基本介紹
- 中文名：田中民
- 畢業院校：西安交通大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：生物化學與分子生物學、生理學
- 職務：西安交通大學生命學院博士生導師
- 任職院校：西安交通大學生命學院
個人經歷,研究方向,學術成果,
個人經歷
生命科學與技術學院大型儀器實驗共享平台副主任。
2000年，西北大學生物系獲碩士學位；
2006-2008年，美國威斯康星醫學院生理系博士後；
2008年入選教育部“新世紀優秀人才”支持計畫；
2009年，美國威斯康星醫學院生理系訪問學者。
學士兼職：
- 中國生理學會腎臟專業委員會委員；
- 中國生物醫學工程委員會第三屆超聲生物效應專業委員會常務委員和副主任委員。
研究方向
研究領域：生物化學與分子生物學，生理學。
研究方向：
(1)鹽敏感高血壓的差異蛋白質組學與代謝組學；
(2)鹽敏感高血壓的藥物靶標篩選以及診斷試劑盒開發；
(3)生物質譜分析技術及食品安全檢測；
(4)鹽敏感高血壓的生物信息學分析。
學術成果
科研項目：
【2】教育部新世紀優秀人才支持計畫。（NCET-080434）；
【3】人事部、省外專局留學人員科技活動擇優資助項目《鹽敏感高血壓臨床檢測試劑盒研製》
【4】 參與科技部國家重點基礎研究973計畫項目《心腦血管易損斑塊的高分辨成像識別與風險評估預警體系重大問題的基礎研究》2010CB732600
【5】國家自然科學基金面上項目《延胡索酸酶基因(Fh)突變在高鹽飲食腎損傷及血壓鹽敏感性形成中的作用》81270767
【6】國家社會科學基金重大項目“生物技術及其產業發展的法律保障機制研究”子項目
【7】國家自然科學基金面上項目 腎臟代謝反饋調節與鹽敏感高血壓的形成機制研究、2016/01-2019/12
【8】國家自然科學基金面上項目 海外及港澳學者合作研究基金項目，81228002、腎臟細胞代謝中產物對鹽敏感性高血壓的調控機制研究
【9】國家自然科學基金面上項目 腎臟胺基酸代謝異常與鹽敏感高血壓形成機制的研究、2018/01-2021/12、在研。
論文：
[1] Zhe Yang*, Rui Cheng, Chenyang Zhao, Na Sun, Huiyan Luo, Ya Chen, Zerong Liu, Xian Li, Jie Liu, Zhongmin Tian* Thermo- and pH-dual responsive polymeric micelles with upper critical solution temperature behavior for photoacoustic imaging-guided synergistic chemo-photothermal therapy against subcutaneous and metastatic breast tumors. Theranostics， 2018; 8(15): 4097-4115.SCI 一區 IF：8.8
[2] Na Sun, Chenyang Zhao, Rui Cheng, Zerong Liu, Xian Li, Axin Lu, Zhongmin Tian*and Zhe Yang. Cargo-Free Nanomedicine with pH Sensitivity for Codelivery of DOX Conjugated Prodrug with SN38 To Synergistically Eradicate Breast Cancer Stem Cells. Mol. Pharmaceutics, DOI: 10.1021/acs.molpharmaceut.8b00367 SCI 二區
[3] Yuan Cheng, Haiying Song,Xiaoqing Pan, Hong Xue, Yifei Wan, Tao Wang, Zhongmin Tian, Entai Hou, Ian R. Lanza, Pengyuan Liu, Yong Liu, Purushottam W. Laud, Kristie Usa, Yongcheng He, Mingyu Liang Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet. Theranostics. 2018; 8(6): 1468-1480 SCI 一區 IF: 8.766
[4] Entai Hou, Na Sun, Fuchang Zhang, Chenyang Zhao, Kristie Usa, Mingyu Liang*, Zhongmin Tian,* Malate and Aspartate Increase L-arginine and Nitric Oxide and Attenuate Salt-Sensitive Hypertension. Cell Reports. 2017 19, 1631–1639 IF: 8.28
[5] Yang Z, Sun N, Cheng R, Zhao C, Liu Z, Li X, Liu J, Tian Z. pH multistage responsive micellar system with charge-switch and PEG layer detachment for co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells. Biomaterials. 2017 Sep 10;147:53-67. doi: 10.1016/j.biomaterials.. SCI 一區IF:8.402
[6] Yang Z., Sun N., Cheng R., Zhao C. Y., Liu J. and Tian Z. Hybrid nanoparticles coated with hyaluronic acid lipoid for targeted co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells (2017). Journal of Materials Chemistry B, 5: 6762-6775. IF:4.543 SCI 一區
