江亞伍 教授 現任美國新澤西州立大學傑出教授（Ⅱ級教授）、癌症預防研究中心副主任、新澤西癌症研究所學術委員會委員及癌症發生與化學預防項目共同負責人、Glaxo藥學講席教授，並長期作為美國NIH科學評審委員會、美國癌症研究所（AICR）基金評審委員會和新加坡醫學研究基金評審委員會等重要基金評審機構的成員。江教授於美國紐約州立大學藥學院獲得博士學位，並在美國NIH藥理學實驗室和細胞生物代謝學實驗室從事博士後科學研究。江亞伍教授在國際癌症化學預防領域具有重要的影響力,他的研究方向包括：中藥化學成分用於癌症化學預防及其機制研究；轉錄因子Nrf2 相關信號轉導及其在氧化應激和抗炎症、抗氧化中的作用；中藥化學成分的藥效學、藥物代謝動力學和個體化藥學。發表科研論文190多篇,包括TIPS, CancerRes, Mol Carcinog, Oncogene, JBC等國際權威雜誌。並擔任Pharm Res、Mol Carcinogenesis、Life Sciences等雜誌的編輯，以及Carcinogenesis、Cancer Prev Res、Biopharm Drug Dispos、Acta Pharma Sinica、Pharmacol Res、J Chin Pharm Sci、Oncol Lett等雜誌的編委。
研究方向
● 膳食植物化學成分介導的信號轉導和癌症化學預防研究；
● 轉錄因子Nrf2 相關信號轉導及其在氧化應激和抗炎症、抗氧化中的作用；
● 中藥化學成分的藥效學、藥物代謝動力學和個體化藥學研究。
發表論文
[1] Saw CL, Yang AY, Guo Y, Kong AN*. Astaxanthin and omega-3 fatty acids individually and incombination protect against oxidative stress via the NRF2-ARE pathway. FoodChem Toxicol. 2013 Oct 21. [Epub ahead of print]
[2] Wu TY, Khor TO, Lee JH, Cheung KL, Shu L, ChenC, Kong AN*. Pharmacogenetics,pharmacogenomics and epigenetics of Nrf2-regulated xenobiotic-metabolizingenzymes and transporters by dietary phytochemical and cancer chemoprevention.Curr Drug Metab. 2013 Jul;14(6):688-94.
[3] Cheung KL, Lee JH, Shu L, Kim JH, Sacks DB, Kong AN*. The RasGTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via themitogen-activated protein kinase/extracellular signal-regulated kinase (ERK)kinase (MEK)-ERK pathway. J Biol Chem. 2013 Aug 2;288(31):22378-86.
[4] Kong AN,Zhang C, Su ZY. Targeting epigenetics for cancer prevention by dietary cancerpreventive compounds--the case of miRNA. Cancer Prev Res (Phila). 2013Jul;6(7):622-4.
[5] Wu TY, Khor TO, Su ZY, Saw CL, Shu L, CheungKL, Huang Y, Yu S, Kong AN*.Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1cell line and in vivo TRAMP prostate tumors. AAPS J. 2013 Jul;15(3):864-74.
[6] Saw CL, Wu Q, Su ZY, Wang H, Yang Y, Xu X,Huang Y, Khor TO, Kong AN*. Effectsof natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated geneexpression of phase II drug metabolizing enzymes and anti-inflammation. Biopharm DrugDispos. 2013 Sep;34(6):303-11.
[7] Su ZY, Khor TO, Shu L, Lee JH, Saw CL, Wu TY,Huang Y, Suh N, Yang CS, Conney AH, Wu Q, Kong AN*. Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis viapromoter CpG demethylation. Chem Res Toxicol. 2013 Mar 18;26(3):477-85.
[8] Zhang C, Su ZY, Khor TO, Shu L, Kong AN*. Sulforaphane enhances Nrf2expression in prostate cancer TRAMP C1 cells through epigenetic regulation.Biochem Pharmacol. 2013 May 1;85(9):1398-404.
[9] Huang Y, Li W, Kong AN*. Anti-oxidative stress regulator NF-E2-related factor 2mediates the adaptive induction of antioxidant and detoxifying enzymes by lipidperoxidation metabolite 4-hydroxynonenal. Cell Biosci. 2012 Nov 28;2(1):40.
[10] Lee JH, Khor TO, Shu L, Su ZY, Fuentes F, Kong AN*. Dietary phytochemicals andcancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms inblocking cancer initiation and progression. Pharmacol Ther. 2013Feb;137(2):153-71.
