謝華鋒，男，博士，華南理工大學生命科學研究院特聘研究員。
基本介紹
- 中文名：謝華鋒
- 畢業院校：阿爾伯特-愛因斯坦醫學院
- 學位/學歷：博士
- 職業：教師
- 專業方向：生物學、生物醫學工程、臨床醫學
- 職務：華南理工大學生命科學研究院博士生導師
- 任職院校：華南理工大學生命科學研究院
- 職稱：特聘研究員
人物經歷,學術成果,
人物經歷
工作經歷
2018-至今，華南理工大學特聘研究員，博士生導師
2014-2017，哈佛大學醫學院，講師
2006-2013，哈佛大學醫學院，Dana-Farber癌症研究所，博士後
2006-2006，阿爾伯特-愛因斯坦醫學院，博士後
教育經歷
2000-2005，阿爾伯特-愛因斯坦醫學院，博士
1992-1996，武漢大學，理學學士
學術成果
實驗室研究概述
以遺傳學，分子生物學以及組學為主要研究方法， 研究表觀遺傳在幹細胞自我複製，體細胞分化，細胞重編程以及白血病細胞中的調控作用。通過對相關表觀遺傳修飾及信號通路的干預，實現：（1）多能幹細胞體外定向分化產生造血幹細胞及血小板；（2）造血幹細胞體外擴增；（3）增強細胞可塑性，促進細胞重編程。同時通過遺傳學篩選尋找針對白血病幹細胞的新的治療靶點。
實驗室科研成果
國際上首次以轉錄因子誘導原代細胞實現細胞重編程， 證明了終末分化的細胞仍然保留了細胞可塑性， 為iPS細胞重編程的實現奠定了基礎。 揭示了表觀遺傳修飾對造血幹細胞自我複製及分化的調控機制，以及白血病幹細胞對表觀遺傳基因EZH2的特異性依賴，為相關白血病的治療提供了一個新的治療靶點和思路。相關結果發表於Cell, Nature, Cell Stem Cell 和Cancer Discovery 等國際頂級學術期刊，目前已被引用2500多次。
實驗室代表論文
1. H. Xie, C. Peng, J. Huang, B. E. Li, W. Kim, E. C. Smith, Y. Fujiwara, J. Qi, G. Cheloni, P. P. Das, M. Nguyen, S. Li, J. E. Bradner, S. H. Orkin, Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2. Cancer discovery 6, 1237-1247 (2016)
2. H. Xie, J. Xu, J. H. Hsu, M. Nguyen, Y. Fujiwara, C. Peng, S. H. Orkin, Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell stem cell 14, 68-80 (2014)
3. H. Xie, C. V. Laiosa, T. Graf, Reprogramming of committed lymphoid cells by enforced transcription factor expression. Methods in molecular biology 636, 219-232
4. H. Xie, S. H. Orkin, Immunology: changed destiny. Nature 449, 410-411 (2007)
5. H. Xie, M. Ye, R. Feng, T. Graf, Stepwise reprogramming of B cells into macrophages. Cell 117, 663-676 (2004)
6. M. A. Erb, T. G. Scott, B. E. Li, H. Xie, J. Paulk, H. S. Seo, A. Souza, J. M. Roberts, S. Dastjerdi, D. L. Buckley, N. E. Sanjana, O. Shalem, B. Nabet, R. Zeid, N. K. Offei-Addo, S. Dhe-Paganon, F. Zhang, S. H. Orkin, G. E. Winter, J. E. Bradner, Transcription control by the ENL YEATS domain in acute leukaemia. Nature 543, 270-274 (2017)
7. S. Ai, Y. Peng, C. Li, F. Gu, X. Yu, Y. Yue, Q. Ma, J. Chen, Z. Lin, P. Zhou, H. Xie, T. W. Prendiville, W. Zheng, Y. Liu, S. H. Orkin, D. Z. Wang, J. Yu, W. T. Pu, A. He, EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. eLife 6,(2017)
8. M. Serresi, G. Gargiulo, N. Proost, B. Siteur, M. Cesaroni, M. Koppens, H. Xie, K. D. Sutherland, D. Hulsman, E. Citterio, S. Orkin, A. Berns, M. van Lohuizen, Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer. Cancer cell 29, 17-31 (2016)
9. F. Mirzamohammadi, G. Papaioannou, J. B. Inloes, E. B. Rankin, H. Xie, E. Schipani, S. H. Orkin, T. Kobayashi, Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-beta signalling. Nature communications 7, 12047 (2016)
10. E. Danis, T. Yamauchi, K. Echanique, X. Zhang, J. N. Haladyna, S. S. Riedel, N. Zhu, H. Xie, S. H. Orkin, S. A. Armstrong, K. M. Bernt, T. Neff, Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia. Cell reports 14, 1953-1965 (2016)
11. J. Yin, J. W. Leavenworth, Y. Li, Q. Luo, H. Xie, X. Liu, S. Huang, H. Yan, Z. Fu, L. Y. Zhang, L. Zhang, J. Hao, X. Wu, X. Deng, C. W. Roberts, S. H. Orkin, H. Cantor, X. Wang, Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. Proceedings of the National Academy of Sciences of the United States of America 112, 15988-15993 (2015)
12. J. Xu, Z. Shao, D. Li, H. Xie, W. Kim, J. Huang, J. E. Taylor, L. Pinello, K. Glass, J. D. Jaffe, G. C. Yuan, S. H. Orkin, Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. Molecular cell 57, 304-316 (2015)
13. P. P. Das, D. A. Hendrix, E. Apostolou, A. H. Buchner, M. C. Canver, S. Beyaz, D. Ljuboja, R. Kuintzle, W. Kim, R. Karnik, Z. Shao, H. Xie, J. Xu, A. De Los Angeles, Y. Zhang, J. Choe, D. L. Jun, X. Shen, R. I. Gregory, G. Q. Daley, A. Meissner, M. Kellis, K. Hochedlinger, J. Kim, S. H. Orkin, PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell reports 12, 1456-1470 (2015)
14. T. Neff, A. U. Sinha, M. J. Kluk, N. Zhu, M. H. Khattab, L. Stein, H. Xie, S. H. Orkin, S. A. Armstrong, Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proceedings of the National Academy of Sciences of the United States of America 109, 5028-5033 (2012)
15. A. He, Q. Ma, J. Cao, A. von Gise, P. Zhou, H. Xie, B. Zhang, M. Hsing, D. C. Christodoulou, P. Cahan, G. Q. Daley, S. W. Kong, S. H. Orkin, C. E. Seidman, J. G. Seidman, W. T. Pu, Polycomb repressive complex 2 regulates normal development of the mouse heart. Circulation research 110, 406-415 (2012)
16. M. Yu, L. Riva, H. Xie, Y. Schindler, T. B. Moran, Y. Cheng, D. Yu, R. Hardison, M. J. Weiss, S. H. Orkin, B. E. Bernstein, E. Fraenkel, A. B. Cantor, Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Molecular cell 36, 682-695 (2009)
17.R. Feng, S. C. Desbordes, H. Xie, E. S. Tillo, F. Pixley, E. R. Stanley, T. Graf, PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells. Proceedings of the National Academy of Sciences of the United States of America 105, 6057-6062 (2008)
18. C. V. Laiosa, M. Stadtfeld, H. Xie, L. de Andres-Aguayo, T. Graf, Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. Immunity 25, 731-744 (2006)
19. M. Ye, H. Iwasaki, C. V. Laiosa, M. Stadtfeld, H. Xie, S. Heck, B. Clausen, K. Akashi, T. Graf, Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential. Immunity 19, 689-699 (2003)
