基本介紹
- 中文名：董春娥
- 國籍：中國
- 職業：教授
- 畢業院校：中國科學院成都有機化學研究所
- 性別：女
基本情況,學習簡歷,研究興趣:,主要科研項目及論文,科研項目,代表性文章,
基本情況
學習簡歷
2000年畢業於中國科學院成都有機化學研究所有機化學專業，獲理學博士學位。2000年至2001年維也納大學有機化學研究所博士後。2002年至2004年加拿大渥太華大學化學系博士後。2004年至2006年美國伊利諾伊大學香檳分校化學系博士後。
研究興趣:
1) 具有潛在藥物活性小分子的新法合成研究。
2) 有機化學新方法研究，特別是碳-雜鍵的構鍵以及不對稱催化研究。
3) 生物模擬離子通道的設計合成和活性研究。
主要科研項目及論文
科研項目
1） 主持國家自然科學基金面上項目(NO: 20972121)，2010.1-2012.12，30萬。
2） 主持武漢大學引進人才科研啟動基金（NO: 306276315），2007.12 -2010.12，10萬。
3） 高等學校博士點新教師基金，2010,1-2012,12, 3.6萬。
4） 教育部留學回國基金，3萬
5）病毒學重點實驗室開放基金，2011，3-2012-12，3萬。
6） 藥物中間體的研發，25萬。
代表性文章
(1) Xin Han, Xiangfei Wu, Chang Min, Hongyu Zhu, Haibing Zhou, Chune Dong*, An Expedient Approach to Highly Enantioenriched Cyclic Nitrones Mediated by Robust and Recoverable C3-Symmetric Cinchonine-Squaramide Catalyst, RSC Advance 2012, 2, 7501-7505.
(2) Zongquan Liao, Xiaoyan Xu, Hai-Bing Zhou, Chune Dong*, A New Pathway for Phthalazine Derivatives via Metal-free Cyclization of ortho-Alkynylphenyl ketones and Hydrazine, J. Heterocycl. Chem., 2013, in press.
(3) Hao Chen, Jianmin Wang, Xuechuan Hong, Haibing Zhou, Chune Dong*, A simple and straightforward approach toward selective C=C bond reduction by hydrazine, Can. J. Chem., 2012, 90, 758-761.
(4) Xin Han, Bin Liu, Hai-Bing Zhou, Chune Dong*, Enhanced efficiency of recyclable C3-symmetric cinchonine-squaramides in the asymmetric Friedel-Crafts reaction of indole with alkyl trifluoro pyruvate, Tetrahedron: Asymmetry, 2012, 23, 1332-1337.
(5) Ze Dong, Guofu Qiu, Hai-Bing Zhou, Chune Dong*, Chiral Squaramide as Multiple H-Bonds Donor Organocatalyst for Asymmetric Michael addition of 1, 3-Dicarbonyl Compounds to Nitroolefins, Tetrahedron: Asymmetry, 2012, 23, 1550-1556.
(6) Pengcheng Wang, Jian Min, Jerome C. Nwachukwu, Valerie Cavett, Kathryn E. Carlson, Pu Guo, Manghong Zhu, Yangfan Zheng, Chune Dong, Haibing Zhou*, Identification and structure-Activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2,2,1]hept-2-ene-7-oxide, J. Med. Chem., 2012, 55 (5), 2324–2341.
(7) Chang Min, Xin Han, Zong quan Liao, Xiangfei Wu, Haibing Zhou, Chune Dong*, C3-symmetric cinchonine-squaramide as new highly efficient and recyclable organocatalyst for enantioselective michael addition, Adv. Syn. Cat. 2011, 353, 2715-2720. Highlighted by ChemInform (2012, 43, 13).
(8) Xiangfei Wu, Chang Min, Enkhtsetseg Nyamzundui, Haibing Zhou, Chune Dong*, A Novel C3-Symmetric Prolinol-Squaramide Catalyst for the Asymmetric Reduction of Ketones by Borane, Tetrahedron: Asymmetry, 2011, 22, 1640-1643.
(9) Ze Dong, Xiao qing Jin, Peng cheng Wang, Chang Min, Haibing Zhou, Chune Dong*, Novel bifunctional chiral squaramide-amine catalysts for highly enantioselective addition of mono diketones to nitroalkenes, Arkivoc 2011, (ix), 367-380.
(10) Chune Dong*, Lingli Xie, Xiaohong Mou, Yashan zhong, Wei Su, Facile synthesis of 1,3,4-benzotriazepines and 1-arylamide-1H-indazoles via palladium catalyzed cyclization of aryl isocyanates and aryl hydrazones under microwave irradiation, Org. Biomol. Chem. 2010, 8, 4827-4830. Highlighted by Synfacts (2011, 1, 16).
(11) Yangfan Zheng, Caihua Wang, Changhao Li, Jinxia Qiao, Feng Zhang, Minjian Huang, Chune Dong, Jian Huang, HaiBing Zhou, Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo [2.2.1]hepte-ne scaffold and evaluation of their antiproliferative effects, Org. Biomol. Chem. 2012, 10, 9689-9699.
(12) Manghong Zhu, Chen Zhang, Jerome C. Nwachukwu, Yangfan Zheng, Chune Dong, John A. Katzenellenbogen, Kendall W. Nettles, Haibing Zhou*, Biocyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfon-amides, Org. Biomol. Chem. 2012, 10, 8692-8700.
(13) Yangfan Zheng, Manghong Zhu, Sathish Srinivasam, Jerome C. Nwachukwu, Valerie Cavett, Jian Min, Kathryn, E. Carlson, Pengcheng Wang, Chune Dong, John A. Katzenelle-nbogen, Kendall W. Nettles, Haibing Zhou*, Development of selective estrogen receptor modulator SERM-like activity through an indirect mechanism of estrogen receptor antagonism defining the binding mode of 7-oxabicyclo[2.2.1] hept-5-ene scaffold core ligands, ChemMedChem. 2012, 7, 1094-1100.
(14) Jian Min, Pengcheng Wang, Chune Dong, Haibing Zhou*, Progress in small molecular inhibitors of protein protein interactions, Chin. J. Org. Chem. 2010, 30, 1778-1789.
