李鮮嬋，女，漢族，理學博士，北京大學藥學院研究員、課題組長、博士生導師。曾任職中央民族大學生命與環境科學學院教授。
基本介紹
- 中文名：李鮮嬋
- 民族：漢族
- 畢業院校：中科院化學所
- 學位/學歷：博士
- 職業：教師
- 專業方向：神經化學信號轉導的分析化學研究等
- 職稱：教授
- 任職院校：中央民族大學
個人簡歷,人物經歷,主講課程,研究方向,研究成果,代表性論文,
個人簡歷
● 2000-2004 北京大學藥學院 學士
● 2004-2009 中國科學院化學研究所 博士
● 2009-2013 中國科學院化學研究所 助理研究員
● 2013-2015 瑞典查爾姆斯理工大學 博士後
● 2015-2018 瑞典哥德堡大學 研究員
● 2019-2021 中央民族大學 教授、課題組長、博士生導師
● 2021-北京大學藥學院 研究員、課題組長、博士生導師
人物經歷
2004年於北京大學取得學士學位，2009年於中科院化學所取得博士學位，隨後留所任助理研究員至2013年4月。2013年4月至2015年4月在瑞典查爾姆斯理工大學從事博士後研究（合作導師Andrew G. Ewing教授）。2015年4月至2018年6月在瑞典哥德堡大學任researcher。
任J. Am. Chem. Soc.、PNAS、Angew. Chem. Int. Ed.、Anal. Chem.、Analyst、Electrochem. Commun.、Anal. Bioanal. Chem.等國際著名期刊同行評閱人。
主講課程
表面與膠體化學
研究方向
● 微納電化學感測策略和藥物分析套用
● 神經化學信號轉導的分析與生理藥理調控
● 生物分析策略與藥物開發
● 神經系統疾病分子機制、藥物新靶點發現及藥物干預機制研究
研究成果
主持教學和科研項目
1.國家自然科學基金面上項目（68萬）：主持（2020-2023）
3.國家自然科學青年基金項目（22萬）：主持（2011-2013）
4.國家自然科學基金委重點項目（300萬）：主要參與人（2012-2016）
5.國家自然科學基金委重大國際合作研究項目（220萬）：主要參與人（2011-2013）
代表性論文
1. Mengying Wang, Yuying Liu, Jinchang Du, Junlan Zhou, Lijiao Cao, Xianchan Li*，Cisplatin Inhibits Neurotransmitter Release during Exocytosis from Single Chromaffin Cells Monitored with Single Cell Amperometry. Electroanalysis, 2021. DOI: 10.1002/elan.202100398
2. Yuying Liu,Jinchang Du,Mengying Wang, Jing Zhang, Chunlan Liu* and Xianchan Li*, Recent Progress in Quantitatively Monitoring Vesicular Neurotransmitter Release and Storage with Micro/Nanoelectrodes. Front. Chem. 2021, 8, 591311. (Invited)
3. Qingwei Yue,Xianchan Li, Fei Wu, Wenliang Ji, Yue Zhang, Ping Yu, Meining Zhang, Wenjie Ma, Ming Wang, Lanqun Mao*. Unveiling the Role of DJ‐1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro‐Tip Electrodes, Angew. Chem. Int. Ed. 2020, 59, 11061– 11065. (Co-first authors)
4. Dalei Wang,Xianchan Li, Ying Jiang, Yanan Jiang, Wenjie Ma, Ping Yu, and Lanqun Mao*. Ischemic Postconditioning Recovers Cortex Ascorbic Acid during Ischemia/Reperfusion Monitored with an Online Electrochemical System. ACS Chem. Neurosci. 2019, 10, 2576-2583. (Co-first authors)
5. Tongfang Xiao,Xianchan Li, Huan Wei, Wenliang Ji, Qingwei Yue, Ping Yu, Lanqun MaoIn Vivo Monitoring of Oxygen Fluctuation Simultaneously at Multiple Sites of Rat Cortex during Spreading Depression. Anal. Chem. 2018, 90, 13783-13789. (Co-first authors)
6. Amir S Mohammadi,Xianchan Li, Andrew G. Ewing*. Mass Spectrometry Imaging Suggests That Cisplatin Affects Exocytotic Release by Alteration of Cell Membrane Lipids. Anal. Chem. 2018, 90, 8509-8516. (Co-first authors)
7. Xianchan Li, Lin Ren, Johan Dunevall, Daixin Ye, Henry S. White, Martin A. Edwards*, Andrew G. Ewing*. On the Nanopore Opening at Flat and Nano-Tip Conical Electrodes during Vesicle Impact Electrochemical Cytometry. ACS Nano, 2018,12, 3010-3019.
8. Xianchan Li, Johan Dunevall, Lin Ren, Andrew G. Ewing*. Mechanistic Aspects of Vesicle Opening during Analysis with Vesicle Impact Electrochemical Cytometry. Anal. Chem. 2017, 89, 9416？9423.
9. Nhu T.N. Phan, Xianchan Li, Andrew G. Ewing*. Measurement of synaptic vesicles: from the chemical content to structure and activity using cellular electrochemistry and nanoscale molecular imaging. Nature Reviews Chemistry, 2017, 1, 0048.
10. Xianchan Li, Johan Dunevall, Andrew G. Ewing*. Quantitative Chemical Measurements of Vesicular Transmitters with Electrochemical Cytometry. Acc. Chem. Res. 2016, 49, 2347-2354.
11. Xianchan Li, Johan Dunevall, Andrew G. Ewing*. Using Single-Cell Amperometry to Reveal How Cisplatin Treatment Modulates the Release of Catecholamine Transmitters during Exocytosis. Angew. Chem. Int. Ed. 2016, 55, 9041-9044. Cover: Angew. Chem. Int. Ed. 2016, 55, 9098.
12. Xianchan Li, Soodabeh Majdi, Johan Dunevall, Hoda Fathali, Andrew G. Ewing*. Quantitative Measurement of Transmitters in Individual Vesicles in the Cytoplasm of Single Cells with Nanotip Electrodes. Angew. Chem. Int. Ed. 2015, 54, 11978-11982.
13. Xianchan Li, Ping Yu, Lifen Yang, Fuyi Wang, Lanqun Mao*. An Electrochemical Method for Investigation of Conformational Flexibility of Active Sites of Trametes versicolor Laccase Based on Sensitive Determination of Copper Ion with Cysteine-Modified Electrodes. Anal.Chem. 2012, 84, 9416-9421.
14. Xianchan Li, Lingzhi Zhao, Zhenling Chen, Yuqing Lin, Ping Yu, Lanqun Mao*. Continuous Electrochemical Monitoring of Extracellular Lactate Production from Neonatal Rat Cardiomyocytes following Myocardial Hypoxia. Anal.Chem. 2012, 84, 5285-5291.
15. Xianchan Li, Wei Zheng, Limin Zhang, Ping Yu, Yuqing Lin, Lei Su, Lanqun Mao*. Effective Electrochemical Method for Investigation of Hemoglobin Unfolding Based on the Redox Property of Heme Groups at Glassy Carbon Electrodes. Anal. Chem. 2009, 81, 8557-8563.
