紀志梁，男，博士，廈門大學生命科學學院教授、博士生導師，專業方向為健康大數據挖掘、系統計算藥物毒理學等。
基本介紹
- 中文名：紀志梁
- 學位/學歷：博士
- 職業：教師
- 專業方向：健康大數據挖掘、系統計算藥物毒理學等
- 職務：博士生導師
- 職稱：教授
- 任職院校：廈門大學
- 性別：男
個人經歷,研究領域,學術成果,
個人經歷
1991-1996 北京清華大學生物科學與技術系理學學士
1997–2000 新加坡國立大學微生物系理學碩士
2000–2004 新加坡國立大學計算科學系理學博士
2003/12 - 2008/7廈門大學生命科學學院副教授
2008/7 - 至今廈門大學生命科學學院教授
“Protein & Peptide Letters”編委（2012-）
衛計委男性生殖健康重點實驗室學術委員會委員（2014-）
中國化學會計算機化學專業委員會委員(2011-)
中國空間科學學會空間生命起源與進化專業委員會委員（2008-）
New Century Excellent Talents of MOE (2006)
Editorial Board Member of journal 'Current Drug Discovery Technologies' (2012-)
Committee Member, Computer Chemistry Committee of China Chemistry Society
研究領域
近年來，課題組的研究重點集中於以下三個方面：
（1）系統計算藥物毒理學：利用機器學習和網路分析等技術，開展對小分子藥物和天然產物的藥物不良反應的分子機制研究和理論預測。
（2）健康大數據挖掘：基於異質性健康大數據，開發藥物信息學資料庫及分析軟體，開展個體化用藥和藥物遺傳學的理論與套用基礎研究。
學術成果
1. Huang LH, He QS, Liu K, Cheng J, Zhong MD, Chen LS, Yao LX, Ji ZL*. ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Research. 2018 Jan; 46: D911-17.
2. Xu Q, Liu K, Lin X, Qin Y, Chen L, Cheng J, Zhong M, He Q, Li Y, Wang T, Pan J, Peng M, Yao L, Ji Z*. ADMETNet: The knowledge base of pharmacokinetics and toxicology network. Journal of Genetics & Genomics. 2017 May 20;44(5):273-276.
3. Wei L, Xing P, Shi G, Ji ZL*, Zou Q*. Fast prediction of protein methylation sites using a sequence-based feature selection technique. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2017 Feb 16.
4. Zhang J, Wang S, Jiang B, Huang L, Ji Z, Li X, Zhou H, Han A, Chen A, Wu Y, Ma H, Zhao W, Zhao Q, Xie C, Sun X, Zhou Y, Huang H, Suleman M, Lin F, Zhou L, Tian F, Jin M, Cai Y, Zhang N, Li Q*. c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis. Nature Communications. 2017 Jan 5; 8:13732.
5. Fan F, He Z, Kong LL, Chen Q, Yuan Q, Zhang S, Ye J, Liu H, Sun X, Geng J, Yuan L, Hong L, Xiao C, Zhang W, Sun X, Li Y, Wang P, Huang L, Wu X, Ji Z, Wu Q, Xia NS, Gray NS, Chen L, Yun CH, Deng X, Zhou D*. Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Science Translational Medicine. 2016 Aug 17; 8(352):352ra108.
6. Shi S#, Liu K#, Chen Y#, Zhang S, Lin J, Gong C, Jin Q, Yang XJ, Chen R*, Ji Z*, Han A*. Competitive inhibition of lysine acetyltransferase 2B by a small motif of the adenoviral oncoprotein E1A. Journal of Biological Chemistry. 2016 Jul 1;291(27):14363-72.
7. Zhang ZF, Ma PF, Jing Y, Yan Y, Cai MC, Zhang MY, Zhang SZ, Peng HX, Ji ZL, Di W, Gu ZY, Gao WQ, Zhuang GL. BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating FoxM1. Theranostics. 2016; 6(2): 219-230
8. Lin S*, Cheng S, Song B, Zhong X, Lin X, Li W, Li L, Zhang Y, Zhang H, Ji Z, Cai M, Zhuang Y, Shi X, Lin L, Wang L, Wang Z, Liu X, Yu S, Zeng P, Hao H, Zou Q, Chen C, Li Y, Wang Y, Xu C, Meng S, Xu X, Wang J, Yang H, Campbell DA, Sturm NR, Dagenais-Bellefeuille S, Morse D. The Symbiodinium kawagutii genome illuminates dinoflagellate gene expression and coral symbiosis. Science. 2015 Nov 6;350(6261):691-4.
9. Cai MC, Xu Q, Pan YJ, Pan W, Ji N, Li YB, Jin HJ, Liu K and Ji ZL*. ADReCS: an ontology database for aiding standardization and hierarchical classification of adverse drug reaction terms. Nucleic Acids Research.,2015 Jan 28;43: D907-13.
10.Xiang YP, Liu K, Cheng XY, Cheng C, Gong F, Pan JB, Ji ZL*. Rapid Assessment of Adverse Drug Reactions by Statistical Solution of Gene Association Network. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2015 Jul-Aug;12(4):844-50.
11. Zhang HP, Pan JB, Zhang C, Ji N, Wang H, Ji ZL*. Network understanding of herb medicine via rapid identification of ingredient-target interactions. Scientific Reports. 2014 Jan 16;4:3719.
12. Wang Q, Wei L, Guan X, Wu Y, Zou Q, Ji ZL*. Briefing in family characteristics of microRNAs and their applications in cancer research. Biochimica et Biophysica Acta-Proteins and Proteomics. 2014 Jan;1844(1 Pt B):191-7
13. Pan JB, Ji N, Pan W, Hong R, Wang H, Ji ZL*. High-throughput Identification of Off-Targets for the Mechanistic Study of Severe Adverse Drug Reactions Induced by Analgesics. Toxicology & Applied Pharmacology. 2013 Oct 29;274(1):24-34
14. Pan JB, Hu SC, Wang H, Zou Q, Ji ZL*. PaGeFinder: quantitative identification of spatiotemporal pattern genes. Bioinformatics. 2012 Jun 1;28(11):1544-5.
