楊金娥,女,博士,中山大學生命科學學院副教授、博士生導師。
基本介紹
研究方向
個人經歷
講授課程
學術成果
承擔課題
- 國家自然基金面上項目(81872259)HASEP短肽在肝癌細胞增殖和凋亡中的作用及其功能網路,直接經費53萬,2019-2022年,主持,在研。
- 廣東自然基金面上項目(2017A030313107)microRNA-125b在肝纖維化中的功能及其機制,10萬,2017-2020年,主持,在研。
- 國家自然基金面上項目(81572400) 長非編碼RNA 在肝癌發生髮展中的作用及機制,68.4萬,2016-2019年,主持,在研。
- 廣東自然基金面上項目(2014A030313119) 凋亡相關長非編碼RNA在肝癌發生髮展中的作用及其機制,10萬,2015-2018年,主持,已結題。
- 國家自然基金面上項目(81172343) 肝癌中microRNA-101表達調控的機制及其臨床意義,58萬,2012-2015年,主持,已結題。
- 高校基本科研業務費中山大學青年教師培育項目(12lgpy25) miR-195的表達調控機制及其在肝癌發生髮展中的作用,10萬,2012-2014年,主持,已結題。
- 國家自然科學基金青年基金項目(30700993) 肝癌發生髮展相關的miRNA 的鑑定及其功能分析,17萬,2008-2010年, 主持,已結題。
- 廣東省自然科學博士啟動基金項目(06300465) 影響Apoptin亞細胞定位的分子機制研究,3萬,2006-2008年,主持,已結題。
- 中山大學青年教師啟動基金(2004-33000-1131087) 作用於凋亡素的蛋白激酶的篩選及其機制研究,2萬,2005-2006年, 主持,已結題。
論文專著
- Wang R, Fu T, You K, Li S, Zhao N,Yang J*, Zhuang SM*, Identification of a TGF-β-miR-195 positive feedback loop in hepatocytes and its deregulation in hepatoma cells.Faseb J, 2018, in press, PMID: 29465312.(IF= 5.5)
- You K, Li SY, Gong J, Fang JH, Zhang C, Zhang M, Yuan Y,Yang J*, Zhuang SM*. MicroRNA-125b promotes hepatic stellate cell activation and liver fibrosis by activating RhoA signaling.Mol Ther-Nucl Acids, 2018, 12: 57-66. (IF=6.4).
- Yang J, Lu Y, Lin YY, Zheng ZY, Fang JH, He S, Zhuang SM. Vascular mimicry formation is promoted by paracrine TGF-beta and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma. Cancer Lett 2016;383:18-27.(IF= 6.4)
- Zhao N, Li S, Wang R, Xiao M, Meng Y, Zeng C, Fang JH,Yang J*, Zhuang SM*. Expression of microRNA-195 is transactivated by Sp1 but inhibited by histone deacetylase 3 in hepatocellular carcinoma cells.BBA- Gene Regul Mech2016;1859: 933-42.(IF= 5.0)
- Liu JJ, Lin XJ, Yang X, Zhou L, He S, Zhuang SM*,Yang J*. A novel AP-1/miR-101 regulatory feedback loop and its implication in the migration and invasion of hepatoma cells.Nucleic Acids Res2014,42(19):12041-51. (IF= 10.2)
- Ge YY, Shi Q, Zheng ZY, Gong J, Zeng C,Yang J, Zhuang SM*. MicroRNA-100 promotes the autophagy of hepatocellular carcinoma cells by inhibiting the expression of mTOR and IGF-1R. Oncotarget2014, 5(15):6218-28. (IF= 5.2)
- Zhou HC, Fang JH, Luo X, Zhang L,Yang J, Zhang C, Zhuang SM*. Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells.Oncotarget2014, 5(23):12177-88. (IF= 5.2)
- Yang J, Hu X, Zimmerman M, Torres CM, Yang D, Smith SB, Liu K. Cutting Edge: IRF8 Regulates Bax Transcription In Vivo in Primary Myeloid Cells.J Immunol2011,187:4426-30.(IF= 4.9)
- Fang JH, Zhou HC, Zeng C,Yang J, Liu Y, Huang X, Zhang JP, et al.MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression.Hepatology2011,54:1729-40.(IF= 13.2)
- Hu X, Yang D, Zimmerman M, Liu F,Yang J, Kannan S, Burchert A, et al.IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia.Cancer Res2011,71:2882-91.(IF= 9.1)
- Zhao J, Yu BY, Wang DY,Yang JE*. Promoter polymorphism of MRP1 associated with reduced survival in hepatocellular carcinoma.World J Gastroenterol2010,16:6104-10. (IF= 3.4)
- Xiong Y, Fang JH, Yun JP,Yang J, Zhang Y, Jia WH, Zhuang SM. Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma.Hepatology,51:836-45.(IF= 13.2)
- Luo J,Yang J, Yu BY, Liu W, Li M, Zhuang SM. Identification of Siah-interacting protein as a potential regulator of apoptosis and curcumin resistance.Oncogene2010,29:6357-66.(IF= 7.5)
- Yang J, Zhou F, Xu T, Deng H, Ge YY, Zhang C, Li J, et al.Analysis of sequence variations in 59 microRNAs in hepatocellular carcinomas.Mutat Res2008,638:205-9.(IF= 1.8)
- Huo DH, Yi LN,Yang J*. Interaction with Ppil3 leads to the cytoplasmic localization of Apoptin in tumor cells.Biochem Bioph Res Co2008,372:14-8. (IF= 2.5)
- Cheng J, Huo DH, Kuang DM,Yang J, Zheng L, Zhuang SM. Human macrophages promote the motility and invasiveness of osteopontin-knockdown tumor cells.Cancer Res2007,67:5141-7.(IF= 9.1)
- Hu LL, Wang XX, Chen X, Chang J, Li C, Zhang Y,Yang J, et al.BCRP gene polymorphisms are associated with susceptibility and survival of diffuse large B-cell lymphoma.Carcinogenesis2007,28:1740-4.(IF= 5.1)