基本介紹
- 中文名:沈圓圓
- 學位/學歷:博士
- 職業:教師
- 專業方向:醫學超聲藥物遞送何神經元調控
- 任職院校:深圳大學醫學部生物醫學工程學院
人物經歷,研究方向,學術成果,
人物經歷
2003年本科畢業於上海交通大學生物醫學工程系後,直接攻讀博士並於2009年獲得工學博士學位。2009年12月進入深圳大學生物醫學工程系。現為碩士生導師,深圳市高層次專業人才後備級人才。
研究方向
醫學超聲藥物遞送和神經元調控
學術成果
主持項目
1.廣東省醫學科學技術研究基金項目,A2017289,超聲聯合微泡輸送聲敏劑入腦膠質瘤的參數研究,2017.07-2019.06,主持。
2.深圳市戰略新興產業發展專項資金基礎研究項目,超聲聯合微泡輸送聲敏劑入腦膠質瘤的聲動力治療研究,2017.02-2019.02,主持。
3.廣東省普通高校特色創新(自然科學)項目,超聲激勵載紫杉醇脂質體微泡開放血腦屏障治療腦膠質瘤的研究,2017.01-2018.12,主持。
4.深圳市戰略新興產業發展專項資金基礎研究項目,低頻聚焦超聲聯合微泡遞送AD多肽藥物安全入腦的基礎研究,2014.12-2016.12,主持。
5.國家自然科學基金青年基金,低頻超聲微泡介導NGF脂質體修復受損膽鹼能神經元的研究,2012.01-2012.12,主持。
6.中國博士後科學基金面上項目,超聲微泡開放血腦屏障介導神經生長因子入腦的研究,2010.06-2011.12,主持。
參與項目
(1)國家自然科學基金-重大科研儀器研製項目“基於聲輻射力-洛倫茲力的超聲-磁電雙模成像方法與儀器研製”(編號61427806),2015年1月-2019年12月。
學術論文
1.Zhaoke Pi, Yongpeng Huang, Yuanyuan Shen*, Xiaojun Zeng, Yaxin Hu, Tie Chen, Chenyang Li, Hao Yu, Siping Chen, Xin Chen*, Sonodynamic therapy on intracranial glioblastoma xenografts using sinoporphyrin sodium delivered by ultrasound with microbubbles, Annals of Biomedical Engineering, 47(2): 549-562, 2019 .
2.Yuanyuan Shen, Zhaoke Pi, Fei Yan*, Chih-Kuang Yeh, Xiaojun Zeng, Xianfen Diao, Yaxin Hu, Siping Chen, Xin Chen*, Hairong Zheng, Enhanced delivery of paclitaxel liposomes using focused ultrasound with microbubbles for treating nude mice bearing intracranial glioblastoma xenografts, International Journal of Nanomedicine, 12: 5613-5629, 2017.
3.Haoming Lin, Xinyu Zhang, Yuanyuan Shen*, Yi Zheng, Yanrong Guo, Ying Zhu, Xianfen Diao, Tianfu Wang, Siping Chen, Xin Chen*, Model-dependent and model-independent approaches for evaluating hepatic fibrosis in rat liver using shearwave dispersion ultrasound vibrometry, Medical Engineering and Physics, 39: 66-72, 2016.
4.Haoming Lin#, Yuanyuan Shen#, Xin Chen*, Ying Zhu, Yi Zheng, Xinyu Zhang, Yanrong Guo, Tianfu Wang, Siping Chen*, Viscoelastic properties of normal rat liver measured by ultrasound elastography: comparison with oscillatory rheometry. Biorheology, 53, 5-6: 193-207, 2016.
5.Yuanyuan Shen, Jinxuan Guo, Gaoshu Chen, Chien Ting Chin, Xin Chen, Jian Chen, Feng Wang, Shiguo Chen, Guo Dan*, Delivery of liposomes with different sizes to mice brain after sonication by focused ultrasound in the presence of microbubbles, Ultrasound in Medicine and Biology, 42(7): 1499-1511, 2016.
6.Ying Zhu, Xin Chen, Xinyu Zhang, Siping Chen, Yuanyuan Shen*, Liang Song, Modeling the mechanical properties of liver fibrosis in rats. Journal of Biomechanics, 49:1461-1467, 2016.
7.Hao Yu, Zhongshi Lin, Liang Xu, Dalong Liu, Yuanyuan Shen*, Theoretical study of microbubble dynamics in sonoporation, Ultrasonics, 61: 136-144, 2015.
8.Yuanyuan Shen, Aili Zhang, Jinxuan Guo, Guo Dan, Siping Chen and Hao Yu,Fluorescence imaging of Evans blue extravasation into mouse brain induced by low frequency ultrasound with microbubble, Bio-Medical Materials and Engineering, 2014, 24(6): 2831-2838.
9.Yuanyuan Shen, Tianfu Wang, Chien Ting Chin, Xianfen Diao and Siping Chen, Interaction Between Microbubble and Elastic Microvessel in Low Frequency Ultrasound Field Using Finite Element Method, Chinese Science Bulletin, 58(3): 291-298, 2013.
專著
Yi Zheng. Xin Chen, Aiping Yao, Haoming Lin, Yuanyuan Shen,Yin Zhu, Minhua Lu, Tianfu Wang and Shiping Chen,Wave Propogation/ Book 2(Chapter 1 Shear Wave Propagation in SoftTissue and Ultrasound Vibrometry),Intech Publisher,2013
《小兒超聲診斷學(第2版)》,人民衛生出版社,2013年7月,編者(第一章第3、5節)