[7] Zhongmin Tian, Yong Liu, Kristie Usa, Domagoj Mladinov, Yi Fang, Xiaoqiang Ding, Andrew S. Greene, Allen W. Cowley, Jr. Mingyu Liang*. Novel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension. Hypertension. 2009, 54: 255-260. IF: 7.194
[8] Zhongmin Tian, Andrew S. Greene, Jennifer Pietrusz, Isaac R. Matus, and Mingyu Liang MicroRNA–target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis Genome Research. 2008.18:404-411. IF: 11.224
[9] Zhongmin Tian, Andrew S. Greene, Kristie Usa, Isaac R. Matus, Jesse Bauwens, Jennifer L. Pietrusz, Allen W. Cowley, Jr. and Mingyu Liang. Renal Regional Proteomes in Young Dahl Salt-Sensitive Rats. Hypertension. 2008,51(4):899-904. IF: 7.194
[10] Alison J. Kriegel, Yi Fang, Yong Liu, Zhongmin Tian，Domagoj Mladinov，Isaac R. Matus, Xiaoqiang Ding, Andrew S. Greene and Mingyu Liang. MicroRNA-Target Pairs in Human Renal Epithelial Cells treated with Transforming Growth Factor β1: A Novel Role of miR-382 Nucleic Acids Research. 2010, 38(22): 8338-8347. IF：7.479
[11] Xiaofeng He, Yong Liu, Kristie Usa , Zhongmin Tian, Allen W. Cowley Jr., Mingyu Liang. Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats. Am J Physiol Renal Physiol. 2014, 15; 306(10):1190-1197. IF：3.3
[12] Mingyu Liang, Yong Liu, Domagoj Mladinov, Allen W. Cowley, Jr., Hariprasad Trivedi, Yi Fang, Xialian Xu, Xiaoqiang Ding, Zhongmin Tian. MicroRNA: A New Frontier in Kidney and Blood Pressure Research. Am J Physiol Renal Physiol, 2009，297:553-558. IF：4.416
[13] Usa K, Liu Y, Geurts AM, Cheng Y, Lazar J, Baker MA, Grzybowski M, He Y, Tian Z*, Liang M*. Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain. Physiol Genomics. 2017 Sep 1;49(9):496-504. IF:3.04
[14] Hou E, Li X, Liu Z, Zhang F, Tian Z. Combined metabolomic and correlation networks analyses reveal fumarase insufficiency altered amino acid metabolism. Biomed Chromatogr. 2017 Nov 11. doi: 10.1002/bmc.4133.
[15] Liqing He, Xiaochang Xue, Zhengjun Wang, Entai Hou, Yong Liu, Mingyu Liang, Yingqi Zhang, and Zhongmin Tian* Transcriptional regulation of heterogeneous nuclear ribonucleoprotein K gene expression, Biochimie, 2015, 109, 27-35 IF: 3.2
[16] Le Wang , Entai Hou, Lijun Wang, Yanjun Wang, Lingjian Yang, Xiaohui Zheng, Guangqi Xie, Qiong Sun, Mingyu Liang, Zhongmin Tian* Reconstruction and analysis of correlation networks based on GC–MS metabolomics data for young hypertensive men, Analytica Chimica Acta , 2015,854: 95–105 IF：4.517
[17] Le Wang, Entai Hou, Liqing He, Zhengjun Wang, Na Sun, Lan Chen, Pu Jia, Xiaohui Zheng, Mingyu Liang, Zhongmin Tian* Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13BN rats. Biochemical and Biophysical Research Communications, 2014, 18, 450 (1): 863-869. IF: 2.4
[18] Zhengjun Wang, Qiong Sun, Na Sun, Mingyu Liang, Zhongmin Tian* Mitochondrial dysfunction and altered renal metabolism in Dahl salt-sensitive rats. Kidney Blood Press Res. 2017, 42(3):587-597. IF:2.9.
