王元相

王元相，男，中山大學藥學院副教授、博士生導師。2017年入選中山大學“百人計畫二期”。主要研究方向為藥物化學：以臨床重大疾病（惡性腫瘤、代謝性疾病、耐藥菌等）為出發點，採取有針對性的策略，開發藥效高、成藥性強的藥物候選物。已發表SCI論文24篇，他引400餘次，以第一作者、或共同通訊作者發表SCI論文12篇。其中在藥物化學國際一級期刊J. Med. Chem.發表論文4篇，國際著名化學綜合性雜誌Angew. Chem. Int. Ed發表論文1篇；作為核心發明人申請國際專利3項，國內專利3項（已授權）。

基本介紹

  • 中文名：王元相
  • 畢業院校：中國科學院
  • 學位/學歷：博士
  • 職業：教師
  • 職務：博士生導師
  • 職稱：副教授
人物經歷,教授課程,社會兼職,發表論文,

人物經歷

2016.09-2017.07 美國亞利桑那大學藥學院，藥物化學，博士後
2014.10-2016.08 美國猶他大學生物化學系，生物化學，博士後
2012.08-2014.10美國亞利桑那大學藥學院，藥物化學，博士後
2007.09-2012.07 中國科學院上海藥物研究所，藥物化學，理學博士，導師：張翱 研究員

