甘文標

甘文標，博士，美國紐約大學醫學院 Skirball研究所終身教授，北京大學深圳研究生院化學生物學與生物技術學院教授。

基本介紹

• 中文名：甘文標
• 屬於：美國紐約大學醫學院 
• 學歷：博士
• 教育經歷：NeurobiologyColumbiaUniversity

人物經歷

教育經歷

1986-1989 B.S. in Laser Physics Tsinghua University, Beijing B.E.

1989-1995 Ph. D. in Neurobiology Columbia University, New York

工作經歷

1995-1999 Postdoc in Neurobiology, Washington University, St. Louis

1999-2006 Assistant Professor, Skirball Institute, Molecular Neurobiology Program and Department of Physiology and Neuroscience, NYU School of Medicine

2006- Tenure Associate professor, Skirball Institute, Molecular Neurobiology Program and Department of Physiology and Neuroscience, NYU School of Medicine

研究方向

We are interested in understanding synaptic structure and function in the living brain.Specifically,we examine the development and maintenance of synapses with various techniques including transcranial two-photon imaging, molecular biology and electrophysiology.We also investigatehow to prevent abnormal synapse loss in mouse models of neurodegenerative diseases.

主要貢獻

1. Liston C, Gan W-B. (2011) Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo. Proc Natl Acad Sci U S A. 108(38):16074-9.

2. Yang G, Chang PC, Bekker A, Blanck TJ, Gan W-B. (2011) Transient effects of anesthetics on dendritic spines and filopodia in the Living Mouse Cortex. Anesthesiology. 115(4):718-726

3. Pan, F., Aldridge, G.M., Greenough, W.T, Gan, W-B.(2010) Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile x syndrome. Proc Natl Acad Sci U S A. 107(41):17768-73.

4. Parkhurst CN, Gan, W-B. (2010) Microglia dynamics and function in the CNS. Curr Opin Neurobiol. 20(5):595-600.

5. Yang, G., Pan, F., Parkhurst, CN., Grutzendler, J., Gan, W-B. (2010) Thinned-skull cranial window technique for long-term imaging of the cortex in live mice. Nat Protoc. 5(2):201-8.

6. Yang, G., Pan, F., Gan, W-B. (2009) Stably maintained dendritic spines are associated with lifelong memories. Nature. 462:920-4.

7. Bhatt, D., Zhang, S., Gan, W-B. (2009) Dendritic spine dynamics. Annual Review of Physiology. 71:261-82.

8. Xu, H.T., Pan, F., Yang, G., Gan, W-B. (2007) Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex. Nat Neurosci. 10:549-51.

9. Grutzendler, J., Helmin, K., Tsai, J., Gan, W-B. (2007) Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer's disease. Ann N Y Acad Sci. 1097:30-9.

10. Grutzendler, J.G., Gan, W-B. (2006) Two-photon imaging of synaptic plasticity and pathology in the living mouse brain. NeuroRx. 3:489-96.

11. Zuo, Y., Yang, G., Kwon, E., Gan, W-B(2005) Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex. Nature. 436:261-5.

12. Davalos, D., Grutzendler, J., Yang, G., Kim, J.V., Zuo, Y., Jung, S., Littmann, D.R., Dustin, M.L., Gan, W-B (2005) ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci. 8:752-8.

13. Zuo, Y., Lin, A., Chang, P., Gan, W-B (2005) Development of long-term dendritic spine stability in diverse regions of cerebral cortex. Neuron. 46:1-9.

14.Tsai, J., Grutzendler, J., Duff, K., Gan, W-B. (2004) Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat Neurosci. 7:1181-3 [Epub ahead of print].

15. Grutzendler, J., Kasthuri, N., Gan, W-B. (2002) Long-term dendritic spine stability in the adult cortex. Nature. 420:812-816.

16. Gan, W-B., Lichtman, J.W. (1998) Synaptic segregation at the developing neuromuscular junction. Science 282:1508-1511

獲獎記錄

1989 First Award for M.S. thesis, Department of Biological Sciences and Biotechnology, Tsinghua University

1991 Science and Technology Award for M.S. thesis work on the studies of the multi-channel VEP topography and its clinical use, Beijing Medical University

1995 The Peter Sajovic Memorial Prize for outstanding work in Biology, Department of Biological Sciences, Columbia University

1996-1999 National Research Service Award, NIH

2000 Whitehead Fellowship for Junior Faculty in Biomedical or Biological Science, New York University

2000-2004 New Scholar Award, Ellison Medical Foundation

2002-2005 Investigator Initiated Research Grant Award, Alzheimer's Association

2006-2007 Dart Scholar in learning and memory, Marine Biological Laboratory