袁林，男，博士，湖南大學化學化工學院教授，博士生導師，國家優秀青年科學基金獲得者。
基本介紹
- 中文名：袁林
- 學位/學歷：博士
- 專業方向：化學化工學
- 任職院校：湖南大學
人物經歷,教育經歷,工作經歷,學術兼職,研究領域,科研項目,學術成果,獎勵榮譽,
人物經歷
教育經歷
2002.9-2006.7 南華大學化學化工學院，工學學士；
2006.9-2008.8 湖南大學化學化工學院，無；
2008.9-2013.5 湖南大學化學化工學院，理學博士.
工作經歷
2012. 6-2015. 9 湖南大學化學化工學院，助理教授
2014. 2-2015. 3 新加坡國立大學化學系，博士後
2015. 10-2017. 1 湖南大學化學化工學院，副教授
2017. 1- 現在 湖南大學化學化工學院，教授
學術兼職
《中國化學快報》青年編委；美國化學會會員；J. Am. Chem. Soc、Chem. Sci.、Anal. Chem.等期刊審稿人。
研究領域
分子探針及生物成像、有機光功能染料合成及套用
科研項目
國家自然科學基金優秀青年基金（2017-2019）
國家自然科學基金面上項目（2019-2022）
國家自然科學基金重點項目(子課題)（2018-2022）
湖湘青年英才項目（2017-2019）
Selected Publications: *(Corresponding Author)
學術成果
24. D. Cheng, J. Peng, Y. Lv, D. Su, D. Liu, M. Chen, L. Yuan*, X. Zhang. De Novo Design of Chemical Stability Near-infrared Molecular Probes for High-fidelity Hepatotoxicity Evaluation in Vivo. J. Am. Chem. Soc. 2019, DOI: 10.1021/jacs.9b01374.
23. L. Su, T. Ren, J. Dong*, L. Liu, S. Xie, L. Yuan*, Y. Zhou*, SF. Yin. Cu (I)-Catalyzed 6-endo-dig Cyclization of Terminal Alkynes, 2-Bromoaryl Ketones, and Amides toward 1-Naphthylamines: Applications and Photophysical Properties. J. Am. Chem. Soc. 2019, 141 (6), 2535–2544. DOI: 10.1021/jacs.8b12495
22. T. Ren, W. Xu, W. Zhang, X. Zhang, Z. Wang, Z. Xiang, L. Yuan*, X. Zhang. A General Method to Increase Stokes Shift by Introducing Alternating Vibronic Structures. J. Am. Chem. Soc. 2018, 140 (24), 7716–7722. DOI: 10.1021/jacs.8b04404
21. T. Ren, W. Xu, Q. Zhang, X. Zhang, S. Wen, H. Yi, L. Yuan*, X. Zhang. Enhancing the Anti-Solvatochromic Two-Photon Fluorescence for Cirrhosis Imaging by Forming a Hydrogen-Bond Network. Angew. Chem. Int. Ed. 2018, 57(25), 7473-7477. DOI:10.1002/anie.201800293
20. Y. Lv, D. Cheng, D. Su, M.Chen, B.-C. Yin, L. Yuan*, X. Zhang. Visualization of Oxidative Injury in the Mouse Kidney by Selective Superoxide Anion Fluorescent Probes. Chem. Sci., 2018, 9, 7606-7613. DOI:10.1039/C8SC03308K
19. T. Ren, Q. Zhang, D. Su, X. Zhang, L. Yuan*, X. Zhang. Detection of Analytes in Mitochondria without Interference from Other Sites Based on an Innovative Ratiometric Fluorophore. Chem Sci, 2018, 9, 5461-5466. DOI:10.1039/C8SC01673A
18. D. Cheng, Y. Pan, L. Wang, Z. Zeng, L. Yuan*, X. Zhang, Y.-T. Chang. Selective visualization of the endogenous peroxynitrite in an inflamed mouse model by a mitochondria-targetable two-photon ratiometric fluorescent probe. J. Am. Chem. Soc. 2017, 139, 285-292. DOI: 10.1021/jacs.6b10508
17. J. Peng*, A. Samanta, X. Zeng, S. Han, L. Wang, D. Su, D. T. B. Loong, N.-Y. Kang, S.-J. Park, A. H. All, W. Jiang, L. Yuan*, X. Liu*, Y.-T. Chang*. Real-time in vivo hepatotoxicity monitoring through chromophore-conjugated upconversion nanoprobes. Angew. Chem. Int. Ed. 2017, 56, 4165 –4169. DOI:10.1002/anie.201612020
16. D. Cheng, W. Xu, L. Yuan*, X. Zhang. Investigation of Drug-Induced Hepatotoxicity and Its Remediation Pathway with Reaction-Based Fluorescent Probes. Anal. Chem. 2017, 89, 7693-7700. DOI: 10.1021/acs.analchem.7b01671
15. T. Ren, W. Xu, F. Jin, D. Cheng, L Zhang, L. Yuan*, X. Zhang. Rational Engineering of Bioinspired Anthocyanidin Fluorophores with Excellent Two-Photon Properties for Sensing and Imaging. Anal. Chem. 2017, 89, 11427-11434. DOI: 10.1021/acs.analchem.7b02538
