薛言學，男，北京大學中國藥物依賴性研究所副研究員、博士生導師。
基本介紹
- 中文名：薛言學
- 職業：教師
- 任職院校：北京大學
- 職稱：副研究員
研究方向,學術成果,
研究方向
1. 套用光遺傳學、神經環路追蹤、記憶痕跡標記等技術手段，探索異常記憶（如成癮記憶和創傷性記憶）的存儲、去穩定化及消除的分子及環路機制
2. 採用人體和動物行為學範式，綜合心理學、sEEG、神經計算、分子生物學等技術，理解情緒（如同情心、抑鬱、焦慮、恐懼等）的心理學基礎和神經編碼機制
學術成果
代表性論著
1. Han Y, Sun CY, Meng SQ, Tabarak S, Yuan K, Cao L, Yan W, Xu LZ, Deng JH, Zhu WL, Li JL, Lu L,Xue YX, Shi J. Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects.Mol Psychiatry. 2019 Aug 2.
2. Chen YY, Zhang LB, Li Y, Meng SQ, Gong YM, Lu L,Xue YX, Shi J. Post-retrieval Extinction Prevents Reconsolidation of Methamphetamine Memory Traces and Subsequent Reinstatement of Methamphetamine Seeking.Front Mol Neurosci. 2019 Jul 2
3. Huang X, Chen YY , Shen Y , Cao X, Li A , Liu Q , Li Z , Zhang LB ,Dai W , Tan T , O Arias-Carrion,Xue YX, Su H and Yuan TF . Methamphetamine abuse impairs motor cortical plasticity and Function.Mol Psychiatry.2017
4. Xue YX,Chen YY, Zhang LB, Zhang LQ, Huang GD, Sun SC, Deng JH, Luo YX, Bao YP, Wu P, Han Y, Hope BT, Shaham Y, Shi J, Lu L. Selective inhibition of amygdala neuronal ensembles encoding nicotine-associated memories inhibits nicotine preference and relapse.Biol Psychiatry. 2017 [Epub ahead of print]
5. Xue YX, Deng JH, Chen YY, Zhang LB, Wu P, Huang GD, Luo YX, Bao YP, Wang YM, Shaham Y, Shi J, Lu L. Effect of selective inhibition of reactivated nicotine-associated memories with propranolol on nicotine craving.JAMA Psychiatry. 2017
6. Zhang Y,Xue Y, Meng S, Luo Y, Liang J, Li J, Ai S, Sun C, Shen H, Zhu W, Wu P, Lu L, Shi J. Inhibition of lactate transport erases drug memory and prevents drug relapse.Biol Psychiatry. 2016
7. Zhu ZZ, Xue YX, Han HB, Liu JF, Meng SQ, Chen C, Yang JL, Wu P, Lu L. Overexpression of Protein Kinase Mζ in the Prelimbic Cortex Enhances the Formation of Long-Term Fear
Memory. Neuropsychopharmacology. 2015
8. Luo YX,Xue YX, Liu JF, Shi HS, Jian M, Han Y, Zhu WL, Bao YP, Wu P, Ding ZB, Shen HW, Shi J, Shaham Y, Lu L.A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking.Nat Commun. 2015
9. Liu J, Zhao L,Xue Y, Shi J, Suo L, Luo Y, Chai B, Yang C, Fang Q, Zhang Y, Bao Y, Pickens CL, Lu L. An unconditioned stimulus retrieval extinction procedure to prevent the return of fear memory.Biol Psychiatry. 2014
10. Xue YX, Xue LF, Liu JF, He J, Deng JH, Sun SC, Han HB, Luo YX, Xu LZ, Wu P, Lu L. Depletion of perineuronal nets in the amygdala to enhance the erasure of drug memories.J Neurosci.2014 May 7
11. Chai N, Liu JF,Xue YX, Yang C, Yan W, Wang HM, Luo YX, Shi HS, Wang JS, Bao YP, Meng SQ, Ding ZB, Wang XY, Lu L. Delayed noradrenergic activation in the dorsal hippocampus promotes the long-term persistence of extinguished fear.Neuropsychopharmacology.2014
12. Ren ZY, Liu MM,Xue YX, Ding ZB, Xue LF, Zhai SD, Lu L.A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory.Neuropsychopharmacology. 2013
13. Xue YX, Luo YX, Wu P, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Bao YP, Shi J, Epstein DH, Shaham Y, Lu L.A memory retrieval-extinction procedure to prevent drug craving and relapse.Science. 2012
14. He YY,Xue YX, Wang JS, Fang Q, Liu JF, Xue LF, Lu L. PKMζ maintains drug reward and aversion memory in the basolateral amygdala and extinction memory in the infralimbic cortex.Neuropsychopharmacology. 2011
15. Li FQ,Xue YX, Wang JS, Fang Q, Li YQ, Zhu WL, He YY, Liu JF, Xue LF, Shaham Y, Lu L. Basolateral amygdala cdk5 activity mediates consolidation and reconsolidation of memories for cocaine cues.J Neurosci.2010