近年發表的論文：
[1] Liqing He, Xiaochang Xue, Zhengjun Wang, Entai Hou, Yong Liu, Mingyu Liang, Yingqi Zhang, and Zhongmin Tian* Transcriptional regulation of heterogeneous nuclear ribonucleoprotein K gene expression, Biochimie, 2015, 109, 27-35 IF: 3.2
[2] Le Wang , Entai Hou, Lijun Wang, Yanjun Wang, Lingjian Yang, Xiaohui Zheng, Guangqi Xie, Qiong Sun, Mingyu Liang, Zhongmin Tian* Reconstruction and analysis of correlation networks based on GC–MS metabolomics data for young hypertensive men, Analytica Chimica Acta , 2015,854: 95–105 IF：4.517
[3] Le Wang, Entai Hou, Liqing He, Zhengjun Wang, Na Sun, Lan Chen, Pu Jia, Xiaohui Zheng, Mingyu Liang, Zhongmin Tian* Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13BN rats. Biochemical and Biophysical Research Communications, 2014, 18, 450 (1): 863-869. IF: 2.4
[4] Zhongmin Tian*, Yu Wang, Chenyang Zhao, Tianshu Wang, Entai Hou and Na Sun Qualitative and quantitative analysis of phosphoproteomic experimental workflow based on phosphoprotein enrichment strategy and two-dimensional difference gel electrophoresis (2D-DIGE) techniques, Current Proteomics, 2014, 11(4), 252 – 263 IF: 0.5
[5]Zhongmin Tian, Yong Liu, Kristie Usa, Domagoj Mladinov, Yi Fang, Xiaoqiang Ding, Andrew S. Greene, Allen W. Cowley, Jr. Mingyu Liang*. Novel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension. Hypertension. 2009, 54: 255-260. IF: 7.194
[6] Zhongmin Tian, Andrew S. Greene, Jennifer Pietrusz, Isaac R. Matus, and Mingyu Liang MicroRNA–target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis Genome Research. 2008.18:404-411. IF: 11.224
[7] Zhongmin Tian, Andrew S. Greene, Kristie Usa, Isaac R. Matus, Jesse Bauwens, Jennifer L. Pietrusz, Allen W. Cowley, Jr. and Mingyu Liang. Renal Regional Proteomes in Young Dahl Salt-Sensitive Rats. Hypertension. 2008,51(4):899-904. IF: 7.194
[8] Zhongmin Tian, Mingxi Wan, Mingzhu Lu, Xiaodong Wang. The alteration of protein profile of walker 256 carinosarcoma cells during the apoptotic process induced by ultrasound. Ultrasound in Medicine & Biology, 2005, 31 (1): 121-128. IF: 2.221
[9] Zhongmin Tian, Mingxi Wan, Supin Wang, Juqing Kang. Effects of ultrasound and excipients on the function and structure of trypsin. Ultrasonics Sonochemistry 2004, 11(6), 399-404. IF: 2.105
[10]Zhongmin Tian, Mingxi Wan, Bo Wang, Supin Wang, Xiaoming Wu and Yusong Ruan. Effects of ultrasound on the structure and function of tumor necrosis factor-α. Ultrasound in Medicine & Biology, 2003, 29 (9): 1331-1339. IF: 2.221
[11]Zhongmin Tian, Mingxi Wan, Zenglu Wang, Bo Wang. The preparation of genistein and LC-MS/MS on line analysis. Drug Development Research, 2004, 66 (1): 6-12. IF: 0.891
[12]Alison J. Kriegel, Yi Fang, Yong Liu, Zhongmin Tian（等同第一作者），Domagoj Mladinov，Isaac R. Matus, Xiaoqiang Ding, Andrew S. Greene and Mingyu Liang. MicroRNA-Target Pairs in Human Renal Epithelial Cells treated with Transforming Growth Factor β1: A Novel Role of miR-382 Nucleic Acids Research. 2010, 38(22): 8338-8347. IF：7.479
[13]Xiaofeng He , Yong Liu , Kristie Usa , Zhongmin Tian, Allen W. Cowley Jr., Mingyu Liang. Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats. Am J Physiol Renal Physiol. 2014, 15; 306(10):1190-1197. IF：3.3
[14]Mingyu Liang, Yong Liu, Domagoj Mladinov, Allen W. Cowley, Jr., Hariprasad Trivedi, Yi Fang, Xialian Xu, Xiaoqiang Ding, Zhongmin Tian. MicroRNA: A New Frontier in Kidney and Blood Pressure Research. Am J Physiol Renal Physiol, 2009，297:553-558. IF：4.416
[15]Yi Feng, Zhongmin Tian, Ming-Xi Wan. Bio-effects of low intensity ultrasound in vitro: apoptosis, alteration of protein profile and potential molecular mechanism. Journal of Ultrasound in Medicine. 2010, 29: 963-974 SCI：607CB
[16]Yi Feng, Zhongmin Tian, Ming-Xi Wan, Zhao-Bin Zheng. Protein profile of human hepatocarcinoma cell line SMMC-7721: Identification and functional analysis. World J Gastroenterol, 2007, 13(18): 2608-2614 SCI :175PE.