14. W. Xu, Z. Zeng, J.-H. Jiang*, Y.-T.Chang*, L. Yuan*. Discerning the chemistry in individual organelles with small molecule fluorescent probes. Angew. Chem. Int. Ed. 2016, 55, 13658-13699. DOI:10.1002/anie.201510721
13. L. Wang, L. Yuan*, X. Zeng, J. Peng, Y. Ni, J. C. Er, W. Xu, B. K. Agrawalla, D. Su, B. Kim, Y.-T. Chang*. A multisite-binding switchable fluorescent probe for monitoring mitochondrial ATP level fluctuation in live cells. Angew. Chem. Int. Ed. 2016, 55, 1773-1776. DOI:10.1002/anie.201510003
12. J. Peng, C. L. Teoh, X. Zeng, A. Samanta, L. Wang, W. Xu, D. Su, L. Yuan*, X. Liu, Y.-T. Chang*. Development of a highly selective, sensitive, and fast response upconversion luminescent platform for hydrogen sulfide detection. Adv. Funct. Mater. 2016, 26, 191-199. DOI:10.1002/adfm.201503715
11. Y. Wei, D. Cheng, T. Ren, Y. Li, Z. Zeng, L. Yuan*. Design of NIR chromenylium–cyanine fluorophore library for “switch-on” and ratiometric detection of bio-active species in vivo. Anal. Chem. 2016, 88, 1842?1849. DOI: 10.1021/acs.analchem.5b04169
10. L. Yuan, L. Wang, K. Bikram, S.-J. Park, H. Zhu, B. Sivaraman, J. Peng, Q. Xu, Y.-T. Chang. Development of targetable two-photon fluorescent probes to image hypochlorous acid in mitochondria and lysosome in live cell and inflamed mouse model. J. Am. Chem.Soc. 2015, 137, 5930?5938.
9. L. Yuan*, F. Jin, Z. Zeng*, C. Liu, S. Luo, J. Wu. Engineering a FRET strategy to achieve a ratiometric two-photon fluorescence response with a large emission shift and its application to fluorescence imaging. Chem Sci, 2015, 6, 2360-2365.
8. L. Yuan, W. Lin*, H. Chen, S. Zhu, L. He. A unique family of rigid analogues of the GFP chromophore with tunable two-photon action cross-sections for biological imaging. Angew. Chem. Int. Ed. 2013, 58, 10018–10022.
7. L. Yuan, W. Lin*, L. Tan, K. Zheng, W. Huang. Lighting up carbon monoxide: fluorescent probes for monitoring CO in living cells. Angew. Chem. Int. Ed. 2013, 52, 1628–1630.
6. L. Yuan, W. Lin*, K. Zheng, L. He, W. Huang, Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging. Chem. Soc. Rev., 2013, 42, 622-661.
5. L. Yuan, W. Lin*, K. Zheng, S. Zhu, FRET-based small-molecule fluorescent probes: rational design and bioimaging applications. Acc. Chem. Res. 2013, 46, 1462-1473.
4. L. Yuan, W. Lin, H. Chen, Analogs of Changsha near-infrared dyes with large Stokes Shifts for bioimaging. Biomaterials, 2013, 34, 9566-9571.
3. L. Yuan, W. Lin*, S. Zhao, W. Gao, B. Chen, L. He, S. Zhu, A unique approach to development of near-infrared fluorescent sensors for in vivo imaging. J. Am. Chem.Soc. 2012, 134, 13510-13523.
2. L. Yuan, W. Lin,* Y. Xie, B. Chen, S. Zhu. Single fluorescent probe responds to H2O2, NO, and H2O2/NO with three different sets of fluorescence Signals. J. Am. Chem. Soc. 2012, 134, 1305-1315.
1. L. Yuan, W. Lin,* Y. Yang, H. Chen. A unique class of near-infrared functional fluorescent dyes with carboxylic-acid-modulated fluorescence ON/OFF switching: rational design, synthesis, optical properties, theoretical calculations, and applications for fluorescence imaging in living animals. J. Am. Chem. Soc. 2012, 134, 1200-1211.
獎勵榮譽
2017年 湖湘青年英才
2016年 國家優青
