納波萊奧內·費拉拉

納波萊奧內·費拉拉（Napoleone Ferrara），美國國家科學院院士、加利福尼亞大學聖迭戈分校教授。

基本介紹

  • 中文名：納波萊奧內·費拉拉
  • 外文名：Napoleone Ferrara
人物簡介,參選院士,所獲榮譽,代表論文,

人物簡介

納波萊奧內·費拉拉（Napoleone Ferrara），加利福尼亞大學聖迭戈分校教授。

參選院士

2015年，當選美國國家科學院院士。

所獲榮譽

2010年，獲拉斯克臨床醫學研究獎。

代表論文

  1. Endothelial Cell Diversity: the Many Facets of the Crystal. FEBS J. 2022 Oct 20. Perez-Gutierrez L, Li P, Ferrara N. PMID: 36266750.
  2. Naturally occurring combinations of receptors from single cell transcriptomics in endothelial cells. Sci Rep. 2022 04 06; 12(1):5807. Domanskyi S, Hakansson A, Meng M, Pham BK, Graff Zivin JS, Piermarocchi C, Paternostro G, Ferrara N. PMID: 35388065; PMCID: PMC8987085.
  3. Vascular heterogeneity: VEGF receptors make blood vessels special. J Exp Med. 2022 03 07; 219(3). Li P, Ferrara N. PMID: 35085381; PMCID: PMC8932539.
  4. LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy. EMBO Mol Med. 2022 01 11; 14(1):e14511. Li P, Li Q, Biswas N, Xin H, Diemer T, Liu L, Perez Gutierrez L, Paternostro G, Piermarocchi C, Domanskyi S, Wang RK, Ferrara N. PMID: 34779136; PMCID: PMC8749470.
  5. Heparin-binding VEGFR1 variants as long-acting VEGF inhibitors for treatment of intraocular neovascular disorders. Proc Natl Acad Sci U S A. 2021 05 25; 118(21). Xin H, Biswas N, Li P, Zhong C, Chan TC, Nudleman E, Ferrara N. PMID: 34006633; PMCID: PMC8166142.
  6. Iron Metabolism in the Tumor Microenvironment: Contributions of Innate Immune Cells. Front Immunol. 2020; 11:626812. Liang W, Ferrara N. PMID: 33679721; PMCID: PMC7928394.
  7. Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways. Nat Commun. 2020 12 10; 11(1):6330. Zhong C, Li P, Argade S, Liu L, Chilla' A, Liang W, Xin H, Eliceiri B, Choudhury B, Ferrara N. PMID: 33303737; PMCID: PMC7730427.
  8. Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21598-21608. Itatani Y, Yamamoto T, Zhong C, Molinolo AA, Ruppel J, Hegde P, Taketo MM, Ferrara N. PMID: 32817421; PMCID: PMC7474657.
  9. Tipifarnib as a Precision Therapy for HRAS-Mutant Head and Neck Squamous Cell Carcinomas. Mol Cancer Ther. 2020 09; 19(9):1784-1796. Gilardi M, Wang Z, Proietto M, Chillà A, Calleja-Valera JL, Goto Y, Vanoni M, Janes MR, Mikulski Z, Gualberto A, Molinolo AA, Ferrara N, Gutkind JS, Burrows F. PMID: 32727882; PMCID: PMC7484242.
  10. VEGF in Signaling and Disease: Beyond Discovery and Development. Cell. 2019 03 07; 176(6):1248-1264. Apte RS, Chen DS, Ferrara N. PMID: 30849371; PMCID: PMC6410740.
  11. Interleukin-22 promotes tumor angiogenesis. Angiogenesis. 2019 05; 22(2):311-323. Protopsaltis NJ, Liang W, Nudleman E, Ferrara N. PMID: 30539314.