教授課程

有機化學；有機化學實驗

社會兼職

中國藥學會高級會員
廣東省藥學會藥物化學專業委員
全國衛生產業企業管理協會精準醫療分會委員

發表論文

  1. Yuanxiang Wang*, Wenhao Hu, Yanqiu Yuan*. Protein Arginine Methyltransferase 5 (PRMT5) as an Anti-Cancer Target and Its Inhibitor Discovery.J. Med. Chem.2018, 61, 9429-9441.
  2. Yuanxiang Wang, Yanmei Hu, Shuting Xu, Yongtao Zhang, Rami Musharrafieh, Raymond Kin Hau, Chunlong Ma, and Jun Wang*. In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses.J. Med. Chem.2018, 61,1074-1085
  3. Yuanxiang Wang, Danny Hung-Chieh Chou*. A Thiol–Ene Coupling Approach to Native Peptide Stapling and Macrocyclization.Angew. Chem. Int. Ed.2015, 54, 10931-10934.
  4. Yuanxiang Wang#, Christine E. Kaiser#, Brendan Frett, Hong-yu Li*. Targeting Mutant KRAS for Anticancer Therapeutics: A Review of Novel Small Molecule Modulators.J. Med. Chem.,2013, 56, 5219-5230.
  5. Yuanxiang Wang#,Jing Ai#,Ying Wang, Yi Chen, Lu Wang,Gang Liu, Meiyu Geng*, Ao Zhang*. Synthesis and c-Met kinase inhibition of 3,5-di- and 3,5,7-tri-substituted quinolines: Identifica- tion of 3-(4-acetylpiperazin-1-yl)-5-(3-nitroben-zylamino)-7-(trifluoromethyl) quinoline as a novel anticancer agent.J. Med. Chem.2011,54, 2127–2142.
  6. Yuanxiang Wang,Benjamin J. Bruno, Sean Cornillie, Jason M. Nogieira, Diao Chen, Thomas E. Cheatham III, Carol S. Lim, and Danny Hung-Chieh Chou*. Application of Thiol-yne/Thiol-ene Reactions for Peptide and Protein Macrocyclizations.Chem. Eur. J.2017, 29, 7087-7092.
  7. Yuanxiang Wang, Brendan Frett, Hong-yu Li*. Efficient Access to 2,3-Diarylimidazo[1,2‑a]pyridines via a One-Pot, Ligand-Free, Palladium-Catalyzed Three-Component Reaction underMicrowave Irradiation.Org. Lett.2014,16, 3016-3019.
  8. Yuanxiang Wang,Brendan Frett, Nick McConnell, Hong-yu Li*.Metal-Free, EfficientHydrazination of Imidazo[1,2-a]pyridine with Diethyl Azodicarboxylate in Neutral Media.Org. Biomol. Chem.2015,13, 2985-2964.
  9. Yuanxiang Wang,Biswajit Saha, Fang Li, Brendan Frett, Hong-yu Li*. An Expeditious Approach to Access 2-Arylimidazo[1,2-a]pyridin-3-ol From 2-amino pyridine Through a Novel Petasis Based Cascade Reaction.Tetrahedron Lett.2014, 55, 1281-1284.
  10. Yuanxiang Wang, Jing Ai, Jinfeng Yue, Xiao Peng, Yichun Ji, Ailing Zhao, Xin Gao, Ying Wang, Yi Chen, Gang Liu, Zhaobing Gao, Meiyu Geng*, Ao Zhang*. Further SAR studies on 3,5-diamino-7-trifluoromethylquinolines as highly potent tyrosine kinase c-Met inhibitors: efforts to correct hERG inhibition.Med. Chem. Commun.2012,3, 1423-1427.
  11. Yuanxiang Wang, Jing Ai, Gang Liu, Meiyu Geng, Ao Zhang. Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: Key precursors to potent c-Met inhibitors.Org. Biomol. Chem.2011,9, 5930-5933.
  12. Yuanxiang Wang,Ao Zhang. Expeditious synthesis of 2,3-dihydro-2-alkoxy-3- methylene- benzofurans from N-benzofuran-3-ylmethyl N,N,N-trialkylammonium bromides.Tetrahedron2009,65, 6986-6990.
  13. Diao Chen, Maria Disotuar, Xiaochun Xiong, Yuanxiang Wang, Danny Hung-Chieh Chou*. Selective N-terminal Functionalization of Native Peptides and Proteins.Chem. Sci.in press.
  14. Fang Li, Yanmei Hu,Yuanxiang Wang, Chunlong Ma, Jun Wang.Expeditious Lead Optimization of Isoxazole-Containing Influenza A Virus M2-S31N Inhibitors Using the Suzuki–Miyaura Cross-Coupling Reaction.J. Med. Chem.,2017,60, 1580-1590.
  15. Fang Li, Chunlong Ma, Yanmei Hu,Yuanxinag Wang, Jun Wang, Discovery of potent antivirals aganist amantadine-resistant influenza A viruses by targeting the M2-S31N proton channel.ACS Infect Dis,2016, 2, 726-733.
  16. Brendan Frett, Nick McConnell, Catherine C. Smith,Yuanxiang Wang, Neil P. Shah, Hong-yu Li. Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors.Eur. J. Med. Chem.2015,94, 123-131.
  17. Brendan Frett,Nick McConnell,Yuanxiang Wang, Zhigang Xu,Andrew Ambrose,Hong-yu Li.Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studies.Med. Chem. Commun.2014,5, 1507-1514.
  18. Brendan Frett,Yuanxiang Wang, Hong-yu Li. Targeting the K-Ras/PDEδ Protein-Protein Interaction: The Solution for Ras-Driven Cancers or Just Another Therapeutic Mirage?ChemMedChem,2013,8, 1620-1622.
  19. Biswajit Saha, Brendan Frett,Yuanxiang Wang, Hong-yu Li. A p-toluenesulfinic acid-catalyzed three-component Ugi-type reaction and its application for the synthesis of a-amino amides and amidines.Tetrahedron Lett.2013, 54, 2340–2343.
  20. Kui Wu, Jing Ai, Qiufeng Liu, TianTian Chen, Ailing Zhao, Xia Peng,Yuanxiang Wang, Yinchun Ji, Qizheng Yao, Yechun Xu, Meiyu Geng, Ao Zhang. Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors.Bioorg. Med. Chem. Lett.2012, 22, 6368-6372.

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