正常及移植頜下腺分泌功能調控的研究

《正常及移植頜下腺分泌功能調控的研究》是俞光岩為項目負責人,北京大學為依託單位的重點項目。

基本介紹

  • 中文名:正常及移植頜下腺分泌功能調控的研究
  • 項目類別 :重點項目
  • 項目負責人:俞光岩
  • 依託單位 :北京大學
科研成果,項目摘要,

科研成果

序號
標題
類型
作者
1
自體頜下腺移植治療重症角結膜乾燥症
會議論文
俞光岩|
2
自體頜下腺移植重塑淚腺功能
會議論文
俞光岩|
3
Long-term follow-up after autologous microvascular submandibular gland transfer for severe keratoconjunctivitis sicca
會議論文
俞光岩|
4
The role of muscarinic receptors in epiphora of the transplanted human submandibular gland
會議論文
丁沖 |
5
Functional Vanilloid Receptor-1 in Human Submandiburlar Glands
期刊論文
Wang Yi-Ni | Yu Guang-Yan|Wang Yang |Zhang Lei |Ding Qian-Wen |Ding Cong | Zhang Yan|Wu Li-Ling |
6
Activation of transient receptor potential vanilloid subtype 1 (TRPV1) increases expression and permeability of tight junction in normal and hyposecretory submandibular gland.
期刊論文
Yu Guang-Yan |Zhang Yan | Ding Qian-Wen | Wu Li-Ling |Ding Chong | Xiang Ruo-Lan | Shi Liang | Yang Ning-Yan |Su Yun-Chao |Cong Xin |
7
Long-term follow-up after autologous microvascular submandibular gland transfer for severe Keratoconjunctivitis Sicca
會議論文
張 雷|
8
Capsaicin upregulates expression of aquaporin 5 in rabbit submandibular gland
會議論文
張 艷|
9
激活辣椒素受體促進頜下腺分泌的機制
會議論文
俞光岩|
10
淚溢期期頜下腺蛋白質的差異表達
會議論文
丁沖|
11
Autologous microvascular submandibular gland transplantation for severe keratoconjunctivitis sicca. A 10-year experience.
會議論文
俞光岩|
12
An experimental study of the management of severe keratoconjunctivitis sicca with autologous reduced-sized submandibular gland transplantation.
期刊論文
Wang Yi-Xiang |Wu Deng-Cheng |Zhang Xiao-Xia | Yu Guang-Yan|Fu Jia |Ge Xi-Yuan | Li Sheng-Lin|
13
部分頜下腺移植治療重症角結膜乾燥症
會議論文
俞光岩|
14
4691例涎腺結石微創治療療效分析
會議論文
張 雷|
15
Replacing tears by saliva: Hope for patients with dry eye syndrome
會議論文
俞光岩|
16
Carbachol improves secretion in early phase after submandibular gland transplantation
會議論文
石亮 |
17
重症角結膜乾燥症自體頜下腺移植術后角膜移植臨床觀察
期刊論文
吳珺|蔡志剛|鄒留河|張雷|呂嵐|俞光岩|朱正宏|毛馳|
18
Isoproterenol improves secrection of transplanted submandibular glands
期刊論文
Zhang Yan |Xiang Bin |Yu Guang-Yan|Zhang You-Yi | Li Yu-Ming| Wu Li-Ling|Shi Liang |Cong Xin |
19
提高自體頜下腺移植術的成功率
期刊論文
俞光岩|
20
角膜乾燥症自體頜下腺移植術后角膜植片存活情況的實驗研究
期刊論文
鄒留河|張琳|
21
Proteomic Analysis of Secretion from Human Transplanted Submandibular Gland Replacing Lacrimal Gland with Severe Keratoconjunctivitis Sicca
期刊論文
Liu Xiao-jing |Zhang Lei |Wu Li-ling |Gan Ye-Hua |Song Bing |Yu Guang-yan | Ding Chong|
22
Clinical and Anatomic study on the Ducts of the Submandibular and Sublingual Glands
期刊論文
Zhang Lei |Xu Heng |Mao Chi | Zhu Zheng-hong |Peng Xin | CaI Zhi-gang|Yu Guang-yan | Wa Yang |
23
重症角膜結膜乾燥症自體頜下腺移植術後眼表長期追蹤
期刊論文
蔡志剛|吳珺|俞光岩|張雷|鄒留河|潘志強|朱正宏|呂嵐|
24
Expression of ghrelin in human salivary glands and its levels in saliva and serum in Chinese obese children and adolescents.
期刊論文
Li Bin-Bin|Wu Li-Ling |Chen Zi-Bin |Li Sheng-Lin | Yu Guang-Yan| Li Bo-Chun|Lin Qing | Li Xiao-Xin| Ding Cong|
25
面動脈伴行靜脈作為自體頜下腺移植回流靜脈的可靠性探討
期刊論文
