焦保衛，香港中文大學生化系環境科學哲學博士，現任中國科學院昆明動物研究所研究員，博士生導師，遺傳資源與進化國家重點實驗室副主任。
基本介紹
- 中文名：焦保衛
- 畢業院校：香港中文大學
- 職業：教育科研工作者
- 職稱：研究員
人物經歷,主要成就,
人物經歷
1996.9-2000.7 西南大學（原西南師範大學）生命科學院理學學士
2000.9-2003.7 西南大學生命科學院動物學專業理學碩士
2003.9-2007.3 香港中文大學生化系環境科學哲學博士
2007.5-2008.10 香港中文大學中醫學院任研究助理
2008.10-2013.4 麻薩諸塞大學醫學院（University of Massachusetts Medical school）博士後
2013.4- 中國科學院昆明動物研究所 研究員 發育的印跡調控與進化學科組負責人
主要成就
焦保衛長期從事發育及生殖生物學研究，鑑定了RLIM基因在乳腺發育中的關鍵作用，發現X染色體失活（XCI）在成體細胞中的新模式，闡明了RLIM基因在乳腺發育和胚胎髮育早期中調控機制及其進化意義。還通過一系列新基因的發現和功能研究揭示了魚類生殖生長的新格局。已在Cell，Nature，Journal of Endocrinology，Journal of Cell Biochemistry，BBRC 等期刊雜誌發表論文17篇。
承擔科研項目
中科院昆明動物所啟動經費 150萬
國家自然科學基金面上項目 110萬
代表論著
1. Jiao B., Taniguchi-Ishigaki N., Güng？r C., Peters MA., Chen YW., Riethdorf S., Drung A., Ahronian LG., Shin J., Pagnis R., Pantel K., Tachibana T., Lewis BC., Johnsen SA., Bach I. 2013. Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleo-cytoplasmic shuttling. Mol Biol Cell. In press
2. Jiao B., Ma H., Shokhirev M., Drung A., Yang Q., Shin J., Lu S., Byron M., Kalantry S., Mercurio AM, Lawrence JB, Hoffmann A. and Bach I. 2012. Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell. 149:630-41.
3. Li MH., Wu FR., Gu Y., Wang TR., Wang H., Yang SJ., Sun YL., Zhou LY., Huang XG., Jiao B., Cheng CH., Wang DS. 2012. Insulin-Like Growth Factor 3 Regulates Expression of Genes Encoding Steroidogenic Enzymes and Key Transcription Factors in the Nile Tilapia Gonad. Biology of Reproduction. 86:163, 1-10.
4. Shin J., Bossenz M., Chung Y., Ma H., Byron M., Taniguchi-Ishigaki N., Zhu X., Jiao B., Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB and Bach I. 2010. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature. 467:977-81.
5. Lin ZX, Jiao B., Che CT., Zuo Z., Mok CF., Zhao M., Ho WK., Tse WP., Lam KY., Fan RQ., Yang ZJ and Cheng CH. 2010. Ethyl acetate fraction of the root of Rubia cordifolia L. inhibits keratinocyte proliferation in vitro and promotes keratinocyte differentiation in vivo: potential application for psoriasis treatment. Phytotherapy Research. 24:1056-64.
6. Jiao B., Yeung E.K.C., Chan C.B. and Cheng C.H.K. 2008. Establishment of a transgenic yeast screening system for estrogenicity and identification of the anti-estrogenic activity of malachite green. Journal of Cellular Biochemistry. 105:1399-409.
7. Zhang Y., Liu Y., Huang X., Liu X., Jiao B., Meng Z., Zhu P., Li S., Lin H. and Cheng C.H.K. 2008. Two alternatively spliced GPR39 transcripts in seabream: molecular cloning, genomic organization, and regulation of gene expression by metabolic signals. Journal of Endocrinology. 199: 457-70.
8. Jiao B. and Cheng C.H.K. 2010. Disrupting actions of bisphenol A and malachite green on growth hormone receptor gene expression and signal transduction in seabream. Fish Physiology and Biochemistry. 36:251-61.
9. Wang D.S., Jiao B.*, Hu C., Huang X., Liu Z. and Cheng C.H.K. 2008. Discovery of a gonad-specific IGF subtype in teleost, Biochemical and Biophysical Research Communications. 367, 336-41.
10. Huang X., Jiao B.*, Fung K.K., Zhang Y., Chan C. B., Lin H., Wang D.S. and Cheng C.H.K. 2007. The presence of two distinct prolactin receptors with different signal pathways and constructive expression pattern under the stimulation of steroid hormones in teleost. Journal of Endocrinology. 194, 373-92.
11. Liu Z., Wu F., Jiao B.*, Zhang X., Hu C., Huang B., Zhou L., Huang X., Wang Z., Zhang Y., Nagahama Y., Cheng C.H.K. and Wang D.S. 2007. Molecular cloning of Dmrt1, Foxl2 and Cyp19 in Southern catfish and their possible roles in sex differentiation. Journal of Endocrinology 194, 223-41.
12. Jiao B., Huang X., Chan C.B., Zhang L., Wang D.S. and Cheng C.H.K. 2006. The co-existence of two growth hormone receptors in teleost fish and their differential signal transduction, tissue distribution and hormonal regulation of expression in seabream. Journal of Molecular Endocrinology 36, 23-40.