  12. Metastatic growth instructed by neutrophil-derived transferrin. Proc Natl Acad Sci U S A. 2018 10 23; 115(43):11060-11065. Liang W, Li Q, Ferrara N. PMID: 30301793; PMCID: PMC6205468.
  13. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 2018 08; 21(3):425-532. Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW. PMID: 29766399; PMCID: PMC6237663.
  14. Introduction by the Guest Editors: Bevacizumab. Cancer J. 2018 Jul/Aug; 24(4):163-164. Ferrara N, Chen DS. PMID: 30119078.
  15. The Prokineticins: Neuromodulators and Mediators of Inflammation and Myeloid Cell-Dependent Angiogenesis. Physiol Rev. 2018 04 01; 98(2):1055-1082. Negri L, Ferrara N. PMID: 29537336.
  16. Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1. Nat Commun. 2017 11 17; 8(1):1574. Eilken HM, Diéguez-Hurtado R, Schmidt I, Nakayama M, Jeong HW, Arf H, Adams S, Ferrara N, Adams RH. PMID: 29146905; PMCID: PMC5691060.
  17. Microvascular Density as a Predictive Biomarker for Bevacizumab Survival Benefit in Ovarian Cancer: Back to First Principles? J Natl Cancer Inst. 2017 11 01; 109(11). Ferrara N. PMID: 29059427.
  18. Dll4 and Notch signalling couples sprouting angiogenesis and artery formation. Nat Cell Biol. 2017 Aug; 19(8):915-927. Pitulescu ME, Schmidt I, Giaimo BD, Antoine T, Berkenfeld F, Ferrante F, Park H, Ehling M, Biljes D, Rocha SF, Langen UH, Stehling M, Nagasawa T, Ferrara N, Borggrefe T, Adams RH. PMID: 28714968.
  19. Evidence for Pro-angiogenic Functions of VEGF-Ax. Cell. 2016 Sep 22; 167(1):275-284.e6. Xin H, Zhong C, Nudleman E, Ferrara N. PMID: 27662093.
  20. Commentary on "Humanization of an Anti-VEGF Monoclonal Antibody for the Therapy of Solid Tumors and Other Disorders". Cancer Res. 2016 09 01; 76(17):4913-5. Ferrara N. PMID: 27587649.
  21. Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell. 2016 Aug 25; 166(5):1338-1340. Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. PMID: 27565353.
  22. Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell. 2016 May 05; 165(4):882-95. Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. PMID: 27133169.
  23. VEGF and Intraocular Neovascularization: From Discovery to Therapy. Transl Vis Sci Technol. 2016 Mar; 5(2):10. Ferrara N. PMID: 26981332; PMCID: PMC4790412.
  24. Decrease of VEGF-A in myeloid cells attenuates glioma progression and prolongs survival in an experimental glioma model. Neuro Oncol. 2016 07; 18(7):939-49. Osterberg N, Ferrara N, Vacher J, Gaedicke S, Niedermann G, Weyerbrock A, Doostkam S, Schaefer HE, Plate KH, Machein MR. PMID: 26951383; PMCID: PMC4896547.
  25. The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis. Cancer Immunol Res. 2016 Feb; 4(2):83-91. Liang W, Ferrara N. PMID: 26839309.
  26. Ten years of anti-vascular endothelial growth factor therapy. Nat Rev Drug Discov. 2016 06; 15(6):385-403. Ferrara N, Adamis AP. PMID: 26775688.
  27. Outer retinal tubulations response to anti-VEGF treatment. Br J Ophthalmol. 2016 06; 100(6):819-23. Espina M, Arcinue CA, Ma F, Camacho N, Barteselli G, Mendoza N, Ferrara N, Freeman WR. PMID: 26423451.
  28. A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain. Cancer Cell. 2015 Jun 08; 27(6):780-96. Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R. PMID: 26058077; PMCID: PMC4469373.
  29. Inhibition of protein kinase C enhances angiogenesis induced by platelet-derived growth factor C in hyperglycemic endothelial cells. Cardiovasc Diabetol. 2015 Feb 07; 14:19. Moriya J, Ferrara N. PMID: 25849290; PMCID: PMC4334399.
