許葉春

許葉春，女，現任中國科學院上海藥物研究所研究員（百人計畫）、博士生導師。

基本介紹

• 中文名：許葉春
• 國籍：中國
• 職業：中國科學院上海藥物研究所研究員
• 畢業院校：華東師範大學

簡歷

1999年畢業於華東師範大學化學系，獲得學士學位；2001年畢業於華東師範大學化學系，獲得理學碩士學位；2004年畢業於中國科學院上海藥物研究所，獲得理學博士學位，其博士論文入選全國百篇優秀博士論文。2005年至2009年在以色列魏茲曼研究所從事博士後研究工作。

研究方向：運用多種計算生物學和結構生物學方法研究老年痴呆疾病密切相關蛋白質靶標以及其他重要膜蛋白的結構與功能關係，並基於此進行藥物設計。

獲獎情況

2009中科院-諾和諾德長城教授獎

2005-2008魏茲曼科學研究所院長獎學金

2006全國百篇優秀博士論文

2005中國科學院優秀博士學位論文；中國藥學會-“施維雅”青年藥物化學獎

研究方向

採用結構生物學和計算生物學的多種方法對老年痴呆症密切相關的重要藥物靶標以及其他重大疾病相關的膜蛋白的結構功能進行研究，並基於此進行藥物設計和改造。

專家類別

研究員；百人計畫

職務

課題組長

獲獎及榮譽

CAS-Novo Nordisk Great Wall Professorship (2009)

Dean of Faculty’s Fellowship, Weizmann Institute of Science (2005-2008)

Awards for the national top-100 excellent doctoral dissertations (2006)

SERVIER young investigator awards prize in medicinal chemistry (2005)

“Baojie” scholarship for outstanding PhD students (2003)

“Zhong Shan Wu Mao” scholarship for outstanding graduate students (2000)

The honors of “invention San Qiang Bei in Shanghai” (2000)

The honors of excellent graduate of the East China Normal University (1999)

Third prize of the sixth national session “Tiao Zhan Bei”(1999)

代表論著

Yechun Xu, Jacques Ph. Colletier, Martin Weik, Hualiang Jiang, John Moult, Israel Silman, Joel L. Sussman. Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray vs MD. Biophys. J.

Yechun Xu, Jacques Ph. Colletier, Hualiang Jiang, Israel Silman, Joel L. Sussman, Martin Weik. Induced-fit of preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design. Prot. Sc

Xinli Liu, Yechun Xu, Honglin Li, Xicheng Wang, Hualiang Jiang, Francisco J. Barrantes. Mechanics of channel gating of the nicotinic acetylcholine receptor. PLoS Comput. Biol

Yechun Xu, Francisco J. Barrantes, Jianhua Shen, Xiaomin Luo, Weiliang Zhu, Kaixian Chen, Hualiang Jiang. Blocking of the nicotinic acetylcholine receptor ion channel by chlorpromazine, a noncompetitive inhibitor: a molecular dynamics simulation study. J. Phys. Chem

Dongxiang Liu, Yechun Xu, Yu Feng, Hong Liu, Xu Shen, Kaixian Chen, Jianpeng Ma, Hualiang Jiang. Inhibitor discovery targeting the intermediate structure of -Amyloid peptide on the conformational transition pathway: implications in the aggregation mechanism of -amyloid peptide. Biochemistry

Yechun Xu, Xiaomin Luo, Jianhua Shen, Weiliang Zhu, Kaixian Chen, Hualiang Jiang. Molecular dynamics of nicotinic acetylcholine receptor correlating biological functions. Current Protein and Peptide Science

Yechun Xu, Jianhua Shen, Xiaomin Luo, Weiliang Zhu, Kaixian Chen, Jianpeng Ma, Hualiang Jiang. Conformational transition of amyloid -peptide. PNAS

Yechun Xu, Francisco J. Barrantes, Xiaomin Luo, Kaixian Chen, Jianhua Shen, Hualiang Jiang. Conformational dynamics of the nicotinic acetylcholine receptor channel: a 35-ns molecular dynamics simulation study. J

Yechun Xu, Jianhua Shen, Weiliang Zhu, Xiaomin Luo, Kaixian Chen, Hualiang Jiang. Influence of water molecule on cation- interaction: ab initio second order Møller-Plesset perturbation theory (MP2) calculations. J. Phys. Chem

Yechun Xu, Jianhua Shen, Xiaomin Luo, Xu Shen, Kaixian Chen, Hualiang Jiang. Steered molecular dynamics simulations of protein-ligand interactions. Science in China Ser. B Chemistry,

Yechun Xu, Jianhua Shen, Xiaomin Luo, Israel Silman, Joel L. Sussman, Kaixian Chen, Hualiang Jiang. How does huperzine A enter and leave the binding gorge of acetylcholinesterase? steered molecular dynamics simulation. J. Am. Chem. Soc