5,496 。
36. Zhao Y.H. Lang P.Z., Wang L.S. A rapid determination method of adsorption-desorption kinetics constants of aromatic hydrocarbons on natural sediment. Environ. Chem. 1994, 13, 222 。
37. Zhao Y.H. Lang P.Z., Wang L.S. A rapid determination method of bioconcentration factors of aromatic hydrocarbons. Environ. Chem. 1994, 13,203 。
38. Zhao Y.H., Wang L. S. QSAR--Relationship between toxicity of organic chemicals to fish and to Photobacterium phosphoreum. Chemosphere 1993,26(11),1971 。
39. Zhao Y.H., Wang L. S. Quantitative structure-activity relationships of organic pollutants. Chinese Sci. Bull. 1993, 38(6),516 。
40. Zhao Y.H. Lang P.Z., Wang L.S. Calculation and determination of sorption-desorption kinetics constants of organic compounds on sediments. Environ. Chem. 1993, 12(2),154 。
41. Zhao Y.H., Wang L.S. Predicting aqueous solubility and octanol/water partition coefficients of organic chemicals from molar volume. Environ. Chem. 1992,11(1),55 。
42. Zhao Y.H., Lang P.Z. Adsorption behaviour of organic pollutants on natural sediments: effect of solid concentration on adsorption partition coefficients. Environ. Sci. 1991,12(5)23 。
43. Zhao Y.H., Lang P.Z. Studies on adsorption model of organic compounds to natural sediments with Langmuir. Environ. Chem. 1990,9(1),12 。
44. Zhao Y.H., Lang P.Z. Adsorption theory of organic compounds on sediments. Progress in Environ. Sci. 1990,11(2),41 。
45. Zhao Y.H., Lang P.Z. and Ding Y.Z. Simulation experiments to determine the volatilization rate of organic compounds in river. Environ. Sci. 1990,11(3),53 。
獲獎記錄
1. Ebert國際獎,美國藥理協會,2002,第一
2. 科學進步三等獎，教育部，1999，第四
3. 第四屆吉林省青年科技獎，吉林省科協、吉林省委組織部、吉林省人事部、吉林省共青團，1996，第一。
2002年獲得美國藥理協會頒布的Ebert國際獎1項（第一作者），1998年獲教育部科技進步三等獎（第四），1996年獲吉林省青年科技進步獎（第一）。目前是國際學術雜誌編委。