彭歆.|俞光岩|張雷|王洋|毛馳|蔡志剛|
26
A型肉毒素對兔失副交感神經頜下腺唾液分泌的影響
期刊論文
蔡志剛|俞光岩|吳立玲|單小峰|
27
Microanatomic study of the vascular and duct system of the submandibular gland.
期刊論文
Zhu Zheng-hong | Peng Xin | Liu Jing-ming|Xu Heng |Yu Guang-yan | Mao Chi |
28
Phenylephrine protects autotransplanted rabbit submandibular gland from apoptosis
期刊論文
Xiang Bin|Zhang Yan |Li Yu-Ming|Wu Li-Ling |Yu Guang-Yan|Gan Ye-Hua|Gao Yan |
29
從頜下腺移植談創新性思維
期刊論文
俞光岩|
30
血管化自體頜下腺移植治療重症角結膜乾燥症指南
期刊論文
俞光岩|
31
Confocal microscopy with double immunofluorescence staining reveals the functional transient receptor potential vanilloid subtype 1 expressed in myoepithelial cells of human submandibular glands
期刊論文
Han Jing-Yan | Su Yun-Chao | Cong Xin |Cai Zhi-Gang | Wu Li-Ling | Zhang Yan| Yu Guang-Yan | Ding Qian-Wen|
32
Establishment of a rabbit model for keratoconjunctivitis sicca
期刊論文
Yu Guang-Yan | Liang Qing-Feng | Chen Zhi-Yuan|
33
頜下腺移植治療重症乾眼遠期淚液生化分析
期刊論文
接英|王海璐|鄒留河|
34
Prevention of radiation-induced xerostomia by submandibular gland transfer.
期刊論文
Yu Guang-Yan |Zhang Ye |Guo Chuan-Bin | Wang Yang |Peng Xin | Zhang Lei | Mao Chi |
35
調控涎腺細胞分泌的受體及其信號轉導的研究進展
期刊論文
俞光岩|吳立玲|
36
Treatment of severe keratoconjunctivitis sicca by parotid duct transposition after tympanic neurectomy in rabbits.
期刊論文
Jie Ying | Yu Guang-Yan | Chen Zhi-Yuan|
37
唾液替代淚液治療重症角結膜乾燥症
會議論文
俞光岩|
38
Proteomic analysis of human transplanted submandibular gland in patients with epiphora after transplantation.
期刊論文
Cong Xin | Wang Yang |Ding Qian-Wen | Xin Peng|Zhang Lei |Yu Guang-Yan | Xiang Ru-Lian | Ding Cong|Zhang Yan | Wu Li-Ling |
39
Microvascular Autologous Submandibular Gland Transfer in Severe Cases of Keratoconjunctivitis Sicca: A 10-year Experience
期刊論文
YU Guang Yan |WU Li Ling |LIU Xiao Jing |
40
辣椒素促進移植早期頜下腺分泌的機制研究
會議論文
張艷|
41
VR1 distribution in human submandibular gland tissue
會議論文
丁謙文 |
42
從頜下腺移植談轉化醫學
會議論文
俞光岩|
43
Activation of transient receptor potential vanilloid subtype 1 increase secretion of the hypofunctional, transplanted submandibular gland
期刊論文
Wu Li-Ling |Zhang Yan | Yu Guang-Yan |Ding Cong | Cong Xin | Ding Qian-Wen | Xiang Bin | Shi Liang |Li Yu-Ming |
44
Activation of vanilloid receptor upregulates expression of tight junction protein zonula occludens-1, claudin-3 and claudin-11 in rabbit submandibular gland
會議論文
叢馨 |
45
Carbachol improves secretion in the early phase after rabbit submandibular gland transplantation.
期刊論文
Shi Liang| Zhang Yan|Yu Guang-Yan| Ding Qian-We|Wu Li-Ling| Cong Xin|Ding Cong |Fu Feng-Ying |

項目摘要

角結膜乾燥症因可導致眼乾、視力減退甚至失明而嚴重影響患者的生活質量。自體頜下腺移植,以頜下腺分泌液代替淚液已成為治療重症角結膜乾燥症行之有效的新方法。但是,移植頜下腺失去交感和副交感神經支配,調控其分泌的機制尚不清楚。本項目聯合口腔科學、眼科學和基礎醫學的力量,採用分子生物學、生理學、病理學和蛋白質組學的方法,以新發現的頜下腺辣椒素受體為重點,探討其調控正常頜下腺分泌的分子機制;在移植頜下腺的研究中以辣椒素受體和M受體為中心, 對人和家兔移植腺體的結構、功能、基因和蛋白表達、細胞信號轉導等進行研究,探討休眠期和淚溢時調控分泌的受體及其信號轉導途徑的變化規律及機制;針對休眠期腺體分泌過少,而術後遠期部分移植腺體分泌過多的臨床問題,探索人工調控移植頜下腺分泌的新途徑。該研究不但可以加深對正常及移植頜下腺分泌機制的理論認識,而且為提高自體頜下腺移植治療重症角結膜乾燥症的近遠期療效奠定基礎。

相關詞條

熱門詞條

聯絡我們