基本介紹
- 中文名：王韻華
- 國籍：中國
- 民族：漢
- 職業：教師
- 職稱：教授
主講課程,研究方向,主要貢獻,
主講課程
主講《普通化學》以及《化學綜合實驗》等課程，主要從事生物無機化學領域基礎理論研究工作。
研究方向
順鉑類無機抗癌藥物研究，金屬蛋白性質、結構、功能間關係研究。
主要貢獻
(1) Effects of charged amino acid mutation on the solution structure of cytochrome b5 and binding between cytochrome b5 and cytochrome c. Protein Science (2001) 10 2451-2459.
(2) Engineering a hydrophilic heme catalytic pocket into microsomal cytochrome b5: construction of novel metalloproteins with high peroxidase-like activity. Chemistry Lett. (2002) 7 674-675.
(3) Crystal structures of V45E and V45Y mutants and structure comparison of a variety of mutants of cytochrome b5. Acta Crystallography (2002) D58 1298-1306.
(4) The distinct heme coordination environments and heme-binding stabilities of His39Ser and His39Cys mutants of cytochrome b5. Protein Engineering (2003) 16 1-8.
(5) Mapping the electron transfer interface between cytochrome b5 and cytochrome c. Biochemistry (2004) 43 3527-3536.