  30. Loss of vascular endothelial growth factor A (VEGFA) isoforms in granulosa cells using pDmrt-1-Cre or Amhr2-Cre reduces fertility by arresting follicular development and by reducing litter size in female mice. PLoS One. 2015; 10(2):e0116332. Sargent KM, Lu N, Clopton DT, Pohlmeier WE, Brauer VM, Ferrara N, Silversides DW, Cupp AS. PMID: 25658474; PMCID: PMC4320103.
  31. Vascular patterning regulates interdigital cell death by a ROS-mediated mechanism. Development. 2015 Feb 15; 142(4):672-80. Eshkar-Oren I, Krief S, Ferrara N, Elliott AM, Zelzer E. PMID: 25617432.
  32. Comparison of binding characteristics and in vitro activities of three inhibitors of vascular endothelial growth factor A. Mol Pharm. 2014 Oct 06; 11(10):3421-30. Yang J, Wang X, Fuh G, Yu L, Wakshull E, Khosraviani M, Day ES, Demeule B, Liu J, Shire SJ, Ferrara N, Yadav S. PMID: 25162961.
  33. A conversation with Napoleone Ferrara. J Clin Invest. 2014 Aug; 124(8):3275-6. Ferrara N, Neill US. PMID: 25083827; PMCID: PMC4109558.
  34. Endothelial cells regulate neural crest and second heart field morphogenesis. Biol Open. 2014 Jul 04; 3(8):679-88. Milgrom-Hoffman M, Michailovici I, Ferrara N, Zelzer E, Tzahor E. PMID: 24996922; PMCID: PMC4133721.
  35. VEGF modulates synaptic activity in the developing spinal cord. Dev Neurobiol. 2014 Nov; 74(11):1110-22. Guérit S, Allain AE, Léon C, Cazenave W, Ferrara N, Branchereau P, Bikfalvi A. PMID: 24782305.
  36. Inhibiting the response to VEGF in diabetes. Sci Signal. 2014 Jan 07; 7(307):pe1. Moriya J, Ferrara N. PMID: 24399294.
  37. A message from the new editor-in-chief. Mol Cancer Ther. 2014 Jan; 13(1):3-4. Ferrara N. PMID: 24385543.
  38. Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling. Development. 2014 Jan; 141(2):448-59. Fan J, Ponferrada VG, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang RA. PMID: 24353059; PMCID: PMC3879820.
  39. Loss of vascular endothelial growth factor A (VEGFA) isoforms in the testes of male mice causes subfertility, reduces sperm numbers, and alters expression of genes that regulate undifferentiated spermatogonia. Endocrinology. 2013 Dec; 154(12):4790-802. Lu N, Sargent KM, Clopton DT, Pohlmeier WE, Brauer VM, McFee RM, Weber JS, Ferrara N, Silversides DW, Cupp AS. PMID: 24169552; PMCID: PMC3836063.
  40. An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy. Nat Med. 2013 Sep; 19(9):1114-23. Chung AS, Wu X, Zhuang G, Ngu H, Kasman I, Zhang J, Vernes JM, Jiang Z, Meng YG, Peale FV, Ouyang W, Ferrara N. PMID: 23913124.
  41. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med. 2013 Sep; 5(9):1415-30. Kim M, Park HJ, Seol JW, Jang JY, Cho YS, Kim KR, Choi Y, Lydon JP, Demayo FJ, Shibuya M, Ferrara N, Sung HK, Nagy A, Alitalo K, Koh GY. PMID: 23853117; PMCID: PMC3799495.
  42. Platelet-derived growth factor C promotes revascularization in ischemic limbs of diabetic mice. J Vasc Surg. 2014 May; 59(5):1402-9.e1-4. Moriya J, Wu X, Zavala-Solorio J, Ross J, Liang XH, Ferrara N. PMID: 23856609.
