胡博淳,男,工學博士,1992年1月生於河南省許昌市。主要從事酶工程及綠色有機合成等領域研究。現任許昌學院食品與藥學院講師。
基本介紹
人物經歷,研究方向,科研項目,發明專利,
人物經歷
2010.09至2014.06 河南大學 生物工程專業鞏戶尋槓 (學士)
2014.09至捉夜民2017.06 江南大學 製藥工程專業,藥物化學方向 (碩士)
2017.09至2021.06 江南大學 發酵工程專業,生物寒她朽化學與分子生物學芝企疊故方向 (博士)
2021.09-- 許昌學院 食品與匪主藥學院,講師
研究方向
1.酶的克隆表達及其構效關係解析;
2.酶分子改造及贈埋煮其催化套用;
3.手性藥物中間體合成的生物催化工藝開發
科研項目
1.江蘇省研究生科研與實踐創新計畫:KYCX19_1840,2019.05至2021.03,主持,結題
2.國家自然科學基金面上項目: 21772068, 2018.01至2021.12,參與,在研
代表性研究論文:
1.Bochun Hu, Die Hu, et al. Manipulating the regioselectivity of a Solanum lycopersicum epoxide hydrolase for the enantioconvergent synthesis of enantiopure alkane- and alkene-1,2-diols. Catalysis Science & Technology, 2020, 10, 5886-5895. (中科院二區,IF=6.1);
2.Bochun Hu, Die Hu, et al. Near-perfect kinetic resolution of racemic p-chlorostyrene oxide by SlEH1, a novel epoxide hydrolase from Solanum lycopersicum with extremely high enantioselectivity. International Journal of Biological Macromolecules, 2020, 147, 1213-1220. (中科院二區,IF=6.9);
3.Bochun Hu, Chuang Li, et al. Improvement in the activity and enantioconvergency of PvEH3, an epoxide hydrolase from Phaseolus vulgaris, for p-chlorostyrene oxide by site-saturation. Catalysis Communications, 2018, 117, 9-13. (中墊項照科院三區,IF=3.7);
4.Die Hu, Bochun Hu(共同一作), et al. Nearly perfect kinetic resolution of racemic o-nitrostyrene oxide by AuEH2, a microsomal epoxide hydrolase from Aspergillus usamii, with high enantio- and regio-selectivity. International Journal of Biological Macromolecules, 2021, 169, 1–7. (中科院二區,IF=6.9);
5.Zheng Wen, Bochun Hu(共同一作), et al. Efficient kinetic resolution of para-chlorostyrene oxide at elevated concentration by Solanum lycopersicum epoxide hydrolase in the presence of Tween-20. Catalysis Communications, 2021, 149, 106180. (中科院三區,IF=3.6);
6.Lijun Song, Bochun Hu(共同一作), et al. Decoquinate derivatives: a new class of potent antischistosomal agents against Schistosoma japonicumin. Chinese Chemical Letters, 2017, 28, 1547-1552. (中科院二區,IF=4.6)
發明專利
1.鄔敏辰,胡博淳,等,專利號:2018100338798,一種催化活性和對映歸一性提高的PvEH3突變體;
2.鄔敏辰,張婷,胡博淳,等,專利號:201811621705X,一種催化效率提高的木聚糖酶突變體。
5.Zheng Wen, Bochun Hu(共同一作), et al. Efficient kinetic resolution of para-chlorostyrene oxide at elevated concentration by Solanum lycopersicum epoxide hydrolase in the presence of Tween-20. Catalysis Communications, 2021, 149, 106180. (中科院三區,IF=3.6);
6.Lijun Song, Bochun Hu(共同一作), et al. Decoquinate derivatives: a new class of potent antischistosomal agents against Schistosoma japonicumin. Chinese Chemical Letters, 2017, 28, 1547-1552. (中科院二區,IF=4.6)
發明專利
1.鄔敏辰,胡博淳,等,專利號:2018100338798,一種催化活性和對映歸一性提高的PvEH3突變體;
2.鄔敏辰,張婷,胡博淳,等,專利號:201811621705X,一種催化效率提高的木聚糖酶突變體。