王皞鵬

王皞鵬

王皞鵬,畢業於田納西大學,任上海科技大學生命科學與技術學院副教授,博士生導師,田納西大學健康醫學中心博士,美國加州大學舊金山分校博士後。

基本介紹

簡介,研究,論文,

簡介

2003年本科畢業於南京大學理科教學強化部;2009年在美國田納西大學健康醫學中心獲博士學位;2009年至2015年在加州大學舊金山分校醫學院進行博士後研究;2015年7月加入上海科技大學生命科學與技術學院任助理教授。

研究

免疫細胞為靶標的腫瘤免疫療法取得了重大的突破。免疫學家利用大分子藥物來增強病人自身T細胞的抗癌能力,成功地治癒了癌症病人。

論文

  1. Tian R*, Wang H*, Pasculescu A, Shi Y, Gish G, Hunter T, Gingras A, Pawson T, Weiss A. Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T cell co-stimulatory receptor PNAS 2015 12; 1594-1603 (*equal contribution)
  2. Punwani D*, Wang H*, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM. Combined Immunodeficiency due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation. J Clin. Immunol. 2015 35 135-146(* equal contribution)
  3. Wang H*, Flach H*, Onizawa M, Wei L, McManus MT, Weiss A. Negative regulation of Hif1α expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. Nature Immunology 2014 15; 393–401 (* equal contribution)
  4. Zhuang M, Guan S, Wang H, Burlingame AL, Wells JA. Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator. Molecular Cell. 2013 49(2):273-82.
  5. Wang H, Kadlecek T, Au-Yeung B, Sjölin Goodfellow H, Hsu LY, Freedman T, Weiss A. ZAP-70: an essential kinase in T cell signaling. Cold Spring Harb Perspect Biol. 2010 1;2(5).
  6. Wang H, Holst J, Woo S, Guy CS, Bettni M, Wang Y, Aaron S, Naramura M, Mingueneau M, Dragone L, Hayes S, Malissen B, Band H, Vignali DA. Tonic Ubiquitylation controls T cell receptor:CD3 complex expression during T cell development. EMBO J. 2010 7;29(7):1285-98.
  7. Wang H, Matsuzawa A, Brown SA, Zhou J, Guy CS, Tseng PH, Forbes K, Nicholsonll TP, Sheppardll PW, Haecker H, Karin M, Vignali DA. Analysis of non-degradative protein ubiquitylation with a monoclonal antibody specific for K63-linked polyubiqutin. PNAS 2008 105(51):20197-202.
  8. Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, Vignali DA, Bergsagel PL, Karin M. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nature Immunology 2008 9(12):1364-70.
  9. Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA. Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nature Immunology 2008 9(6):658-66.
  10. Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science 2008 321(5889):663-8.

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