  43. Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response. Neoplasia. 2013 Jul; 15(7):694-711. Sampath D, Oeh J, Wyatt SK, Cao TC, Koeppen H, Eastham-Anderson J, Robillard L, Ho CC, Ross J, Zhuang G, Reslan HB, Vitorino P, Barck KH, Ungersma SE, Vernes JM, Caunt M, Van Bruggen N, Ye W, Vijapurkar U, Meng YJ, Ferrara N, Friedman LS, Carano RA. PMID: 23814482; PMCID: PMC3689233.
  44. Development and preclinical characterization of a humanized antibody targeting CXCL12. Clin Cancer Res. 2013 Aug 15; 19(16):4433-45. Zhong C, Wang J, Li B, Xiang H, Ultsch M, Coons M, Wong T, Chiang NY, Clark S, Clark R, Quintana L, Gribling P, Suto E, Barck K, Corpuz R, Yao J, Takkar R, Lee WP, Damico-Beyer LA, Carano RD, Adams C, Kelley RF, Wang W, Ferrara N. PMID: 23812669.
  45. Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. Elife. 2013 Jun 18; 2:e00324. Luo L, Uehara H, Zhang X, Das SK, Olsen T, Holt D, Simonis JM, Jackman K, Singh N, Miya TR, Huang W, Ahmed F, Bastos-Carvalho A, Le YZ, Mamalis C, Chiodo VA, Hauswirth WW, Baffi J, Lacal PM, Orecchia A, Ferrara N, Gao G, Young-Hee K, Fu Y, Owen L, Albuquerque R, Baehr W, Thomas K, Li DY, Chalam KV, Shibuya M, Grisanti S, Wilson DJ, Ambati J, Ambati BK. PMID: 23795287; PMCID: PMC3687373.
  46. Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies. Clin Cancer Res. 2013 Jul 01; 19(13):3681-92. Brauer MJ, Zhuang G, Schmidt M, Yao J, Wu X, Kaminker JS, Jurinka SS, Kolumam G, Chung AS, Jubb A, Modrusan Z, Ozawa T, James CD, Phillips H, Haley B, Tam RN, Clermont AC, Cheng JH, Yang SX, Swain SM, Chen D, Scherer SJ, Koeppen H, Yeh RF, Yue P, Stephan JP, Hegde P, Ferrara N, Singh M, Bais C. PMID: 23685835.
  47. Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases. Sci Signal. 2013 Apr 16; 6(271):ra25. Zhuang G, Yu K, Jiang Z, Chung A, Yao J, Ha C, Toy K, Soriano R, Haley B, Blackwood E, Sampath D, Bais C, Lill JR, Ferrara N. PMID: 23592840.
  48. Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):6079-84. Phan VT, Wu X, Cheng JH, Sheng RX, Chung AS, Zhuang G, Tran C, Song Q, Kowanetz M, Sambrone A, Tan M, Meng YG, Jackson EL, Peale FV, Junttila MR, Ferrara N. PMID: 23530240; PMCID: PMC3625253.
  49. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell. 2013 Feb 28; 152(5):1065-76. Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK. PMID: 23452854; PMCID: PMC3587980.
  50. A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature. 2013 Feb 14; 494(7436):243-6. Rao S, Chun C, Fan J, Kofron JM, Yang MB, Hegde RS, Ferrara N, Copenhagen DR, Lang RA. PMID: 23334418; PMCID: PMC3746810.
  51. Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair. Blood. 2013 Mar 28; 121(13):2574-8. Stefater JA, Rao S, Bezold K, Aplin AC, Nicosia RF, Pollard JW, Ferrara N, Lang RA. PMID: 23303818; PMCID: PMC3612865.
  52. Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. Cell. 2012 Oct 12; 151(2):384-99. Jin J, Sison K, Li C, Tian R, Wnuk M, Sung HK, Jeansson M, Zhang C, Tucholska M, Jones N, Kerjaschki D, Shibuya M, Fantus IG, Nagy A, Gerber HP, Ferrara N, Pawson T, Quaggin SE. PMID: 23063127.
  53. Vascular endothelial growth factor a in intraocular vascular disease. Ophthalmology. 2013 Jan; 120(1):106-14. Miller JW, Le Couter J, Strauss EC, Ferrara N. PMID: 23031671.
  54. S1P1 inhibits sprouting angiogenesis during vascular development. Development. 2012 Oct; 139(20):3859-69. Ben Shoham A, Malkinson G, Krief S, Shwartz Y, Ely Y, Ferrara N, Yaniv K, Zelzer E. PMID: 22951644.
  55. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. 1989. Biochem Biophys Res Commun. 2012 Aug 31; 425(3):540-7. Ferrara N, Henzel WJ. PMID: 22925671.
  56. Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest. 2012 Sep; 122(9):3101-13. Liu Y, Berendsen AD, Jia S, Lotinun S, Baron R, Ferrara N, Olsen BR. PMID: 22886301; PMCID: PMC3428080.
  57. Modeling and predicting clinical efficacy for drugs targeting the tumor milieu. Nat Biotechnol. 2012 Jul 10; 30(7):648-57. Singh M, Ferrara N. PMID: 22781694.
  58. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. EMBO J. 2012 Aug 29; 31(17):3513-23. Zhuang G, Wu X, Jiang Z, Kasman I, Yao J, Guan Y, Oeh J, Modrusan Z, Bais C, Sampath D, Ferrara N. PMID: 22773185; PMCID: PMC3433782.
  59. Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors. J Pathol. 2012 Aug; 227(4):404-16. Chung AS, Kowanetz M, Wu X, Zhuang G, Ngu H, Finkle D, Komuves L, Peale F, Ferrara N. PMID: 22611017.
  60. Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models. J Pathol. 2012 Aug; 227(4):417-30. Singh M, Couto SS, Forrest WF, Lima A, Cheng JH, Molina R, Long JE, Hamilton P, McNutt A, Kasman I, Nannini MA, Reslan HB, Cao TC, Ho CC, Barck KH, Carano RA, Foreman O, Eastham-Anderson J, Jubb AM, Ferrara N, Johnson L. PMID: 22611036.
  61. Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. J Clin Invest. 2012 Jul; 122(7):2454-68. Argaw AT, Asp L, Zhang J, Navrazhina K, Pham T, Mariani JN, Mahase S, Dutta DJ, Seto J, Kramer EG, Ferrara N, Sofroniew MV, John GR. PMID: 22653056; PMCID: PMC3386814.
  62. CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood. 2012 Jul 19; 120(3):613-25. Willenborg S, Lucas T, van Loo G, Knipper JA, Krieg T, Haase I, Brachvogel B, Hammerschmidt M, Nagy A, Ferrara N, Pasparakis M, Eming SA. PMID: 22577176.
  63. Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling. J Biol Chem. 2012 Jun 01; 287(23):19574-84. Qu X, Zhuang G, Yu L, Meng G, Ferrara N. PMID: 22528488; PMCID: PMC3365993.
  64. The heart endocardium is derived from vascular endothelial progenitors. Development. 2011 Nov; 138(21):4777-87. Milgrom-Hoffman M, Harrelson Z, Ferrara N, Zelzer E, Evans SM, Tzahor E. PMID: 21989917; PMCID: PMC3190386.
  65. Developmental and pathological angiogenesis. Annu Rev Cell Dev Biol. 2011; 27:563-84. Chung AS, Ferrara N. PMID: 21756109.
  66. Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11590-5. Yao J, Wu X, Zhuang G, Kasman IM, Vogt T, Phan V, Shibuya M, Ferrara N, Bais C. PMID: 21709213; PMCID: PMC3136309.
  67. Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature. 2011 May 29; 474(7352):511-5. Stefater JA, Lewkowich I, Rao S, Mariggi G, Carpenter AC, Burr AR, Fan J, Ajima R, Molkentin JD, Williams BO, Wills-Karp M, Pollard JW, Yamaguchi T, Ferrara N, Gerhardt H, Lang RA. PMID: 21623369; PMCID: PMC3214992.
  68. Multiple effects of angiopoietin-2 blockade on tumors. Cancer Cell. 2011 Apr 12; 19(4):431-3. Lewis CE, Ferrara N. PMID: 21481783.
  69. Comparing protein VEGF inhibitors: In vitro biological studies. Biochem Biophys Res Commun. 2011 May 06; 408(2):276-81. Yu L, Liang XH, Ferrara N. PMID: 21501594.
  70. From the discovery of vascular endothelial growth factor to the introduction of avastin in clinical trials - an interview with Napoleone Ferrara by Domenico Ribatti. Int J Dev Biol. 2011; 55(4-5):383-8. Ferrara N. PMID: 21858763.
  71. Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21248-55. Kowanetz M, Wu X, Lee J, Tan M, Hagenbeek T, Qu X, Yu L, Ross J, Korsisaari N, Cao T, Bou-Reslan H, Kallop D, Weimer R, Ludlam MJ, Kaminker JS, Modrusan Z, van Bruggen N, Peale FV, Carano R, Meng YG, Ferrara N. PMID: 21081700; PMCID: PMC3003076.
  72. Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy. Nat Med. 2010 Oct; 16(10):1107-11. Ferrara N. PMID: 20930754.
  73. Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature. PLoS One. 2010 Jul 29; 5(7):e11863. Scott A, Powner MB, Gandhi P, Clarkin C, Gutmann DH, Johnson RS, Ferrara N, Fruttiger M. PMID: 20686684; PMCID: PMC2912336.
  74. Targeting the tumour vasculature: insights from physiological angiogenesis. Nat Rev Cancer. 2010 07; 10(7):505-14. Chung AS, Lee J, Ferrara N. PMID: 20574450.
  75. Vegf regulates embryonic erythroid development through Gata1 modulation. Blood. 2010 Sep 23; 116(12):2141-51. Drogat B, Kalucka J, Gutiérrez L, Hammad H, Goossens S, Farhang Ghahremani M, Bartunkova S, Haigh K, Deswarte K, Nyabi O, Naessens M, Ferrara N, Klingmüller U, Lambrecht BN, Nagy A, Philipsen S, Haigh JJ. PMID: 20554972.
  76. Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis. Curr Opin Hematol. 2010 May; 17(3):219-24. Ferrara N. PMID: 20308892.
  77. PlGF blockade does not inhibit angiogenesis during primary tumor growth. Cell. 2010 Apr 02; 141(1):166-77. Bais C, Wu X, Yao J, Yang S, Crawford Y, McCutcheon K, Tan C, Kolumam G, Vernes JM, Eastham-Anderson J, Haughney P, Kowanetz M, Hagenbeek T, Kasman I, Reslan HB, Ross J, Van Bruggen N, Carano RA, Meng YJ, Hongo JA, Stephan JP, Shibuya M, Ferrara N. PMID: 20371352.
  78. A therapeutic anti-VEGF antibody with increased potency independent of pharmacokinetic half-life. Cancer Res. 2010 Apr 15; 70(8):3269-77. Yeung YA, Wu X, Reyes AE, Vernes JM, Lien S, Lowe J, Maia M, Forrest WF, Meng YG, Damico LA, Ferrara N, Lowman HB. PMID: 20354184.
  79. Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor action. Mol Biol Cell. 2010 Mar 01; 21(5):687-90. Ferrara N. PMID: 20185770; PMCID: PMC2828956.
  80. Functions of type II pneumocyte-derived vascular endothelial growth factor in alveolar structure, acute inflammation, and vascular permeability. Am J Pathol. 2010 Apr; 176(4):1725-34. Mura M, Binnie M, Han B, Li C, Andrade CF, Shiozaki A, Zhang Y, Ferrara N, Hwang D, Waddell TK, Keshavjee S, Liu M. PMID: 20167862; PMCID: PMC2843464.
  81. Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors. Am J Pathol. 2010 Apr; 176(4):1564-76. Coffelt SB, Lewis CE, Naldini L, Brown JM, Ferrara N, De Palma M. PMID: 20167863; PMCID: PMC2843445.
  82. Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation. Dis Model Mech. 2010 Mar-Apr; 3(3-4):224-35. Ortega N, Wang K, Ferrara N, Werb Z, Vu TH. PMID: 20142327; PMCID: PMC2869494.
  83. Targeting the tumor microenvironment with SRC kinase inhibition. Clin Cancer Res. 2010 Feb 01; 16(3):775-7. Chung AS, Ferrara N. PMID: 20103657.
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  289. Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells. J Clin Invest. 1993 Jan; 91(1):160-70. Ferrara N, Winer J, Burton T, Rowland A, Siegel M, Phillips HS, Terrell T, Keller GA, Levinson AD. PMID: 8423215; PMCID: PMC330010.
  290. Leukemia inhibitory factor expression in human carotid plaques: possible mechanism for inhibition of large vessel endothelial regrowth. Growth Factors. 1993; 9(4):301-5. Gillett NA, Lowe D, Lu L, Chan C, Ferrara N. PMID: 8148158.
  291. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem. 1992 Dec 25; 267(36):26031-7. Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N. PMID: 1464614.
  292. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun. 1992 Dec 15; 189(2):824-31. Pepper MS, Ferrara N, Orci L, Montesano R. PMID: 1281999.
  293. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol. 1992 Dec; 153(3):557-62. Unemori EN, Ferrara N, Bauer EA, Amento EP. PMID: 1447317.
  294. Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary. Endocrinology. 1992 Jul; 131(1):254-60. Ravindranath N, Little-Ihrig L, Phillips HS, Ferrara N, Zeleznik AJ. PMID: 1612003.
  295. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science. 1992 Feb 21; 255(5047):989-91. de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. PMID: 1312256.
  296. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev. 1992 Feb; 13(1):18-32. Ferrara N, Houck K, Jakeman L, Leung DW. PMID: 1372863.
  297. Pituitary follicular cells secrete an inhibitor of aortic endothelial cell growth: identification as leukemia inhibitory factor. Proc Natl Acad Sci U S A. 1992 Jan 15; 89(2):698-702. Ferrara N, Winer J, Henzel WJ. PMID: 1370585; PMCID: PMC48306.
  298. The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors. 1992; 7(1):53-64. Kim KJ, Li B, Houck K, Winer J, Ferrara N. PMID: 1380254.
  299. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest. 1992 Jan; 89(1):244-53. Jakeman LB, Winer J, Bennett GL, Altar CA, Ferrara N. PMID: 1729274; PMCID: PMC442842.
  300. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun. 1991 Dec 16; 181(2):902-6. Pepper MS, Ferrara N, Orci L, Montesano R. PMID: 1755866.
  301. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol. 1991 Dec; 5(12):1806-14. Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW. PMID: 1791831.
  302. The vascular endothelial growth factor family of polypeptides. J Cell Biochem. 1991 Nov; 47(3):211-8. Ferrara N, Houck KA, Jakeman LB, Winer J, Leung DW. PMID: 1791185.
  303. The 16K fragment of prolactin specifically inhibits basal or fibroblast growth factor stimulated growth of capillary endothelial cells. Endocrinology. 1991 Aug; 129(2):896-900. Ferrara N, Clapp C, Weiner R. PMID: 1855480.
  304. Purification and cloning of vascular endothelial growth factor secreted by pituitary folliculostellate cells. Methods Enzymol. 1991; 198:391-405. Ferrara N, Leung DW, Cachianes G, Winer J, Henzel WJ. PMID: 1857232.
  305. Aortic smooth muscle cells express and secrete vascular endothelial growth factor. Growth Factors. 1991; 5(2):141-8. Ferrara N, Winer J, Burton T. PMID: 1768437.
  306. Vascular endothelial growth factor is expressed in rat corpus luteum. Endocrinology. 1990 Aug; 127(2):965-7. Phillips HS, Hains J, Leung DW, Ferrara N. PMID: 2197082.
  307. Conditioned medium from mouse sarcoma 180 cells contains vascular endothelial growth factor. Growth Factors. 1990; 4(1):53-9. Rosenthal RA, Megyesi JF, Henzel WJ, Ferrara N, Folkman J. PMID: 2085441.
  308. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989 Dec 08; 246(4935):1306-9. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. PMID: 2479986.
  309. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun. 1989 Jun 15; 161(2):851-8. Ferrara N, Henzel WJ. PMID: 2735925.
  310. Fibroblast growth factor and the control of pituitary and gonad development and function. J Steroid Biochem. 1989 Jan; 32(1B):183-91. Gospodarowicz D, Ferrara N. PMID: 2643740.
  311. Regulation of ion transport in hypophysial pars intermedia follicular cell monolayers. Biochem Biophys Res Commun. 1988 Dec 30; 157(3):1376-82. Ferrara N, Gospodarowicz D. PMID: 2462871.
  312. Bovine brain astrocytes express basic fibroblast growth factor, a neurotropic and angiogenic mitogen. Brain Res. 1988 Oct 18; 462(2):223-32. Ferrara N, Ousley F, Gospodarowicz D. PMID: 3191384.
  313. Basic fibroblast growth factor: expression in cultured cells derived from corneal endothelium and lens epithelium. Exp Eye Res. 1988 Jan; 46(1):71-80. Schweigerer L, Ferrara N, Haaparanta T, Neufeld G, Gospodarowicz D. PMID: 2893740.
  314. Bovine granulosa cells produce basic fibroblast growth factor. Endocrinology. 1987 Aug; 121(2):597-603. Neufeld G, Ferrara N, Schweigerer L, Mitchell R, Gospodarowicz D. PMID: 3036478.
  315. Pituitary follicular cells produce basic fibroblast growth factor. Proc Natl Acad Sci U S A. 1987 Aug; 84(16):5773-7. Ferrara N, Schweigerer L, Neufeld G, Mitchell R, Gospodarowicz D. PMID: 2441393; PMCID: PMC298945.
  316. Structural characterization and biological functions of fibroblast growth factor. Endocr Rev. 1987 May; 8(2):95-114. Gospodarowicz D, Ferrara N, Schweigerer L, Neufeld G. PMID: 2440668.
  317. Transport epithelial characteristics of cultured bovine pituitary follicular cells. Am J Physiol. 1987 Mar; 252(3 Pt 1):E304-12. Ferrara N, Fujii DK, Goldsmith PC, Widdicombe JH, Weiner RI. PMID: 2881486.
  318. Culture and characterization of follicular cells of the bovine anterior pituitary and pars tuberalis. Methods Enzymol. 1986; 124:245-53. Ferrara N, Goldsmith P, Fujii D, Weiner R. PMID: 3520214.
  319. Prolactin influences sexual behavior during aging. J Endocrinol Invest. 1985; 8 Suppl 2:23-32. Ferrara N, Bernardini R, Nicoletti F, Drago F, Matera M, Ceravolo A, Scapagnini U. PMID: 4031395.
  320. Influence of sex steroids and prolactin on haloperidol-induced catalepsy. Brain Res. 1983 Nov 21; 279(1-2):352-8. Nicoletti F, Ferrara N, Patti F, Viglianesi M, Rampello L, Bianchi A, Reggio A, Scapagnini U. PMID: 6315179.

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